Constitutive androstane receptor pathway

Pathway network for the Constitutive androstane receptor pathway SuperPath

Sources:

WikiPathways
PharmGKB

Pathways in the Constitutive androstane receptor pathway SuperPath

#	Name	Source	Genes
1	Constitutive androstane receptor pathway	WikiPathways	ABCB1 ABCC2 ABCC3 ALAS1 CYP2A6 CYP2B6 CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP4A11 DNAJC7 EHHADH FOXO1 GSTA2 HSP90AA1 NCOA1 NCOA2 NCOA6 NR1I3 PPARGC1A PTPA RXRA SMC1A SP1 SULT1A1 SULT2A1 UGT1A1 UGT1A4 UGT1A6 UGT1A9 (see all 31) (see less)
2	Pregnane X receptor pathway	WikiPathways	ABCB1 ABCC2 ABCC3 ABCC4 CYP2A6 CYP2B6 CYP2C19 CYP2C9 CYP3A4 CYP3A5 CYP3A7 CYP4F12 DNAJC7 FOXO1 GSTA2 HSP90AA1 NCOA1 NCOA2 NCOA3 NR1I2 NRIP1 PPARGC1A PSMC5 RXRA SLCO1B1 SRC SRPX2 SULT2A1 UGT1A1 UGT1A4 UGT1A6 UGT1A9 (see all 32) (see less)
3	Propofol Pathway, Pharmacokinetics	PharmGKB	CYP2B6 CYP2C9 SULT1A1 UGT1A9

Gene overlap in member pathways for Constitutive androstane receptor pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	3
2	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	3
3	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	3
4	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	2
5	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	2
6	DNAJC7	DnaJ Heat Shock Protein Family (Hsp40) Member C7	Protein Coding	2
7	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	2
8	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	2
9	RXRA	Retinoid X Receptor Alpha	Protein Coding	2
10	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	2
11	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	2
12	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	2
13	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	2
14	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
15	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	2
16	FOXO1	Forkhead Box O1	Protein Coding	2
17	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	2
18	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	2
19	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	2
20	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	2
21	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	2
22	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	2
23	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	2
24	NR1I3	Nuclear Receptor Subfamily 1 Group I Member 3	Protein Coding	1
25	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
26	SP1	Sp1 Transcription Factor	Protein Coding	1
27	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
28	NCOA6	Nuclear Receptor Coactivator 6	Protein Coding	1
29	ALAS1	5''-Aminolevulinate Synthase 1	Protein Coding	1
30	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	1
31	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	1
32	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
33	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
34	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	1
35	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
36	CYP4F12	Cytochrome P450 Family 4 Subfamily F Member 12	Protein Coding	1
37	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
38	SRPX2	Sushi Repeat Containing Protein X-Linked 2	Protein Coding	1
39	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	1
40	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	1
41	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1

Disorders associated with Constitutive androstane receptor pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gilbert syndrome	Enrichment	SLCO1B1, UGT1A1, UGT1A4, UGT1A6, UGT1A9	10.39
2	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	8.33
3	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	8.33
4	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	8.33
5	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	8.33
6	Bilirubin metabolic disorder	Enrichment	UGT1A1, UGT1A4, UGT1A6, UGT1A9	8.14
7	Coumarin resistance	Enrichment	CYP2A6, CYP2C9	4.82
8	Efavirenz, poor metabolism of	Enrichment	CYP2B6	3.53
9	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.64
10	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.64
11	Colchicine resistance	Enrichment	ABCB1	2.64
12	Fanconi renotubular syndrome 3	Enrichment	EHHADH	2.64
13	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.64
14	Encephalopathy, acute transient	Enrichment	ABCB1	2.64
15	Inflammatory bowel disease 13	Enrichment	ABCB1	2.64
16	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.64
17	Letrozole toxicity	Enrichment	CYP2A6	2.64
18	Rolandic epilepsy, impaired intellectual development, and speech dyspraxia, x-linked	Enrichment	SRPX2	2.63
19	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.63
20	Thrombocytopenia 6	Enrichment	SRC	2.63
21	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.34
22	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	SRPX2	2.33
23	Dubin-johnson syndrome	Enrichment	ABCC2	2.16
24	D-bifunctional protein deficiency	Enrichment	EHHADH	2.16
25	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1	2.15
26	Tobacco addiction	Enrichment	CYP2A6	2.04
27	Primary fanconi renotubular syndrome	Enrichment	EHHADH	2.04
28	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.94
29	Pseudoxanthoma elasticum	Enrichment	ABCC2	1.87
30	Wiedemann-steiner syndrome	Enrichment	SMC1A	1.87
31	Myelofibrosis	Enrichment	SRC	1.79
32	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	SRPX2	1.79
33	Rett syndrome, congenital variant	Enrichment	SMC1A	1.74
34	Cornelia de lange syndrome 1	Enrichment	SMC1A	1.69
35	Cornelia de lange syndrome	Enrichment	SMC1A	1.69
36	Bilateral perisylvian polymicrogyria	Enrichment	SRPX2	1.68
37	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.60
38	Osteoporosis	Enrichment	SRC	1.49
39	Hypertension, essential	Enrichment	CYP3A5	1.42
40	Semilobar holoprosencephaly	Enrichment	SMC1A	1.39
41	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.37
42	Lung cancer	Enrichment	CYP2A6	1.15
43	Cakut	Enrichment	NRIP1	1.11
44	Centralopathic epilepsy	Enrichment	SRPX2	1.01
45	Thrombocytopenia	Enrichment	SRC	0.97
46	Myeloma, multiple	Enrichment	RXRA	0.92
47	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.90
48	Colorectal cancer	Enrichment	SRC	0.73
49	Congenital nervous system abnormality	Enrichment	SMC1A	0.67
50	Nervous system disease	Enrichment	SMC1A	0.67
51	Microcephaly	Enrichment	SMC1A	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Constitutive androstane receptor pathway

Pathway Network for Constitutive androstane receptor pathway

Pathway network for the Constitutive androstane receptor pathway SuperPath

Member Pathways for Constitutive androstane receptor pathway

Pathways in the Constitutive androstane receptor pathway SuperPath

Gene overlap in member pathways for Constitutive androstane receptor pathway SuperPath

Associated Genes for Constitutive androstane receptor pathway

Associated Disorders for Constitutive androstane receptor pathway

Disorders associated with Constitutive androstane receptor pathway SuperPath

STRING Interaction Network for Constitutive androstane receptor pathway

Sources for Constitutive androstane receptor pathway