Constitutive Signaling by AKT1 E17K in Cancer

Pathway network for the Constitutive Signaling by AKT1 E17K in Cancer SuperPath

Sources:

Reactome
PubChem

Pathways in the Constitutive Signaling by AKT1 E17K in Cancer SuperPath

#	Name	Source	Genes
1	Constitutive Signaling by AKT1 E17K in Cancer	Reactome	AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK CREB1 FOXO1 FOXO3 FOXO4 GSK3A GSK3B MAPKAP1 MDM2 MLST8 MTOR NR4A1 PDPK1 PRR5 RICTOR RPS6KB2 TSC2 (see all 25) (see less)
2	Class I PI3K signaling events mediated by Akt	PubChem	AKT1 AKT2 AKT3 BAD BCL2L1 CASP9 CDKN1A CDKN1B CHUK FOXO1 GSK3B HSP90AA1 KPNA1 MAP3K5 MAPKAP1 MLST8 MTOR PDPK1 PRKACA PRKDC RAF1 RICTOR SFN SLC2A4 SRC TBC1D4 YWHAZ (see all 27) (see less)
3	AKT phosphorylates targets in the cytosol	Reactome	AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK GSK3A GSK3B MDM2 MKRN1 TSC2 (see all 14) (see less)
4	AKT phosphorylates targets in the nucleus	Reactome	AKT1 AKT2 AKT3 CREB1 FOXO1 FOXO3 FOXO4 NR4A1 RPS6KB2 (see all 9) (see less)
5	AKT-mediated inactivation of FOXO1A	Reactome	AKT1 AKT2 AKT3 FOXO1

Gene overlap in member pathways for Constitutive Signaling by AKT1 E17K in Cancer SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	5
2	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5
3	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	5
4	FOXO1	Forkhead Box O1	Protein Coding	4
5	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	3
6	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	3
7	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
8	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	3
9	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	3
10	CASP9	Caspase 9	Protein Coding	3
11	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
12	FOXO3	Forkhead Box O3	Protein Coding	2
13	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
14	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	2
15	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	2
16	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	2
17	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
18	FOXO4	Forkhead Box O4	Protein Coding	2
19	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
20	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	2
21	MLST8	MTOR Associated Protein MLST8	Protein Coding	2
22	TSC2	TSC Complex Subunit 2	Protein Coding	2
23	MAPKAP1	MAPK Associated Protein 1	Protein Coding	2
24	AKT1S1	AKT1 Substrate 1	Protein Coding	2
25	PRR5	Proline Rich 5	Protein Coding	1
26	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
27	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
28	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
29	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
30	TBC1D4	TBC1 Domain Family Member 4	Protein Coding	1
31	SFN	Stratifin	Protein Coding	1
32	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
33	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
34	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
35	BCL2L1	BCL2 Like 1	Protein Coding	1
36	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
37	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
38	MKRN1	Makorin Ring Finger Protein 1	Protein Coding	1

Disorders associated with Constitutive Signaling by AKT1 E17K in Cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC2	4.71
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC2	4.71
3	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	4.68
4	Hemimegalencephaly	Enrichment	AKT3, MTOR	4.49
5	Type 2 diabetes mellitus	Enrichment	AKT2, SLC2A4, TBC1D4	4.12
6	Ovarian cancer	Enrichment	AKT1, CDKN1B, TSC2	3.86
7	Proteus syndrome	Enrichment	AKT1	3.53
8	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	3.53
9	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	3.53
10	Cowden syndrome 6	Enrichment	AKT1	3.53
11	Capillary hemangioma	Enrichment	AKT3	3.53
12	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	3.53
13	Senior-loken syndrome 7	Enrichment	AKT3	3.23
14	Bardet-biedl syndrome 16	Enrichment	AKT3	3.23
15	Fetal encasement syndrome	Enrichment	CHUK	2.99
16	Accelerated tumor formation	Enrichment	MDM2	2.99
17	Lessel-kubisch syndrome	Enrichment	MDM2	2.99
18	Neuroendocrine tumor	Enrichment	CDKN1B	2.99
19	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.99
20	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.99
21	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.93
22	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.93
23	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.88
24	Rhabdomyosarcoma 2	Enrichment	FOXO1	2.83
25	Breast adenocarcinoma	Enrichment	AKT1	2.75
26	Melanoma of soft tissue	Enrichment	CREB1	2.70
27	Noonan syndrome 5	Enrichment	RAF1	2.70
28	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.70
29	Type 2 diabetes 5	Enrichment	TBC1D4	2.70
30	Leopard syndrome 2	Enrichment	RAF1	2.70
31	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.70
32	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.70
33	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.70
34	Thrombocytopenia 6	Enrichment	SRC	2.70
35	Trigonitis	Enrichment	RAF1	2.70
36	Megacolon	Enrichment	AKT3	2.69
37	Lymphangioleiomyomatosis	Enrichment	TSC2	2.69
38	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.69
39	Cowden syndrome	Enrichment	AKT1	2.58
40	Polymicrogyria	Enrichment	AKT3	2.53
41	Tuberous sclerosis 1	Enrichment	TSC2	2.51
42	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.51
43	Tuberous sclerosis 2	Enrichment	TSC2	2.51
44	Dedifferentiated liposarcoma	Enrichment	MDM2	2.51
45	Hamartoma	Enrichment	TSC2	2.51
46	Xanthinuria, type ii	Enrichment	TSC2	2.51
47	Well-differentiated liposarcoma	Enrichment	MDM2	2.51
48	Meningioma	Enrichment	AKT1	2.45
49	Cebalid syndrome	Enrichment	MTOR	2.43
50	Smith-kingsmore syndrome	Enrichment	MTOR	2.43
51	Fibrolamellar carcinoma	Enrichment	PRKACA	2.40
52	Tuberous sclerosis	Enrichment	TSC2	2.38
53	Primary hyperparathyroidism	Enrichment	CDKN1B	2.38
54	Diffuse large b-cell lymphoma	Enrichment	FOXO1	2.25
55	Li-fraumeni syndrome	Enrichment	MDM2	2.21
56	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	2.14
57	Polycystic kidney disease 1	Enrichment	TSC2	2.14
58	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, TSC2	2.10
59	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	2.10
60	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.10
61	Adult hepatocellular carcinoma	Enrichment	TSC2	2.03
62	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.89
63	Overgrowth syndrome	Enrichment	MTOR	1.89
64	Colorectal cancer	Enrichment	AKT1, SRC	1.89
65	Hereditary breast carcinoma	Enrichment	AKT1	1.89
66	Myelofibrosis	Enrichment	SRC	1.86
67	Noonan syndrome 3	Enrichment	RAF1	1.86
68	Pilomyxoid astrocytoma	Enrichment	RAF1	1.86
69	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.81
70	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.80
71	Ellis-van creveld syndrome	Enrichment	PRKACA	1.75
72	Breast cancer	Enrichment	AKT1	1.66
73	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.56
74	Rare genetic intellectual disability	Enrichment	MTOR	1.56
75	Osteoporosis	Enrichment	SRC	1.56
76	Noonan syndrome and noonan-related syndrome	Enrichment	RAF1	1.53
77	Bladder cancer	Enrichment	CDKN1A	1.53
78	West syndrome	Enrichment	TSC2	1.35
79	Noonan syndrome 1	Enrichment	RAF1	1.35
80	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.33
81	Rasopathy	Enrichment	RAF1	1.30
82	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.20
83	Left ventricular noncompaction	Enrichment	RAF1	1.17
84	Thrombocytopenia	Enrichment	SRC	1.04
85	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	1.02
86	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.00
87	Primary ovarian insufficiency	Enrichment	RICTOR	0.99
88	Congenital nervous system abnormality	Enrichment	TSC2	0.98
89	Nervous system disease	Enrichment	TSC2	0.98
90	Autism spectrum disorder	Enrichment	TSC2	0.97
91	Dilated cardiomyopathy	Enrichment	RAF1	0.83

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Constitutive Signaling by AKT1 E17K in Cancer

Pathway Network for Constitutive Signaling by AKT1 E17K in Cancer

Pathway network for the Constitutive Signaling by AKT1 E17K in Cancer SuperPath

Member Pathways for Constitutive Signaling by AKT1 E17K in Cancer

Pathways in the Constitutive Signaling by AKT1 E17K in Cancer SuperPath

Gene overlap in member pathways for Constitutive Signaling by AKT1 E17K in Cancer SuperPath

Associated Genes for Constitutive Signaling by AKT1 E17K in Cancer

Associated Disorders for Constitutive Signaling by AKT1 E17K in Cancer

Disorders associated with Constitutive Signaling by AKT1 E17K in Cancer SuperPath

STRING Interaction Network for Constitutive Signaling by AKT1 E17K in Cancer

Sources for Constitutive Signaling by AKT1 E17K in Cancer