Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Pathway network for the Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

Sources:

Reactome

Pathways in the Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

#	Name	Source	Genes
1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Reactome	ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC (see all 58) (see less)
2	Signaling by NOTCH1	Reactome	ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CCNC CDK8 CNTN1 CREBBP CUL1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A ITCH JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NBEA NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC (see all 74) (see less)
3	Signaling by NOTCH1 PEST Domain Mutants in Cancer	Reactome	ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC (see all 58) (see less)
4	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	Reactome	ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC (see all 58) (see less)
5	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Reactome	ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC (see all 58) (see less)
6	Signaling by NOTCH1 in Cancer	Reactome	ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 DLL1 DLL4 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL JAG1 JAG2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MIB1 MIB2 MYC NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 PSEN1 PSEN2 PSENEN RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 UBA52 UBB UBC (see all 58) (see less)
7	NOTCH1 Intracellular Domain Regulates Transcription	Reactome	CCNC CDK8 CREBBP CUL1 EP300 FBXW7 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MYC NBEA NCOR1 NCOR2 NOTCH1 RBPJ RBX1 RPS27A SKP1 SNW1 TBL1X TBL1XR1 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC (see all 48) (see less)

Gene overlap in member pathways for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HDAC6	Histone Deacetylase 6	Protein Coding	7
2	HDAC5	Histone Deacetylase 5	Protein Coding	7
3	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	7
4	CDK8	Cyclin Dependent Kinase 8	Protein Coding	7
5	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	7
6	EP300	EP300 Lysine Acetyltransferase	Protein Coding	7
7	SNW1	SNW Domain Containing 1	Protein Coding	7
8	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	7
9	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	7
10	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	7
11	HEYL	Hes Related Family BHLH Transcription Factor With YRPW Motif Like	Protein Coding	7
12	HDAC1	Histone Deacetylase 1	Protein Coding	7
13	HDAC2	Histone Deacetylase 2	Protein Coding	7
14	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	7
15	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	7
16	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	7
17	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	7
18	NOTCH1	Notch Receptor 1	Protein Coding	7
19	HDAC7	Histone Deacetylase 7	Protein Coding	7
20	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	7
21	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	7
22	HDAC8	Histone Deacetylase 8	Protein Coding	7
23	RPS27A	Ribosomal Protein S27a	Protein Coding	7
24	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	7
25	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	7
26	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	7
27	UBB	Ubiquitin B	Protein Coding	7
28	UBC	Ubiquitin C	Protein Coding	7
29	TBL1XR1	TBL1X/Y Related 1	Protein Coding	7
30	HDAC11	Histone Deacetylase 11	Protein Coding	7
31	HDAC10	Histone Deacetylase 10	Protein Coding	7
32	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	7
33	CUL1	Cullin 1	Protein Coding	7
34	HDAC3	Histone Deacetylase 3	Protein Coding	7
35	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	7
36	CCNC	Cyclin C	Protein Coding	7
37	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	7
38	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	7
39	HDAC9	Histone Deacetylase 9	Protein Coding	7
40	HDAC4	Histone Deacetylase 4	Protein Coding	7
41	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	7
42	RBX1	Ring-Box 1	Protein Coding	7
43	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	6
44	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	6
45	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	6
46	NCSTN	Nicastrin	Protein Coding	6
47	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	6
48	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	6
49	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	6
50	NEURL1B	Neuralized E3 Ubiquitin Protein Ligase 1B	Protein Coding	6
51	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	6
52	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	6
53	PSEN1	Presenilin 1	Protein Coding	6
54	PSEN2	Presenilin 2	Protein Coding	6
55	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	6
56	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	6
57	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	6
58	NEURL1	Neuralized E3 Ubiquitin Protein Ligase 1	Protein Coding	6
59	NBEA	Neurobeachin	Protein Coding	2
60	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	2
61	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	2
62	TLE2	TLE Family Member 2, Transcriptional Corepressor	Protein Coding	2
63	TLE3	TLE Family Member 3, Transcriptional Corepressor	Protein Coding	2
64	TLE4	TLE Family Member 4, Transcriptional Corepressor	Protein Coding	2
65	DTX2	Deltex E3 Ubiquitin Ligase 2	Protein Coding	1
66	CNTN1	Contactin 1	Protein Coding	1
67	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
68	DTX4	Deltex E3 Ubiquitin Ligase 4	Protein Coding	1
69	ARRB1	Arrestin Beta 1	Protein Coding	1
70	ARRB2	Arrestin Beta 2	Protein Coding	1
71	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
72	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
73	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
74	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1

Disorders associated with Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-cell acute lymphoblastic leukemia	Direct
2	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	5.59
3	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	4.27
4	Tetralogy of fallot	Enrichment	HEY2, JAG1, NOTCH1	3.75
5	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.74
6	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.74
7	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	3.43
8	Myeloma, multiple	Enrichment	CREBBP, HDAC4, NCOR2	3.00
9	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.90
10	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TBL1XR1	2.70
11	Heart, malformation of	Enrichment	CDK8, JAG1	2.58
12	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.45
13	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.45
14	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.45
15	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.45
16	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.45
17	Hypospadias 2, x-linked	Enrichment	MAMLD1	2.45
18	Neurodevelopmental disorder with or without early-onset generalized epilepsy	Enrichment	NBEA	2.45
19	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.45
20	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.45
21	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.45
22	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.45
23	Menke-hennekam syndrome	Enrichment	CREBBP	2.45
24	46,xy ovotesticular disorder of sex development	Enrichment	MAMLD1	2.45
25	Acne inversa, familial, 1	Enrichment	NCSTN	2.37
26	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.37
27	Adams-oliver syndrome 6	Enrichment	DLL4	2.37
28	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.37
29	Alzheimer disease 18	Enrichment	ADAM10	2.37
30	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.37
31	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.37
32	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.37
33	Acne inversa, familial, 3	Enrichment	PSEN1	2.37
34	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.37
35	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.37
36	Pash syndrome	Enrichment	NCSTN	2.37
37	Huntington's disease-like	Enrichment	PSEN2	2.37
38	Congenital myopathy 12	Enrichment	CNTN1	2.26
39	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.26
40	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.26
41	Burkitt lymphoma	Enrichment	MYC	2.15
42	Thumb deformity	Enrichment	CREBBP	2.15
43	Ebstein anomaly	Enrichment	CDK8	2.15
44	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.15
45	Syndactyly, type iii	Enrichment	HDAC8	2.15
46	Adams-oliver syndrome 3	Enrichment	RBPJ	2.15
47	Cerebellar, ocular, craniofacial, and genital syndrome	Enrichment	NBEA	2.15
48	Menke-hennekam syndrome 2	Enrichment	EP300	2.15
49	Wilson-turner syndrome	Enrichment	HDAC8	2.15
50	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.15
51	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	2.15
52	Posterior hypospadias	Enrichment	MAMLD1	2.15
53	X-linked myotubular myopathy-abnormal genitalia syndrome	Enrichment	MAMLD1	2.15
54	Submucosal cleft palate	Enrichment	UBB	2.15
55	Cleft hard palate	Enrichment	UBB	2.15
56	Alzheimer disease 3	Enrichment	PSEN1	2.07
57	Pick disease of brain	Enrichment	PSEN1	2.07
58	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.07
59	Left ventricular noncompaction 7	Enrichment	MIB1	2.07
60	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.07
61	Left ventricular noncompaction	Enrichment	MIB1, MIB2	2.01
62	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	HEY2, NOTCH1	1.98
63	Uvula, bifid	Enrichment	UBB	1.98
64	Pierpont syndrome	Enrichment	TBL1XR1	1.98
65	Cleft soft palate	Enrichment	UBB	1.98
66	Tethered spinal cord syndrome	Enrichment	CREBBP	1.98
67	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.98
68	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.98
69	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.98
70	Enchondromatosis	Enrichment	HIF1A	1.98
71	Keratoacanthoma	Enrichment	NOTCH1	1.98
72	Central precocious puberty	Enrichment	DLK1	1.96
73	Alagille syndrome 1	Enrichment	JAG1	1.89
74	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	1.89
75	Precocious puberty, central, 2	Enrichment	DLK1	1.79
76	Dowling-degos disease 1	Enrichment	ADAM10	1.77
77	Dowling-degos disease	Enrichment	PSENEN	1.77
78	Middle aortic syndrome	Enrichment	JAG1	1.77
79	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.76
80	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.76
81	Pervasive developmental disorder	Enrichment	FBXW7	1.76
82	Rare pervasive developmental disorder	Enrichment	FBXW7	1.76
83	Hypertrichosis	Enrichment	CREBBP	1.68
84	Aplasia cutis congenita	Enrichment	DLL4	1.67
85	Dementia	Enrichment	PSEN1	1.67
86	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	1.67
87	Kagami-ogata syndrome	Enrichment	DLK1	1.66
88	Temple syndrome	Enrichment	DLK1	1.66
89	Genetic central precocious puberty in male	Enrichment	DLK1	1.66
90	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.61
91	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.60
92	Autism	Enrichment	CREBBP, NBEA	1.57
93	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.55
94	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.55
95	Semantic dementia	Enrichment	PSEN1	1.53
96	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1, NBEA	1.52
97	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.50
98	Charge syndrome	Enrichment	EP300	1.50
99	Cornelia de lange syndrome	Enrichment	HDAC8	1.50
100	Progressive non-fluent aphasia	Enrichment	PSEN1	1.42
101	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.42
102	Colorectal cancer	Enrichment	EP300, FBXW7	1.42
103	Atrial heart septal defect	Enrichment	HDAC8	1.42
104	Interatrial communication	Enrichment	HDAC8	1.42
105	Aortic valve disease 1	Enrichment	NOTCH1	1.35
106	Diaphragmatic hernia, congenital	Enrichment	CDK8	1.35
107	Acute promyelocytic leukemia	Enrichment	TBL1XR1	1.35
108	Frontotemporal dementia 1	Enrichment	PSEN1	1.34
109	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.31
110	Heart disease	Enrichment	CREBBP	1.31
111	Polydactyly, postaxial, type a1	Enrichment	EP300	1.29
112	Corpus callosum, agenesis of	Enrichment	CREBBP	1.29
113	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.29
114	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.29
115	Alzheimer's disease	Enrichment	PSEN1	1.27
116	Hydrocephalus, congenital, 1	Enrichment	CDK8	1.26
117	Polycystic kidney disease	Enrichment	HDAC8	1.21
118	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.21
119	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.21
120	Microform holoprosencephaly	Enrichment	DLL1	1.18
121	Lobar holoprosencephaly	Enrichment	DLL1	1.18
122	Microcephaly	Enrichment	EP300, HDAC8	1.15
123	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.15
124	Alobar holoprosencephaly	Enrichment	DLL1	1.15
125	Semilobar holoprosencephaly	Enrichment	DLL1	1.13
126	Congenital nervous system abnormality	Enrichment	CREBBP, PSEN1	1.12
127	Nervous system disease	Enrichment	CREBBP, PSEN1	1.12
128	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.11
129	Scoliosis	Enrichment	CREBBP	1.09
130	Hepatoblastoma	Enrichment	JAG1	1.06
131	Skin disease	Enrichment	NCSTN	1.05
132	Connective tissue disease	Enrichment	NOTCH1	0.97
133	Epilepsy	Enrichment	NBEA	0.88
134	Type 2 diabetes mellitus	Enrichment	RBPJ	0.86
135	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.66
136	Autism spectrum disorder	Enrichment	NBEA	0.49
137	Complex neurodevelopmental disorder	Enrichment	CDK8	0.45
138	Hereditary retinal dystrophy	Enrichment	JAG1	0.15
139	Fundus dystrophy	Enrichment	JAG1	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Pathway Network for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Pathway network for the Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

Member Pathways for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Pathways in the Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

Gene overlap in member pathways for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

Associated Genes for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Associated Disorders for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Disorders associated with Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SuperPath

STRING Interaction Network for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Sources for Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants