Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Pathway network for the Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

Sources:

Reactome

Pathways in the Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

#	Name	Source	Genes
1	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	Reactome	ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 (see all 33) (see less)
2	Prefoldin mediated transfer of substrate to CCT/TriC	Reactome	ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 TUBA1A TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 (see all 28) (see less)
3	Formation of tubulin folding intermediates by CCT/TriC	Reactome	CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 TCP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 (see all 26) (see less)
4	Folding of actin by CCT/TriC	Reactome	ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 TCP1 (see all 10) (see less)

Gene overlap in member pathways for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CCT7	Chaperonin Containing TCP1 Subunit 7	Protein Coding	4
2	CCT4	Chaperonin Containing TCP1 Subunit 4	Protein Coding	4
3	CCT2	Chaperonin Containing TCP1 Subunit 2	Protein Coding	4
4	CCT6B	Chaperonin Containing TCP1 Subunit 6B	Protein Coding	4
5	CCT8	Chaperonin Containing TCP1 Subunit 8	Protein Coding	4
6	CCT5	Chaperonin Containing TCP1 Subunit 5	Protein Coding	4
7	TCP1	T-Complex 1	Protein Coding	4
8	CCT3	Chaperonin Containing TCP1 Subunit 3	Protein Coding	4
9	CCT6A	Chaperonin Containing TCP1 Subunit 6A	Protein Coding	4
10	TUBB3	Tubulin Beta 3 Class III	Protein Coding	3
11	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	3
12	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	3
13	TUBA3D	Tubulin Alpha 3d	Protein Coding	3
14	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	3
15	ACTB	Actin Beta	Protein Coding	3
16	TUBA4A	Tubulin Alpha 4a	Protein Coding	3
17	TUBA3C	Tubulin Alpha 3c	Protein Coding	3
18	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	3
19	TUBA1A	Tubulin Alpha 1a	Protein Coding	3
20	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	3
21	TUBB6	Tubulin Beta 6 Class V	Protein Coding	3
22	TUBA1C	Tubulin Alpha 1c	Protein Coding	3
23	TUBA1B	Tubulin Alpha 1b	Protein Coding	2
24	PFDN6	Prefoldin Subunit 6	Protein Coding	2
25	TUBA3E	Tubulin Alpha 3e	Protein Coding	2
26	TUBA8	Tubulin Alpha 8	Protein Coding	2
27	PFDN1	Prefoldin Subunit 1	Protein Coding	2
28	PFDN2	Prefoldin Subunit 2	Protein Coding	2
29	PFDN4	Prefoldin Subunit 4	Protein Coding	2
30	PFDN5	Prefoldin Subunit 5	Protein Coding	2
31	VBP1	VHL Binding Protein 1	Protein Coding	2
32	TUBAL3	Tubulin Alpha Like 3	Protein Coding	2
33	TUBA4B	Tubulin Alpha 4b	Protein Coding	2

Disorders associated with Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	8.20
2	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	7.60
3	Lissencephaly	Enrichment	TUBA1A, TUBA3E, TUBB2B, TUBB3	7.21
4	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	6.90
5	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	4.13
6	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.90
7	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	3.80
8	Baraitser-winter syndrome 1	Enrichment	ACTB	3.13
9	Intellectual developmental disorder with polymicrogyria and seizures	Enrichment	TCP1	3.13
10	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	3.13
11	Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive	Enrichment	CCT5	3.13
12	Autosomal recessive sensory neuropathy with spastic paraplegia	Enrichment	CCT5	3.13
13	Becker nevus syndrome	Enrichment	ACTB	3.13
14	Dystonia-deafness syndrome 1	Enrichment	ACTB	3.13
15	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	3.13
16	Baraitser-winter syndrome	Enrichment	ACTB	3.13
17	Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination	Enrichment	CCT3	3.13
18	Congenital smooth muscle hamartoma	Enrichment	ACTB	3.13
19	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	3.13
20	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	2.83
21	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.72
22	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.72
23	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.72
24	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.72
25	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.72
26	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.72
27	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.72
28	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.72
29	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.72
30	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.72
31	Congenital myopathy 26	Enrichment	TUBA4A	2.72
32	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.72
33	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.72
34	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.72
35	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	2.60
36	Aminoacylase 1 deficiency	Enrichment	ACTB	2.53
37	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.53
38	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.42
39	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.42
40	Keratoconus 9	Enrichment	TUBA3D	2.42
41	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.42
42	Lissencephaly 3	Enrichment	TUBA1A	2.42
43	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.42
44	Torsion dystonia 4	Enrichment	TUBB4A	2.42
45	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.42
46	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	2.24
47	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	2.24
48	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	2.24
49	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.94
50	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.94
51	Leber plus disease	Enrichment	CCT2, TUBB4B	1.85
52	Cryptorchidism	Enrichment	TUBA1A	1.82
53	Myocardial infarction	Enrichment	CCT7	1.79
54	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.77
55	Congenital nervous system abnormality	Enrichment	TUBA1A, TUBB4A	1.76
56	Nervous system disease	Enrichment	TUBA1A, TUBB4A	1.76
57	Congenital hypothyroidism	Enrichment	TUBB1	1.64
58	Microcephaly	Enrichment	ACTB, TUBB4A	1.58
59	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.55
60	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.55
61	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.55
62	Isolated congenital microcephaly	Enrichment	TUBA3E	1.52
63	Dandy-walker syndrome	Enrichment	TUBA1A	1.49
64	Auditory neuropathy	Enrichment	TUBB4A	1.31
65	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	1.16
66	Optic atrophy plus syndrome	Enrichment	TUBB6	1.09
67	West syndrome	Enrichment	TUBA1A	1.09
68	Thrombocytopenia	Enrichment	TUBB1	1.05
69	Spastic ataxia	Enrichment	TUBB3	1.01

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Pathway Network for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Pathway network for the Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

Member Pathways for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Pathways in the Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

Gene overlap in member pathways for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

Associated Genes for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Associated Disorders for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Disorders associated with Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding SuperPath

STRING Interaction Network for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding

Sources for Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding