COPI-independent Golgi-to-ER retrograde traffic

Pathway network for the COPI-independent Golgi-to-ER retrograde traffic SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the COPI-independent Golgi-to-ER retrograde traffic SuperPath

#	Name	Source	Genes
1	COPI-independent Golgi-to-ER retrograde traffic	Reactome	ACTR10 ACTR1A AGPAT3 BICD1 BICD2 CAPZA1 CAPZA2 CAPZA3 CAPZB DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 GALNT1 GALNT2 PAFAH1B1 PAFAH1B2 PAFAH1B3 PLA2G4A PLA2G6 RAB18 RAB3GAP1 RAB3GAP2 RAB6A RAB6B TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 53) (see less)
2	Cell cycle Spindle assembly and chromosome separation	GeneGo (Thomson Reuters)	ACTB ACTR10 ACTR1A ACTR1B ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 AURKA AURKB CAPZA1 CAPZA2 CAPZA3 CAPZB CCNB1 CCNB2 CCNB3 CDC16 CDC20 CDC23 CDC26 CDC27 CDK1 CSE1L DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 ESPL1 IPO5 KIF11 KIF22 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA6 KPNB1 MAD1L1 MAD2L1 NDC80 NEK2 NUMA1 PTTG1 RAD21 RAN RCC1 SMC1A SMC3 STAG1 STAG2 TNPO1 TPX2 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 UBA52 UBB UBC ZW10 (see all 95) (see less)
3	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Reactome	ACTR10 ACTR1A AR CAPZA1 CAPZA2 CAPZA3 CAPZB DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DNAJA1 DNAJA2 DNAJA4 DNAJB1 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 FKBP4 FKBP5 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 NR3C1 NR3C2 PGR PTGES3 STIP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B (see all 57) (see less)
4	Cytoskeleton remodeling Neurofilaments	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR10 ACTR1A ACTR1B CAPZA1 CAPZA2 CAPZA3 CAPZB CDK5 CDK5R1 DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DES DST GFAP INA KIF5A KIF5B KIF5C NEFH NEFL NEFM NES PLEC PRPH STXBP1 SYNM TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 TUBG1 TUBG2 VIM (see all 55) (see less)

Gene overlap in member pathways for COPI-independent Golgi-to-ER retrograde traffic SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTR1A	Actin Related Protein 1A	Protein Coding	4
2	TUBA1B	Tubulin Alpha 1b	Protein Coding	4
3	TUBB3	Tubulin Beta 3 Class III	Protein Coding	4
4	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	4
5	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	4
6	DCTN2	Dynactin Subunit 2	Protein Coding	4
7	DCTN6	Dynactin Subunit 6	Protein Coding	4
8	DCTN3	Dynactin Subunit 3	Protein Coding	4
9	TUBA3E	Tubulin Alpha 3e	Protein Coding	4
10	TUBA3D	Tubulin Alpha 3d	Protein Coding	4
11	DCTN1	Dynactin Subunit 1	Protein Coding	4
12	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	4
13	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	4
14	DCTN4	Dynactin Subunit 4	Protein Coding	4
15	TUBA8	Tubulin Alpha 8	Protein Coding	4
16	ACTR10	Actin Related Protein 10	Protein Coding	4
17	TUBA4A	Tubulin Alpha 4a	Protein Coding	4
18	TUBA3C	Tubulin Alpha 3c	Protein Coding	4
19	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	4
20	TUBA1A	Tubulin Alpha 1a	Protein Coding	4
21	TUBAL3	Tubulin Alpha Like 3	Protein Coding	4
22	TUBA4B	Tubulin Alpha 4b	Protein Coding	4
23	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	4
24	CAPZA1	Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1	Protein Coding	4
25	CAPZA2	Capping Actin Protein Of Muscle Z-Line Subunit Alpha 2	Protein Coding	4
26	CAPZB	Capping Actin Protein Of Muscle Z-Line Subunit Beta	Protein Coding	4
27	DCTN5	Dynactin Subunit 5	Protein Coding	4
28	TUBB6	Tubulin Beta 6 Class V	Protein Coding	4
29	TUBA1C	Tubulin Alpha 1c	Protein Coding	4
30	CAPZA3	Capping Actin Protein Of Muscle Z-Line Subunit Alpha 3	Protein Coding	4
31	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	3
32	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	3
33	DYNC1I1	Dynein Cytoplasmic 1 Intermediate Chain 1	Protein Coding	3
34	DYNC1I2	Dynein Cytoplasmic 1 Intermediate Chain 2	Protein Coding	3
35	DYNC1LI2	Dynein Cytoplasmic 1 Light Intermediate Chain 2	Protein Coding	3
36	DYNC1LI1	Dynein Cytoplasmic 1 Light Intermediate Chain 1	Protein Coding	3
37	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	3
38	TUBB8B	Tubulin Beta 8B	Protein Coding	2
39	ACTB	Actin Beta	Protein Coding	2
40	ACTR1B	Actin Related Protein 1B	Protein Coding	2
41	TUBB7P	Tubulin Beta 7 Pseudogene	Pseudogene	2
42	TUBB	Tubulin Beta Class I	Protein Coding	2
43	RAB3GAP1	RAB3 GTPase Activating Protein Catalytic Subunit 1	Protein Coding	1
44	RAB18	RAB18, Member RAS Oncogene Family	Protein Coding	1
45	BICD2	BICD Cargo Adaptor 2	Protein Coding	1
46	RAB3GAP2	RAB3 GTPase Activating Non-Catalytic Protein Subunit 2	Protein Coding	1
47	GALNT1	Polypeptide N-Acetylgalactosaminyltransferase 1	Protein Coding	1
48	GALNT2	Polypeptide N-Acetylgalactosaminyltransferase 2	Protein Coding	1
49	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	1
50	PAFAH1B2	Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 2	Protein Coding	1
51	PAFAH1B3	Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 3	Protein Coding	1
52	RAB6B	RAB6B, Member RAS Oncogene Family	Protein Coding	1
53	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
54	AGPAT3	1-Acylglycerol-3-Phosphate O-Acyltransferase 3	Protein Coding	1
55	RAB6A	RAB6A, Member RAS Oncogene Family	Protein Coding	1
56	BICD1	BICD Cargo Adaptor 1	Protein Coding	1
57	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
58	CCNB1	Cyclin B1	Protein Coding	1
59	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
60	CDC20	Cell Division Cycle 20	Protein Coding	1
61	CDC27	Cell Division Cycle 27	Protein Coding	1
62	RCC1	Regulator Of Chromosome Condensation 1	Protein Coding	1
63	CSE1L	Chromosome Segregation 1 Like	Protein Coding	1
64	KIF11	Kinesin Family Member 11	Protein Coding	1
65	KIF22	Kinesin Family Member 22	Protein Coding	1
66	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
67	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
68	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	1
69	KPNA3	Karyopherin Subunit Alpha 3	Protein Coding	1
70	KPNA4	Karyopherin Subunit Alpha 4	Protein Coding	1
71	KPNA5	Karyopherin Subunit Alpha 5	Protein Coding	1
72	TNPO1	Transportin 1	Protein Coding	1
73	IPO5	Importin 5	Protein Coding	1
74	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	1
75	NEK2	NIMA Related Kinase 2	Protein Coding	1
76	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	1
77	RAD21	RAD21 Cohesin Complex Component	Protein Coding	1
78	RAN	RAN, Member RAS Oncogene Family	Protein Coding	1
79	AURKA	Aurora Kinase A	Protein Coding	1
80	DYNLT3	Dynein Light Chain Tctex-Type 3	Protein Coding	1
81	DYNLT1	Dynein Light Chain Tctex-Type 1	Protein Coding	1
82	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
83	UBB	Ubiquitin B	Protein Coding	1
84	UBC	Ubiquitin C	Protein Coding	1
85	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
86	MAD1L1	Mitotic Arrest Deficient 1 Like 1	Protein Coding	1
87	CDC23	Cell Division Cycle 23	Protein Coding	1
88	CDC16	Cell Division Cycle 16	Protein Coding	1
89	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	1
90	CCNB2	Cyclin B2	Protein Coding	1
91	ZW10	Zw10 Kinetochore Protein	Protein Coding	1
92	AURKB	Aurora Kinase B	Protein Coding	1
93	PTTG1	PTTG1 Regulator Of Sister Chromatid Separation, Securin	Protein Coding	1
94	ESPL1	Extra Spindle Pole Bodies Like 1, Separase	Protein Coding	1
95	STAG1	STAG1 Cohesin Complex Component	Protein Coding	1
96	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	1
97	NDC80	NDC80 Kinetochore Complex Component	Protein Coding	1
98	STAG2	STAG2 Cohesin Complex Component	Protein Coding	1
99	TPX2	TPX2 Microtubule Nucleation Factor	Protein Coding	1
100	KPNA6	Karyopherin Subunit Alpha 6	Protein Coding	1
101	ANAPC13	Anaphase Promoting Complex Subunit 13	Protein Coding	1
102	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	1
103	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	1
104	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	1
105	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	1
106	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	1
107	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	1
108	DYNLRB2	Dynein Light Chain Roadblock-Type 2	Protein Coding	1
109	DYNLRB1	Dynein Light Chain Roadblock-Type 1	Protein Coding	1
110	CCNB3	Cyclin B3	Protein Coding	1
111	CDC26	Cell Division Cycle 26	Protein Coding	1
112	DNAJA2	DnaJ Heat Shock Protein Family (Hsp40) Member A2	Protein Coding	1
113	PTGES3	Prostaglandin E Synthase 3	Protein Coding	1
114	STIP1	Stress Induced Phosphoprotein 1	Protein Coding	1
115	FKBP4	FKBP Prolyl Isomerase 4	Protein Coding	1
116	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	1
117	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
118	DNAJA1	DnaJ Heat Shock Protein Family (Hsp40) Member A1	Protein Coding	1
119	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
120	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
121	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	1
122	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	1
123	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
124	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
125	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
126	DNAJB1	DnaJ Heat Shock Protein Family (Hsp40) Member B1	Protein Coding	1
127	AR	Androgen Receptor	Protein Coding	1
128	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	1
129	PGR	Progesterone Receptor	Protein Coding	1
130	DNAJA4	DnaJ Heat Shock Protein Family (Hsp40) Member A4	Protein Coding	1
131	ACTG1	Actin Gamma 1	Protein Coding	1
132	DST	Dystonin	Protein Coding	1
133	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
134	DES	Desmin	Protein Coding	1
135	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	1
136	KIF5A	Kinesin Family Member 5A	Protein Coding	1
137	KIF5B	Kinesin Family Member 5B	Protein Coding	1
138	KIF5C	Kinesin Family Member 5C	Protein Coding	1
139	NEFM	Neurofilament Medium Chain	Protein Coding	1
140	NEFH	Neurofilament Heavy Chain	Protein Coding	1
141	NEFL	Neurofilament Light Chain	Protein Coding	1
142	PLEC	Plectin	Protein Coding	1
143	PRPH	Peripherin	Protein Coding	1
144	STXBP1	Syntaxin Binding Protein 1	Protein Coding	1
145	TUBG1	Tubulin Gamma 1	Protein Coding	1
146	VIM	Vimentin	Protein Coding	1
147	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
148	INA	Internexin Neuronal Intermediate Filament Protein Alpha	Protein Coding	1
149	NES	Nestin	Protein Coding	1
150	SYNM	Synemin	Protein Coding	1
151	TUBG2	Tubulin Gamma 2	Protein Coding	1

Disorders associated with COPI-independent Golgi-to-ER retrograde traffic SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	ACTG1, TUBA1A, TUBA3E, TUBB, TUBB2B, TUBB3, TUBG1	11.09
2	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	7.25
3	Warburg micro syndrome 1	Enrichment	RAB18, RAB3GAP1, RAB3GAP2	6.65
4	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	6.65
5	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	5.95
6	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1, NEFH, PRPH	5.13
7	Spinal muscular atrophy with lower extremity predominant	Enrichment	BICD2, DYNC1H1	4.82
8	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.79
9	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	4.57
10	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	4.57
11	Martsolf syndrome 1	Enrichment	RAB3GAP1, RAB3GAP2	3.83
12	Auditory neuropathy	Enrichment	KIF5A, NEFL, TUBB4A	3.81
13	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.51
14	Cryptorchidism	Enrichment	RAB3GAP1, TUBA1A	3.38
15	Cryptorchidism, unilateral or bilateral	Enrichment	RAB3GAP1, TUBA1A	3.28
16	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.28
17	Charcot-marie-tooth disease	Enrichment	DCTN1, DST, NEFL	3.22
18	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	3.18
19	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	3.15
20	Congenital nervous system abnormality	Enrichment	DYNC1H1, PLA2G6, TUBA1A, TUBB4A	3.11
21	Nervous system disease	Enrichment	DYNC1H1, PLA2G6, TUBA1A, TUBB4A	3.11
22	Multiple sclerosis	Enrichment	DST, PLEC	2.85
23	Microcephaly	Enrichment	ACTB, ACTG1, STXBP1, TUBB4A	2.81
24	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DCTN1, NEFH, PRPH	2.78
25	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	KIF5A, NEFL	2.58
26	Perry syndrome	Enrichment	DCTN1	2.41
27	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.41
28	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	2.41
29	Warburg micro syndrome 2	Enrichment	RAB3GAP2	2.41
30	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.41
31	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.41
32	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	2.41
33	Spinal muscular atrophy, lower extremity-predominant, 2b, prenatal onset, autosomal dominant	Enrichment	BICD2	2.41
34	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.41
35	Spinal muscular atrophy, lower extremity-predominant, 2a, childhood onset, autosomal dominant	Enrichment	BICD2	2.41
36	Martsolf syndrome 2	Enrichment	RAB3GAP1	2.41
37	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	2.41
38	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	2.41
39	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	2.41
40	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.41
41	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.41
42	Congenital disorder of glycosylation, type iit	Enrichment	GALNT2	2.41
43	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.41
44	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.41
45	Warburg micro syndrome 3	Enrichment	RAB18	2.41
46	Dync1h1-related disorders	Enrichment	DYNC1H1	2.41
47	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.41
48	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.41
49	Neurodevelopmental disorder with microcephaly and structural brain anomalies	Enrichment	DYNC1I2	2.41
50	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.41
51	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.41
52	Congenital myopathy 26	Enrichment	TUBA4A	2.41
53	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.41
54	Autosomal dominant distal hereditary motor neuronopathy	Enrichment	BICD2	2.41
55	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.41
56	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.41
57	Autosomal recessive spastic paraplegia type 69	Enrichment	RAB3GAP2	2.41
58	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.41
59	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	2.41
60	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	2.39
61	Baraitser-winter syndrome 1	Enrichment	ACTB	2.39
62	Spastic paraplegia 10, autosomal dominant	Enrichment	KIF5A	2.39
63	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	2.39
64	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.39
65	Scapuloperoneal syndrome, neurogenic, kaeser type	Enrichment	DES	2.39
66	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.39
67	Charcot-marie-tooth disease, axonal, type 2cc	Enrichment	NEFH	2.39
68	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.39
69	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.39
70	Myoclonus, intractable, neonatal	Enrichment	KIF5A	2.39
71	Amyotrophic lateral sclerosis 25	Enrichment	KIF5A	2.39
72	Becker nevus syndrome	Enrichment	ACTB	2.39
73	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.39
74	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.39
75	Cortical dysplasia, complex, with other brain malformations 2	Enrichment	KIF5C	2.39
76	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.39
77	Baraitser-winter syndrome	Enrichment	ACTB	2.39
78	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.39
79	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.39
80	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.39
81	Qualitative or quantitative defects of plectin	Enrichment	PLEC	2.39
82	Autosomal dominant charcot-marie-tooth disease type 2 due to kif5a mutation	Enrichment	KIF5A	2.39
83	Premature aging	Enrichment	VIM	2.39
84	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.38
85	Androgen insensitivity, partial	Enrichment	AR	2.38
86	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.38
87	Progesterone resistance	Enrichment	PGR	2.38
88	Hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy	Enrichment	NR3C2	2.38
89	Pseudohyperaldosteronism type 2	Enrichment	NR3C2	2.38
90	Complete androgen insensitivity syndrome	Enrichment	AR	2.38
91	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	2.16
92	Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development	Enrichment	KIF11	2.15
93	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.15
94	Holoprosencephaly 13, x-linked	Enrichment	STAG2	2.15
95	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.15
96	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	2.15
97	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	2.15
98	Mullegama-klein-martinez syndrome	Enrichment	STAG2	2.15
99	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.15
100	Intellectual developmental disorder, autosomal dominant 47	Enrichment	STAG1	2.15
101	Spondyloepimetaphyseal dysplasia with joint laxity, type 2	Enrichment	KIF22	2.15
102	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.15
103	Mungan syndrome	Enrichment	RAD21	2.15
104	Retinitis pigmentosa 67	Enrichment	NEK2	2.15
105	Xq25 microduplication syndrome	Enrichment	STAG2	2.15
106	Spastic paraplegia 88, autosomal dominant	Enrichment	KPNA3	2.15
107	Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	Enrichment	MAD1L1	2.15
108	Infection-induced acute-onset axonal neuropathy	Enrichment	RCC1	2.15
109	Peripheral nervous system disease	Enrichment	KIF5A, NEFL	2.13
110	Neuropathy	Enrichment	KIF5A, NEFL	2.13
111	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	2.11
112	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.11
113	Fanconi anemia, complementation group n	Enrichment	DCTN5	2.11
114	Lissencephaly 1	Enrichment	PAFAH1B1	2.11
115	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.11
116	Pancreatic cancer 3	Enrichment	DCTN5	2.11
117	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Enrichment	DYNC1I2	2.11
118	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	2.11
119	Keratoconus 9	Enrichment	TUBA3D	2.11
120	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.11
121	Lissencephaly 3	Enrichment	TUBA1A	2.11
122	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.11
123	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	2.11
124	Intellectual developmental disorder, autosomal dominant 45	Enrichment	PAFAH1B3	2.11
125	Torsion dystonia 4	Enrichment	TUBB4A	2.11
126	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	2.11
127	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	2.11
128	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.11
129	Epidermolysis bullosa simplex 5a, ogna type	Enrichment	PLEC	2.09
130	Alexander disease	Enrichment	GFAP	2.09
131	Epidermolysis bullosa simplex 5b, with muscular dystrophy	Enrichment	PLEC	2.09
132	Hereditary motor and sensory neuropathy, type iic	Enrichment	NEFH	2.09
133	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.09
134	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.09
135	Cardiomyopathy, dilated, 1i	Enrichment	DES	2.09
136	Muscular dystrophy, limb-girdle, autosomal recessive 17	Enrichment	PLEC	2.09
137	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	GFAP	2.09
138	Cortical dysplasia, complex, with other brain malformations 4	Enrichment	TUBG1	2.09
139	Autosomal recessive limb-girdle muscular dystrophy type 2q	Enrichment	PLEC	2.09
140	Progressive familial heart block	Enrichment	DES	2.09
141	Cataract 30	Enrichment	VIM	2.09
142	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	KIF5A	2.09
143	9q33.3q34.11 microdeletion syndrome	Enrichment	STXBP1	2.09
144	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	2.09
145	Demyelinating polyneuropathy	Enrichment	KIF5A	2.09
146	Skeletal muscle disease	Enrichment	KIF5B	2.09
147	Galactosemia ii	Enrichment	NR3C1	2.08
148	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.08
149	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	NR3C2	2.08
150	46,xy sex reversal 1	Enrichment	AR	2.08
151	Androgen insensitivity syndrome	Enrichment	AR	2.08
152	Hypospadias 1, x-linked	Enrichment	AR	2.08
153	Fibrolamellar carcinoma	Enrichment	DNAJB1	2.08
154	Posterior hypospadias	Enrichment	AR	2.08
155	Pseudohypoaldosteronism	Enrichment	NR3C2	2.08
156	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	1.99
157	Myopathy	Enrichment	BICD2, DYNC1H1	1.97
158	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.93
159	Band heterotopia	Enrichment	PAFAH1B1	1.93
160	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.93
161	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1	1.93
162	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1	1.93
163	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	1.93
164	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.93
165	Breast-ovarian cancer, familial 5	Enrichment	DCTN5	1.93
166	Distal myopathy	Enrichment	BICD2	1.93
167	Muscular atrophy	Enrichment	BICD2	1.93
168	Myopathy, myofibrillar, 1	Enrichment	DES	1.92
169	Epidermolysis bullosa simplex 3, localized or generalized intermediate, with bp230 deficiency	Enrichment	DST	1.92
170	Epidermolysis bullosa simplex 5d, generalized intermediate, autosomal recessive	Enrichment	PLEC	1.92
171	West syndrome	Enrichment	STXBP1, TUBA1A	1.86
172	Microcephaly and chorioretinopathy, autosomal recessive, 1	Enrichment	KIF11	1.86
173	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.86
174	Microcephaly and chorioretinopathy 1	Enrichment	KIF11	1.86
175	Spastic paraplegia 37, autosomal dominant	Enrichment	KPNA3	1.86
176	Submucosal cleft palate	Enrichment	UBB	1.86
177	Cleft hard palate	Enrichment	UBB	1.86
178	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	PLEC	1.79
179	Developmental and epileptic encephalopathy 4	Enrichment	STXBP1	1.79
180	Aminoacylase 1 deficiency	Enrichment	ACTB	1.79
181	Neuropathy, hereditary sensory and autonomic, type vi	Enrichment	DST	1.79
182	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.79
183	Spastic ataxia	Enrichment	PLA2G6, TUBB3	1.74
184	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1	1.71
185	Congenital ptosis	Enrichment	RAB3GAP1	1.71
186	Spinal muscular atrophy	Enrichment	DYNC1H1	1.71
187	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.71
188	Genetic motor neuron disease	Enrichment	DCTN1	1.71
189	Epidermolysis bullosa simplex 2f, with mottled pigmentation	Enrichment	PLEC	1.70
190	Epidermolysis bullosa simplex 1a, generalized severe	Enrichment	PLEC	1.70
191	Kearns-sayre syndrome	Enrichment	KIF5B	1.70
192	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	1.70
193	Histiocytoid hemangioma	Enrichment	VIM	1.70
194	2q23.1 microduplication syndrome	Enrichment	KIF5C	1.70
195	Aplasia cutis congenita	Enrichment	PLEC	1.70
196	Coloboma of choroid and retina	Enrichment	ACTG1	1.70
197	Major depressive disorder	Enrichment	FKBP5	1.68
198	Uvula, bifid	Enrichment	UBB	1.68
199	Cleft soft palate	Enrichment	UBB	1.68
200	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.63
201	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.63
202	Hypertrichosis	Enrichment	RAB3GAP1	1.63
203	Metachromatic leukodystrophy	Enrichment	GFAP	1.62
204	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	PLEC	1.62
205	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	1.56
206	Pregnancy loss, recurrent 1	Enrichment	CCNB3	1.56
207	Epidermolysis bullosa simplex	Enrichment	PLEC	1.55
208	Myofibrillar myopathy	Enrichment	DES	1.55
209	Difference of sex development	Enrichment	AR	1.48
210	Mosaic variegated aneuploidy syndrome 1	Enrichment	MAD1L1	1.46
211	Primary hyperaldosteronism	Enrichment	NR3C1	1.43
212	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	1.42
213	Polymicrogyria	Enrichment	DYNC1H1	1.42
214	Cat eye syndrome	Enrichment	ACTG1	1.40
215	Cataract 30, multiple types	Enrichment	VIM	1.40
216	Syndromic rod-cone dystrophy	Enrichment	KIF11	1.38
217	Dilated cardiomyopathy	Enrichment	DES, KIF5B	1.38
218	Frontotemporal dementia 1	Enrichment	DCTN1	1.38
219	Movement disease	Enrichment	RAB3GAP1	1.38
220	Asthma	Enrichment	FKBP5	1.34
221	46,xy complete gonadal dysgenesis	Enrichment	AR	1.34
222	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1	1.34
223	Congenital hypothyroidism	Enrichment	TUBB1	1.34
224	Rett syndrome, congenital variant	Enrichment	SMC1A	1.26
225	Mosaic variegated aneuploidy syndrome	Enrichment	MAD1L1	1.26
226	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.24
227	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.24
228	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.24
229	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	1.22
230	Isolated congenital microcephaly	Enrichment	TUBA3E	1.22
231	Hydrocephalus, congenital, 1	Enrichment	TUBB	1.20
232	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DES	1.20
233	Cleft palate, isolated	Enrichment	RAB3GAP1	1.19
234	Dandy-walker syndrome	Enrichment	TUBA1A	1.19
235	Cardiomyopathy, dilated, 1e	Enrichment	DES	1.18
236	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1	1.17
237	Neuromuscular disease	Enrichment	DES	1.15
238	Esophageal atresia/tracheoesophageal fistula	Enrichment	RAB3GAP2	1.14
239	Autism spectrum disorder	Enrichment	DYNC1H1, NR3C2	1.11
240	Attention deficit-hyperactivity disorder	Enrichment	KIF5B	1.07
241	Skin disease	Enrichment	PLEC	1.07
242	Acute promyelocytic leukemia	Enrichment	NUMA1	1.06
243	Nk-cell enteropathy	Enrichment	AURKB	1.06
244	Scoliosis	Enrichment	GFAP	1.03
245	Strabismus	Enrichment	STXBP1	0.98
246	Alobar holoprosencephaly	Enrichment	STAG2	0.95
247	Prostate cancer	Enrichment	AR	0.94
248	Cystic fibrosis	Enrichment	DCTN4	0.93
249	Colorectal cancer	Enrichment	AURKA, DCTN5	0.91
250	Familial hypertrophic cardiomyopathy	Enrichment	DES	0.90
251	Cakut	Enrichment	ACTG1	0.89
252	Male infertility	Enrichment	AR	0.87
253	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.87
254	Developmental and epileptic encephalopathy	Enrichment	STXBP1	0.87
255	Non-syndromic genetic deafness	Enrichment	ACTG1	0.87
256	Distal arthrogryposis	Enrichment	BICD2	0.82
257	Hereditary spastic paraplegia	Enrichment	KIF5A	0.80
258	Nonsyndromic hearing loss	Enrichment	ACTG1	0.80
259	Optic atrophy plus syndrome	Enrichment	TUBB6	0.80
260	Hereditary breast carcinoma	Enrichment	DCTN5	0.80
261	Hypertrophic cardiomyopathy	Enrichment	KIF5B	0.79
262	Thrombocytopenia	Enrichment	TUBB1	0.77
263	Sensorineural hearing loss	Enrichment	NEFL	0.75
264	Autosomal dominant non-syndromic intellectual disability	Enrichment	DYNC1H1	0.75
265	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.72
266	Hereditary breast ovarian cancer syndrome	Enrichment	DCTN5	0.71
267	Familial isolated dilated cardiomyopathy	Enrichment	DES	0.71
268	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.68
269	Autism	Enrichment	STXBP1	0.59
270	Breast cancer	Enrichment	DCTN5	0.59
271	Rare genetic deafness	Enrichment	ACTG1	0.56
272	Leber plus disease	Enrichment	TUBB4B	0.51
273	Myeloma, multiple	Enrichment	AURKA	0.49
274	Ovarian cancer	Enrichment	AR	0.46
275	Inherited cancer-predisposing syndrome	Enrichment	DCTN5	0.39
276	Retinitis pigmentosa	Enrichment	KIF11, NEK2	0.36
277	Hereditary retinal dystrophy	Enrichment	KIF11, NEK2	0.22
278	Fundus dystrophy	Enrichment	KIF11, NEK2	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

COPI-independent Golgi-to-ER retrograde traffic

Pathway Network for COPI-independent Golgi-to-ER retrograde traffic

Pathway network for the COPI-independent Golgi-to-ER retrograde traffic SuperPath

Member Pathways for COPI-independent Golgi-to-ER retrograde traffic

Pathways in the COPI-independent Golgi-to-ER retrograde traffic SuperPath

Gene overlap in member pathways for COPI-independent Golgi-to-ER retrograde traffic SuperPath

Associated Genes for COPI-independent Golgi-to-ER retrograde traffic

Associated Disorders for COPI-independent Golgi-to-ER retrograde traffic

Disorders associated with COPI-independent Golgi-to-ER retrograde traffic SuperPath

STRING Interaction Network for COPI-independent Golgi-to-ER retrograde traffic

Sources for COPI-independent Golgi-to-ER retrograde traffic