Corticotropin-releasing hormone signaling pathway

No Pathway Network information available for Corticotropin-releasing hormone signaling pathway

Pathways in the Corticotropin-releasing hormone signaling pathway SuperPath

#	Name	Source	Genes
1	Corticotropin-releasing hormone signaling pathway	WikiPathways	ACACA AKT1 ARRB1 ARRB2 BCL2 BRAF CACNA1H CAMK2A CASP12 CASP3 CASP9 CREB1 CRH CRHBP CRHR1 CRHR2 CTNNB1 CXCL8 CYP11A1 CYP11B1 CYP21A2 ECE1 ELK1 ERN1 FOS FOSB FOSL1 FOSL2 GJA1 GNA11 GNAI1 GNAI2 GNAO1 GNAQ GNAS GNAZ GNB1 GNB2 GNB3 GNB5 GRK3 GRK6 GSK3B HSD3B1 HSD3B2 HSP90AA1 IL18 IL2 IVL JUNB JUND JUP KRT1 KRT14 MAP2K1 MAP3K5 MAPK1 MAPK14 MAPK3 MAPK8 MAPK9 NCOA2 NFKB1 NFKBIA NOS3 NR4A1 NR4A2 PARP1 PLCG1 PLCG2 POMC PRKAA2 PRKCA PRKCB PRKCD PRKCI PRKCQ PTK2 RAP1B RAPGEF3 RELA RHOA SP1 STAR SULT2A1 TBX19 TCF4 TFAP2A TGFB1 TLR4 TRIM28 (see all 91) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
2	TBX19	T-Box Transcription Factor 19	Protein Coding	1
3	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	1
4	CASP9	Caspase 9	Protein Coding	1
5	CASP3	Caspase 3	Protein Coding	1
6	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
7	TLR4	Toll Like Receptor 4	Protein Coding	1
8	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
9	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	1
10	TCF4	Transcription Factor 4	Protein Coding	1
11	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	1
12	STAR	Steroidogenic Acute Regulatory Protein	Protein Coding	1
13	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
14	SP1	Sp1 Transcription Factor	Protein Coding	1
15	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
16	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
17	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
18	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
19	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
20	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
21	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
22	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
23	PRKCQ	Protein Kinase C Theta	Protein Coding	1
24	PRKCI	Protein Kinase C Iota	Protein Coding	1
25	PRKCD	Protein Kinase C Delta	Protein Coding	1
26	PRKCB	Protein Kinase C Beta	Protein Coding	1
27	PRKCA	Protein Kinase C Alpha	Protein Coding	1
28	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
29	POMC	Proopiomelanocortin	Protein Coding	1
30	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
31	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
32	NR4A2	Nuclear Receptor Subfamily 4 Group A Member 2	Protein Coding	1
33	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
34	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
35	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
36	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
37	ARRB2	Arrestin Beta 2	Protein Coding	1
38	ARRB1	Arrestin Beta 1	Protein Coding	1
39	RHOA	Ras Homolog Family Member A	Protein Coding	1
40	KRT14	Keratin 14	Protein Coding	1
41	KRT1	Keratin 1	Protein Coding	1
42	JUP	Junction Plakoglobin	Protein Coding	1
43	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
44	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
45	IVL	Involucrin	Protein Coding	1
46	IL18	Interleukin 18	Protein Coding	1
47	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
48	IL2	Interleukin 2	Protein Coding	1
49	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
50	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	1
51	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	1
52	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
53	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	1
54	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
55	GRK6	G Protein-Coupled Receptor Kinase 6	Protein Coding	1
56	GNB3	G Protein Subunit Beta 3	Protein Coding	1
57	GNB1	G Protein Subunit Beta 1	Protein Coding	1
58	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
59	GNAS	GNAS Complex Locus	Protein Coding	1
60	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
61	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
62	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
63	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
64	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
65	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
66	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
67	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
68	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
69	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	1
70	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
71	ECE1	Endothelin Converting Enzyme 1	Protein Coding	1
72	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	1
73	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	1
74	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	1
75	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
76	CTNNB1	Catenin Beta 1	Protein Coding	1
77	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
78	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
79	CRHR2	Corticotropin Releasing Hormone Receptor 2	Protein Coding	1
80	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	1
81	CRHBP	Corticotropin Releasing Hormone Binding Protein	Protein Coding	1
82	CRH	Corticotropin Releasing Hormone	Protein Coding	1
83	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
84	GNB5	G Protein Subunit Beta 5	Protein Coding	1
85	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
86	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	1
87	TRIM28	Tripartite Motif Containing 28	Protein Coding	1
88	CASP12	Caspase 12 (Gene/Pseudogene)	Protein Coding	1
89	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
90	GNB2	G Protein Subunit Beta 2	Protein Coding	1
91	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with Corticotropin-releasing hormone signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP11B1, CYP21A2, HSD3B2, STAR	7.63
2	Primary hyperaldosteronism	Enrichment	BRAF, CACNA1H, GNAS	4.62
3	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.35
4	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	3.88
5	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	3.88
6	Hypertension, essential	Enrichment	ECE1, GNB3, NOS3	3.73
7	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	3.58
8	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	3.58
9	Craniopharyngioma	Enrichment	BRAF, CTNNB1	3.58
10	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.36
11	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.36
12	Melanoma, uveal	Enrichment	GNA11, GNAQ	3.18
13	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1, CYP21A2	3.18
14	Wilms tumor 5	Enrichment	BRAF, TRIM28	3.18
15	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP21A2	3.18
16	Gallbladder cancer	Enrichment	BRAF, CTNNB1	3.04
17	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS, TCF4	2.92
18	Microcephaly	Enrichment	CTNNB1, GNAO1, GNB1, MAPK1, TCF4	2.85
19	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1	2.63
20	Epicanthus	Enrichment	TCF4, TFAP2A	2.55
21	Wilms tumor 1	Enrichment	BRAF, TRIM28	2.36
22	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1	2.36
23	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, GNB1, TCF4	2.34
24	Autism spectrum disorder	Enrichment	GNB1, MAP2K1, NR4A2, TCF4	2.21
25	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.17
26	Ichthyosis hystrix, curth-macklin type	Enrichment	KRT1	2.17
27	Dermatopathia pigmentosa reticularis	Enrichment	KRT14	2.17
28	Proteus syndrome	Enrichment	AKT1	2.17
29	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.17
30	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.17
31	Palmoplantar keratoderma, nonepidermolytic	Enrichment	KRT1	2.17
32	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.17
33	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.17
34	Melorheostosis, isolated	Enrichment	MAP2K1	2.17
35	Oculodentodigital dysplasia	Enrichment	GJA1	2.17
36	Osseous heteroplasia, progressive	Enrichment	GNAS	2.17
37	Noonan syndrome 7	Enrichment	BRAF	2.17
38	Leopard syndrome 3	Enrichment	BRAF	2.17
39	Naegeli-franceschetti-jadassohn syndrome	Enrichment	KRT14	2.17
40	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.17
41	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Enrichment	CYP11A1	2.17
42	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.17
43	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.17
44	Sturge-weber syndrome	Enrichment	GNAQ	2.17
45	Ventricular tachycardia, familial	Enrichment	GNAI2	2.17
46	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.17
47	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.17
48	Naxos disease	Enrichment	JUP	2.17
49	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.17
50	Noonan syndrome 13	Enrichment	MAPK1	2.17
51	Ichthyosis, annular epidermolytic, 2	Enrichment	KRT1	2.17
52	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.17
53	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.17
54	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	2.17
55	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.17
56	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.17
57	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.17
58	Keratosis palmoplantaris striata iii	Enrichment	KRT1	2.17
59	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.17
60	Lymphangioma	Enrichment	BRAF	2.17
61	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.17
62	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.17
63	Phace association	Enrichment	BRAF	2.17
64	Melorheostosis	Enrichment	MAP2K1	2.17
65	Hirschsprung disease, cardiac defects, and autonomic dysfunction	Enrichment	ECE1	2.17
66	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.17
67	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.17
68	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.17
69	Cowden syndrome 6	Enrichment	AKT1	2.17
70	Macular degeneration, age-related, 10	Enrichment	TLR4	2.17
71	Disorders of gnas inactivation	Enrichment	GNAS	2.17
72	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.17
73	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.17
74	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.17
75	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.17
76	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.17
77	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.17
78	Sick sinus syndrome 4	Enrichment	GNB2	2.17
79	Intellectual developmental disorder with language impairment and early-onset dopa-responsive dystonia-parkinsonism	Enrichment	NR4A2	2.17
80	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.17
81	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.17
82	Adenoid ameloblastoma	Enrichment	CTNNB1	2.17
83	Palmoplantar keratoderma, epidermolytic, 2	Enrichment	KRT1	2.17
84	Conn's syndrome	Enrichment	CACNA1H	2.17
85	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	2.17
86	Wilms tumor 7	Enrichment	TRIM28	2.17
87	Non-classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	2.17
88	Syringocystadenoma papilliferum	Enrichment	BRAF	2.17
89	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.17
90	Ganglioglioma	Enrichment	BRAF	2.17
91	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.17
92	Monostotic fibrous dysplasia	Enrichment	GNAS	2.17
93	Phace syndrome	Enrichment	BRAF	2.17
94	Gnao1-related disorder	Enrichment	GNAO1	2.17
95	Classic hairy cell leukemia	Enrichment	BRAF	2.17
96	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.17
97	Mazabraud syndrome	Enrichment	GNAS	2.17
98	Microcystic stromal tumor	Enrichment	CTNNB1	2.17
99	Classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	2.17
100	Noonan syndrome 1	Enrichment	BRAF, MAP2K1	1.99
101	Rasopathy	Enrichment	BRAF, MAP2K1	1.89
102	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.87
103	Camurati-engelmann disease 1	Enrichment	TGFB1	1.87
104	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.87
105	Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	Enrichment	HSD3B2	1.87
106	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.87
107	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.87
108	Toe syndactyly, telecanthus, and anogenital and renal malformations	Enrichment	STAR	1.87
109	Pulmonic stenosis	Enrichment	BRAF	1.87
110	Epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT14	1.87
111	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.87
112	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	1.87
113	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.87
114	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	KRT1	1.87
115	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.87
116	Hallermann-streiff syndrome	Enrichment	GJA1	1.87
117	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.87
118	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.87
119	Syndactyly, type iii	Enrichment	GJA1	1.87
120	Syndactyly, type v	Enrichment	GJA1	1.87
121	Acth deficiency, isolated	Enrichment	TBX19	1.87
122	Sjogren-larsson syndrome	Enrichment	KRT14	1.87
123	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.87
124	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.87
125	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.87
126	Hypospadias 1, x-linked	Enrichment	HSD3B2	1.87
127	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.87
128	Craniometaphyseal dysplasia	Enrichment	GJA1	1.87
129	Rela fusion-positive ependymoma	Enrichment	RELA	1.87
130	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.87
131	Pseudohypoparathyroidism	Enrichment	GNAS	1.87
132	Camurati-engelmann disease	Enrichment	TGFB1	1.87
133	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.87
134	Hypopituitarism	Enrichment	GNAI2	1.87
135	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.87
136	3 beta-hydroxysteroid dehydrogenase deficiency	Enrichment	HSD3B2	1.87
137	Esotropia	Enrichment	TFAP2A	1.87
138	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.87
139	Congenital isolated adrenocorticotropic hormone deficiency	Enrichment	TBX19	1.87
140	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.87
141	Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion	Enrichment	NR4A2	1.87
142	Teratoma	Enrichment	CTNNB1	1.87
143	Common variable immunodeficiency 12	Enrichment	NFKB1	1.87
144	Lens subluxation	Enrichment	TFAP2A	1.87
145	Cerebral visual impairment	Enrichment	GNB1	1.87
146	Desmoid disease, hereditary	Enrichment	CTNNB1	1.70
147	Mccune-albright syndrome	Enrichment	GNAS	1.70
148	Palmoplantar keratoderma, epidermolytic, 1	Enrichment	KRT1	1.70
149	Adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency	Enrichment	CYP11B1	1.70
150	Ataxia-telangiectasia	Enrichment	BRAF	1.70
151	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	1.70
152	Ichthyosis with confetti	Enrichment	KRT1	1.70
153	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.70
154	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.70
155	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.70
156	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.70
157	Ichthyosis, annular epidermolytic, 1	Enrichment	KRT1	1.70
158	Anus, imperforate	Enrichment	CTNNB1	1.70
159	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.70
160	Tethered spinal cord syndrome	Enrichment	BRAF	1.70
161	Desmoid tumor	Enrichment	CTNNB1	1.70
162	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.70
163	Keratosis palmoplantaris striata	Enrichment	KRT1	1.70
164	Deficiency of steroid 11-beta-monooxygenase	Enrichment	CYP11B1	1.70
165	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	NR4A2	1.70
166	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.70
167	Melanoma of soft tissue	Enrichment	CREB1	1.70
168	Annular epidermolytic ichthyosis	Enrichment	KRT1	1.70
169	Autosomal dominant epidermolytic ichthyosis	Enrichment	KRT1	1.70
170	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	1.70
171	Colorectal cancer	Enrichment	AKT1, BRAF, CTNNB1	1.69
172	Epidermolysis bullosa simplex 1b, generalized intermediate	Enrichment	KRT14	1.58
173	Branchiooculofacial syndrome	Enrichment	TFAP2A	1.58
174	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.58
175	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.58
176	Pitt-hopkins syndrome	Enrichment	TCF4	1.58
177	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.58
178	Pilomatrixoma	Enrichment	CTNNB1	1.58
179	Alazami syndrome	Enrichment	CTNNB1	1.58
180	Congenital generalized lipodystrophy	Enrichment	FOS	1.58
181	Epidermolysis bullosa simplex generalized type	Enrichment	KRT14	1.58
182	Noonan syndrome with multiple lentigines	Enrichment	BRAF	1.58
183	Newborn respiratory distress syndrome	Enrichment	BRAF	1.58
184	Epidermolytic hyperkeratosis	Enrichment	KRT1	1.58
185	Familial sick sinus syndrome	Enrichment	GNB2	1.58
186	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.58
187	Epidermolysis bullosa simplex 2f, with mottled pigmentation	Enrichment	KRT14	1.48
188	Epidermolysis bullosa simplex 1a, generalized severe	Enrichment	KRT14	1.48
189	Alzheimer disease 2	Enrichment	NOS3	1.48
190	Epidermolytic hyperkeratosis 1	Enrichment	KRT1	1.48
191	Epidermolysis bullosa simplex 1c, localized	Enrichment	KRT14	1.48
192	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.48
193	Cholangitis, primary sclerosing	Enrichment	TCF4	1.48
194	Pre-eclampsia	Enrichment	NOS3	1.48
195	Follicular lymphoma	Enrichment	BCL2	1.48
196	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.48
197	Amblyopia	Enrichment	TFAP2A	1.48
198	Cleft upper lip	Enrichment	GJA1	1.48
199	Familial glucocorticoid deficiency	Enrichment	STAR	1.48
200	Congenital nervous system abnormality	Enrichment	CTNNB1, GNAO1, GNB5	1.46
201	Nervous system disease	Enrichment	CTNNB1, GNAO1, GNB5	1.46
202	Hyperaldosteronism, familial, type i	Enrichment	CYP11B1	1.40
203	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.40
204	Branchiootorenal syndrome 1	Enrichment	TFAP2A	1.40
205	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.40
206	Hemihyperplasia, isolated	Enrichment	RHOA	1.40
207	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.40
208	Adrenocortical carcinoma	Enrichment	CTNNB1	1.40
209	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.40
210	Breast adenocarcinoma	Enrichment	AKT1	1.40
211	Childhood absence epilepsy	Enrichment	CACNA1H	1.40
212	Body mass index quantitative trait locus 11	Enrichment	GNAS, POMC	1.35
213	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.34
214	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.34
215	Brachydactyly	Enrichment	GNAS	1.34
216	Branchiootorenal syndrome	Enrichment	TFAP2A	1.34
217	Pilomyxoid astrocytoma	Enrichment	BRAF	1.34
218	Common variable immunodeficiency	Enrichment	NFKB1	1.34
219	Follicular thyroid carcinoma	Enrichment	BRAF	1.34
220	Epidermolysis bullosa simplex	Enrichment	KRT14	1.34
221	Autosomal dominant sleep-related hypermotor epilepsy	Enrichment	CRH	1.34
222	Melanocytic nevus syndrome, congenital	Enrichment	BRAF	1.28
223	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.28
224	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.28
225	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.28
226	Hypothyroidism	Enrichment	GNB1	1.28
227	Choreatic disease	Enrichment	GNAO1	1.28
228	Hypoplastic left heart syndrome	Enrichment	GJA1	1.28
229	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.23
230	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.23
231	Arteriovenous malformation	Enrichment	MAP2K1	1.23
232	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.23
233	Ventricular septal defect	Enrichment	BRAF	1.23
234	Cowden syndrome	Enrichment	AKT1	1.23
235	Cat eye syndrome	Enrichment	TFAP2A	1.19
236	Stroke, ischemic	Enrichment	NOS3	1.19
237	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.19
238	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.19
239	Melanoma	Enrichment	BRAF	1.19
240	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.15
241	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.15
242	Myelodysplastic syndrome	Enrichment	GNB1	1.15
243	Movement disease	Enrichment	GNAO1	1.15
244	Specific learning disability	Enrichment	MAPK1	1.15
245	Meningioma	Enrichment	AKT1	1.11
246	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.11
247	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.11
248	Lip and oral cavity carcinoma	Enrichment	BRAF	1.11
249	Stereotypic movement disorder	Enrichment	TCF4	1.08
250	Medulloblastoma	Enrichment	CTNNB1	1.05
251	Lung cancer susceptibility 3	Enrichment	BRAF	1.05
252	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.05
253	Breast cancer	Enrichment	AKT1, IL2	1.04
254	Rare genetic intellectual disability	Enrichment	GNAO1	1.02
255	Dilated cardiomyopathy	Enrichment	BRAF, JUP	1.00
256	Wolff-parkinson-white syndrome	Enrichment	JUP	0.99
257	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	0.99
258	Gliosarcoma	Enrichment	NFKBIA	0.99
259	Alzheimer disease, familial, 1	Enrichment	NOS3	0.97
260	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.97
261	Cleft palate, isolated	Enrichment	GNB1	0.97
262	Dandy-walker syndrome	Enrichment	BRAF	0.97
263	Polycystic liver disease	Enrichment	CTNNB1	0.97
264	Giant cell glioblastoma	Enrichment	NFKBIA	0.97
265	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.97
266	Heart, malformation of	Enrichment	MAPK1	0.94
267	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	0.94
268	Arteriovenous malformations of the brain	Enrichment	BRAF	0.92
269	Behcet syndrome	Enrichment	TLR4	0.92
270	Diffuse large b-cell lymphoma	Enrichment	BRAF	0.92
271	Parkinson's disease	Enrichment	NR4A2	0.92
272	Hepatoblastoma	Enrichment	CTNNB1	0.88
273	Hepatocellular carcinoma	Enrichment	CTNNB1	0.86
274	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.86
275	Microphthalmia	Enrichment	TFAP2A	0.86
276	Skin disease	Enrichment	KRT14	0.86
277	Congenital stationary night blindness	Enrichment	GNB3	0.84
278	Ovarian cancer	Enrichment	AKT1, CTNNB1	0.83
279	Parkinson disease, late-onset	Enrichment	NR4A2	0.83
280	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.81
281	Strabismus	Enrichment	GNB1	0.78
282	Bladder cancer	Enrichment	CTNNB1	0.75
283	Hirschsprung disease 1	Enrichment	ECE1	0.75
284	Differentiated thyroid carcinoma	Enrichment	BRAF	0.75
285	Lung cancer	Enrichment	BRAF	0.71
286	Cystic fibrosis	Enrichment	TGFB1	0.71
287	Complex neurodevelopmental disorder	Enrichment	GNB2, NR4A2	0.69
288	Dystonia	Enrichment	GNB1	0.68
289	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.67
290	Cerebral palsy	Enrichment	GNB1	0.64
291	Epilepsy	Enrichment	NR4A2	0.63
292	West syndrome	Enrichment	GNAO1	0.59
293	Hereditary breast carcinoma	Enrichment	AKT1	0.59
294	Hypertelorism	Enrichment	TFAP2A	0.53
295	Myeloma, multiple	Enrichment	BRAF	0.50
296	Primary ovarian insufficiency	Enrichment	NOS3	0.48
297	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Corticotropin-releasing hormone signaling pathway

Pathway Network for Corticotropin-releasing hormone signaling pathway

Member Pathways for Corticotropin-releasing hormone signaling pathway

Pathways in the Corticotropin-releasing hormone signaling pathway SuperPath

Associated Genes for Corticotropin-releasing hormone signaling pathway

Associated Disorders for Corticotropin-releasing hormone signaling pathway

Disorders associated with Corticotropin-releasing hormone signaling pathway SuperPath

STRING Interaction Network for Corticotropin-releasing hormone signaling pathway

Sources for Corticotropin-releasing hormone signaling pathway