COVID-19 adverse outcome pathway

No Pathway Network information available for COVID-19 adverse outcome pathway

#	Name	Source	Genes
1	COVID-19 adverse outcome pathway	WikiPathways	ACE2 AGT CCL2 CCL3 CXCL10 CXCL8 IL2 IL2RA IL6 TMPRSS2 (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	1
2	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
3	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
4	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
5	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
6	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
7	IL6	Interleukin 6	Protein Coding	1
8	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
9	IL2	Interleukin 2	Protein Coding	1
10	AGT	Angiotensinogen	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus type 1	Enrichment	CCL2, CCL3	4.13
2	Type 1 diabetes mellitus 10	Enrichment	IL2RA	3.13
3	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.83
4	Kaposi sarcoma	Enrichment	IL6	2.53
5	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.53
6	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.43
7	Type 1 diabetes mellitus	Enrichment	IL6	2.35
8	Renal tubular dysgenesis	Enrichment	AGT	2.35
9	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA	2.29
10	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA	2.29
11	Inflammatory bowel disease 1	Enrichment	IL6	2.18
12	Hypertension, essential	Enrichment	AGT	1.90
13	Arteriovenous malformations of the brain	Enrichment	IL6	1.86
14	Type 2 diabetes mellitus	Enrichment	IL6	1.52
15	Breast cancer	Enrichment	IL2	1.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for COVID-19 adverse outcome pathway