CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Pathway network for the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

Sources:

Reactome

Pathways in the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

#	Name	Source	Genes
1	CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling	Reactome	ACTN2 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CREB1 DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2B GRIN2D HRAS KRAS MAPK1 MAPK3 NEFL NRAS PDPK1 RASGRF1 RASGRF2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 (see all 29) (see less)
2	Ras activation upon Ca2+ influx through NMDA receptor	Reactome	ACTN2 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2B GRIN2D HRAS KRAS NEFL NRAS RASGRF1 RASGRF2 (see all 21) (see less)
3	RSK activation	Reactome	MAPK1 MAPK3 PDPK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 (see all 7) (see less)

Gene overlap in member pathways for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	2
2	DLG2	Discs Large MAGUK Scaffold Protein 2	Protein Coding	2
3	DLG3	Discs Large MAGUK Scaffold Protein 3	Protein Coding	2
4	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	2
5	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	2
6	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	2
7	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	2
8	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	2
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
10	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
11	NEFL	Neurofilament Light Chain	Protein Coding	2
12	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
13	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
14	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
15	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
16	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	2
17	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	2
18	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
19	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	2
20	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	2
21	CALM1	Calmodulin 1	Protein Coding	2
22	CALM2	Calmodulin 2	Protein Coding	2
23	CALM3	Calmodulin 3	Protein Coding	2
24	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	2
25	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	2
26	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	2
27	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	2
28	ACTN2	Actinin Alpha 2	Protein Coding	2
29	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1

Disorders associated with CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.89
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	6.95
3	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.75
4	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	6.28
5	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GRIN1, GRIN2B	6.03
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	5.84
7	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.64
8	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	5.26
9	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.16
10	Rasopathy	Enrichment	HRAS, KRAS, NRAS	5.09
11	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.94
12	Specific learning disability	Enrichment	MAPK1, RPS6KA3	4.90
13	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.90
14	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.86
15	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.32
16	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.32
17	Noonan syndrome 3	Enrichment	HRAS, KRAS	4.32
18	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.32
19	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.20
20	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.83
21	Coffin-lowry syndrome	Enrichment	RPS6KA3	3.29
22	Noonan syndrome 13	Enrichment	MAPK1	3.29
23	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	3.29
24	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	3.29
25	Bladder cancer	Enrichment	HRAS, KRAS	3.04
26	Long qt syndrome	Enrichment	CALM1, CALM2	2.99
27	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.99
28	Oculoectodermal syndrome	Enrichment	KRAS	2.81
29	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.81
30	Melanosis, neurocutaneous	Enrichment	NRAS	2.81
31	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.81
32	Noonan syndrome 6	Enrichment	NRAS	2.81
33	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.81
34	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.81
35	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.81
36	Congenital myopathy 8	Enrichment	ACTN2	2.81
37	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.81
38	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.81
39	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.81
40	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.81
41	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.81
42	Long qt syndrome 16	Enrichment	CALM3	2.81
43	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.81
44	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.81
45	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.81
46	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.81
47	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.81
48	Long qt syndrome 15	Enrichment	CALM2	2.81
49	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.81
50	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.81
51	Congenital pulmonary airway malformation	Enrichment	KRAS	2.81
52	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.81
53	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.81
54	Neurocutaneous melanocytosis	Enrichment	NRAS	2.81
55	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.76
56	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.69
57	West syndrome	Enrichment	GRIN1, GRIN2B	2.68
58	Microcephaly	Enrichment	CAMK2B, GRIN2B, MAPK1	2.65
59	Non-syndromic x-linked intellectual disability	Enrichment	DLG3, RPS6KA3	2.58
60	Costello syndrome	Enrichment	HRAS	2.51
61	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.51
62	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.51
63	Long qt syndrome 14	Enrichment	CALM1	2.51
64	Intellectual developmental disorder, x-linked 90	Enrichment	DLG3	2.51
65	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.51
66	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.51
67	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.51
68	Wooly hair nevus	Enrichment	HRAS	2.51
69	Gastroesophageal reflux	Enrichment	RPS6KA3	2.38
70	Orthostatic intolerance	Enrichment	RPS6KA3	2.38
71	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.37
72	Ventricular septal defect	Enrichment	RPS6KA3	2.33
73	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.33
74	Langerhans cell histiocytosis	Enrichment	NRAS	2.33
75	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.33
76	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.33
77	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.33
78	Dlg4-related synaptopathy	Enrichment	DLG4	2.33
79	Spermatocytoma	Enrichment	HRAS	2.33
80	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.21
81	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.21
82	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.21
83	Astigmatism	Enrichment	GRIN2B	2.21
84	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.21
85	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.21
86	Pilocytic astrocytoma	Enrichment	KRAS	2.21
87	Epidermolytic nevus	Enrichment	HRAS	2.21
88	Melanoma of soft tissue	Enrichment	CREB1	2.19
89	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	2.11
90	Sleep disorder	Enrichment	GRIN2B	2.11
91	Heart, malformation of	Enrichment	MAPK1	2.03
92	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.03
93	Breast adenocarcinoma	Enrichment	KRAS	2.03
94	Lung squamous cell carcinoma	Enrichment	KRAS	2.03
95	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.97
96	Gallbladder cancer	Enrichment	KRAS	1.97
97	Pilomyxoid astrocytoma	Enrichment	KRAS	1.97
98	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.91
99	Arteriovenous malformation	Enrichment	HRAS	1.86
100	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.81
101	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIN2B	1.81
102	Lip and oral cavity carcinoma	Enrichment	HRAS	1.73
103	Protein-deficiency anemia	Enrichment	NRAS	1.70
104	Lung cancer susceptibility 3	Enrichment	KRAS	1.67
105	Cleft lip/palate	Enrichment	DLG1	1.67
106	Lynch syndrome	Enrichment	KRAS	1.64
107	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	1.61
108	Rhabdomyosarcoma	Enrichment	HRAS	1.61
109	Sudden infant death syndrome	Enrichment	CALM2	1.58
110	Hypertelorism	Enrichment	RPS6KA3	1.58
111	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.56
112	Arteriovenous malformations of the brain	Enrichment	KRAS	1.54
113	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	NEFL	1.54
114	Craniosynostosis	Enrichment	GRIN2B	1.52
115	Scoliosis	Enrichment	GRIN2B	1.44
116	Pancreatic cancer	Enrichment	KRAS	1.42
117	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.42
118	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.40
119	Auditory neuropathy	Enrichment	NEFL	1.40
120	Lung cancer	Enrichment	KRAS	1.31
121	Peripheral nervous system disease	Enrichment	NEFL	1.31
122	Neuropathy	Enrichment	NEFL	1.31
123	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2	1.30
124	Left ventricular noncompaction	Enrichment	ACTN2	1.28
125	Dystonia	Enrichment	CAMK2B	1.28
126	Cerebral palsy	Enrichment	GRIN2B	1.23
127	Epilepsy	Enrichment	GRIN2B	1.22
128	Charcot-marie-tooth disease	Enrichment	NEFL	1.21
129	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1	1.21
130	Centralopathic epilepsy	Enrichment	GRIN1	1.19
131	Gastric cancer	Enrichment	KRAS	1.19
132	Hypertrophic cardiomyopathy	Enrichment	ACTN2	1.19
133	Hereditary breast carcinoma	Enrichment	KRAS	1.18
134	Sensorineural hearing loss	Enrichment	NEFL	1.14
135	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2	1.10
136	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.09
137	Myeloma, multiple	Enrichment	KRAS	1.08
138	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	1.08
139	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	1.06
140	Schizophrenia	Enrichment	DLG2	1.06
141	Autism	Enrichment	CAMK2G	0.98
142	Breast cancer	Enrichment	KRAS	0.96
143	Dilated cardiomyopathy	Enrichment	ACTN2	0.93
144	Colorectal cancer	Enrichment	NRAS	0.90
145	Ovarian cancer	Enrichment	KRAS	0.84
146	Congenital nervous system abnormality	Enrichment	CAMK2B	0.82
147	Nervous system disease	Enrichment	CAMK2B	0.82
148	Autism spectrum disorder	Enrichment	GRIN2B	0.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Pathway Network for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Pathway network for the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

Member Pathways for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Pathways in the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

Gene overlap in member pathways for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

Associated Genes for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Associated Disorders for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Disorders associated with CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling SuperPath

STRING Interaction Network for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Sources for CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling