CTL Mediated Apoptosis

No Pathway Network information available for CTL Mediated Apoptosis

Pathways in the CTL Mediated Apoptosis SuperPath

#	Name	Source	Genes
1	CTL Mediated Apoptosis	QIAGEN	APAF1 BID CASP3 CASP6 CASP7 CASP8 CASP9 CD247 CD3D CD3E CD3G CYCS DFFA FADD FAS FASLG GZMB HLA-A HLA-B HLA-C HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 HLA-E HLA-F HLA-G LIPF PRF1 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
2	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
3	CASP3	Caspase 3	Protein Coding	1
4	CASP6	Caspase 6	Protein Coding	1
5	CASP7	Caspase 7	Protein Coding	1
6	CASP8	Caspase 8	Protein Coding	1
7	CASP9	Caspase 9	Protein Coding	1
8	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
9	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
10	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
11	CD247	CD247 Molecule	Protein Coding	1
12	CYCS	Cytochrome C, Somatic	Protein Coding	1
13	DFFA	DNA Fragmentation Factor Subunit Alpha	Protein Coding	1
14	FADD	Fas Associated Via Death Domain	Protein Coding	1
15	GZMB	Granzyme B	Protein Coding	1
16	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	1
17	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
18	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	1
19	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	1
20	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	1
21	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	1
22	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	1
23	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	1
24	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	1
25	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	1
26	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	1
27	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
28	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	1
29	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	1
30	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	1
31	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	1
32	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	1
33	HLA-F	Major Histocompatibility Complex, Class I, F	Protein Coding	1
34	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	1
35	LIPF	Lipase F, Gastric Type	Protein Coding	1
36	PRF1	Perforin 1	Protein Coding	1
37	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
38	FASLG	Fas Ligand	Protein Coding	1

Disorders associated with CTL Mediated Apoptosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.69
2	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G	5.69
3	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	5.12
4	Severe cutaneous adverse reaction	Enrichment	HLA-A, HLA-B	5.12
5	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	5.12
6	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	5.12
7	Vogt-koyanagi-harada disease	Enrichment	FAS, HLA-DRB1	4.64
8	Temporal arteritis	Enrichment	HLA-B, HLA-DRB1	4.34
9	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	4.34
10	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	4.34
11	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	4.12
12	Lung cancer	Enrichment	CASP8, FAS, FASLG	4.02
13	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	3.67
14	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	3.17
15	Behcet syndrome	Enrichment	FAS, HLA-B	2.90
16	Spondyloarthropathy 1	Enrichment	HLA-B	2.55
17	Hemophagocytic lymphohistiocytosis, familial, 2	Enrichment	PRF1	2.55
18	Caspase 8 deficiency	Enrichment	CASP8	2.55
19	Psoriasis 1	Enrichment	HLA-C	2.55
20	Immunodeficiency 18	Enrichment	CD3E	2.55
21	Ankylosing spondylitis 1	Enrichment	HLA-B	2.55
22	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.55
23	Immunodeficiency 25	Enrichment	CD247	2.55
24	Thrombocytopenia 4	Enrichment	CYCS	2.55
25	Birdshot chorioretinopathy	Enrichment	HLA-A	2.55
26	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.55
27	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.55
28	Reactive arthritis	Enrichment	HLA-B	2.55
29	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.55
30	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.55
31	Immunodeficiency 19	Enrichment	CD3D	2.55
32	Fatal post-viral neurodegenerative disorder	Enrichment	PRF1	2.55
33	Severe covid-19	Enrichment	HLA-A, HLA-DQB1	2.53
34	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	2.25
35	Sarcoidosis 1	Enrichment	HLA-DRB1	2.25
36	Stevens-johnson syndrome	Enrichment	HLA-B	2.25
37	Immunodeficiency 17	Enrichment	CD3G	2.25
38	Oculootodental syndrome	Enrichment	FADD	2.25
39	Takayasu arteritis	Enrichment	HLA-B	2.08
40	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.08
41	Adult-onset myasthenia gravis	Enrichment	HLA-DQA1	2.08
42	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.95
43	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	PRF1	1.86
44	Follicular lymphoma	Enrichment	HLA-DRB1	1.86
45	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.86
46	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.86
47	Idiopathic aplastic anemia	Enrichment	PRF1	1.86
48	Granulomatosis with polyangiitis	Enrichment	HLA-DPA1	1.78
49	Limited scleroderma	Enrichment	HLA-DRB1	1.78
50	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.71
51	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.71
52	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	HLA-C	1.71
53	Lymphoma, non-hodgkin, familial	Enrichment	PRF1	1.65
54	Adult hepatocellular carcinoma	Enrichment	CASP8	1.60
55	Aplastic anemia	Enrichment	PRF1	1.56
56	Asthma	Enrichment	HLA-G	1.52
57	Human immunodeficiency virus type 1	Enrichment	HLA-C	1.31
58	Hepatocellular carcinoma	Enrichment	CASP8	1.22
59	Autoinflammatory disease	Enrichment	PRF1	1.19
60	Systemic lupus erythematosus	Enrichment	HLA-DRB1	0.98
61	Thrombocytopenia	Enrichment	CYCS	0.90
62	Breast cancer	Enrichment	CASP8	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CTL Mediated Apoptosis

Pathway Network for CTL Mediated Apoptosis

Member Pathways for CTL Mediated Apoptosis

Pathways in the CTL Mediated Apoptosis SuperPath

Associated Genes for CTL Mediated Apoptosis

Associated Disorders for CTL Mediated Apoptosis

Disorders associated with CTL Mediated Apoptosis SuperPath

STRING Interaction Network for CTL Mediated Apoptosis

Sources for CTL Mediated Apoptosis