CTNNB1 S45 mutants aren't phosphorylated

Pathway network for the CTNNB1 S45 mutants aren't phosphorylated SuperPath

Sources:

Reactome

Pathways in the CTNNB1 S45 mutants aren't phosphorylated SuperPath

#	Name	Source	Genes
1	CTNNB1 S45 mutants aren't phosphorylated	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 15) (see less)
2	Signaling by WNT in cancer	Reactome	AMER1 APC AXIN1 CSNK1A1 CTBP1 CTBP2 CTNNB1 DKK1 DKK2 DKK4 FZD4 FZD5 FZD6 FZD8 GSK3B KREMEN1 KREMEN2 LRP5 LRP6 PORCN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RNF43 TCF7L2 TNKS TNKS2 WNT3A (see all 34) (see less)
3	Disassembly of the destruction complex and recruitment of AXIN to the membrane	Reactome	AMER1 APC AXIN1 CAV1 CSNK1A1 CSNK1G2 CTNNB1 DVL1 DVL2 DVL3 FRAT1 FRAT2 FZD1 FZD2 FZD5 GSK3B LRP5 LRP6 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E WNT1 WNT3A WNT8A WNT8B (see all 31) (see less)
4	Beta-catenin phosphorylation cascade	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 FRAT1 FRAT2 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 17) (see less)
5	Signaling by CTNNB1 phospho-site mutants	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 15) (see less)
6	Signaling by GSK3beta mutants	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 15) (see less)
7	CTNNB1 S33 mutants aren't phosphorylated	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 15) (see less)
8	CTNNB1 S37 mutants aren't phosphorylated	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 15) (see less)
9	CTNNB1 T41 mutants aren't phosphorylated	Reactome	AMER1 APC AXIN1 CSNK1A1 CTNNB1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 15) (see less)
10	Signaling by APC mutants	Reactome	AMER1 APC AXIN1 CSNK1A1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 14) (see less)
11	AXIN missense mutants destabilize the destruction complex	Reactome	AMER1 APC AXIN1 CSNK1A1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 14) (see less)
12	Signaling by AXIN mutants	Reactome	AMER1 APC AXIN1 CSNK1A1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 14) (see less)
13	APC truncation mutants have impaired AXIN binding	Reactome	AMER1 APC AXIN1 CSNK1A1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 14) (see less)
14	Truncations of AMER1 destabilize the destruction complex	Reactome	AMER1 APC AXIN1 CSNK1A1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 14) (see less)
15	Signaling by AMER1 mutants	Reactome	AMER1 APC AXIN1 CSNK1A1 GSK3B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E (see all 14) (see less)

Gene overlap in member pathways for CTNNB1 S45 mutants aren't phosphorylated SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AMER1	APC Membrane Recruitment Protein 1	Protein Coding	15
2	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	15
3	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	15
4	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	15
5	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	15
6	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	15
7	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	15
8	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	15
9	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	15
10	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	15
11	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	15
12	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	15
13	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	15
14	AXIN1	Axin 1	Protein Coding	15
15	CTNNB1	Catenin Beta 1	Protein Coding	9
16	LRP6	LDL Receptor Related Protein 6	Protein Coding	2
17	LRP5	LDL Receptor Related Protein 5	Protein Coding	2
18	FZD5	Frizzled Class Receptor 5	Protein Coding	2
19	WNT3A	Wnt Family Member 3A	Protein Coding	2
20	FRAT1	FRAT Regulator Of Wnt Signaling Pathway 1	Protein Coding	2
21	FRAT2	FRAT Regulator Of Wnt Signaling Pathway 2	Protein Coding	2
22	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
23	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
24	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
25	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
26	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1
27	RNF43	Ring Finger Protein 43	Protein Coding	1
28	PORCN	Porcupine O-Acyltransferase	Protein Coding	1
29	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
30	KREMEN2	Kringle Containing Transmembrane Protein 2	Protein Coding	1
31	TNKS2	Tankyrase 2	Protein Coding	1
32	FZD4	Frizzled Class Receptor 4	Protein Coding	1
33	FZD6	Frizzled Class Receptor 6	Protein Coding	1
34	FZD8	Frizzled Class Receptor 8	Protein Coding	1
35	KREMEN1	Kringle Containing Transmembrane Protein 1	Protein Coding	1
36	TNKS	Tankyrase	Protein Coding	1
37	CSNK1G2	Casein Kinase 1 Gamma 2	Protein Coding	1
38	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
39	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
40	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
41	FZD2	Frizzled Class Receptor 2	Protein Coding	1
42	WNT1	Wnt Family Member 1	Protein Coding	1
43	WNT8A	Wnt Family Member 8A	Protein Coding	1
44	WNT8B	Wnt Family Member 8B	Protein Coding	1
45	FZD1	Frizzled Class Receptor 1	Protein Coding	1
46	CAV1	Caveolin 1	Protein Coding	1

Disorders associated with CTNNB1 S45 mutants aren't phosphorylated SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leukemia, chronic myeloid	Direct
2	Kidney cancer	Direct
3	Wilms tumor 1	Direct
4	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3, FZD2	7.36
5	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3, FZD2	7.36
6	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3, FZD2	6.97
7	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3, FZD2	6.97
8	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	6.84
9	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3, FZD2	6.67
10	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	6.10
11	Osteopathia striata with cranial sclerosis	Enrichment	AMER1, CTNNB1	5.94
12	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	5.78
13	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	5.47
14	Desmoid tumor	Enrichment	APC, CTNNB1	5.47
15	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3, FZD2	5.30
16	Craniopharyngioma	Enrichment	APC, CTNNB1	5.16
17	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	5.14
18	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	5.14
19	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	4.82
20	Retinopathy of prematurity	Enrichment	FZD4, LRP5	4.44
21	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	4.39
22	Medulloblastoma	Enrichment	APC, CTNNB1	3.99
23	Colorectal cancer	Enrichment	AMER1, APC, CTNNB1	3.96
24	Hepatoblastoma	Enrichment	APC, CTNNB1	3.63
25	Osteoporosis	Enrichment	LRP5, WNT1	3.34
26	Caudal duplication anomaly	Enrichment	AXIN1	2.99
27	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.99
28	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.99
29	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.99
30	Familial adenomatous polyposis	Enrichment	APC	2.99
31	Gardner syndrome	Enrichment	APC	2.99
32	5q22 microdeletion syndrome	Enrichment	APC	2.99
33	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.99
34	Attenuated familial adenomatous polyposis	Enrichment	APC	2.99
35	Adenoid ameloblastoma	Enrichment	CTNNB1	2.96
36	Microcystic stromal tumor	Enrichment	CTNNB1	2.96
37	Brittle bone disorder	Enrichment	LRP5, WNT1	2.91
38	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.69
39	Periampullary adenoma	Enrichment	APC	2.69
40	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.69
41	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.69
42	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.66
43	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.66
44	Teratoma	Enrichment	CTNNB1	2.66
45	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.64
46	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.64
47	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.64
48	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.64
49	Omodysplasia 2	Enrichment	FZD2	2.64
50	Tooth agenesis, selective, 7	Enrichment	LRP6	2.64
51	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.64
52	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.64
53	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.64
54	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.64
55	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.64
56	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.64
57	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.64
58	Microphthalmia/coloboma 11	Enrichment	FZD5	2.64
59	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.64
60	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.64
61	Chiari malformation type i	Enrichment	DKK1	2.60
62	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	2.60
63	Focal dermal hypoplasia	Enrichment	PORCN	2.60
64	Sessile serrated polyposis cancer syndrome	Enrichment	RNF43	2.60
65	Ectodermal dysplasia 13, hair/tooth type	Enrichment	KREMEN1	2.60
66	Hyperplastic polyposis syndrome	Enrichment	RNF43	2.60
67	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.51
68	Colon adenocarcinoma	Enrichment	APC	2.51
69	Apc-associated polyposis conditions	Enrichment	APC	2.51
70	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.48
71	Anus, imperforate	Enrichment	CTNNB1	2.48
72	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.48
73	Pilomatrixoma	Enrichment	CTNNB1	2.35
74	Alazami syndrome	Enrichment	CTNNB1	2.35
75	Van buchem disease	Enrichment	LRP5	2.34
76	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.34
77	Osteosclerosis	Enrichment	LRP5	2.34
78	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.30
79	Familial adenomatous polyposis 1	Enrichment	APC	2.29
80	Ovarian cancer	Enrichment	APC, CTNNB1	2.27
81	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.18
82	Adrenocortical carcinoma	Enrichment	CTNNB1	2.18
83	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	2.16
84	Nail disease	Enrichment	FZD6	2.12
85	Gallbladder cancer	Enrichment	CTNNB1	2.11
86	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	2.04
87	Orofacial cleft	Enrichment	LRP6	2.04
88	Eyelid coloboma	Enrichment	FZD5	2.04
89	Vitreoretinopathy	Enrichment	LRP5	2.04
90	Orofacial clefting syndrome	Enrichment	LRP6	2.04
91	Lens coloboma	Enrichment	FZD5	2.04
92	Colonic benign neoplasm	Enrichment	APC	2.03
93	Coloboma of choroid and retina	Enrichment	FZD5	1.94
94	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.94
95	Norrie disease	Enrichment	FZD4	1.90
96	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.90
97	Coloboma of optic nerve	Enrichment	FZD5	1.87
98	Limited scleroderma	Enrichment	CAV1	1.87
99	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.83
100	Cleft palate, isolated	Enrichment	AMER1	1.76
101	Coats disease	Enrichment	FZD4	1.76
102	Cat eye syndrome	Enrichment	FZD5	1.65
103	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.60
104	Microphthalmia/coloboma 12	Enrichment	FZD5	1.53
105	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.53
106	Bladder cancer	Enrichment	CTNNB1	1.50
107	Lung cancer	Enrichment	PPP2R1B	1.49
108	Coloboma of macula	Enrichment	FZD5	1.47
109	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.47
110	Complex neurodevelopmental disorder	Enrichment	PPP2CA, TCF7L2	1.42
111	Gastric cancer	Enrichment	APC	1.36
112	Hereditary breast carcinoma	Enrichment	APC	1.35
113	Macs syndrome	Enrichment	PORCN	1.31
114	Tooth agenesis	Enrichment	LRP6	1.31
115	Hydrops fetalis, nonimmune	Enrichment	FZD6	1.20
116	Breast cancer	Enrichment	APC	1.13
117	Non-immune hydrops fetalis	Enrichment	FZD6	1.13
118	Type 2 diabetes mellitus	Enrichment	TCF7L2	1.00
119	Congenital nervous system abnormality	Enrichment	CTNNB1	0.95
120	Nervous system disease	Enrichment	CTNNB1	0.95
121	Microcephaly	Enrichment	CTNNB1	0.89
122	Inherited cancer-predisposing syndrome	Enrichment	APC	0.89
123	Hereditary retinal dystrophy	Enrichment	FZD4, LRP5	0.79
124	Fundus dystrophy	Enrichment	FZD4, LRP5	0.79
125	Autism	Enrichment	TCF7L2	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CTNNB1 S45 mutants aren't phosphorylated

Pathway Network for CTNNB1 S45 mutants aren't phosphorylated

Pathway network for the CTNNB1 S45 mutants aren't phosphorylated SuperPath

Member Pathways for CTNNB1 S45 mutants aren't phosphorylated

Pathways in the CTNNB1 S45 mutants aren't phosphorylated SuperPath

Gene overlap in member pathways for CTNNB1 S45 mutants aren't phosphorylated SuperPath

Associated Genes for CTNNB1 S45 mutants aren't phosphorylated

Associated Disorders for CTNNB1 S45 mutants aren't phosphorylated

Disorders associated with CTNNB1 S45 mutants aren't phosphorylated SuperPath

STRING Interaction Network for CTNNB1 S45 mutants aren't phosphorylated

Sources for CTNNB1 S45 mutants aren't phosphorylated