CXCR3-mediated signaling events

No Pathway Network information available for CXCR3-mediated signaling events

Pathways in the CXCR3-mediated signaling events SuperPath

#	Name	Source	Genes
1	CXCR3-mediated signaling events	PubChem	AKT1 ARRB1 CCL11 CXCL10 CXCL11 CXCL13 CXCL9 CXCR3 DNM1 GNAI2 GNAI3 GNB1 GNG2 MAP2K1 MAP2K3 MAPK14 MAPK3 MAPKAP1 MLST8 MTOR PDPK1 PF4 PIK3CA PIK3CB PIK3R1 RAF1 RICTOR SRC (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	1
2	CXCL11	C-X-C Motif Chemokine Ligand 11	Protein Coding	1
3	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
4	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
5	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
6	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
7	PF4	Platelet Factor 4	Protein Coding	1
8	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
9	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	1
10	CXCR3	C-X-C Motif Chemokine Receptor 3	Protein Coding	1
11	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
12	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
13	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1
14	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
15	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
16	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
17	DNM1	Dynamin 1	Protein Coding	1
18	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
19	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
20	GNB1	G Protein Subunit Beta 1	Protein Coding	1
21	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
22	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
23	ARRB1	Arrestin Beta 1	Protein Coding	1
24	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
25	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
26	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
27	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
28	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1

Disorders associated with CXCR3-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.91
2	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	4.54
3	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	4.39
4	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.21
5	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	4.07
6	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	4.07
7	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.83
8	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.83
9	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.74
10	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	3.65
11	Meningioma	Enrichment	AKT1, PIK3CA	3.57
12	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, RAF1	3.37
13	Noonan syndrome 1	Enrichment	MAP2K1, RAF1	2.99
14	Rasopathy	Enrichment	MAP2K1, RAF1	2.89
15	Macrodactyly	Enrichment	PIK3CA	2.69
16	Proteus syndrome	Enrichment	AKT1	2.69
17	Noonan syndrome 5	Enrichment	RAF1	2.69
18	Melorheostosis, isolated	Enrichment	MAP2K1	2.69
19	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.69
20	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.69
21	Cowden syndrome 5	Enrichment	PIK3CA	2.69
22	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.69
23	Ventricular tachycardia, familial	Enrichment	GNAI2	2.69
24	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.69
25	Short syndrome	Enrichment	PIK3R1	2.69
26	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.69
27	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.69
28	Melorheostosis	Enrichment	MAP2K1	2.69
29	Leopard syndrome 2	Enrichment	RAF1	2.69
30	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.69
31	Cowden syndrome 6	Enrichment	AKT1	2.69
32	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.69
33	Thrombocytopenia 6	Enrichment	SRC	2.69
34	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.69
35	Trigonitis	Enrichment	RAF1	2.69
36	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.69
37	Hypospadias	Enrichment	PIK3CA	2.69
38	Rare venous malformation	Enrichment	PIK3CA	2.69
39	Diaphragmatic eventration	Enrichment	PIK3CA	2.69
40	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.69
41	Rare combined vascular malformation	Enrichment	PIK3CA	2.69
42	Cavernous lymphangioma	Enrichment	PIK3CA	2.69
43	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.69
44	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.69
45	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.69
46	Macrodactyly of toe	Enrichment	PIK3CA	2.69
47	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.43
48	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.38
49	Keratosis, seborrheic	Enrichment	PIK3CA	2.38
50	Noonan syndrome 8	Enrichment	PIK3CA	2.38
51	Cebalid syndrome	Enrichment	MTOR	2.38
52	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.38
53	Hypopituitarism	Enrichment	GNAI2	2.38
54	Smith-kingsmore syndrome	Enrichment	MTOR	2.38
55	Cerebral visual impairment	Enrichment	GNB1	2.38
56	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.21
57	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.21
58	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.21
59	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.21
60	Immunodeficiency 14	Enrichment	PIK3R1	2.21
61	Keratoacanthoma	Enrichment	PIK3CA	2.21
62	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.08
63	Auriculocondylar syndrome 1	Enrichment	GNAI3	2.08
64	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.08
65	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.08
66	Achromatopsia 4	Enrichment	GNAI3	2.08
67	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.08
68	Cerebrovascular disease	Enrichment	PIK3CA	2.08
69	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.08
70	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.08
71	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.08
72	Capillary malformations, congenital	Enrichment	PIK3CA	1.99
73	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.99
74	Breast cancer	Enrichment	AKT1, PIK3CA	1.98
75	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.91
76	Cowden syndrome 1	Enrichment	PIK3CA	1.91
77	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.91
78	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.91
79	Nevus, epidermal	Enrichment	PIK3CA	1.84
80	Myelofibrosis	Enrichment	SRC	1.84
81	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.84
82	Noonan syndrome 3	Enrichment	RAF1	1.84
83	Gallbladder cancer	Enrichment	PIK3CA	1.84
84	Pilomyxoid astrocytoma	Enrichment	RAF1	1.84
85	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.79
86	Lennox-gastaut syndrome	Enrichment	DNM1	1.79
87	Hypothyroidism	Enrichment	GNB1	1.79
88	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.74
89	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.73
90	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.69
91	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	1.68
92	Asthma	Enrichment	CCL11	1.65
93	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.65
94	Myelodysplastic syndrome	Enrichment	GNB1	1.65
95	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.61
96	Stereotypic movement disorder	Enrichment	DNM1	1.58
97	Nk-cell enteropathy	Enrichment	PIK3CB	1.58
98	Osteoporosis	Enrichment	SRC	1.54
99	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.52
100	Lynch syndrome	Enrichment	PIK3CA	1.52
101	Rare genetic intellectual disability	Enrichment	MTOR	1.52
102	Cleft palate, isolated	Enrichment	GNB1	1.46
103	Human immunodeficiency virus type 1	Enrichment	CCL11	1.44
104	Endometrial cancer	Enrichment	PIK3CA	1.37
105	Hepatocellular carcinoma	Enrichment	PIK3CA	1.35
106	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.31
107	Strabismus	Enrichment	GNB1	1.27
108	Bladder cancer	Enrichment	PIK3CA	1.23
109	Prostate cancer	Enrichment	PIK3CA	1.23
110	Lung cancer	Enrichment	PIK3CA	1.19
111	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.18
112	Left ventricular noncompaction	Enrichment	RAF1	1.16
113	Dystonia	Enrichment	GNB1	1.16
114	Cerebral palsy	Enrichment	GNB1	1.11
115	Gastric cancer	Enrichment	PIK3CA	1.07
116	West syndrome	Enrichment	DNM1	1.06
117	Thrombocytopenia	Enrichment	SRC	1.02
118	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.01
119	Hypertelorism	Enrichment	PIK3CA	0.99
120	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.98
121	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.96
122	Primary ovarian insufficiency	Enrichment	RICTOR	0.94
123	Dilated cardiomyopathy	Enrichment	RAF1	0.82
124	Microcephaly	Enrichment	GNB1	0.65

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CXCR3-mediated signaling events

Pathway Network for CXCR3-mediated signaling events

Member Pathways for CXCR3-mediated signaling events

Pathways in the CXCR3-mediated signaling events SuperPath

Associated Genes for CXCR3-mediated signaling events

Associated Disorders for CXCR3-mediated signaling events

Disorders associated with CXCR3-mediated signaling events SuperPath

STRING Interaction Network for CXCR3-mediated signaling events

Sources for CXCR3-mediated signaling events