CXCR4-mediated signaling events

No Pathway Network information available for CXCR4-mediated signaling events

Pathways in the CXCR4-mediated signaling events SuperPath

#	Name	Source	Genes
1	CXCR4-mediated signaling events	PubChem	AKT1 ARR3 ARRB2 BAD BCAR1 CD247 CD3D CD3E CD3G CD4 CFL1 CRK CSK CXCL12 CXCR4 DNM1 FOXO1 GNA13 GNB1 GNG2 GRK2 GRK6 HGS HLA-DRA ITCH JAK2 LCK LIMK1 MAPKAP1 MLST8 MMP9 MTOR PAG1 PAK1 PDPK1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R6 PRKCZ PTK2 PTK2B PTPN6 PTPRC PXN RACK1 RALB RAP1B RAP2A RGS1 RICTOR SSH1 STAT1 STAT2 UBQLN1 VAV1 (see all 57) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UBQLN1	Ubiquilin 1	Protein Coding	1
2	RAP2A	RAP2A, Member Of RAS Oncogene Family	Protein Coding	1
3	GRK6	G Protein-Coupled Receptor Kinase 6	Protein Coding	1
4	SSH1	Slingshot Protein Phosphatase 1	Protein Coding	1
5	ARR3	Arrestin 3	Protein Coding	1
6	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
7	CD247	CD247 Molecule	Protein Coding	1
8	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
9	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
10	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
11	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
12	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
13	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
14	CD4	CD4 Molecule	Protein Coding	1
15	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
16	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
17	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
18	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1
19	RALB	RAS Like Proto-Oncogene B	Protein Coding	1
20	PAG1	Phosphoprotein Membrane Anchor With Glycosphingolipid Microdomains 1	Protein Coding	1
21	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
22	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
23	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
24	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
25	CSK	C-Terminal Src Kinase	Protein Coding	1
26	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
27	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
28	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
29	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
30	ARRB2	Arrestin Beta 2	Protein Coding	1
31	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
32	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
33	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
34	PXN	Paxillin	Protein Coding	1
35	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
36	FOXO1	Forkhead Box O1	Protein Coding	1
37	DNM1	Dynamin 1	Protein Coding	1
38	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
39	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
40	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
41	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
42	CFL1	Cofilin 1	Protein Coding	1
43	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
44	LIMK1	LIM Domain Kinase 1	Protein Coding	1
45	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	1
46	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
47	JAK2	Janus Kinase 2	Protein Coding	1
48	GNB1	G Protein Subunit Beta 1	Protein Coding	1
49	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
50	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
51	RGS1	Regulator Of G Protein Signaling 1	Protein Coding	1
52	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
53	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
54	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
55	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
56	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
57	MMP9	Matrix Metallopeptidase 9	Protein Coding	1

Disorders associated with CXCR4-mediated signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, LCK, PTPRC	8.37
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	7.15
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.28
4	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	3.76
5	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.59
6	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.44
7	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.21
8	Meningioma	Enrichment	AKT1, PIK3CA	2.95
9	Macrodactyly	Enrichment	PIK3CA	2.38
10	Proteus syndrome	Enrichment	AKT1	2.38
11	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.38
12	Cowden syndrome 5	Enrichment	PIK3CA	2.38
13	Whim syndrome 1	Enrichment	CXCR4	2.38
14	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.38
15	Pseudo-torch syndrome 3	Enrichment	STAT2	2.38
16	Short syndrome	Enrichment	PIK3R1	2.38
17	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.38
18	Okt4 epitope deficiency	Enrichment	CD4	2.38
19	Myopia 26, x-linked, female-limited	Enrichment	ARR3	2.38
20	Immunodeficiency 18	Enrichment	CD3E	2.38
21	Immunodeficiency 25	Enrichment	CD247	2.38
22	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.38
23	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.38
24	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.38
25	Immunodeficiency 31a	Enrichment	STAT1	2.38
26	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.38
27	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.38
28	Cowden syndrome 6	Enrichment	AKT1	2.38
29	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.38
30	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.38
31	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.38
32	Immunodeficiency 31b	Enrichment	STAT1	2.38
33	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.38
34	Immunodeficiency 22	Enrichment	LCK	2.38
35	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.38
36	Immunodeficiency 79	Enrichment	CD4	2.38
37	Cd45 deficiency	Enrichment	PTPRC	2.38
38	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.38
39	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.38
40	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.38
41	Hypospadias	Enrichment	PIK3CA	2.38
42	Rare venous malformation	Enrichment	PIK3CA	2.38
43	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.38
44	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.38
45	Diaphragmatic eventration	Enrichment	PIK3CA	2.38
46	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.38
47	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.38
48	Immunodeficiency 19	Enrichment	CD3D	2.38
49	Rare combined vascular malformation	Enrichment	PIK3CA	2.38
50	Cavernous lymphangioma	Enrichment	PIK3CA	2.38
51	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.38
52	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.38
53	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.38
54	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.38
55	Macrodactyly of toe	Enrichment	PIK3CA	2.38
56	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.24
57	Keratosis, seborrheic	Enrichment	PIK3CA	2.08
58	Noonan syndrome 8	Enrichment	PIK3CA	2.08
59	Thrombocythemia 3	Enrichment	JAK2	2.08
60	Immunodeficiency 31c	Enrichment	STAT1	2.08
61	Cebalid syndrome	Enrichment	MTOR	2.08
62	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.08
63	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.08
64	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.08
65	Immunodeficiency 17	Enrichment	CD3G	2.08
66	Smith-kingsmore syndrome	Enrichment	MTOR	2.08
67	Polycythemia	Enrichment	JAK2	2.08
68	Metaphyseal anadysplasia	Enrichment	MMP9	2.08
69	Hypereosinophilic syndrome	Enrichment	JAK2	2.08
70	Cerebral visual impairment	Enrichment	GNB1	2.08
71	Polycythemia vera	Enrichment	JAK2	1.90
72	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.90
73	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.90
74	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.90
75	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.90
76	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.90
77	Immunodeficiency 14	Enrichment	PIK3R1	1.90
78	Immunodeficiency 44	Enrichment	STAT2	1.90
79	Keratoacanthoma	Enrichment	PIK3CA	1.90
80	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.83
81	Erythrocytosis, familial, 1	Enrichment	JAK2	1.78
82	Budd-chiari syndrome	Enrichment	JAK2	1.78
83	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.78
84	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.78
85	Cerebrovascular disease	Enrichment	PIK3CA	1.78
86	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.78
87	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.78
88	Capillary malformations, congenital	Enrichment	PIK3CA	1.68
89	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.68
90	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.68
91	Myeloproliferative neoplasm	Enrichment	JAK2	1.68
92	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1, LIMK1	1.64
93	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.60
94	Cowden syndrome 1	Enrichment	PIK3CA	1.60
95	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.60
96	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.60
97	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.60
98	Primary ovarian insufficiency	Enrichment	JAK2, RICTOR	1.59
99	Nevus, epidermal	Enrichment	PIK3CA	1.54
100	Myelofibrosis	Enrichment	JAK2	1.54
101	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.54
102	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.54
103	Essential thrombocythemia	Enrichment	JAK2	1.54
104	Gallbladder cancer	Enrichment	PIK3CA	1.54
105	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.54
106	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.54
107	Lennox-gastaut syndrome	Enrichment	DNM1	1.48
108	Hypothyroidism	Enrichment	GNB1	1.48
109	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.43
110	Arteriovenous malformation	Enrichment	PIK3CA	1.43
111	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.43
112	Breast cancer	Enrichment	AKT1, PIK3CA	1.40
113	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.38
114	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.38
115	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.34
116	Myelodysplastic syndrome	Enrichment	GNB1	1.34
117	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.34
118	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.31
119	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.27
120	Stereotypic movement disorder	Enrichment	DNM1	1.27
121	Nk-cell enteropathy	Enrichment	PIK3CB	1.27
122	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.21
123	Lynch syndrome	Enrichment	PIK3CA	1.21
124	Rare genetic intellectual disability	Enrichment	MTOR	1.21
125	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.17
126	Cleft palate, isolated	Enrichment	GNB1	1.16
127	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.14
128	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.11
129	Williams-beuren syndrome	Enrichment	LIMK1	1.09
130	Endometrial cancer	Enrichment	PIK3CA	1.07
131	Hepatocellular carcinoma	Enrichment	PIK3CA	1.05
132	Jeune thoracic dystrophy	Enrichment	GRK2	1.00
133	Strabismus	Enrichment	GNB1	0.97
134	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.95
135	Bladder cancer	Enrichment	PIK3CA	0.94
136	Prostate cancer	Enrichment	PIK3CA	0.94
137	Lung cancer	Enrichment	PIK3CA	0.90
138	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.89
139	Dystonia	Enrichment	GNB1	0.86
140	Cerebral palsy	Enrichment	GNB1	0.82
141	Leukemia, acute myeloid	Enrichment	JAK2	0.81
142	Gastric cancer	Enrichment	PIK3CA	0.78
143	West syndrome	Enrichment	DNM1	0.77
144	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.72
145	Hypertelorism	Enrichment	PIK3CA	0.71
146	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.68
147	Autism spectrum disorder	Enrichment	GNB1	0.43
148	Microcephaly	Enrichment	GNB1	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CXCR4-mediated signaling events

Pathway Network for CXCR4-mediated signaling events

Member Pathways for CXCR4-mediated signaling events

Pathways in the CXCR4-mediated signaling events SuperPath

Associated Genes for CXCR4-mediated signaling events

Associated Disorders for CXCR4-mediated signaling events

Disorders associated with CXCR4-mediated signaling events SuperPath

STRING Interaction Network for CXCR4-mediated signaling events

Sources for CXCR4-mediated signaling events