Cyclins and Cell Cycle Regulation

Pathway network for the Cyclins and Cell Cycle Regulation SuperPath

Sources:
  • QIAGEN

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Cyclins and Cell Cycle Regulation SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Multiple endocrine neoplasia, type iEnrichmentCDKN1A, CDKN1B, CDKN2B, CDKN2C8.51
2Bladder cancerEnrichmentATM, CDKN1A, CDKN2A, RB1, TP537.55
3Inherited cancer-predisposing syndromeEnrichmentATM, CDK4, CDKN1B, CDKN2A, RB1, TP535.46
4Leukemia, chronic lymphocyticEnrichmentATM, CCND1, TP535.46
5Lip and oral cavity carcinomaEnrichmentCDKN2A, RB1, TP535.19
6Loeys-dietz syndrome 4EnrichmentTGFB2, TGFB35.01
7Gastric cancerEnrichmentATM, CDK4, CDKN2A, TP535.01
8Ovarian cancerEnrichmentATM, CDKN1B, CDKN2A, RB1, TP534.80
9Melanoma, cutaneous malignant 1EnrichmentCDK4, CDKN2A, CDKN2B4.71
10Myeloma, multipleEnrichmentATM, CCND1, CDKN2C, TP534.54
11Osteogenic sarcomaEnrichmentRB1, TP534.53
12Squamous cell carcinomaEnrichmentRB1, TP534.53
13AdenocarcinomaEnrichmentATM, TP534.53
14Bone osteosarcomaEnrichmentRB1, TP534.53
15Small cell cancer of the lungEnrichmentRB1, TP534.23
16Mantle cell lymphomaEnrichmentATM, CCND14.23
17Pancreatic cancerEnrichmentATM, CDKN2A, TP534.19
18Li-fraumeni syndromeEnrichmentCDKN2A, TP533.84
19Adrenocortical carcinomaEnrichmentCDKN2A, TP533.84
20B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentCDKN2A, TP533.69
21Loeys-dietz syndromeEnrichmentTGFB2, TGFB33.46
22Lung cancer susceptibility 3EnrichmentRB1, TP533.06
23GliosarcomaEnrichmentATM, TP532.94
24Giant cell glioblastomaEnrichmentATM, TP532.89
25Breast cancerEnrichmentATM, CDKN2B, TP532.77
26Melanoma, cutaneous malignant 3EnrichmentCDK42.63
27Spinocerebellar ataxia 12EnrichmentPPP2R2B2.63
28Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual developmentEnrichmentPTPA2.63
29Houge-janssens syndrome 4EnrichmentPPP2R5C2.63
30Houge-janssens syndrome 2EnrichmentPPP2R1A2.63
31Trilateral retinoblastomaEnrichmentRB12.63
32Ppp2r1a-related neurodevelopmental disorderEnrichmentPPP2R1A2.63
33Lung oat cell carcinomaEnrichmentRB12.63
34Colorectal cancerEnrichmentATM, CCND1, TP532.58
35Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmiaEnrichmentHDAC62.50
36Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3EnrichmentCCND22.50
37Seckel syndrome 1EnrichmentATR2.50
38Microcephaly 12, primary, autosomal recessiveEnrichmentCDK62.50
39Auriculocondylar syndrome 4EnrichmentHDAC92.50
40Cornelia de lange syndrome 5EnrichmentHDAC82.50
41Bone marrow failure syndrome 5EnrichmentTP532.50
42Papilloma of choroid plexusEnrichmentTP532.50
43Basal cell carcinoma 7EnrichmentTP532.50
44Anaplastic thyroid carcinomaEnrichmentTP532.50
45Camurati-engelmann disease 2EnrichmentTGFB22.50
46Neuroendocrine tumorEnrichmentCDKN1B2.50
47Cutaneous telangiectasia and cancer syndrome, familialEnrichmentATR2.50
48Endometrial serous adenocarcinomaEnrichmentATM2.50
49Ductal carcinoma in situEnrichmentTP532.50
50Loeys-dietz syndrome 5EnrichmentTGFB32.50
51Thyroid gland undifferentiated carcinomaEnrichmentTP532.50
52Small-cell carcinoma of the ovary of hypercalcemic typeEnrichmentTP532.50
53Cdkn2a cancer predispositionEnrichmentCDKN2A2.50
54Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtypeEnrichmentTP532.50
55B-cell non-hodgkin lymphomaEnrichmentATM2.50
56Choroid plexus cancerEnrichmentTP532.50
57Pleomorphic xanthoastrocytomaEnrichmentTP532.50
58Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndromeEnrichmentATR2.50
59Prostate cancerEnrichmentATM, TP532.42
60Chromosome 13q14 deletion syndromeEnrichmentRB12.33
61Houge-janssens syndrome 3EnrichmentPPP2CA2.33
62Familial retinoblastomaEnrichmentRB12.33
63Noonan syndrome 5EnrichmentRAF12.32
64Cardiomyopathy, dilated, 1nnEnrichmentRAF12.32
65Leopard syndrome 2EnrichmentRAF12.32
66TrigonitisEnrichmentRAF12.32
67Melanoma-astrocytoma syndromeEnrichmentCDKN2A2.20
68Adrenocortical carcinoma, hereditaryEnrichmentTP532.20
69Camurati-engelmann disease 1EnrichmentTGFB12.20
70Cervical cancerEnrichmentTP532.20
71Melanoma, cutaneous malignant 2EnrichmentCDKN2A2.20
72Lymphoma, hodgkin, classicEnrichmentTP532.20
73Syndactyly, type iiiEnrichmentHDAC82.20
74Multiple endocrine neoplasia, type ivEnrichmentCDKN1B2.20
75Cardiac valvular dysplasia, x-linkedEnrichmentATM2.20
76Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB12.20
77Wilson-turner syndromeEnrichmentHDAC82.20
78Melanoma-pancreatic cancer syndromeEnrichmentCDKN2A2.20
79Camurati-engelmann diseaseEnrichmentTGFB12.20
80Congenital fibrosarcomaEnrichmentTP532.20
81High grade gliomaEnrichmentATM2.20
82Li-fraumeni syndrome 1EnrichmentTP532.20
83SarcomaEnrichmentTP532.20
84Cervix carcinomaEnrichmentTP532.20
85Hodgkin's lymphomaEnrichmentTP532.20
86T-cell prolymphocytic leukemiaEnrichmentATM2.20
87Pleomorphic rhabdomyosarcomaEnrichmentTP532.20
88RetinoblastomaEnrichmentRB12.15
89Woolly hair, autosomal recessive 3EnrichmentRB12.15
90Hypotrichosis 8EnrichmentRB12.15
91Dedifferentiated liposarcomaEnrichmentCDK42.15
92Well-differentiated liposarcomaEnrichmentCDK42.15
93Familial thoracic aortic aneurysm and aortic dissectionEnrichmentTGFB2, TGFB32.07
94Hereditary breast carcinomaEnrichmentATM, TP532.07
95Lynch syndrome 4EnrichmentRB12.03
96Ataxia-telangiectasiaEnrichmentATM2.02
97Polycythemia veraEnrichmentATM2.02
98Nasopharyngeal carcinomaEnrichmentTP532.02
99Koolen-de vries syndromeEnrichmentATM2.02
100Atypical teratoid rhabdoid tumorEnrichmentTP532.02
101Anaplastic astrocytomaEnrichmentTP532.02
102Von hippel-lindau syndromeEnrichmentCCND11.93
103Thyroid cancer, nonmedullary, 1EnrichmentTP531.90
104Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1EnrichmentCCND21.90
105Lung sarcomatoid carcinomaEnrichmentTP531.90
106Embryonal rhabdomyosarcomaEnrichmentTP531.90
107Primary hyperparathyroidismEnrichmentCDKN1B1.90
108Oculomotor apraxiaEnrichmentATM1.90
109Hereditary breast ovarian cancer syndromeEnrichmentATM, TP531.88
110Wieacker-wolff syndromeEnrichmentCCNH1.84
111Arrhythmogenic right ventricular dysplasia, familial, 1EnrichmentTGFB31.80
112Rhabdomyosarcoma 2EnrichmentTP531.80
113LymphomaEnrichmentTP531.80
114GlioblastomaEnrichmentATM1.80
115Arrhythmogenic right ventricular dysplasia 1EnrichmentTGFB31.80
116Acute megakaryocytic leukemiaEnrichmentTP531.80
117Atrial septal defect 1EnrichmentTGFB21.72
118Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.72
119Clear cell renal cell carcinomaEnrichmentATM1.72
120Il10-related early-onset inflammatory bowel diseaseEnrichmentTGFB11.72
121Breast adenocarcinomaEnrichmentTP531.72
122Lung squamous cell carcinomaEnrichmentCDKN2A1.72
123Noonan syndrome with multiple lentiginesEnrichmentRAF11.72
124Pregnancy loss, recurrent 1EnrichmentCCNB31.72
125Esophageal cancerEnrichmentTP531.66
126Squamous cell carcinoma, head and neckEnrichmentTP531.66
127Renal cell carcinoma, papillary, 1EnrichmentATM1.66
128Essential thrombocythemiaEnrichmentTP531.66
129Gallbladder cancerEnrichmentTP531.66
130Capillary malformations, congenitalEnrichmentCCNH1.62
131Glioma susceptibility 1EnrichmentTP531.60
132Fanconi anemia, complementation group cEnrichmentHDAC81.60
133Lymphoma, non-hodgkin, familialEnrichmentTP531.60
134Cornelia de lange syndrome 1EnrichmentHDAC81.55
135Adult hepatocellular carcinomaEnrichmentTP531.55
136Primary hyperaldosteronismEnrichmentTP531.55
137Colonic benign neoplasmEnrichmentATM1.55
138Cornelia de lange syndromeEnrichmentHDAC81.55
139Klippel-trenaunay-weber syndromeEnrichmentCCNH1.55
140Telangiectasia, hereditary hemorrhagic, type 1EnrichmentCCNH1.55
141Hemangioma, capillary infantileEnrichmentCCNH1.55
142Basal cell carcinoma 1EnrichmentCCNH1.55
143Lynch syndrome 1EnrichmentATM1.50
144Marfan syndromeEnrichmentTGFB21.50
145MelanomaEnrichmentCDKN2A1.50
146Familial colorectal cancerEnrichmentTP531.50
147Capillary malformation-arteriovenous malformation 1EnrichmentCCNH1.48
148Noonan syndrome 3EnrichmentRAF11.48
149Hereditary hemorrhagic telangiectasiaEnrichmentCCNH1.48
150Pilomyxoid astrocytomaEnrichmentRAF11.48
151Immune deficiency diseaseEnrichmentATM1.46
152Leukemia, acute lymphoblasticEnrichmentCDKN2A1.46
153Myelodysplastic syndromeEnrichmentTP531.46
154Atrial heart septal defectEnrichmentHDAC81.46
155Uterine corpus cancerEnrichmentATM1.46
156Interatrial communicationEnrichmentHDAC81.46
157Familial colorectal cancer type xEnrichmentATM1.46
158Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variantEnrichmentTGFB31.43
159Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variantEnrichmentTGFB31.43
160Melanocytic nevus syndrome, congenitalEnrichmentRAF11.42
161Breast-ovarian cancer, familial 1EnrichmentATM1.39
162Arteriovenous malformationEnrichmentCCNH1.37
163Seckel syndromeEnrichmentATR1.36
164Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variantEnrichmentTGFB31.36
165Renal cell carcinoma, nonpapillaryEnrichmentATM1.33
166Myopathy, x-linked, with excessive autophagyEnrichmentCCNH1.33
167RhabdomyosarcomaEnrichmentTP531.30
168Polycystic liver diseaseEnrichmentCDC25A1.28
169Autosomal dominant polycystic liver diseaseEnrichmentCDC25A1.28
170Polycystic kidney diseaseEnrichmentHDAC81.26
171Diffuse large b-cell lymphomaEnrichmentTP531.23
172Ehlers-danlos syndromeEnrichmentTGFB21.23
173Endometrial cancerEnrichmentATM1.19
174HepatoblastomaEnrichmentTP531.19
175Hepatocellular carcinomaEnrichmentTP531.17
176Visceral heterotaxyEnrichmentLEFTY21.17
177Noonan syndrome and noonan-related syndromeEnrichmentRAF11.16
178Diamond-blackfan anemia 1EnrichmentTP531.15
179Precursor t-cell acute lymphoblastic leukemiaEnrichmentCDKN2A1.15
180Lung cancerEnrichmentPPP2R1B1.14
181Cystic fibrosisEnrichmentTGFB11.01
182Primary autosomal recessive microcephalyEnrichmentCDK61.01
183Noonan syndrome 1EnrichmentRAF10.98
184Diamond-blackfan anemiaEnrichmentTP530.97
185Cardiomyopathy, familial hypertrophic, 1EnrichmentRAF10.96
186RasopathyEnrichmentRAF10.93
187Leukemia, acute myeloidEnrichmentTP530.92
188Familial hypertrophic cardiomyopathyEnrichmentRAF10.83
189Left ventricular noncompactionEnrichmentRAF10.81
190Familial isolated dilated cardiomyopathyEnrichmentRAF10.65
191Complex neurodevelopmental disorderEnrichmentPPP2CA0.59
192Dilated cardiomyopathyEnrichmentRAF10.50
193MicrocephalyEnrichmentHDAC80.49

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