Cyclophosphamide Pathway, Pharmacodynamics

No Pathway Network information available for Cyclophosphamide Pathway, Pharmacodynamics

Pathways in the Cyclophosphamide Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Cyclophosphamide Pathway, Pharmacodynamics	PharmGKB	ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 AKR1A1 AKR1B1 AKR1B10 ALDH1A1 ALDH2 ALDH3A1 ALDH5A1 ERCC1 ERCC4 MGMT (see all 17) (see less)
2	Ifosfamide Pathway, Pharmacodynamics	PharmGKB	ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 AKR1A1 AKR1B1 AKR1B10 ALDH1A1 ALDH2 ALDH3A1 GSTP1 (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKR1B10	Aldo-Keto Reductase Family 1 Member B10	Protein Coding	2
2	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	2
3	ALDH3A1	Aldehyde Dehydrogenase 3 Family Member A1	Protein Coding	2
4	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	2
5	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	2
6	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	2
7	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	2
8	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	2
9	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	2
10	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	2
11	ADH5	Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide	Protein Coding	2
12	ADH6	Alcohol Dehydrogenase 6 (Class V)	Protein Coding	2
13	ADH7	Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide	Protein Coding	2
14	ALDH5A1	Aldehyde Dehydrogenase 5 Family Member A1	Protein Coding	1
15	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	1
16	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	1
17	ERCC4	ERCC Excision Repair 4, Endonuclease Catalytic Subunit	Protein Coding	1
18	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1

Disorders associated with Cyclophosphamide Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alcohol dependence	Enrichment	ADH1B, ADH1C, ALDH2	7.76
2	Amed syndrome, digenic	Enrichment	ADH5, ALDH2	6.00
3	Alcohol sensitivity, acute	Enrichment	ALDH2	2.99
4	Cerebrooculofacioskeletal syndrome 4	Enrichment	ERCC1	2.90
5	Xfe progeroid syndrome	Enrichment	ERCC4	2.90
6	Kala-azar 2	Enrichment	GSTP1	2.69
7	Xeroderma pigmentosum, complementation group f	Enrichment	ERCC4	2.60
8	Fanconi anemia, complementation group q	Enrichment	ERCC4	2.60
9	Xeroderma pigmentosum group f	Enrichment	ERCC4	2.60
10	Succinic semialdehyde dehydrogenase deficiency	Enrichment	ALDH5A1	2.43
11	Parkinson disease, mitochondrial	Enrichment	ADH1C	2.38
12	Hutchinson-gilford progeria syndrome	Enrichment	ERCC4	2.30
13	Keratoconus	Enrichment	ALDH3A1	2.21
14	Cockayne syndrome a	Enrichment	ERCC4	2.20
15	Autosomal recessive cerebellar ataxia	Enrichment	ERCC4	2.20
16	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC4	2.20
17	Cockayne syndrome b	Enrichment	ERCC1	2.13
18	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC1	2.13
19	Cockayne syndrome	Enrichment	ERCC4	2.06
20	Leukemia, acute lymphoblastic 3	Enrichment	ERCC4	1.95
21	Xeroderma pigmentosum, variant type	Enrichment	ERCC4	1.86
22	Premature menopause	Enrichment	ERCC1	1.79
23	Gliosarcoma	Enrichment	MGMT	1.70
24	Melanoma, cutaneous malignant 1	Enrichment	MGMT	1.68
25	Giant cell glioblastoma	Enrichment	MGMT	1.68
26	Parkinson disease, late-onset	Enrichment	ADH1C	1.61
27	Pancreatic cancer	Enrichment	ERCC4	1.51
28	Fanconi anemia, complementation group a	Enrichment	ERCC4	1.37
29	Fetal akinesia deformation sequence 1	Enrichment	ALDH5A1	1.34
30	Distal arthrogryposis	Enrichment	ALDH5A1	1.29
31	Spastic ataxia	Enrichment	ERCC4	1.19
32	Primary ovarian insufficiency	Enrichment	ERCC1	1.15
33	Ovarian cancer	Enrichment	ERCC4	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cyclophosphamide Pathway, Pharmacodynamics

Pathway Network for Cyclophosphamide Pathway, Pharmacodynamics

Member Pathways for Cyclophosphamide Pathway, Pharmacodynamics

Pathways in the Cyclophosphamide Pathway, Pharmacodynamics SuperPath

Associated Genes for Cyclophosphamide Pathway, Pharmacodynamics

Associated Disorders for Cyclophosphamide Pathway, Pharmacodynamics

Disorders associated with Cyclophosphamide Pathway, Pharmacodynamics SuperPath

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