Cytokine production by Th17 cells in CF (Mouse model)

No Pathway Network information available for Cytokine production by Th17 cells in CF (Mouse model)

Pathways in the Cytokine production by Th17 cells in CF (Mouse model) SuperPath

#	Name	Source	Genes
1	Cytokine production by Th17 cells in CF (Mouse model)	GeneGo (Thomson Reuters)	CD14 CFTR CHUK CSF2 CSF3 CXCL1 CXCL6 CXCL8 FOXP3 IKBKB IKBKG IL12B IL12RB1 IL17A IL17F IL17RA IL17RC IL21 IL21R IL23A IL23R IL2RG IL6 IL6R IL6ST IRF4 JAK2 JAK3 LBP LY96 MAP3K7 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB RORC SMAD2 SMAD3 SMAD4 STAT3 TGFB1 TGFBR1 TGFBR2 TLR4 TRAF3IP2 TRAF6 ZFYVE9 (see all 52) (see less)
2	Cytokine production by Th17 cells in CF	GeneGo (Thomson Reuters)	CD14 CFTR CHUK CSF2 CSF3 CXCL1 CXCL6 CXCL8 ICAM1 IKBKB IKBKG IL12B IL12RB1 IL17A IL17F IL17RA IL17RC IL23A IL23R IL6 IL6R IL6ST JAK1 JAK2 LBP LY96 MAP3K7 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE REL RELA RELB RORC STAT3 TLR4 TRAF3IP2 TRAF6 (see all 41) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD14	CD14 Molecule	Protein Coding	2
2	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	2
3	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
4	CSF2	Colony Stimulating Factor 2	Protein Coding	2
5	CSF3	Colony Stimulating Factor 3	Protein Coding	2
6	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	2
7	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
8	IL6	Interleukin 6	Protein Coding	2
9	IL6R	Interleukin 6 Receptor	Protein Coding	2
10	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	2
11	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	2
12	IL12B	Interleukin 12B	Protein Coding	2
13	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	2
14	IL17A	Interleukin 17A	Protein Coding	2
15	JAK2	Janus Kinase 2	Protein Coding	2
16	LBP	Lipopolysaccharide Binding Protein	Protein Coding	2
17	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	2
18	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
19	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
20	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
21	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
22	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
23	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	2
24	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
25	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	2
26	RORC	RAR Related Orphan Receptor C	Protein Coding	2
27	CXCL6	C-X-C Motif Chemokine Ligand 6	Protein Coding	2
28	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
29	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
30	TLR4	Toll Like Receptor 4	Protein Coding	2
31	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
32	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
33	TRAF3IP2	TRAF3 Interacting Protein 2	Protein Coding	2
34	LY96	Lymphocyte Antigen 96	Protein Coding	2
35	IL17RA	Interleukin 17 Receptor A	Protein Coding	2
36	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	2
37	IL17RC	Interleukin 17 Receptor C	Protein Coding	2
38	IL17F	Interleukin 17F	Protein Coding	2
39	IL23R	Interleukin 23 Receptor	Protein Coding	2
40	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
41	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
42	JAK3	Janus Kinase 3	Protein Coding	1
43	SMAD2	SMAD Family Member 2	Protein Coding	1
44	SMAD3	SMAD Family Member 3	Protein Coding	1
45	SMAD4	SMAD Family Member 4	Protein Coding	1
46	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
47	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
48	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
49	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	1
50	IL21R	Interleukin 21 Receptor	Protein Coding	1
51	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
52	IL21	Interleukin 21	Protein Coding	1
53	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
54	JAK1	Janus Kinase 1	Protein Coding	1

Disorders associated with Cytokine production by Th17 cells in CF (Mouse model) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic mucocutaneous candidiasis	Enrichment	IL17F, IL17RA, IL17RC, TRAF3IP2	8.96
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFBR1, TGFBR2	7.62
3	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.59
4	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	7.27
5	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFBR1, TGFBR2	6.18
6	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.05
7	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.84
8	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.07
9	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.73
10	Type 1 diabetes mellitus	Enrichment	FOXP3, IL6	3.67
11	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.20
12	Lynch syndrome	Enrichment	CFTR, TGFBR2	2.83
13	Behcet syndrome	Enrichment	IL23R, TLR4	2.83
14	Diffuse large b-cell lymphoma	Enrichment	MYD88, STAT3	2.83
15	Malaria	Enrichment	ICAM1, IKBKG	2.66
16	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	2.63
17	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.52
18	Incontinentia pigmenti	Enrichment	IKBKG	2.52
19	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.52
20	Immunodeficiency 68	Enrichment	MYD88	2.52
21	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.52
22	Immunodeficiency 30	Enrichment	IL12RB1	2.52
23	Fetal encasement syndrome	Enrichment	CHUK	2.52
24	Candidiasis, familial, 6	Enrichment	IL17F	2.52
25	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.52
26	Immunodeficiency 15b	Enrichment	IKBKB	2.52
27	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.52
28	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.52
29	Immunodeficiency 15a	Enrichment	IKBKB	2.52
30	Immunodeficiency 92	Enrichment	REL	2.52
31	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.52
32	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.52
33	Immunodeficiency 42	Enrichment	RORC	2.52
34	Psoriasis 7	Enrichment	IL23R	2.52
35	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.52
36	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.52
37	Immunodeficiency 29	Enrichment	IL12B	2.52
38	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.52
39	Candidiasis, familial, 9	Enrichment	IL17RC	2.52
40	Inflammatory bowel disease 17	Enrichment	IL23R	2.52
41	Macular degeneration, age-related, 10	Enrichment	TLR4	2.52
42	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.52
43	Psoriasis	Enrichment	IL17RA	2.52
44	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.52
45	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.52
46	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.52
47	Immunodeficiency 53	Enrichment	RELB	2.52
48	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.52
49	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.52
50	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.52
51	Waldenstram macroglobulinemia	Enrichment	MYD88	2.52
52	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.52
53	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.52
54	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.52
55	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	2.42
56	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.42
57	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.42
58	Immunodeficiency 131	Enrichment	IRF4	2.42
59	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.42
60	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.42
61	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.42
62	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.42
63	Heritable thoracic aortic disease	Enrichment	SMAD4	2.42
64	Whipple disease	Enrichment	IRF4	2.42
65	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.22
66	Immunodeficiency 33	Enrichment	IKBKG	2.22
67	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.22
68	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.22
69	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.22
70	Thrombocythemia 3	Enrichment	JAK2	2.22
71	Immunodeficiency 51	Enrichment	IL17RA	2.22
72	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.22
73	Rela fusion-positive ependymoma	Enrichment	RELA	2.22
74	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.22
75	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.22
76	Polycythemia	Enrichment	JAK2	2.22
77	Hypereosinophilic syndrome	Enrichment	JAK2	2.22
78	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	2.22
79	Common variable immunodeficiency 12	Enrichment	NFKB1	2.22
80	Discoid lupus erythematosus	Enrichment	TRAF3IP2	2.22
81	Cystic fibrosis	Enrichment	CFTR, TGFB1	2.18
82	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.18
83	Severe combined immunodeficiency	Enrichment	IKBKB, JAK3	2.15
84	Myhre syndrome	Enrichment	SMAD4	2.12
85	Camurati-engelmann disease 1	Enrichment	TGFB1	2.12
86	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	2.12
87	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.12
88	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.12
89	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.12
90	Immunodeficiency 31c	Enrichment	IL21R	2.12
91	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.12
92	Immunodeficiency 56	Enrichment	IL21R	2.12
93	Camurati-engelmann disease	Enrichment	TGFB1	2.12
94	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.04
95	Takayasu arteritis	Enrichment	IL12B	2.04
96	Polycythemia vera	Enrichment	JAK2	2.04
97	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.04
98	Nuchal bleb, familial	Enrichment	CFTR	2.04
99	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.04
100	Psoriasis 13	Enrichment	TRAF3IP2	2.04
101	Hyper ige syndrome	Enrichment	STAT3	2.04
102	Candidiasis, familial, 8	Enrichment	TRAF3IP2	2.04
103	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.04
104	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.04
105	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.94
106	Juvenile polyposis syndrome	Enrichment	SMAD4	1.94
107	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.94
108	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.94
109	Immunodeficiency, common variable, 11	Enrichment	IL21	1.94
110	Kaposi sarcoma	Enrichment	IL6	1.92
111	Erythrocytosis, familial, 1	Enrichment	JAK2	1.92
112	Budd-chiari syndrome	Enrichment	JAK2	1.92
113	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.92
114	Idiopathic bronchiectasis	Enrichment	CFTR	1.92
115	Cerebral malaria	Enrichment	ICAM1	1.92
116	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.92
117	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.82
118	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.82
119	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.82
120	Myeloproliferative neoplasm	Enrichment	JAK2	1.82
121	Adenosine deaminase deficiency	Enrichment	JAK3	1.82
122	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.72
123	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.72
124	Myelofibrosis	Enrichment	JAK2	1.68
125	Essential thrombocythemia	Enrichment	JAK2	1.68
126	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.64
127	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.64
128	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.64
129	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.62
130	Esophageal cancer	Enrichment	TGFBR2	1.58
131	Gallbladder cancer	Enrichment	SMAD4	1.58
132	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.58
133	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.57
134	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.57
135	Inflammatory bowel disease 1	Enrichment	IL6	1.57
136	Coronary heart disease 5	Enrichment	IKBKG	1.57
137	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.57
138	Primary biliary cholangitis	Enrichment	IL12RB1	1.57
139	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.53
140	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.47
141	Hydrops fetalis	Enrichment	FOXP3	1.47
142	Omenn syndrome	Enrichment	IL2RG	1.42
143	Acute promyelocytic leukemia	Enrichment	STAT3	1.41
144	Pectus excavatum	Enrichment	TGFBR1	1.38
145	Combined immunodeficiency	Enrichment	IL2RG	1.38
146	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.38
147	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.38
148	Hereditary chronic pancreatitis	Enrichment	CFTR	1.38
149	Gliosarcoma	Enrichment	NFKBIA	1.33
150	Nk-cell enteropathy	Enrichment	JAK3	1.31
151	Pancreatitis, hereditary	Enrichment	CFTR	1.30
152	Giant cell glioblastoma	Enrichment	NFKBIA	1.30
153	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.28
154	Arteriovenous malformations of the brain	Enrichment	IL6	1.25
155	Centronuclear myopathy	Enrichment	FOXP3	1.11
156	Pancreatic cancer	Enrichment	SMAD4	1.04
157	Male infertility	Enrichment	CFTR	1.01
158	Severe covid-19	Enrichment	JAK3	0.98
159	Leukemia, acute myeloid	Enrichment	JAK2	0.94
160	Type 2 diabetes mellitus	Enrichment	IL6	0.92
161	Gastric cancer	Enrichment	SMAD4	0.82
162	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.81
163	Primary ovarian insufficiency	Enrichment	JAK2	0.79
164	Thrombocytopenia	Enrichment	SMAD4	0.77
165	Colorectal cancer	Enrichment	SMAD4	0.55
166	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cytokine production by Th17 cells in CF (Mouse model)

Pathway Network for Cytokine production by Th17 cells in CF (Mouse model)

Member Pathways for Cytokine production by Th17 cells in CF (Mouse model)

Pathways in the Cytokine production by Th17 cells in CF (Mouse model) SuperPath

Associated Genes for Cytokine production by Th17 cells in CF (Mouse model)

Associated Disorders for Cytokine production by Th17 cells in CF (Mouse model)

Disorders associated with Cytokine production by Th17 cells in CF (Mouse model) SuperPath

STRING Interaction Network for Cytokine production by Th17 cells in CF (Mouse model)

Sources for Cytokine production by Th17 cells in CF (Mouse model)