Cytoskeletal Signaling

No Pathway Network information available for Cytoskeletal Signaling

Pathways in the Cytoskeletal Signaling SuperPath

#	Name	Source	Genes
1	Cytoskeletal Signaling	Cell Signaling Technology	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 ACTN1 ACTN4 ACTR2 ACTR3 ADAM9 ADD1 AFAP1L2 AFDN AJUBA AMOT ANXA7 AP2M1 APPL1 ARC ARF6 ARHGAP31 ARHGAP35 ARHGAP42 ARHGAP5 ARHGDIA ARHGEF1 ARHGEF2 ARHGEF6 ARHGEF7 ATL1 ATP1A1 ATP1B1 BAP1 CALD1 CAP1 CAV1 CAV2 CAVIN1 CCDC88A CD151 CD2AP CDC37 CDC42 CDH1 CDH11 CEP55 CETN2 CFL1 CHMP2B CHN2 CKAP5 CLDN1 CLDN2 CLDN3 CLIP1 CLTC CNN1 CORO1A COX4I1 CTNND1 CTTN CXADR DAB2 DBN1 DCTN1 DCX DES DIAPH1 DIAPH2 DIXDC1 DNM1 DNM1L DNM2 DPYSL2 EEA1 ELMO1 EMD EML4 ENAH EPCAM ERC1 ERLIN1 ERLIN2 EVL EZR F2RL1 FBL FERMT1 FERMT2 FEZ1 FLII FLNA FLNB FLNC FLOT1 FLOT2 FRMD6 FSCN1 GAP43 GIT2 GJA1 GOLGA2 GOPC GSN HTATIP2 IBSP ICAM2 IGF2BP1 IQGAP1 IQGAP2 ITGA2B ITGA5 ITGAV ITGB1 ITGB2 ITGB5 JUP KIF1B KIF3A KIF3B KIFC1 KLC1 KPNA2 KPNB1 KRT10 KRT13 KRT17 KRT18 KRT19 KRT20 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT8 KTN1 LAMP1 LASP1 LIMA1 LIMD1 LIMK1 LIMK2 LIMS1 LLGL1 LMAN1 LMNA LMNB1 LMNB2 LPP LPXN MAPRE1 MAPT MARCKSL1 MARK1 MARK2 MARK3 MARK4 MCF2 MIS18A MPRIP MRTFA MSN MTSS1 MUC1 MYH10 MYH14 MYH9 MYL9 MYO6 NCK1 NEFL NF2 NISCH NSF NUAK2 NUP88 NUP98 NUTF2 OXSR1 PAFAH1B1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PALLD PARVA PCM1 PDLIM2 PDPN PDXP PFN1 PKN2 PLEC PPP1R12A PPP3CA PPP3CB PPP3CC PRC1 PREX1 PRKG1 PTPN12 PVR PXN RAB10 RAB11A RAB11B RAB11FIP1 RAB1A RAB25 RAB27A RAB35 RAB38 RAB3A RAB4A RAB5A RAB6A RAB7A RAB8A RAB9A RAC1 RAC2 RAC3 RACK1 RALA RALB RALBP1 RAN RANBP1 RANBP3 RANBP9 RAP1A RAP1B RAPGEF3 RAPGEF4 RAPH1 RASAL2 RASGRP3 RCC1 RCC2 RDX REPS1 RHOA RHOB RHOC RND3 ROCK1 ROCK2 RRAS SCAI SCRIB SEC23A SEC24A SEC24B SEC24C SEC31A SH3KBP1 SPTAN1 SRCIN1 SRF SSH1 SSH3 STK24 STK26 STK3 STK39 STK4 STMN1 STX6 TESK1 TFRC TJP1 TJP3 TLN1 TMOD1 TMPO TNNI3 TNNT2 TNS2 TOR1A TPM1 TPT1 TUBA1A TUBA1B TUBB TUBB3 TUBG1 TWF1 USP9X VASP VAV1 VAV2 VAV3 VCL VCP VDAC1 VDAC2 VIL1 VIM WAS WASF2 WASF3 WASL ZFYVE26 (see all 308) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TWF1	Twinfilin Actin Binding Protein 1	Protein Coding	1
2	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
3	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
4	ACTB	Actin Beta	Protein Coding	1
5	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
6	ACTG1	Actin Gamma 1	Protein Coding	1
7	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
8	ACTN1	Actinin Alpha 1	Protein Coding	1
9	ACTN4	Actinin Alpha 4	Protein Coding	1
10	ADAM9	ADAM Metallopeptidase Domain 9	Protein Coding	1
11	ADD1	Adducin 1	Protein Coding	1
12	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
13	AFAP1L2	Actin Filament Associated Protein 1 Like 2	Protein Coding	1
14	AMOT	Angiomotin	Protein Coding	1
15	ANXA7	Annexin A7	Protein Coding	1
16	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	1
17	APPL1	Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1	Protein Coding	1
18	ARF6	ARF GTPase 6	Protein Coding	1
19	ARC	Activity Regulated Cytoskeleton Associated Protein	Protein Coding	1
20	CHN2	Chimerin 2	Protein Coding	1
21	ARHGAP42	Rho GTPase Activating Protein 42	Protein Coding	1
22	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
23	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
24	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
25	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
26	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
27	ACTR2	Actin Related Protein 2	Protein Coding	1
28	ACTR3	Actin Related Protein 3	Protein Coding	1
29	ATL1	Atlastin GTPase 1	Protein Coding	1
30	ATP1A1	ATPase Na+/K+ Transporting Subunit Alpha 1	Protein Coding	1
31	ATP1B1	ATPase Na+/K+ Transporting Subunit Beta 1	Protein Coding	1
32	BAP1	BRCA1 Associated Deubiquitinase 1	Protein Coding	1
33	CALD1	Caldesmon 1	Protein Coding	1
34	CNN1	Calponin 1	Protein Coding	1
35	CAP1	Cyclase Associated Actin Cytoskeleton Regulatory Protein 1	Protein Coding	1
36	CAV1	Caveolin 1	Protein Coding	1
37	CAV2	Caveolin 2	Protein Coding	1
38	CD151	CD151 Molecule (Raph Blood Group)	Protein Coding	1
39	CD2AP	CD2 Associated Protein	Protein Coding	1
40	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	1
41	CDC42	Cell Division Cycle 42	Protein Coding	1
42	ARHGAP31	Rho GTPase Activating Protein 31	Protein Coding	1
43	CDH1	Cadherin 1	Protein Coding	1
44	CDH11	Cadherin 11	Protein Coding	1
45	CEP55	Centrosomal Protein 55	Protein Coding	1
46	CETN2	Centrin 2	Protein Coding	1
47	CHMP2B	Charged Multivesicular Body Protein 2B	Protein Coding	1
48	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	1
49	CLDN1	Claudin 1	Protein Coding	1
50	CLDN2	Claudin 2	Protein Coding	1
51	CLDN3	Claudin 3	Protein Coding	1
52	CLTC	Clathrin Heavy Chain	Protein Coding	1
53	CFL1	Cofilin 1	Protein Coding	1
54	CORO1A	Coronin 1A	Protein Coding	1
55	CTTN	Cortactin	Protein Coding	1
56	COX4I1	Cytochrome C Oxidase Subunit 4I1	Protein Coding	1
57	DPYSL2	Dihydropyrimidinase Like 2	Protein Coding	1
58	CTNND1	Catenin Delta 1	Protein Coding	1
59	JUP	Junction Plakoglobin	Protein Coding	1
60	CXADR	CXADR Cell Adhesion Molecule	Protein Coding	1
61	DAB2	DAB Adaptor Protein 2	Protein Coding	1
62	DBN1	Drebrin 1	Protein Coding	1
63	DES	Desmin	Protein Coding	1
64	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
65	DIAPH2	Diaphanous Related Formin 2	Protein Coding	1
66	DIXDC1	DIX Domain Containing 1	Protein Coding	1
67	DCX	Doublecortin	Protein Coding	1
68	DNM1L	Dynamin 1 Like	Protein Coding	1
69	DNM1	Dynamin 1	Protein Coding	1
70	DNM2	Dynamin 2	Protein Coding	1
71	DCTN1	Dynactin Subunit 1	Protein Coding	1
72	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	1
73	EEA1	Early Endosome Antigen 1	Protein Coding	1
74	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
75	EMD	Emerin	Protein Coding	1
76	EML4	EMAP Like 4	Protein Coding	1
77	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	1
78	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	1
79	LIMA1	LIM Domain And Actin Binding 1	Protein Coding	1
80	ERC1	ELKS/RAB6-Interacting/CAST Family Member 1	Protein Coding	1
81	EVL	Enah/Vasp-Like	Protein Coding	1
82	EZR	Ezrin	Protein Coding	1
83	F2RL1	F2R Like Trypsin Receptor 1	Protein Coding	1
84	FSCN1	Fascin Actin-Bundling Protein 1	Protein Coding	1
85	FBL	Fibrillarin	Protein Coding	1
86	FEZ1	Fasciculation And Elongation Protein Zeta 1	Protein Coding	1
87	FLII	FLII Actin Remodeling Protein	Protein Coding	1
88	FLNA	Filamin A	Protein Coding	1
89	FLNB	Filamin B	Protein Coding	1
90	FLNC	Filamin C	Protein Coding	1
91	FLOT1	Flotillin 1	Protein Coding	1
92	FLOT2	Flotillin 2	Protein Coding	1
93	FRMD6	FERM Domain Containing 6	Protein Coding	1
94	GAP43	Growth Associated Protein 43	Protein Coding	1
95	GSN	Gelsolin	Protein Coding	1
96	CCDC88A	Coiled-Coil And HOOK Domain Protein 88A	Protein Coding	1
97	GIT2	GIT ArfGAP 2	Protein Coding	1
98	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
99	GOLGA2	Golgin A2	Protein Coding	1
100	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
101	HTATIP2	HIV-1 Tat Interactive Protein 2	Protein Coding	1
102	ICAM2	Intercellular Adhesion Molecule 2	Protein Coding	1
103	IGF2BP1	Insulin Like Growth Factor 2 MRNA Binding Protein 1	Protein Coding	1
104	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
105	IQGAP2	IQ Motif Containing GTPase Activating Protein 2	Protein Coding	1
106	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
107	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
108	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
109	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
110	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
111	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
112	AJUBA	Ajuba LIM Protein	Protein Coding	1
113	KRT10	Keratin 10	Protein Coding	1
114	KRT13	Keratin 13	Protein Coding	1
115	KRT17	Keratin 17	Protein Coding	1
116	KRT18	Keratin 18	Protein Coding	1
117	KRT19	Keratin 19	Protein Coding	1
118	KRT20	Keratin 20	Protein Coding	1
119	KRT4	Keratin 4	Protein Coding	1
120	KRT5	Keratin 5	Protein Coding	1
121	KRT6A	Keratin 6A	Protein Coding	1
122	KRT6C	Keratin 6C	Protein Coding	1
123	KRT7	Keratin 7	Protein Coding	1
124	KRT8	Keratin 8	Protein Coding	1
125	KIF1B	Kinesin Family Member 1B	Protein Coding	1
126	KIF3A	Kinesin Family Member 3A	Protein Coding	1
127	KIF3B	Kinesin Family Member 3B	Protein Coding	1
128	KIFC1	Kinesin Family Member C1	Protein Coding	1
129	FERMT1	FERM Domain Containing Kindlin 1	Protein Coding	1
130	FERMT2	FERM Domain Containing Kindlin 2	Protein Coding	1
131	KLC1	Kinesin Light Chain 1	Protein Coding	1
132	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	1
133	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
134	KRT6B	Keratin 6B	Protein Coding	1
135	KTN1	Kinectin 1	Protein Coding	1
136	LMNA	Lamin A/C	Protein Coding	1
137	LMNB1	Lamin B1	Protein Coding	1
138	LMNB2	Lamin B2	Protein Coding	1
139	LAMP1	Lysosomal Associated Membrane Protein 1	Protein Coding	1
140	LASP1	LIM And SH3 Protein 1	Protein Coding	1
141	LPXN	Leupaxin	Protein Coding	1
142	LIMD1	LIM Domain Containing 1	Protein Coding	1
143	LIMK1	LIM Domain Kinase 1	Protein Coding	1
144	LIMK2	LIM Domain Kinase 2	Protein Coding	1
145	LIMS1	LIM Zinc Finger Domain Containing 1	Protein Coding	1
146	LLGL1	LLGL Scribble Cell Polarity Complex Component 1	Protein Coding	1
147	LMAN1	Lectin, Mannose Binding 1	Protein Coding	1
148	LPP	LIM Domain Containing Preferred Translocation Partner In Lipoma	Protein Coding	1
149	MARK1	Microtubule Affinity Regulating Kinase 1	Protein Coding	1
150	MARK2	Microtubule Affinity Regulating Kinase 2	Protein Coding	1
151	MARK3	Microtubule Affinity Regulating Kinase 3	Protein Coding	1
152	MARK4	Microtubule Affinity Regulating Kinase 4	Protein Coding	1
153	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	1
154	ENAH	ENAH Actin Regulator	Protein Coding	1
155	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	1
156	MIS18A	MIS18 Kinetochore Protein A	Protein Coding	1
157	MRTFA	Myocardin Related Transcription Factor A	Protein Coding	1
158	MARCKSL1	MARCKS Like 1	Protein Coding	1
159	MSN	Moesin	Protein Coding	1
160	MPRIP	Myosin Phosphatase Rho Interacting Protein	Protein Coding	1
161	MYL9	Myosin Light Chain 9	Protein Coding	1
162	STK4	Serine/Threonine Kinase 4	Protein Coding	1
163	STK3	Serine/Threonine Kinase 3	Protein Coding	1
164	STK24	Serine/Threonine Kinase 24	Protein Coding	1
165	STK26	Serine/Threonine Kinase 26	Protein Coding	1
166	MTSS1	MTSS I-BAR Domain Containing 1	Protein Coding	1
167	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	1
168	MYH10	Myosin Heavy Chain 10	Protein Coding	1
169	MYH14	Myosin Heavy Chain 14	Protein Coding	1
170	MYH9	Myosin Heavy Chain 9	Protein Coding	1
171	MYO6	Myosin VI	Protein Coding	1
172	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
173	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
174	NCK1	NCK Adaptor Protein 1	Protein Coding	1
175	NEFL	Neurofilament Light Chain	Protein Coding	1
176	NISCH	Nischarin	Protein Coding	1
177	NSF	N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase	Protein Coding	1
178	NUAK2	NUAK Family Kinase 2	Protein Coding	1
179	NUP88	Nucleoporin 88	Protein Coding	1
180	NUP98	Nucleoporin 98 And 96 Precursor	Protein Coding	1
181	NUTF2	Nuclear Transport Factor 2	Protein Coding	1
182	OXSR1	Oxidative Stress Responsive Kinase 1	Protein Coding	1
183	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	1
184	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
185	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
186	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
187	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
188	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
189	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
190	PALLD	Palladin, Cytoskeletal Associated Protein	Protein Coding	1
191	PARVA	Parvin Alpha	Protein Coding	1
192	PCM1	Pericentriolar Material 1	Protein Coding	1
193	PDLIM2	PDZ And LIM Domain 2	Protein Coding	1
194	PDPN	Podoplanin	Protein Coding	1
195	PDXP	Pyridoxal Phosphatase	Protein Coding	1
196	GOPC	Golgi Associated PDZ And Coiled-Coil Motif Containing	Protein Coding	1
197	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
198	PKN2	Protein Kinase N2	Protein Coding	1
199	PLEC	Plectin	Protein Coding	1
200	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
201	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
202	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
203	PRC1	Protein Regulator Of Cytokinesis 1	Protein Coding	1
204	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	1
205	PFN1	Profilin 1	Protein Coding	1
206	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	1
207	CAVIN1	Caveolae Associated Protein 1	Protein Coding	1
208	PVR	PVR Cell Adhesion Molecule	Protein Coding	1
209	PXN	Paxillin	Protein Coding	1
210	RAB10	RAB10, Member RAS Oncogene Family	Protein Coding	1
211	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1
212	RAB11B	RAB11B, Member RAS Oncogene Family	Protein Coding	1
213	RAB11FIP1	RAB11 Family Interacting Protein 1	Protein Coding	1
214	RAB1A	RAB1A, Member RAS Oncogene Family	Protein Coding	1
215	RAB25	RAB25, Member RAS Oncogene Family	Protein Coding	1
216	RAB27A	RAB27A, Member RAS Oncogene Family	Protein Coding	1
217	RAB35	RAB35, Member RAS Oncogene Family	Protein Coding	1
218	RAB38	RAB38, Member RAS Oncogene Family	Protein Coding	1
219	RAB3A	RAB3A, Member RAS Oncogene Family	Protein Coding	1
220	RAB4A	RAB4A, Member RAS Oncogene Family	Protein Coding	1
221	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
222	RAB6A	RAB6A, Member RAS Oncogene Family	Protein Coding	1
223	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
224	RAB8A	RAB8A, Member RAS Oncogene Family	Protein Coding	1
225	RAB9A	RAB9A, Member RAS Oncogene Family	Protein Coding	1
226	RAC1	Rac Family Small GTPase 1	Protein Coding	1
227	RAC2	Rac Family Small GTPase 2	Protein Coding	1
228	RAC3	Rac Family Small GTPase 3	Protein Coding	1
229	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
230	RDX	Radixin	Protein Coding	1
231	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
232	RALB	RAS Like Proto-Oncogene B	Protein Coding	1
233	RALBP1	RalA Binding Protein 1	Protein Coding	1
234	RAN	RAN, Member RAS Oncogene Family	Protein Coding	1
235	RANBP1	RAN Binding Protein 1	Protein Coding	1
236	RANBP3	RAN Binding Protein 3	Protein Coding	1
237	RANBP9	RAN Binding Protein 9	Protein Coding	1
238	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
239	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
240	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	1
241	RAPH1	Ras Association (RalGDS/AF-6) And Pleckstrin Homology Domains 1	Protein Coding	1
242	RASAL2	RAS Protein Activator Like 2	Protein Coding	1
243	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
244	RCC1	Regulator Of Chromosome Condensation 1	Protein Coding	1
245	REPS1	RALBP1 Associated Eps Domain Containing 1	Protein Coding	1
246	CLIP1	CAP-Gly Domain Containing Linker Protein 1	Protein Coding	1
247	RHOA	Ras Homolog Family Member A	Protein Coding	1
248	RHOB	Ras Homolog Family Member B	Protein Coding	1
249	RHOC	Ras Homolog Family Member C	Protein Coding	1
250	RND3	Rho Family GTPase 3	Protein Coding	1
251	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
252	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
253	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
254	RRAS	RAS Related	Protein Coding	1
255	SCAI	Suppressor Of Cancer Cell Invasion	Protein Coding	1
256	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	1
257	SEC23A	SEC23 Homolog A, COPII Component	Protein Coding	1
258	SEC24A	SEC24 Homolog A, COPII Component	Protein Coding	1
259	SEC24B	SEC24 Homolog B, COPII Component	Protein Coding	1
260	SEC24C	SEC24 Homolog C, COPII Component	Protein Coding	1
261	SEC31A	SEC31 Homolog A, COPII Component	Protein Coding	1
262	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	1
263	IBSP	Integrin Binding Sialoprotein	Protein Coding	1
264	SRCIN1	SRC Kinase Signaling Inhibitor 1	Protein Coding	1
265	ERLIN1	ER Lipid Raft Associated 1	Protein Coding	1
266	ERLIN2	ER Lipid Raft Associated 2	Protein Coding	1
267	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	1
268	SRF	Serum Response Factor	Protein Coding	1
269	SSH1	Slingshot Protein Phosphatase 1	Protein Coding	1
270	SSH3	Slingshot Protein Phosphatase 3	Protein Coding	1
271	STK39	Serine/Threonine Kinase 39	Protein Coding	1
272	STMN1	Stathmin 1	Protein Coding	1
273	STX6	Syntaxin 6	Protein Coding	1
274	TLN1	Talin 1	Protein Coding	1
275	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
276	RCC2	Regulator Of Chromosome Condensation 2	Protein Coding	1
277	TNS2	Tensin 2	Protein Coding	1
278	TESK1	Testis Associated Actin Remodelling Kinase 1	Protein Coding	1
279	TFRC	Transferrin Receptor	Protein Coding	1
280	TMOD1	Tropomodulin 1	Protein Coding	1
281	TMPO	Thymopoietin	Protein Coding	1
282	TNNI3	Troponin I3, Cardiac Type	Protein Coding	1
283	TNNT2	Troponin T2, Cardiac Type	Protein Coding	1
284	TOR1A	Torsin Family 1 Member A	Protein Coding	1
285	TPM1	Tropomyosin 1	Protein Coding	1
286	TPT1	Tumor Protein, Translationally-Controlled 1	Protein Coding	1
287	TUBA1A	Tubulin Alpha 1a	Protein Coding	1
288	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
289	TUBB	Tubulin Beta Class I	Protein Coding	1
290	TUBB3	Tubulin Beta 3 Class III	Protein Coding	1
291	TUBG1	Tubulin Gamma 1	Protein Coding	1
292	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	1
293	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
294	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
295	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
296	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
297	VCP	Valosin Containing Protein	Protein Coding	1
298	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	1
299	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	1
300	VIL1	Villin 1	Protein Coding	1
301	VIM	Vimentin	Protein Coding	1
302	VCL	Vinculin	Protein Coding	1
303	WASF3	WASP Family Member 3	Protein Coding	1
304	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
305	WASF2	WASP Family Member 2	Protein Coding	1
306	ZFYVE26	Zinc Finger FYVE-Type Containing 26	Protein Coding	1
307	TJP1	Tight Junction Protein 1	Protein Coding	1
308	TJP3	Tight Junction Protein 3	Protein Coding	1

Disorders associated with Cytoskeletal Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1, DES, EMD, FLII, FLNC, JUP, LMNA, TNNI3, TNNT2, TPM1, VCL	6.64
2	Lissencephaly	Enrichment	ACTG1, DCX, PAFAH1B1, TUBA1A, TUBB, TUBB3, TUBG1	6.59
3	Neuromuscular disease	Enrichment	ACTA1, DES, EMD, GOLGA2, LMNA, SPTAN1	5.72
4	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, DES, LMNA, TMPO, TNNI3, TNNT2, TPM1, VCL	4.63
5	Pachyonychia congenita 1	Enrichment	KRT17, KRT6A, KRT6B	4.34
6	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1, DES, FLNC, TNNI3, TNNT2, TPM1	4.06
7	Cardiomyopathy, familial hypertrophic, 1	Enrichment	FLNC, LMNA, TNNI3, TNNT2, TPM1	3.76
8	Familial isolated restrictive cardiomyopathy	Enrichment	FLNC, TNNI3, TNNT2	3.42
9	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DES, FLNC, JUP, LMNA	3.42
10	Blepharocheilodontic syndrome 1	Enrichment	CDH1, CTNND1	3.29
11	Cardiomyopathy, dilated, 1d	Enrichment	LMNA, TNNT2	3.29
12	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.29
13	White sponge nevus	Enrichment	KRT13, KRT4	3.29
14	Myocarditis	Enrichment	LMNA, TNNI3, TNNT2	3.22
15	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD, LMNA, NEFL, VCP	3.11
16	Progressive non-fluent aphasia	Enrichment	CHMP2B, MAPT, VCP	3.06
17	Behavioral variant of frontotemporal dementia	Enrichment	CHMP2B, MAPT, VCP	3.06
18	Left ventricular noncompaction	Enrichment	ACTC1, LMNA, TNNI3, TNNT2, TPM1	2.96
19	Band heterotopia	Enrichment	DCX, PAFAH1B1	2.82
20	Cryptogenic cirrhosis	Enrichment	KRT18, KRT8	2.82
21	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB3	2.82
22	Restrictive cardiomyopathy	Enrichment	FLNC, TNNI3, TNNT2	2.66
23	Hereditary spastic paraplegia	Enrichment	ATL1, ERLIN1, ERLIN2, SPTAN1, ZFYVE26	2.60
24	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD, LMNA	2.52
25	Emery-dreifuss muscular dystrophy	Enrichment	EMD, LMNA	2.52
26	Sick sinus syndrome	Enrichment	CORO1A, LMNA	2.52
27	Epidermolysis bullosa simplex 2f, with mottled pigmentation	Enrichment	KRT5, PLEC	2.31
28	Epidermolysis bullosa simplex 1a, generalized severe	Enrichment	KRT5, PLEC	2.31
29	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	2.31
30	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL, VCP	2.31
31	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1, TUBG1	2.31
32	Histiocytoid hemangioma	Enrichment	LMNA, VIM	2.31
33	Cardiomyopathy, dilated, 1e	Enrichment	DES, LMNA, TPM1	2.21
34	Moyamoya disease 1	Enrichment	ACTA2, DIAPH1	2.14
35	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6, PLEC	2.14
36	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB3	2.14
37	Cleft lip with or without cleft palate	Enrichment	CDH1, CTNND1	2.14
38	Patent foramen ovale	Enrichment	ACTC1, FLNA, FLNC	2.13
39	Non-syndromic genetic deafness	Enrichment	ACTG1, MYH14, MYO6, RDX	2.06
40	Semantic dementia	Enrichment	CHMP2B, MAPT	2.00
41	Epidermolysis bullosa simplex	Enrichment	KRT5, PLEC	2.00
42	Myofibrillar myopathy	Enrichment	DES, FLNC	2.00
43	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHMP2B, DCTN1, MAPT, PFN1, VCP	2.00
44	Cardiomyopathy, dilated, 1a	Enrichment	FLNC, LMNA, TNNI3	1.94
45	Myopathy	Enrichment	ACTA1, DNM2, EMD, PLEC	1.90
46	Skin disease	Enrichment	FERMT1, KRT17, PLEC	1.89
47	Charcot-marie-tooth disease	Enrichment	DCTN1, DNM2, LMNA, NEFL	1.87
48	Nonsyndromic hearing loss	Enrichment	ACTG1, MYH14, MYO6, RDX	1.83
49	Hypertrophic cardiomyopathy	Enrichment	ACTC1, TNNI3, TNNT2, TPM1	1.79
50	Cardiomyopathy, familial hypertrophic, 4	Enrichment	TNNI3, TNNT2	1.78
51	Nemaline myopathy	Enrichment	ACTA1, FLNC	1.69
52	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1, ITGA2B	1.69
53	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	1.64
54	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	1.64
55	Cardiomyopathy, familial hypertrophic, 2	Enrichment	TNNT2	1.64
56	Cardiomyopathy, familial hypertrophic, 3	Enrichment	TPM1	1.64
57	Kindler syndrome	Enrichment	FERMT1	1.64
58	Boomerang dysplasia	Enrichment	FLNB	1.64
59	Charcot-marie-tooth disease, axonal, type 2a1	Enrichment	KIF1B	1.64
60	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	1.64
61	Perry syndrome	Enrichment	DCTN1	1.64
62	Pachyonychia congenita 2	Enrichment	KRT17	1.64
63	Elsahy-waters syndrome	Enrichment	CDH11	1.64
64	Hypoplastic left heart syndrome 1	Enrichment	GJA1	1.64
65	Spastic paraplegia 3, autosomal dominant	Enrichment	ATL1	1.64
66	Baraitser-winter syndrome 1	Enrichment	ACTB	1.64
67	Thrombocytopenia 1	Enrichment	WAS	1.64
68	Pulmonary atresia with intact ventricular septum	Enrichment	TPM1	1.64
69	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	1.64
70	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.64
71	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	1.64
72	Griscelli syndrome, type 2	Enrichment	RAB27A	1.64
73	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	1.64
74	Immunodeficiency 50	Enrichment	MSN	1.64
75	Otopalatodigital syndrome, type i	Enrichment	FLNA	1.64
76	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	1.64
77	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	1.64
78	Immunodeficiency 61	Enrichment	SH3KBP1	1.64
79	Cardiomyopathy, dilated, 2a	Enrichment	TNNI3	1.64
80	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	1.64
81	Dystonia 1, torsion, autosomal dominant	Enrichment	TOR1A	1.64
82	Deafness, autosomal recessive 24	Enrichment	RDX	1.64
83	Deafness, autosomal dominant 17	Enrichment	MYH9	1.64
84	Spastic paraplegia 18b, autosomal recessive	Enrichment	ERLIN2	1.64
85	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.64
86	Tubulointerstitial kidney disease, autosomal dominant 2	Enrichment	MUC1	1.64
87	Cardiomyopathy, familial restrictive, 3	Enrichment	TNNT2	1.64
88	Cone-rod dystrophy 9	Enrichment	ADAM9	1.64
89	Melanoma, uveal 2	Enrichment	BAP1	1.64
90	Craniolenticulosutural dysplasia	Enrichment	SEC23A	1.64
91	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	1.64
92	Oculodentodigital dysplasia	Enrichment	GJA1	1.64
93	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	1.64
94	Raph blood group system	Enrichment	CD151	1.64
95	Cardiomyopathy, familial hypertrophic, 7	Enrichment	TNNI3	1.64
96	Schwannomatosis, vestibular	Enrichment	NF2	1.64
97	Amyloidosis, finnish type	Enrichment	GSN	1.64
98	Deafness, autosomal dominant 22	Enrichment	MYO6	1.64
99	Optic atrophy 5	Enrichment	DNM1L	1.64
100	Atelosteogenesis, type iii	Enrichment	FLNB	1.64
101	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	1.64
102	Atelosteogenesis, type i	Enrichment	FLNB	1.64
103	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	1.64
104	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	1.64
105	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	1.64
106	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	1.64
107	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	1.64
108	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	1.64
109	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	1.64
110	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	1.64
111	Encephalopathy due to defective mitochondrial and peroxisomal fission 1	Enrichment	DNM1L	1.64
112	Neuroblastoma 1	Enrichment	KIF1B	1.64
113	Pachyonychia congenita 3	Enrichment	KRT6A	1.64
114	Scapuloperoneal syndrome, neurogenic, kaeser type	Enrichment	DES	1.64
115	Pulmonary hypertension, primary, 3	Enrichment	CAV1	1.64
116	Steatocystoma multiplex	Enrichment	KRT17	1.64
117	White sponge nevus 1	Enrichment	KRT4	1.64
118	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	1.64
119	Immunodeficiency 62	Enrichment	ARHGEF1	1.64
120	Fetal akinesia deformation sequence 4	Enrichment	NUP88	1.64
121	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	1.64
122	Naxos disease	Enrichment	JUP	1.64
123	Halperin-birk syndrome	Enrichment	SEC31A	1.64
124	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	1.64
125	Teebi hypertelorism syndrome 2	Enrichment	CDH11	1.64
126	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	1.64
127	Anencephaly 2	Enrichment	NUAK2	1.64
128	Knobloch syndrome 2	Enrichment	PAK2	1.64
129	Deafness, autosomal dominant 4a	Enrichment	MYH14	1.64
130	Terminal osseous dysplasia	Enrichment	FLNA	1.64
131	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.64
132	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	1.64
133	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.64
134	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.64
135	Cardiomyopathy, dilated, 2j	Enrichment	FLII	1.64
136	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	1.64
137	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.64
138	Lissencephaly, x-linked, 1	Enrichment	DCX	1.64
139	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	1.64
140	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.64
141	Fg syndrome 2	Enrichment	FLNA	1.64
142	Premature ovarian failure 2a	Enrichment	DIAPH2	1.64
143	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	1.64
144	Neurodegeneration with brain iron accumulation 7	Enrichment	REPS1	1.64
145	Azoospermia, obstructive, with nephrolithiasis	Enrichment	CLDN2	1.64
146	Deafness, autosomal recessive 37	Enrichment	MYO6	1.64
147	Parkinson-dementia syndrome	Enrichment	MAPT	1.64
148	Spastic paraplegia 15, autosomal recessive	Enrichment	ZFYVE26	1.64
149	Immunodeficiency 110 with lymphoproliferation	Enrichment	STK4	1.64
150	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	1.64
151	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	1.64
152	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.64
153	Intellectual developmental disorder, autosomal dominant 76	Enrichment	MARK2	1.64
154	Supranuclear palsy, progressive, 1	Enrichment	MAPT	1.64
155	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	1.64
156	Palmoplantar keratoderma, nonepidermolytic, focal or diffuse	Enrichment	KRT6C	1.64
157	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	1.64
158	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	1.64
159	Epilepsy, progressive myoclonic, 9	Enrichment	LMNB2	1.64
160	White sponge nevus 2	Enrichment	KRT13	1.64
161	Cardiomyopathy, dilated, 1w	Enrichment	VCL	1.64
162	Progressive supranuclear palsy	Enrichment	MAPT	1.64
163	Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter	Enrichment	RAB11B	1.64
164	Hereditary spastic paraplegia 18	Enrichment	ERLIN2	1.64
165	Lipodystrophy, partial, acquired	Enrichment	LMNB2	1.64
166	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	1.64
167	Becker nevus syndrome	Enrichment	ACTB	1.64
168	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	1.64
169	Pancreatic cancer 1	Enrichment	PALLD	1.64
170	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.64
171	Epidermolysis bullosa simplex 7, with nephropathy and deafness	Enrichment	CD151	1.64
172	Focal segmental glomerulosclerosis 3	Enrichment	CD2AP	1.64
173	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	1.64
174	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	1.64
175	Charcot-marie-tooth disease type 2a1	Enrichment	KIF1B	1.64
176	Lethal congenital contracture syndrome 5	Enrichment	DNM2	1.64
177	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	1.64
178	Developmental delay with hypotonia, myopathy, and brain abnormalities	Enrichment	GOLGA2	1.64
179	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	1.64
180	Neuropathy, hereditary sensory, type id	Enrichment	ATL1	1.64
181	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	1.64
182	Immunodeficiency 46	Enrichment	TFRC	1.64
183	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	1.64
184	Retinitis pigmentosa 89	Enrichment	KIF3B	1.64
185	Peripheral neuropathy, myopathy, hoarseness, and hearing loss	Enrichment	MYH14	1.64
186	Pachyonychia congenita 4	Enrichment	KRT6B	1.64
187	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	1.64
188	Lynch syndrome 8	Enrichment	EPCAM	1.64
189	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	1.64
190	Lipodystrophy, congenital generalized, type 4	Enrichment	CAVIN1	1.64
191	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	1.64
192	Visual impairment and progressive phthisis bulbi	Enrichment	MARK3	1.64
193	Atypical werner syndrome	Enrichment	LMNA	1.64
194	Was-related disorders	Enrichment	WAS	1.64
195	X-linked ehlers-danlos syndrome	Enrichment	FLNA	1.64
196	Maturity-onset diabetes of the young, type 14	Enrichment	APPL1	1.64
197	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	1.64
198	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.64
199	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	1.64
200	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.64
201	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	1.64
202	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	1.64
203	Low density lipoprotein cholesterol level quantitative trait locus 8	Enrichment	LIMA1	1.64
204	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.64
205	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	1.64
206	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.64
207	Peho-like syndrome	Enrichment	CCDC88A	1.64
208	Arthrogryposis multiplex congenita 5	Enrichment	TOR1A	1.64
209	Mitochondrial complex iv deficiency, nuclear type 16	Enrichment	COX4I1	1.64
210	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.64
211	Multisystem proteinopathy	Enrichment	VCP	1.64
212	Griscelli syndrome	Enrichment	RAB27A	1.64
213	Microcephaly 27, primary, autosomal dominant	Enrichment	LMNB2	1.64
214	Spastic paraplegia 62, autosomal recessive	Enrichment	ERLIN1	1.64
215	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	1.64
216	Developmental delay with or without epilepsy	Enrichment	SPTAN1	1.64
217	Baraitser-winter syndrome	Enrichment	ACTB	1.64
218	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	1.64
219	Dcx-related disorders	Enrichment	DCX	1.64
220	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	1.64
221	Mandibuloacral dysplasia	Enrichment	LMNA	1.64
222	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	1.64
223	Atrioventricular block	Enrichment	LMNA	1.64
224	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	1.64
225	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	1.64
226	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	1.64
227	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	1.64
228	Flnb-related disorders	Enrichment	FLNB	1.64
229	Spastic paraplegia 18a, autosomal dominant	Enrichment	ERLIN2	1.64
230	Breast lobular carcinoma	Enrichment	CDH1	1.64
231	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	1.64
232	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	1.64
233	Focal palmoplantar keratoderma	Enrichment	KRT6C	1.64
234	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	1.64
235	Zebra body myopathy	Enrichment	ACTA1	1.64
236	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.64
237	Acoustic neuroma	Enrichment	NF2	1.64
238	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.64
239	Capillary leak syndrome	Enrichment	TLN1	1.64
240	Dyt1 early-onset isolated dystonia	Enrichment	TOR1A	1.64
241	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.64
242	Nocarh syndrome	Enrichment	CDC42	1.64
243	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.64
244	Qualitative or quantitative defects of plectin	Enrichment	PLEC	1.64
245	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	1.64
246	Infection-induced acute-onset axonal neuropathy	Enrichment	RCC1	1.64
247	Autosomal recessive epidermolytic ichthyosis	Enrichment	KRT10	1.64
248	Distal monosomy 12p	Enrichment	ERC1	1.64
249	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	1.64
250	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	1.64
251	Recessive intellectual disability-motor dysfunction-multiple joint contractures syndrome	Enrichment	ERLIN2	1.64
252	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	1.64
253	Spastic paraplegia 3a	Enrichment	ATL1	1.64
254	Actin-accumulation myopathy	Enrichment	ACTA1	1.64
255	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.64
256	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	1.64
257	Premature aging	Enrichment	VIM	1.64
258	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	1.64
259	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.64
260	Encephalopathy due to mitochondrial and peroxisomal fission defect	Enrichment	DNM1L	1.64
261	Actg2 visceral myopathy	Enrichment	ACTG2	1.64
262	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	1.64
263	Laminopathy	Enrichment	LMNA	1.64
264	Thrombocytopenia	Enrichment	ACTN1, ITGA2B, MYH9, WAS	1.63
265	Frontotemporal dementia 1	Enrichment	DCTN1, MAPT	1.61
266	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC, DPYSL2, PPP3CA, RAB11A	1.58
267	Cardiac conduction defect	Enrichment	FLNC, LMNA	1.53
268	Meningioma	Enrichment	BAP1, NF2	1.53
269	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP, LMNA	1.53
270	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP, LMNA	1.53
271	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, MYH14, MYH9, MYO6	1.52
272	Rare genetic deafness	Enrichment	ACTG1, DIAPH1, MYH9, MYO6, RDX	1.47
273	Neural tube defects	Enrichment	ITGB1, SCRIB	1.47
274	Alzheimer's disease	Enrichment	MAPT, VCP	1.47
275	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, DNM1, LIMK1, PPP3CA	1.42
276	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP, LMNA	1.41
277	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4, ARHGDIA, CD2AP	1.38
278	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.35
279	Epidermolysis bullosa simplex 5a, ogna type	Enrichment	PLEC	1.35
280	Ichthyosis hystrix, lambert type	Enrichment	KRT10	1.35
281	Cardiomyopathy, familial restrictive, 1	Enrichment	TNNI3	1.35
282	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	CEP55	1.35
283	Epidermolysis bullosa simplex 5b, with muscular dystrophy	Enrichment	PLEC	1.35
284	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	1.35
285	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.35
286	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	1.35
287	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.35
288	Otopalatodigital syndrome, type ii	Enrichment	FLNA	1.35
289	Melnick-needles syndrome	Enrichment	FLNA	1.35
290	Cataract 35	Enrichment	MYH9	1.35
291	Wiskott-aldrich syndrome	Enrichment	WAS	1.35
292	Frontometaphyseal dysplasia 1	Enrichment	FLNA	1.35
293	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.35
294	Epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT5	1.35
295	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	1.35
296	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.35
297	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1	1.35
298	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	1.35
299	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	LMNB2	1.35
300	Schwannomatosis 1	Enrichment	NF2	1.35
301	Pick disease of brain	Enrichment	MAPT	1.35
302	Epidermolysis bullosa simplex 2e, with migratory circinate erythema	Enrichment	KRT5	1.35
303	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.35
304	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.35
305	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	1.35
306	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.35
307	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.35
308	Melanoma, cutaneous malignant 6	Enrichment	KLC1	1.35
309	Primary lateral sclerosis, juvenile	Enrichment	ERLIN2	1.35
310	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.35
311	Lissencephaly 1	Enrichment	PAFAH1B1	1.35
312	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.35
313	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.35
314	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.35
315	Hallermann-streiff syndrome	Enrichment	GJA1	1.35
316	Cardiomyopathy, dilated, 1i	Enrichment	DES	1.35
317	Cardiomyopathy, familial hypertrophic, 25	Enrichment	TNNI3	1.35
318	Moyamoya disease 5	Enrichment	ACTA2	1.35
319	Cardiomyopathy, dilated, 1dd	Enrichment	TNNT2	1.35
320	Diarrhea 5, with tufting enteropathy, congenital	Enrichment	EPCAM	1.35
321	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	1.35
322	Muscular dystrophy, limb-girdle, autosomal recessive 17	Enrichment	PLEC	1.35
323	Syndactyly, type iii	Enrichment	GJA1	1.35
324	Syndactyly, type v	Enrichment	GJA1	1.35
325	Cardiomyopathy, dilated, 1ff	Enrichment	TNNI3	1.35
326	Atrial septal defect 5	Enrichment	ACTC1	1.35
327	Encephalopathy, acute, infection-induced 10	Enrichment	TPT1	1.35
328	Cortical dysplasia, complex, with other brain malformations 4	Enrichment	TUBG1	1.35
329	Sinoatrial node disease	Enrichment	CORO1A	1.35
330	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.35
331	Restrictive dermopathy 2	Enrichment	LMNA	1.35
332	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	1.35
333	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.35
334	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.35
335	Charcot-marie-tooth disease, axonal, type 2dd	Enrichment	ATP1A1	1.35
336	Epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT5	1.35
337	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	1.35
338	Epidermolytic hyperkeratosis 2a, autosomal dominant	Enrichment	KRT10	1.35
339	Immunodeficiency 66	Enrichment	MRTFA	1.35
340	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	1.35
341	Craniometaphyseal dysplasia	Enrichment	GJA1	1.35
342	Lissencephaly 3	Enrichment	TUBA1A	1.35
343	Autosomal recessive limb-girdle muscular dystrophy type 2q	Enrichment	PLEC	1.35
344	Progressive familial heart block	Enrichment	DES	1.35
345	Cataract 30	Enrichment	VIM	1.35
346	Cardiovascular system disease	Enrichment	FLNC	1.35
347	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.35
348	Developmental and epileptic encephalopathy 96	Enrichment	NSF	1.35
349	Macrocephaly, dysmorphic facies, and psychomotor retardation	Enrichment	ERC1	1.35
350	Hypomagnesemia, seizures, and impaired intellectual development 2	Enrichment	ATP1A1	1.35
351	Epidermolytic acanthoma	Enrichment	KRT10	1.35
352	Ocular melanoma	Enrichment	BAP1	1.35
353	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.35
354	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	1.35
355	Pseudosarcomatous fibromatosis	Enrichment	MYH9	1.35
356	Immune system disease	Enrichment	CDC42	1.35
357	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.35
358	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.35
359	Kury-isidor syndrome	Enrichment	BAP1	1.35
360	Epidermolysis bullosa simplex 2a, generalized severe	Enrichment	KRT5	1.35
361	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	1.35
362	Combined deficiency of factor v and factor viii	Enrichment	LMAN1	1.35
363	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	1.35
364	Familial partial lipodystrophy	Enrichment	LMNA	1.35
365	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.35
366	Continuous spikes and waves during sleep	Enrichment	TUBA1A	1.35
367	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.35
368	Intestinal obstruction	Enrichment	ACTG2	1.35
369	Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)	Enrichment	MRTFA	1.35
370	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	1.35
371	Wolff-parkinson-white syndrome	Enrichment	JUP, TNNT2	1.30
372	Fetal akinesia deformation sequence 1	Enrichment	ACTA1, NUP88, TUBA1A	1.29
373	Alzheimer disease, familial, 1	Enrichment	MAPT, VCP	1.25
374	Hypertension, essential	Enrichment	ADD1, ATP1B1	1.25
375	Prune belly syndrome	Enrichment	FLNA	1.18
376	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	1.18
377	Larsen syndrome	Enrichment	FLNB	1.18
378	Mesothelioma, malignant	Enrichment	BAP1	1.18
379	Arterial tortuosity syndrome	Enrichment	FLNA	1.18
380	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B	1.18
381	Nail disorder, nonsyndromic congenital, 4	Enrichment	KRT17	1.18
382	Periventricular nodular heterotopia 1	Enrichment	FLNA	1.18
383	Factor v and factor viii, combined deficiency of, 1	Enrichment	LMAN1	1.18
384	Myopathy, myofibrillar, 1	Enrichment	DES	1.18
385	Restrictive dermopathy 1	Enrichment	LMNA	1.18
386	Myopathy, myofibrillar, 5	Enrichment	FLNC	1.18
387	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.18
388	Spondylocarpotarsal synostosis syndrome	Enrichment	FLNB	1.18
389	Ichthyosis with confetti	Enrichment	KRT10	1.18
390	Leber congenital amaurosis 13	Enrichment	ZFYVE26	1.18
391	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.18
392	Congenital short bowel syndrome	Enrichment	FLNA	1.18
393	Ichthyosis, annular epidermolytic, 1	Enrichment	KRT10	1.18
394	Adams-oliver syndrome 1	Enrichment	ARHGAP31	1.18
395	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.18
396	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1	1.18
397	Myopathy, distal, 4	Enrichment	FLNC	1.18
398	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.18
399	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1	1.18
400	Tumor predisposition syndrome 1	Enrichment	BAP1	1.18
401	Immunodeficiency 8 with lymphoproliferation	Enrichment	CORO1A	1.18
402	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	1.18
403	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.18
404	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.18
405	Epidermolysis bullosa simplex 2b, generalized intermediate	Enrichment	KRT5	1.18
406	Epidermolytic hyperkeratosis 2b, autosomal recessive	Enrichment	KRT10	1.18
407	Coronin-1a deficiency	Enrichment	CORO1A	1.18
408	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	1.18
409	Torsion dystonia 1	Enrichment	TOR1A	1.18
410	Epidermolysis bullosa simplex 5d, generalized intermediate, autosomal recessive	Enrichment	PLEC	1.18
411	Frontometaphyseal dysplasia	Enrichment	FLNA	1.18
412	Cellular ependymoma	Enrichment	NF2	1.18
413	Tanycytic ependymoma	Enrichment	NF2	1.18
414	Papillary ependymoma	Enrichment	NF2	1.18
415	Epidermolysis bullosa simplex 2c, localized	Enrichment	KRT5	1.18
416	Bap1 tumor predisposition syndrome	Enrichment	BAP1	1.18
417	Restrictive dermopathy	Enrichment	LMNA	1.18
418	Spindle cell sarcoma	Enrichment	NF2	1.18
419	Clear cell ependymoma	Enrichment	NF2	1.18
420	Annular epidermolytic ichthyosis	Enrichment	KRT10	1.18
421	Autosomal dominant optic atrophy, classic form	Enrichment	DNM1L	1.18
422	Hyperpigmentation of the skin	Enrichment	USP9X	1.18
423	Autosomal dominant epidermolytic ichthyosis	Enrichment	KRT10	1.18
424	West syndrome	Enrichment	DNM1, SPTAN1, TUBA1A	1.11
425	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, FLNA, PRKG1	1.11
426	Centronuclear myopathy	Enrichment	ACTA1, DNM2	1.09
427	Epidermolysis bullosa simplex 1b, generalized intermediate	Enrichment	KRT5	1.06
428	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.06
429	Dowling-degos disease 1	Enrichment	KRT5	1.06
430	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.06
431	Fucosidosis	Enrichment	DCX	1.06
432	Nemaline myopathy 2	Enrichment	ACTA1	1.06
433	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.06
434	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.06
435	Microtia-anotia	Enrichment	LMNA	1.06
436	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	PLEC	1.06
437	Aminoacylase 1 deficiency	Enrichment	ACTB	1.06
438	Cardiomyopathy, familial hypertrophic, 26	Enrichment	FLNC	1.06
439	Congenital generalized lipodystrophy	Enrichment	CAVIN1	1.06
440	Macular dystrophy with or without cone dysfunction	Enrichment	ZFYVE26	1.06
441	Dowling-degos disease	Enrichment	KRT5	1.06
442	Epidermolysis bullosa simplex generalized type	Enrichment	KRT5	1.06
443	Tubulinopathy	Enrichment	TUBA1A	1.06
444	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.06
445	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.06
446	Epidermolytic nevus	Enrichment	KRT10	1.06
447	Epidermolytic hyperkeratosis	Enrichment	KRT10	1.06
448	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	1.06
449	Knobloch syndrome	Enrichment	PAK2	1.06
450	Full schwannomatosis	Enrichment	NF2	1.06
451	Intermediate nemaline myopathy	Enrichment	ACTA1	1.06
452	Benign ependymoma	Enrichment	NF2	1.06
453	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.06
454	Body mass index quantitative trait locus 11	Enrichment	DIXDC1, DNM1L, MYH9	0.98
455	Hemifacial hyperplasia	Enrichment	FLNC	0.96
456	Epidermolytic hyperkeratosis 1	Enrichment	KRT10	0.96
457	Dementia, lewy body	Enrichment	VCP	0.96
458	Visceral myopathy 1	Enrichment	ACTG2	0.96
459	Epidermolysis bullosa simplex 1c, localized	Enrichment	KRT5	0.96
460	Smith-magenis syndrome	Enrichment	FLII	0.96
461	Multiple endocrine neoplasia, type iia	Enrichment	KIF1B	0.96
462	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	0.96
463	Deafness, autosomal recessive 63	Enrichment	MYH9	0.96
464	Knobloch syndrome 1	Enrichment	PAK2	0.96
465	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	0.96
466	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	0.96
467	Heart conduction disease	Enrichment	FLNC	0.96
468	Congenital ptosis	Enrichment	MYH10	0.96
469	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	0.96
470	Epidermolysis bullosa	Enrichment	KRT5	0.96
471	Aplasia cutis congenita	Enrichment	PLEC	0.96
472	Cleft upper lip	Enrichment	GJA1	0.96
473	Dementia	Enrichment	MAPT	0.96
474	Coloboma of choroid and retina	Enrichment	ACTG1	0.96
475	Genetic motor neuron disease	Enrichment	DCTN1	0.96
476	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	0.96
477	Severe congenital nemaline myopathy	Enrichment	ACTA1	0.96
478	Tetralogy of fallot	Enrichment	FLNC, TPM1	0.93
479	Auditory neuropathy	Enrichment	DIAPH1, NEFL	0.93
480	Spastic ataxia	Enrichment	FLNC, SPTAN1, TUBB3	0.92
481	Atrial septal defect 1	Enrichment	TPM1	0.89
482	Melanoma, uveal	Enrichment	BAP1	0.89
483	Dystonia 11, myoclonic	Enrichment	TOR1A	0.89
484	Myopathy, centronuclear, 1	Enrichment	DNM2	0.89
485	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	0.89
486	Hemihyperplasia, isolated	Enrichment	RHOA	0.89
487	Hemangioma, capillary infantile	Enrichment	MYH9	0.89
488	Pendred syndrome	Enrichment	DIAPH1	0.89
489	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	0.89
490	Inflammatory myofibroblastic tumor	Enrichment	CLTC	0.89
491	Intestinal pseudo-obstruction	Enrichment	ACTG2	0.89
492	Patent ductus arteriosus	Enrichment	FLNA	0.89
493	Clear cell renal cell carcinoma	Enrichment	BAP1	0.89
494	Early myoclonic encephalopathy	Enrichment	TUBA1A	0.89
495	Limited scleroderma	Enrichment	CAV1	0.89
496	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2B	0.89
497	Inherited arrhythmogenic cardiomyopathy	Enrichment	FLNC	0.89
498	Typical nemaline myopathy	Enrichment	ACTA1	0.89
499	Differentiated thyroid carcinoma	Enrichment	ERC1, PCM1	0.85
500	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1, MYH9, MYO6, RDX	0.84
501	Bethlem myopathy 1a	Enrichment	LMNA	0.83
502	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A	0.83
503	Glanzmann thrombasthenia 1	Enrichment	ITGA2B	0.83
504	Noonan syndrome 3	Enrichment	CLTC	0.83
505	Adams-oliver syndrome	Enrichment	ARHGAP31	0.83
506	Hereditary sensory and autonomic neuropathy type 1	Enrichment	ATL1	0.83
507	Renal cell carcinoma with mit translocations	Enrichment	CLTC	0.83
508	Focal epilepsy	Enrichment	SPTAN1	0.83
509	Vesicoureteral reflux	Enrichment	AFAP1L2	0.83
510	Childhood-onset nemaline myopathy	Enrichment	ACTA1	0.83
511	Complex neurodevelopmental disorder	Enrichment	BAP1, MYH10, PAK3, RAC3, RALA	0.82
512	Connective tissue disease	Enrichment	ACTA2, FLNB	0.79
513	Peripheral nervous system disease	Enrichment	LMNA, NEFL	0.79
514	Neuropathy	Enrichment	LMNA, NEFL	0.79
515	Glioma susceptibility 1	Enrichment	BAP1	0.77
516	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	0.77
517	Fanconi anemia, complementation group c	Enrichment	FLNA	0.77
518	Ewing sarcoma	Enrichment	BAP1	0.77
519	Lennox-gastaut syndrome	Enrichment	DNM1	0.77
520	Cryptorchidism	Enrichment	TUBA1A	0.77
521	Congenital muscular dystrophy	Enrichment	LMNA	0.77
522	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	0.77
523	Neuroblastoma	Enrichment	KIF1B	0.77
524	Hypoplastic left heart syndrome	Enrichment	GJA1	0.77
525	Male infertility due to globozoospermia	Enrichment	GOPC	0.77
526	Severe combined immunodeficiency	Enrichment	CORO1A, STK4	0.76
527	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	ADD1	0.73
528	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	0.73
529	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	0.73
530	Myoclonic-atonic epilepsy	Enrichment	AP2M1	0.73
531	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.73
532	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A	0.73
533	Colonic benign neoplasm	Enrichment	EPCAM	0.73
534	Juvenile amyotrophic lateral sclerosis	Enrichment	ERLIN1	0.73
535	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6, USP9X	0.71
536	Developmental and epileptic encephalopathy	Enrichment	SEC24C, SPTAN1	0.71
537	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	0.69
538	Cat eye syndrome	Enrichment	ACTG1	0.69
539	Cataract 30, multiple types	Enrichment	VIM	0.69
540	Lynch syndrome 1	Enrichment	EPCAM	0.69
541	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	0.69
542	Peters-plus syndrome	Enrichment	ARHGAP35	0.69
543	Neurodegeneration with brain iron accumulation	Enrichment	REPS1	0.69
544	Isolated tracheo-esophageal fistula	Enrichment	ADD1	0.69
545	Congenital nervous system abnormality	Enrichment	ATL1, DCX, ERLIN2, TUBA1A	0.66
546	Nervous system disease	Enrichment	ATL1, DCX, ERLIN2, TUBA1A	0.66
547	Cerebral palsy	Enrichment	ARHGAP31, TUBA1A	0.65
548	Meningioma, familial	Enrichment	NF2	0.65
549	Combined immunodeficiency	Enrichment	TFRC	0.65
550	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	0.65
551	Heritable pulmonary arterial hypertension	Enrichment	CAV1	0.65
552	Combined t and b cell immunodeficiency	Enrichment	TFRC	0.65
553	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	0.62
554	Digeorge syndrome	Enrichment	SEC24C	0.62
555	Juvenile myelomonocytic leukemia	Enrichment	RRAS	0.62
556	Breast cancer	Enrichment	CDH1, EPCAM, KLC1	0.62
557	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	0.61
558	Gastric cancer	Enrichment	CDH1, EPCAM	0.59
559	Microphthalmia/coloboma 12	Enrichment	MYH10	0.59
560	Chromosome 1p36 deletion syndrome	Enrichment	PDPN	0.59
561	Stereotypic movement disorder	Enrichment	DNM1	0.59
562	Hereditary breast carcinoma	Enrichment	CDH1, EPCAM	0.58
563	Multiple sclerosis	Enrichment	PLEC	0.56
564	Lung cancer susceptibility 3	Enrichment	ACTA2	0.56
565	Periventricular nodular heterotopia	Enrichment	FLNA	0.56
566	Cox deficiency, benign infantile mitochondrial myopathy	Enrichment	COX4I1	0.56
567	Cleft lip/palate	Enrichment	CDH1	0.56
568	Coloboma of macula	Enrichment	MYH10	0.54
569	Renal cell carcinoma, nonpapillary	Enrichment	BAP1	0.54
570	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	0.54
571	Corpus callosum, agenesis of	Enrichment	TUBA1A	0.54
572	Lynch syndrome	Enrichment	EPCAM	0.54
573	Isolated corpus callosum agenesis	Enrichment	TUBA1A	0.54
574	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	0.54
575	Microcephaly	Enrichment	ACTB, ACTG1, DIAPH1, PAK3	0.51
576	Hydrocephalus, congenital, 1	Enrichment	TUBB	0.51
577	Hypertension	Enrichment	MYH9	0.51
578	Isolated congenital microcephaly	Enrichment	RAB11A	0.51
579	Colorectal cancer	Enrichment	CDH1, EPCAM, PTPN12	0.50
580	Melanoma, cutaneous malignant 1	Enrichment	BAP1	0.49
581	Cleft palate, isolated	Enrichment	FLNA	0.49
582	Dandy-walker syndrome	Enrichment	TUBA1A	0.49
583	Sudden infant death syndrome	Enrichment	TNNI3	0.49
584	Inherited cancer-predisposing syndrome	Enrichment	BAP1, CDH1, EPCAM, NF2	0.45
585	Esophageal atresia/tracheoesophageal fistula	Enrichment	ADD1	0.45
586	Congenital myopathy	Enrichment	ACTA1	0.45
587	Williams-beuren syndrome	Enrichment	LIMK1	0.43
588	Maturity-onset diabetes of the young	Enrichment	APPL1	0.43
589	Autosomal recessive non-syndromic intellectual disability	Enrichment	CLIP1, EZR	0.42
590	Endometrial cancer	Enrichment	CDH1	0.42
591	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	KIF1B	0.42
592	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	COX4I1	0.40
593	Multisystem inflammatory syndrome in children	Enrichment	RAB27A	0.40
594	Noonan syndrome 1	Enrichment	RRAS	0.39
595	Ear malformation	Enrichment	MYO6	0.37
596	Parkinson disease, late-onset	Enrichment	MAPT	0.37
597	Autoinflammatory disease	Enrichment	RAB27A	0.37
598	Muscular dystrophy	Enrichment	LMNA	0.37
599	Pancreatic cancer	Enrichment	PALLD	0.36
600	Jeune thoracic dystrophy	Enrichment	SPTAN1	0.36
601	Hydrops fetalis, nonimmune	Enrichment	ACTA1	0.35
602	Brugada syndrome	Enrichment	LMNA	0.35
603	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	0.32
604	Hirschsprung disease 1	Enrichment	NUP98	0.31
605	Prostate cancer	Enrichment	CDH1	0.31
606	Severe covid-19	Enrichment	ITGAV	0.31
607	Long qt syndrome	Enrichment	LMNA	0.29
608	Non-immune hydrops fetalis	Enrichment	ACTA1	0.29
609	Lung cancer	Enrichment	ACTA2	0.28
610	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	0.27
611	Male infertility	Enrichment	CLDN2	0.27
612	Cakut	Enrichment	ACTG1	0.27
613	Dystonia	Enrichment	TOR1A	0.26
614	Eye disease	Enrichment	ZFYVE26	0.26
615	Leukemia, acute myeloid	Enrichment	LPP	0.22
616	Epilepsy	Enrichment	DIAPH1	0.22
617	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	0.21
618	Centralopathic epilepsy	Enrichment	SPTAN1	0.20
619	Sensorineural hearing loss	Enrichment	NEFL	0.17
620	Ovarian cancer	Enrichment	CDH1, KIF1B	0.17
621	Hypertelorism	Enrichment	MYH10	0.16
622	Myeloma, multiple	Enrichment	BAP1	0.14
623	Schizophrenia	Enrichment	LPP	0.13
624	Deafness, autosomal recessive	Enrichment	MYH9	0.12
625	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.11
626	Cone-rod dystrophy 2	Enrichment	ADAM9	0.10
627	Mitochondrial disease	Enrichment	DNM1L	0.06
628	Leber plus disease	Enrichment	ZFYVE26	0.05
629	Autism spectrum disorder	Enrichment	MARK2	0.04
630	Retinitis pigmentosa	Enrichment	ADAM9, ZFYVE26	0.02
631	Hereditary retinal dystrophy	Enrichment	ADAM9, ZFYVE26	0.00
632	Fundus dystrophy	Enrichment	ADAM9, ZFYVE26	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cytoskeletal Signaling

Pathway Network for Cytoskeletal Signaling

Member Pathways for Cytoskeletal Signaling

Pathways in the Cytoskeletal Signaling SuperPath

Associated Genes for Cytoskeletal Signaling

Associated Disorders for Cytoskeletal Signaling

Disorders associated with Cytoskeletal Signaling SuperPath

STRING Interaction Network for Cytoskeletal Signaling

Sources for Cytoskeletal Signaling