Cytoskeleton remodeling_RalA regulation pathway

No Pathway Network information available for Cytoskeleton remodeling_RalA regulation pathway

Pathways in the Cytoskeleton remodeling_RalA regulation pathway SuperPath

#	Name	Source	Genes
1	Cytoskeleton remodeling_RalA regulation pathway	GeneGo (Thomson Reuters)	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 AP2M1 ARF1 ARRB1 ARRB2 AURKA CALM1 CALM2 CALM3 CDC42 EXOC2 EXOC3 EXOC6B FLNA FNTA FPR1 HRAS HSF1 PGGT1B PLD1 RAC1 RALA RALBP1 RALGDS RALGPS1 RAP1A REPS1 REPS2 RGL1 RGL2 (see all 35) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
2	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
3	ACTB	Actin Beta	Protein Coding	1
4	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
5	ACTG1	Actin Gamma 1	Protein Coding	1
6	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
7	ARF1	ARF GTPase 1	Protein Coding	1
8	ARRB1	Arrestin Beta 1	Protein Coding	1
9	ARRB2	Arrestin Beta 2	Protein Coding	1
10	CALM1	Calmodulin 1	Protein Coding	1
11	CALM2	Calmodulin 2	Protein Coding	1
12	CALM3	Calmodulin 3	Protein Coding	1
13	CDC42	Cell Division Cycle 42	Protein Coding	1
14	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	1
15	FLNA	Filamin A	Protein Coding	1
16	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
17	FPR1	Formyl Peptide Receptor 1	Protein Coding	1
18	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
19	HSF1	Heat Shock Transcription Factor 1	Protein Coding	1
20	PGGT1B	Protein Geranylgeranyltransferase Type I Subunit Beta	Protein Coding	1
21	PLD1	Phospholipase D1	Protein Coding	1
22	RGL2	Ral Guanine Nucleotide Dissociation Stimulator Like 2	Protein Coding	1
23	RAC1	Rac Family Small GTPase 1	Protein Coding	1
24	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
25	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
26	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
27	AURKA	Aurora Kinase A	Protein Coding	1
28	REPS2	RALBP1 Associated Eps Domain Containing 2	Protein Coding	1
29	RALGPS1	Ral GEF With PH Domain And SH3 Binding Motif 1	Protein Coding	1
30	RALBP1	RalA Binding Protein 1	Protein Coding	1
31	EXOC3	Exocyst Complex Component 3	Protein Coding	1
32	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	1
33	EXOC6B	Exocyst Complex Component 6B	Protein Coding	1
34	EXOC2	Exocyst Complex Component 2	Protein Coding	1
35	REPS1	RALBP1 Associated Eps Domain Containing 1	Protein Coding	1

Disorders associated with Cytoskeleton remodeling_RalA regulation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.06
2	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.19
3	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.22
4	Periventricular nodular heterotopia	Enrichment	ARF1, FLNA	3.24
5	Patent foramen ovale	Enrichment	ACTC1, FLNA	3.02
6	Hydrops fetalis, nonimmune	Enrichment	ACTA1, HRAS	2.69
7	Baraitser-winter syndrome 1	Enrichment	ACTB	2.59
8	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.59
9	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.59
10	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.59
11	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.59
12	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.59
13	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	2.59
14	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.59
15	Terminal osseous dysplasia	Enrichment	FLNA	2.59
16	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.59
17	Fg syndrome 2	Enrichment	FLNA	2.59
18	Neurodegeneration with brain iron accumulation 7	Enrichment	REPS1	2.59
19	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.59
20	Becker nevus syndrome	Enrichment	ACTB	2.59
21	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.59
22	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.59
23	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.59
24	Long qt syndrome 16	Enrichment	CALM3	2.59
25	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.59
26	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.59
27	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.59
28	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.59
29	Spondyloepimetaphyseal dysplasia with joint laxity, type 3	Enrichment	EXOC6B	2.59
30	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.59
31	Long qt syndrome 15	Enrichment	CALM2	2.59
32	Baraitser-winter syndrome	Enrichment	ACTB	2.59
33	Exoc6b-related spondyloepimetaphyseal dysplasia with joint laxity	Enrichment	EXOC6B	2.59
34	Zebra body myopathy	Enrichment	ACTA1	2.59
35	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.59
36	Nocarh syndrome	Enrichment	CDC42	2.59
37	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.59
38	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.59
39	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.59
40	Actin-accumulation myopathy	Enrichment	ACTA1	2.59
41	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.59
42	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.59
43	Actg2 visceral myopathy	Enrichment	ACTG2	2.59
44	Long qt syndrome	Enrichment	CALM1, CALM2	2.54
45	Non-immune hydrops fetalis	Enrichment	ACTA1, HRAS	2.54
46	Costello syndrome	Enrichment	HRAS	2.29
47	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.29
48	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.29
49	Melnick-needles syndrome	Enrichment	FLNA	2.29
50	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.29
51	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.29
52	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.29
53	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.29
54	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.29
55	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.29
56	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.29
57	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.29
58	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.29
59	Moyamoya disease 5	Enrichment	ACTA2	2.29
60	Long qt syndrome 14	Enrichment	CALM1	2.29
61	Atrial septal defect 5	Enrichment	ACTC1	2.29
62	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.29
63	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.29
64	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.29
65	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.29
66	Immune system disease	Enrichment	CDC42	2.29
67	Neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia	Enrichment	EXOC2	2.29
68	Intestinal obstruction	Enrichment	ACTG2	2.29
69	Wooly hair nevus	Enrichment	HRAS	2.29
70	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	2.28
71	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, FLNA	2.24
72	Prune belly syndrome	Enrichment	FLNA	2.11
73	Arterial tortuosity syndrome	Enrichment	FLNA	2.11
74	Periventricular nodular heterotopia 1	Enrichment	FLNA	2.11
75	Congenital short bowel syndrome	Enrichment	FLNA	2.11
76	Large congenital melanocytic nevus	Enrichment	HRAS	2.11
77	Frontometaphyseal dysplasia	Enrichment	FLNA	2.11
78	Spermatocytoma	Enrichment	HRAS	2.11
79	Aggressive periodontitis	Enrichment	FPR1	2.11
80	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.99
81	Nemaline myopathy 2	Enrichment	ACTA1	1.99
82	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.99
83	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.99
84	Aminoacylase 1 deficiency	Enrichment	ACTB	1.99
85	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.99
86	Epidermolytic nevus	Enrichment	HRAS	1.99
87	Intermediate nemaline myopathy	Enrichment	ACTA1	1.99
88	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.99
89	Visceral myopathy 1	Enrichment	ACTG2	1.89
90	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.89
91	Coloboma of choroid and retina	Enrichment	ACTG1	1.89
92	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.89
93	Moyamoya disease 1	Enrichment	ACTA2	1.81
94	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.81
95	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.81
96	Patent ductus arteriosus	Enrichment	FLNA	1.81
97	Typical nemaline myopathy	Enrichment	ACTA1	1.81
98	Nevus, epidermal	Enrichment	HRAS	1.75
99	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.75
100	Noonan syndrome 3	Enrichment	HRAS	1.75
101	Follicular thyroid carcinoma	Enrichment	HRAS	1.75
102	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.75
103	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1	1.74
104	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.69
105	Fanconi anemia, complementation group c	Enrichment	FLNA	1.69
106	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.69
107	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.64
108	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.64
109	Arteriovenous malformation	Enrichment	HRAS	1.64
110	Cat eye syndrome	Enrichment	ACTG1	1.59
111	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.59
112	Neurodegeneration with brain iron accumulation	Enrichment	REPS1	1.59
113	Nemaline myopathy	Enrichment	ACTA1	1.59
114	Lung non-small cell carcinoma	Enrichment	HRAS	1.55
115	Lip and oral cavity carcinoma	Enrichment	HRAS	1.52
116	Lung cancer susceptibility 3	Enrichment	ACTA2	1.45
117	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.42
118	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.42
119	Microcephaly	Enrichment	ACTB, ACTG1	1.40
120	Rhabdomyosarcoma	Enrichment	HRAS	1.39
121	Cleft palate, isolated	Enrichment	FLNA	1.37
122	Sudden infant death syndrome	Enrichment	CALM2	1.37
123	Neuromuscular disease	Enrichment	ACTA1	1.34
124	Congenital myopathy	Enrichment	ACTA1	1.32
125	Lissencephaly	Enrichment	ACTG1	1.28
126	Centronuclear myopathy	Enrichment	ACTA1	1.28
127	Noonan syndrome 1	Enrichment	HRAS	1.24
128	Rasopathy	Enrichment	HRAS	1.19
129	Bladder cancer	Enrichment	HRAS	1.14
130	Differentiated thyroid carcinoma	Enrichment	HRAS	1.14
131	Lung cancer	Enrichment	ACTA2	1.10
132	Connective tissue disease	Enrichment	ACTA2	1.10
133	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	1.09
134	Cakut	Enrichment	ACTG1	1.07
135	Left ventricular noncompaction	Enrichment	ACTC1	1.06
136	Non-syndromic genetic deafness	Enrichment	ACTG1	1.05
137	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	1.04
138	Myopathy	Enrichment	ACTA1	1.01
139	Nonsyndromic hearing loss	Enrichment	ACTG1	0.99
140	Hypertrophic cardiomyopathy	Enrichment	ACTC1	0.98
141	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.90
142	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1	0.89
143	Myeloma, multiple	Enrichment	AURKA	0.87
144	Rare genetic deafness	Enrichment	ACTG1	0.73
145	Colorectal cancer	Enrichment	AURKA	0.69
146	Complex neurodevelopmental disorder	Enrichment	RALA	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cytoskeleton remodeling_RalA regulation pathway

Pathway Network for Cytoskeleton remodeling_RalA regulation pathway

Member Pathways for Cytoskeleton remodeling_RalA regulation pathway

Pathways in the Cytoskeleton remodeling_RalA regulation pathway SuperPath

Associated Genes for Cytoskeleton remodeling_RalA regulation pathway

Associated Disorders for Cytoskeleton remodeling_RalA regulation pathway

Disorders associated with Cytoskeleton remodeling_RalA regulation pathway SuperPath

STRING Interaction Network for Cytoskeleton remodeling_RalA regulation pathway

Sources for Cytoskeleton remodeling_RalA regulation pathway