Cytoskeleton remodeling Role of PDGFs in cell migration

Pathway network for the Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways
PubChem

Pathways in the Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

#	Name	Source	Genes
1	Cytoskeleton remodeling Role of PDGFs in cell migration	GeneGo (Thomson Reuters)	ARFIP2 CDC42 NET1 PAK1 PAK4 PAK5 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 RAC1 RHOA TIAM1 VAV1 VAV2 WASL (see all 23) (see less)
2	PDGF pathway	WikiPathways	ARFIP2 CDC42 CHUK GRB2 HRAS JAK1 MAP2K4 MAPK1 MAPK3 MT-CO2 NFKB1 PAK1 PDGFA PDGFB PDGFRB PIK3R1 PLA2G4A PLCG1 RAC1 RAF1 RASA1 RHOA SHC1 SOS1 SRC STAT1 STAT3 TIAM1 VAV1 VAV2 WASL (see all 31) (see less)
3	PDGF receptor signaling network	PubChem	PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB (see all 6) (see less)
4	Osteoblast signaling	WikiPathways	PDGFB PDGFRA

Gene overlap in member pathways for Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	4
2	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	3
3	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	3
4	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	3
5	RHOA	Ras Homolog Family Member A	Protein Coding	2
6	CDC42	Cell Division Cycle 42	Protein Coding	2
7	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
8	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
9	RAC1	Rac Family Small GTPase 1	Protein Coding	2
10	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	2
11	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
12	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
13	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
14	ARFIP2	ARF Interacting Protein 2	Protein Coding	2
15	PDGFC	Platelet Derived Growth Factor C	Protein Coding	2
16	PDGFD	Platelet Derived Growth Factor D	Protein Coding	2
17	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
18	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
19	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
20	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
21	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	1
22	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
23	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
24	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
25	MT-CO2	Mitochondrially Encoded Cytochrome C Oxidase II	Protein Coding	1
26	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
27	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
28	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
29	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
30	SHC1	SHC Adaptor Protein 1	Protein Coding	1
31	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
32	JAK1	Janus Kinase 1	Protein Coding	1
33	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
34	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
35	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
36	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
37	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
38	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
39	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
40	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
41	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1

Disorders associated with Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	6.42
2	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	5.79
3	Immune system disease	Enrichment	CDC42, PIK3CD	5.56
4	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	5.34
5	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, RAF1, SOS1	5.32
6	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.08
7	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	5.08
8	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	5.08
9	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.82
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.78
11	Noonan syndrome 1	Enrichment	HRAS, RAF1, SOS1	4.73
12	Rasopathy	Enrichment	HRAS, RAF1, SOS1	4.57
13	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.39
14	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.91
15	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.85
16	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	3.83
17	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	3.83
18	Gist-plus syndrome	Enrichment	PDGFRA	3.83
19	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	3.83
20	Meningioma	Enrichment	PDGFB, PIK3CA	3.75
21	Arteriovenous malformation	Enrichment	HRAS, RASA1	3.74
22	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, RASA1	3.65
23	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	3.53
24	Chronic eosinophilic leukemia	Enrichment	PDGFRA	3.53
25	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	3.53
26	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	3.35
27	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	3.35
28	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	3.35
29	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	3.35
30	Kosaki overgrowth syndrome	Enrichment	PDGFRB	3.35
31	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	3.35
32	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	3.05
33	Infantile myofibromatosis	Enrichment	PDGFRB	3.05
34	Gastrointestinal stromal tumor	Enrichment	PDGFRA	2.99
35	Meningioma, familial	Enrichment	PDGFB	2.79
36	Macrodactyly	Enrichment	PIK3CA	2.77
37	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.77
38	Cowden syndrome 5	Enrichment	PIK3CA	2.77
39	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.77
40	Short syndrome	Enrichment	PIK3R1	2.77
41	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.77
42	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.77
43	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.77
44	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.77
45	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.77
46	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.77
47	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.77
48	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.77
49	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.77
50	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.77
51	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.77
52	Hypospadias	Enrichment	PIK3CA	2.77
53	Rare venous malformation	Enrichment	PIK3CA	2.77
54	Diaphragmatic eventration	Enrichment	PIK3CA	2.77
55	Nocarh syndrome	Enrichment	CDC42	2.77
56	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.77
57	Rare combined vascular malformation	Enrichment	PIK3CA	2.77
58	Cavernous lymphangioma	Enrichment	PIK3CA	2.77
59	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.77
60	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.77
61	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.77
62	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.77
63	Macrodactyly of toe	Enrichment	PIK3CA	2.77
64	Cleft lip/palate	Enrichment	PDGFRA	2.69
65	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.64
66	Noonan syndrome 5	Enrichment	RAF1	2.64
67	Noonan syndrome 4	Enrichment	SOS1	2.64
68	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.64
69	Fetal encasement syndrome	Enrichment	CHUK	2.64
70	Noonan syndrome 13	Enrichment	MAPK1	2.64
71	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.64
72	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.64
73	Leopard syndrome 2	Enrichment	RAF1	2.64
74	Immunodeficiency 31a	Enrichment	STAT1	2.64
75	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.64
76	Immunodeficiency 31b	Enrichment	STAT1	2.64
77	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.64
78	Thrombocytopenia 6	Enrichment	SRC	2.64
79	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.64
80	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.64
81	Trigonitis	Enrichment	RAF1	2.64
82	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.64
83	Gorham's disease	Enrichment	RASA1	2.64
84	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.64
85	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.64
86	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.64
87	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.64
88	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.64
89	Keratosis, seborrheic	Enrichment	PIK3CA	2.47
90	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.47
91	Noonan syndrome 8	Enrichment	PIK3CA	2.47
92	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.47
93	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.47
94	Fibromatosis, gingival, 1	Enrichment	SOS1	2.34
95	Costello syndrome	Enrichment	HRAS	2.34
96	Pulmonic stenosis	Enrichment	SOS1	2.34
97	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
98	Immunodeficiency 31c	Enrichment	STAT1	2.34
99	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.34
100	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
101	Wooly hair nevus	Enrichment	HRAS	2.34
102	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.29
103	Keratoacanthoma	Enrichment	PIK3CA	2.29
104	Hydrocephalus	Enrichment	PDGFRB	2.18
105	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.17
106	Cerebrovascular disease	Enrichment	PIK3CA	2.17
107	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.17
108	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.17
109	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.16
110	Nuchal bleb, familial	Enrichment	SOS1	2.16
111	Large congenital melanocytic nevus	Enrichment	HRAS	2.16
112	Hyper ige syndrome	Enrichment	STAT3	2.16
113	Wieacker-wolff syndrome	Enrichment	RASA1	2.16
114	Spermatocytoma	Enrichment	HRAS	2.16
115	Dandy-walker syndrome	Enrichment	PDGFRB	2.13
116	Capillary malformations, congenital	Enrichment	PIK3CA	2.07
117	Hemimegalencephaly	Enrichment	PIK3CA	2.07
118	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.04
119	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.04
120	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.04
121	Epidermolytic nevus	Enrichment	HRAS	2.04
122	Gingival fibromatosis	Enrichment	SOS1	2.04
123	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.03
124	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.99
125	Cowden syndrome 1	Enrichment	PIK3CA	1.99
126	Breast adenocarcinoma	Enrichment	PIK3CA	1.99
127	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.99
128	Nevus, epidermal	Enrichment	PIK3CA	1.93
129	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.93
130	Gallbladder cancer	Enrichment	PIK3CA	1.93
131	Overgrowth syndrome	Enrichment	PIK3R1	1.93
132	Ovarian cancer	Enrichment	PDGFRA, PIK3CA	1.90
133	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.87
134	Hemangioma, capillary infantile	Enrichment	RASA1	1.87
135	Basal cell carcinoma 1	Enrichment	RASA1	1.87
136	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.87
137	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.82
138	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.82
139	Cowden syndrome	Enrichment	PIK3CA	1.82
140	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.80
141	Myelofibrosis	Enrichment	SRC	1.80
142	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.80
143	Pilomyxoid astrocytoma	Enrichment	RAF1	1.80
144	Common variable immunodeficiency	Enrichment	NFKB1	1.80
145	Follicular thyroid carcinoma	Enrichment	HRAS	1.80
146	Cerebral palsy	Enrichment	PDGFRB	1.77
147	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.74
148	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.73
149	Inherited cancer-predisposing syndrome	Enrichment	PDGFRA	1.71
150	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.70
151	Mitochondrial myopathy, infantile, transient	Enrichment	MT-CO2	1.69
152	Nk-cell enteropathy	Enrichment	PIK3CB	1.66
153	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
154	Familial colorectal cancer	Enrichment	MT-CO2	1.65
155	Mitochondrial myopathy with reversible cytochrome c oxidase deficiency	Enrichment	MT-CO2	1.65
156	Specific learning disability	Enrichment	MAPK1	1.60
157	Lynch syndrome	Enrichment	PIK3CA	1.60
158	Aortic valve disease 1	Enrichment	SOS1	1.53
159	Acute promyelocytic leukemia	Enrichment	STAT3	1.53
160	Osteoporosis	Enrichment	SRC	1.50
161	Cox deficiency, benign infantile mitochondrial myopathy	Enrichment	MT-CO2	1.50
162	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.50
163	Endometrial cancer	Enrichment	PIK3CA	1.46
164	Rhabdomyosarcoma	Enrichment	HRAS	1.44
165	Hepatocellular carcinoma	Enrichment	PIK3CA	1.44
166	Heart, malformation of	Enrichment	MAPK1	1.39
167	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.37
168	Bladder cancer	Enrichment	PIK3CA	1.32
169	Prostate cancer	Enrichment	PIK3CA	1.32
170	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	MT-CO2	1.31
171	Lung cancer	Enrichment	PIK3CA	1.28
172	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.27
173	Tetralogy of fallot	Enrichment	MT-CO2	1.24
174	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.24
175	Mitochondrial complex v deficiency, mitochondrial type 1	Enrichment	MT-CO2	1.24
176	Neuropathy, ataxia, and retinitis pigmentosa	Enrichment	MT-CO2	1.24
177	Striatonigral degeneration, infantile, mitochondrial	Enrichment	MT-CO2	1.24
178	Camptodactyly of fingers	Enrichment	MT-CO2	1.24
179	Differentiated thyroid carcinoma	Enrichment	HRAS	1.19
180	Non-immune hydrops fetalis	Enrichment	HRAS	1.16
181	Gastric cancer	Enrichment	PIK3CA	1.15
182	Hereditary breast carcinoma	Enrichment	PIK3CA	1.14
183	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.14
184	Left ventricular noncompaction	Enrichment	RAF1	1.11
185	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-CO2	1.09
186	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-CO2	1.08
187	Hypertelorism	Enrichment	PIK3CA	1.07
188	Myeloma, multiple	Enrichment	PIK3R2	1.04
189	Thrombocytopenia	Enrichment	SRC	0.98
190	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.94
191	Breast cancer	Enrichment	PIK3CA	0.92
192	Leigh syndrome, nuclear	Enrichment	MT-CO2	0.83
193	Leigh disease	Enrichment	MT-CO2	0.80
194	Dilated cardiomyopathy	Enrichment	RAF1	0.78
195	Mitochondrial disease	Enrichment	MT-CO2	0.74
196	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.72
197	Leber plus disease	Enrichment	MT-CO2	0.71
198	Microcephaly	Enrichment	MAPK1	0.61
199	Retinitis pigmentosa	Enrichment	MT-CO2	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cytoskeleton remodeling Role of PDGFs in cell migration

Pathway Network for Cytoskeleton remodeling Role of PDGFs in cell migration

Pathway network for the Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

Member Pathways for Cytoskeleton remodeling Role of PDGFs in cell migration

Pathways in the Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

Gene overlap in member pathways for Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

Associated Genes for Cytoskeleton remodeling Role of PDGFs in cell migration

Associated Disorders for Cytoskeleton remodeling Role of PDGFs in cell migration

Disorders associated with Cytoskeleton remodeling Role of PDGFs in cell migration SuperPath

STRING Interaction Network for Cytoskeleton remodeling Role of PDGFs in cell migration

Sources for Cytoskeleton remodeling Role of PDGFs in cell migration