Cytosolic sensors of pathogen-associated DNA

Pathway network for the Cytosolic sensors of pathogen-associated DNA SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Cytosolic sensors of pathogen-associated DNA SuperPath

#	Name	Source	Genes
1	Cytosolic sensors of pathogen-associated DNA	Reactome	AIM2 CGAS CHUK CRCP CREBBP CTNNB1 DDX41 DHX36 DHX9 DTX4 EP300 IFI16 IKBKB IKBKG IRF3 IRF7 LRRFIP1 MRE11 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC3 NLRP4 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K PRKDC RELA RIPK1 RIPK3 RPS27A STAT6 STING1 TBK1 TICAM1 TLR3 TREX1 TRIM21 TRIM32 TRIM56 UBA52 UBB UBC XRCC5 XRCC6 ZBP1 (see all 64) (see less)
2	Cytosolic DNA-sensing pathway	WikiPathways	ADAR AIM2 ATG12 ATG5 CASP1 CASP10 CASP8 CCL4 CCL4L2 CCL5 CGAS CHUK CXCL10 CYLD FADD IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKB IKBKE IKBKG IL18 IL1B IL33 IL6 IRF3 IRF7 ISG15 MAVS NFKB1 NFKBIA NFKBIB NLRX1 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K PYCARD RELA RIGI RIPK1 RIPK3 RNF125 STING1 TBK1 TRADD TREX1 TRIM25 ZBP1 (see all 73) (see less)
3	ZBP1(DAI) mediated induction of type I IFNs	Reactome	CHUK DHX9 DTX4 IKBKB IKBKG IRF3 MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRP4 RELA RIPK1 RIPK3 TBK1 TICAM1 TLR3 ZBP1 (see all 21) (see less)
4	RIP-mediated NFkB activation via ZBP1	Reactome	CHUK DHX9 IKBKB IKBKG MYD88 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA RIPK1 RIPK3 TICAM1 TLR3 ZBP1 (see all 17) (see less)
5	STING mediated induction of host immune responses	Reactome	CGAS DDX41 DTX4 IFI16 IRF3 MRE11 NLRC3 NLRP4 PRKDC STAT6 STING1 TBK1 TREX1 TRIM21 XRCC5 XRCC6 (see all 16) (see less)
6	Regulation of innate immune responses to cytosolic DNA	Reactome	DDX41 DTX4 IRF3 NLRP4 RPS27A STING1 TBK1 TREX1 TRIM21 TRIM32 TRIM56 UBA52 UBB UBC ZBP1 (see all 15) (see less)
7	IRF3-mediated induction of type I IFN	Reactome	DDX41 DTX4 IFI16 IRF3 MRE11 NLRC3 NLRP4 PRKDC STING1 TBK1 TREX1 XRCC5 XRCC6 (see all 13) (see less)
8	IkBA variant leads to EDA-ID	Reactome	CHUK IKBKB IKBKG NFKB1 NFKB2 NFKBIA RELA (see all 7) (see less)
9	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	Reactome	DHX36 DHX9 IRF7 MYD88 NFKB1 NFKB2 RELA (see all 7) (see less)
10	IRF3 mediated activation of type 1 IFN	Reactome	DTX4 IRF3 NLRP4 TBK1 ZBP1
11	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	Reactome	CREBBP CTNNB1 EP300 IRF3 LRRFIP1
12	CLEC7A/inflammasome pathway	Reactome	CASP8 IL1B NFKB1 PYCARD RELA
13	STAT6-mediated induction of chemokines	Reactome	STAT6 STING1 TBK1
14	Selenium micronutrient network	WikiPathways	NFKB1 NFKB2 RELA
15	Regulation by TREX1	Reactome	TREX1

Gene overlap in member pathways for Cytosolic sensors of pathogen-associated DNA SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TBK1	TANK Binding Kinase 1	Protein Coding	8
2	IRF3	Interferon Regulatory Factor 3	Protein Coding	8
3	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	8
4	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	8
5	TREX1	Three Prime Repair Exonuclease 1	Protein Coding	6
6	NLRP4	NLR Family Pyrin Domain Containing 4	Protein Coding	6
7	DTX4	Deltex E3 Ubiquitin Ligase 4	Protein Coding	6
8	STING1	Stimulator Of Interferon Response CGAMP Interactor 1	Protein Coding	6
9	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	6
10	ZBP1	Z-DNA Binding Protein 1	Protein Coding	6
11	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	5
12	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	5
13	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	5
14	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	5
15	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	4
16	DHX9	DExH-Box Helicase 9	Protein Coding	4
17	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	4
18	NFKBIB	NFKB Inhibitor Beta	Protein Coding	4
19	DDX41	DEAD-Box Helicase 41	Protein Coding	4
20	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	4
21	CGAS	Cyclic GMP-AMP Synthase	Protein Coding	3
22	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	3
23	NLRC3	NLR Family CARD Domain Containing 3	Protein Coding	3
24	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	3
25	NKIRAS2	NFKB Inhibitor Interacting Ras Like 2	Protein Coding	3
26	NKIRAS1	NFKB Inhibitor Interacting Ras Like 1	Protein Coding	3
27	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	3
28	IRF7	Interferon Regulatory Factor 7	Protein Coding	3
29	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	3
30	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	3
31	TRIM21	Tripartite Motif Containing 21	Protein Coding	3
32	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	3
33	TLR3	Toll Like Receptor 3	Protein Coding	3
34	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	3
35	POLR3F	RNA Polymerase III Subunit F	Protein Coding	2
36	POLR3G	RNA Polymerase III Subunit G	Protein Coding	2
37	POLR3C	RNA Polymerase III Subunit C	Protein Coding	2
38	POLR3A	RNA Polymerase III Subunit A	Protein Coding	2
39	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
40	CTNNB1	Catenin Beta 1	Protein Coding	2
41	DHX36	DEAH-Box Helicase 36	Protein Coding	2
42	POLR3H	RNA Polymerase III Subunit H	Protein Coding	2
43	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
44	TRIM32	Tripartite Motif Containing 32	Protein Coding	2
45	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	2
46	POLR3K	RNA Polymerase III Subunit K	Protein Coding	2
47	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	2
48	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	2
49	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	2
50	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	2
51	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	2
52	POLR3B	RNA Polymerase III Subunit B	Protein Coding	2
53	POLR3E	RNA Polymerase III Subunit E	Protein Coding	2
54	RPS27A	Ribosomal Protein S27a	Protein Coding	2
55	POLR3D	RNA Polymerase III Subunit D	Protein Coding	2
56	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
57	UBB	Ubiquitin B	Protein Coding	2
58	UBC	Ubiquitin C	Protein Coding	2
59	TRIM56	Tripartite Motif Containing 56	Protein Coding	2
60	POLR3GL	RNA Polymerase III Subunit GL	Protein Coding	2
61	LRRFIP1	LRR Binding FLII Interacting Protein 1	Protein Coding	2
62	AIM2	Absent In Melanoma 2	Protein Coding	2
63	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	2
64	CASP8	Caspase 8	Protein Coding	2
65	IL1B	Interleukin 1 Beta	Protein Coding	2
66	PYCARD	PYD And CARD Domain Containing	Protein Coding	2
67	CRCP	CGRP Receptor Component	Protein Coding	1
68	ISG15	ISG15 Ubiquitin Like Modifier	Protein Coding	1
69	ATG5	Autophagy Related 5	Protein Coding	1
70	IL33	Interleukin 33	Protein Coding	1
71	FADD	Fas Associated Via Death Domain	Protein Coding	1
72	CASP10	Caspase 10	Protein Coding	1
73	CASP1	Caspase 1	Protein Coding	1
74	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
75	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	1
76	RNF125	Ring Finger Protein 125	Protein Coding	1
77	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
78	IL18	Interleukin 18	Protein Coding	1
79	IL6	Interleukin 6	Protein Coding	1
80	IFNB1	Interferon Beta 1	Protein Coding	1
81	IFNA10	Interferon Alpha 10	Protein Coding	1
82	IFNA5	Interferon Alpha 5	Protein Coding	1
83	IFNA2	Interferon Alpha 2	Protein Coding	1
84	IFNA1	Interferon Alpha 1	Protein Coding	1
85	RIGI	RNA Sensor RIG-I	Protein Coding	1
86	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
87	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
88	CCL4L2	C-C Motif Chemokine Ligand 4 Like 2	Protein Coding	1
89	ATG12	Autophagy Related 12	Protein Coding	1
90	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
91	NLRX1	NLR Family Member X1	Protein Coding	1
92	TRIM25	Tripartite Motif Containing 25	Protein Coding	1
93	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
94	IFNA21	Interferon Alpha 21	Protein Coding	1
95	IFNA17	Interferon Alpha 17	Protein Coding	1
96	IFNA16	Interferon Alpha 16	Protein Coding	1
97	IFNA14	Interferon Alpha 14	Protein Coding	1
98	IFNA13	Interferon Alpha 13	Protein Coding	1
99	IFNA8	Interferon Alpha 8	Protein Coding	1
100	IFNA7	Interferon Alpha 7	Protein Coding	1
101	IFNA6	Interferon Alpha 6	Protein Coding	1
102	IFNA4	Interferon Alpha 4	Protein Coding	1
103	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1

Disorders associated with Cytosolic sensors of pathogen-associated DNA SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immune deficiency disease	Direct
2	Herpes simplex virus encephalitis	Enrichment	TBK1, TICAM1, TLR3	7.50
3	Multisystem inflammatory syndrome in children	Enrichment	IFNA21, IFNA4, IFNA6, IFNB1, IRF3	7.02
4	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	6.16
5	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C, POLR3A, POLR3B	6.00
6	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.83
7	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	5.79
8	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	5.79
9	Familial chilblain lupus	Enrichment	STING1, TREX1	5.59
10	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	4.94
11	Polr3-related leukodystrophy	Enrichment	POLR3A, POLR3B	4.18
12	Hypomyelinating leukodystrophy 7	Enrichment	POLR3A, POLR3B	3.88
13	Sting-associated vasculopathy, infantile-onset	Enrichment	STING1	3.66
14	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	3.66
15	Sting-associated vasculopathy with onset in infancy	Enrichment	STING1	3.66
16	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	3.66
17	Corticobasal syndrome	Enrichment	TBK1	3.66
18	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	3.66
19	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	3.66
20	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	TREX1	3.66
21	Chilblain lupus 1	Enrichment	TREX1	3.66
22	Chilblain lupus	Enrichment	TREX1	3.66
23	Aicardi-goutieres syndrome 1	Enrichment	TREX1	3.53
24	Thrombotic microangiopathy	Enrichment	TREX1	3.53
25	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	3.43
26	Menke-hennekam syndrome 1	Enrichment	CREBBP	3.43
27	Adenoid ameloblastoma	Enrichment	CTNNB1	3.43
28	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	3.43
29	Menke-hennekam syndrome	Enrichment	CREBBP	3.43
30	Microcystic stromal tumor	Enrichment	CTNNB1	3.43
31	Caspase 8 deficiency	Enrichment	CASP8	3.43
32	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	TREX1	3.43
33	Vascular dementia	Enrichment	TREX1	3.43
34	Colorectal cancer	Enrichment	CTNNB1, EP300	3.40
35	Hemangiopericytoma, malignant	Enrichment	STAT6	3.35
36	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	3.35
37	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	3.35
38	Immunodeficiency, common variable, 10	Enrichment	NFKB2	3.35
39	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	3.35
40	Rela fusion-positive ependymoma	Enrichment	RELA	3.35
41	Common variable immunodeficiency 12	Enrichment	NFKB1	3.35
42	Treacher collins syndrome 1	Enrichment	POLR1C, POLR1D	3.34
43	Immunodeficiency 68	Enrichment	MYD88	3.29
44	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	3.29
45	Immunodeficiency 39 viral infections	Enrichment	IRF7	3.29
46	Immunodeficiency 39	Enrichment	IRF7	3.29
47	Intellectual developmental disorder, autosomal dominant 75	Enrichment	DHX9	3.29
48	Waldenstram macroglobulinemia	Enrichment	MYD88	3.29
49	Congenital nervous system abnormality	Enrichment	CREBBP, CTNNB1	3.22
50	Nervous system disease	Enrichment	CREBBP, CTNNB1	3.22
51	Aicardi-goutiares syndrome	Enrichment	TREX1	3.18
52	Thumb deformity	Enrichment	CREBBP	3.13
53	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	3.13
54	Menke-hennekam syndrome 2	Enrichment	EP300	3.13
55	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	3.13
56	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	3.13
57	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	3.13
58	Teratoma	Enrichment	CTNNB1	3.13
59	Aicardi-goutieres syndrome	Enrichment	TREX1	3.13
60	Microcephaly	Enrichment	CTNNB1, EP300	3.10
61	Immunodeficiency, common variable, 1	Enrichment	NFKB2	3.05
62	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	3.02
63	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	3.02
64	Myeloproliferative/lymphoproliferative neoplasms, familial	Enrichment	DDX41	3.02
65	Ddx41-related hematologic malignancy predisposition syndrome	Enrichment	DDX41	3.02
66	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	MYD88	2.99
67	Desmoid disease, hereditary	Enrichment	CTNNB1	2.96
68	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.96
69	Anus, imperforate	Enrichment	CTNNB1	2.96
70	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.96
71	Tethered spinal cord syndrome	Enrichment	CREBBP	2.96
72	Desmoid tumor	Enrichment	CTNNB1	2.96
73	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.96
74	Incontinentia pigmenti	Enrichment	IKBKG	2.90
75	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.90
76	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.90
77	Fetal encasement syndrome	Enrichment	CHUK	2.90
78	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.90
79	Immunodeficiency 15b	Enrichment	IKBKB	2.90
80	Immunodeficiency 15a	Enrichment	IKBKB	2.90
81	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.90
82	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.90
83	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.90
84	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.90
85	Pilomatrixoma	Enrichment	CTNNB1	2.83
86	Alazami syndrome	Enrichment	CTNNB1	2.83
87	Craniopharyngioma	Enrichment	CTNNB1	2.83
88	Motor neuron disease	Enrichment	TBK1	2.81
89	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.73
90	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.73
91	Progressive non-fluent aphasia	Enrichment	TBK1	2.70
92	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.66
93	Adrenocortical carcinoma	Enrichment	CTNNB1	2.66
94	Hypertrichosis	Enrichment	CREBBP	2.66
95	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	2.66
96	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.66
97	Muscular dystrophy, limb-girdle, autosomal recessive 8	Enrichment	TRIM32	2.66
98	Bardet-biedl syndrome 11	Enrichment	TRIM32	2.66
99	Autosomal recessive limb-girdle muscular dystrophy type 2h	Enrichment	TRIM32	2.66
100	Submucosal cleft palate	Enrichment	UBB	2.66
101	Cleft hard palate	Enrichment	UBB	2.66
102	Immunodeficiency 33	Enrichment	IKBKG	2.60
103	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.60
104	Diamond-blackfan anemia 12	Enrichment	NKIRAS1	2.60
105	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.60
106	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.60
107	Gallbladder cancer	Enrichment	CTNNB1	2.59
108	Systemic lupus erythematosus	Enrichment	TREX1	2.54
109	Exudative vitreoretinopathy	Enrichment	CTNNB1	2.53
110	Charge syndrome	Enrichment	EP300	2.48
111	Adult hepatocellular carcinoma	Enrichment	CTNNB1	2.48
112	Uvula, bifid	Enrichment	UBB	2.48
113	Cleft soft palate	Enrichment	UBB	2.48
114	Diffuse large b-cell lymphoma	Enrichment	CREBBP, MYD88	2.45
115	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.43
116	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.42
117	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11	2.42
118	Leukodystrophy	Enrichment	POLR3A, POLR3B	2.40
119	Immunodeficiency 101	Enrichment	POLR3F	2.33
120	Leukodystrophy, hypomyelinating, 21	Enrichment	POLR3K	2.33
121	Treacher collins syndrome 2	Enrichment	POLR1D	2.33
122	Odontoleukodystrophy	Enrichment	POLR3A	2.33
123	Inherited acute myeloid leukemia	Enrichment	DDX41	2.32
124	Medulloblastoma	Enrichment	CTNNB1	2.29
125	Heart disease	Enrichment	CREBBP	2.29
126	Tenorio syndrome	Enrichment	RNF125	2.27
127	Immunodeficiency 38 with basal ganglia calcification	Enrichment	ISG15	2.27
128	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.27
129	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.27
130	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.27
131	Singleton-merten syndrome 2	Enrichment	RIGI	2.27
132	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	2.27
133	Polydactyly, postaxial, type a1	Enrichment	EP300	2.26
134	Corpus callosum, agenesis of	Enrichment	CREBBP	2.26
135	Isolated corpus callosum agenesis	Enrichment	CREBBP	2.26
136	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	2.26
137	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.20
138	Polycystic liver disease	Enrichment	CTNNB1	2.20
139	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	2.20
140	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.13
141	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.13
142	Hepatoblastoma	Enrichment	CTNNB1	2.11
143	Hepatocellular carcinoma	Enrichment	CTNNB1	2.09
144	Colonic benign neoplasm	Enrichment	MRE11	2.07
145	Scoliosis	Enrichment	CREBBP	2.05
146	Treacher collins syndrome 3	Enrichment	POLR1C	2.03
147	Leukodystrophy, hypomyelinating, 4	Enrichment	POLR3A	2.03
148	Waardenburg syndrome, type 4c	Enrichment	POLR2F	2.03
149	Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR3B	2.03
150	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	2.03
151	Charcot-marie-tooth disease, demyelinating, type 1i	Enrichment	POLR3B	2.03
152	Short stature, oligodontia, dysmorphic facies, and motor delay	Enrichment	POLR3GL	2.03
153	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	2.03
154	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	2.03
155	Hyperostosis	Enrichment	POLR3GL	2.03
156	Limb-girdle muscular dystrophy	Enrichment	TRIM32	2.00
157	Myelodysplastic syndrome	Enrichment	DDX41	1.98
158	Bladder cancer	Enrichment	CTNNB1	1.97
159	Cylindromatosis, familial	Enrichment	CYLD	1.97
160	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	1.97
161	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	1.97
162	Aicardi-goutieres syndrome 6	Enrichment	ADAR	1.97
163	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	1.97
164	Brooke-spiegler syndrome	Enrichment	CYLD	1.97
165	Singleton-merten syndrome	Enrichment	RIGI	1.97
166	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	1.97
167	Oculootodental syndrome	Enrichment	FADD	1.97
168	Coronary heart disease 5	Enrichment	IKBKG	1.95
169	Lung cancer	Enrichment	CASP8	1.93
170	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	1.89
171	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.85
172	Wiedemann-rautenstrauch syndrome	Enrichment	POLR3A	1.85
173	Infantile cerebellar-retinal degeneration	Enrichment	POLR3H	1.85
174	Optic atrophy 9	Enrichment	POLR3H	1.85
175	Viss syndrome	Enrichment	POLR3B	1.85
176	Neonatal pseudo-hydrocephalic progeroid syndrome	Enrichment	POLR3A	1.85
177	Gastric cancer	Enrichment	IL1B	1.80
178	Creatine phosphokinase, elevated serum	Enrichment	TRIM32	1.76
179	Isolated elevated serum creatine phosphokinase levels	Enrichment	TRIM32	1.76
180	Gliosarcoma	Enrichment	NFKBIA	1.70
181	Myeloma, multiple	Enrichment	CREBBP	1.69
182	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	TRIM32	1.68
183	Charcot-marie-tooth disease	Enrichment	DHX9	1.68
184	Giant cell glioblastoma	Enrichment	NFKBIA	1.68
185	Kaposi sarcoma	Enrichment	IL6	1.67
186	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	1.67
187	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.67
188	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	1.67
189	Hereditary retinal dystrophy	Enrichment	TREX1	1.67
190	Fundus dystrophy	Enrichment	TREX1	1.67
191	Human immunodeficiency virus type 1	Enrichment	TLR3	1.65
192	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.63
193	Autism	Enrichment	CREBBP	1.58
194	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.57
195	Breast cancer	Enrichment	CASP8	1.56
196	Hereditary breast ovarian cancer syndrome	Enrichment	MRE11, RIPK1	1.56
197	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.55
198	Waardenburg syndrome	Enrichment	POLR2F	1.55
199	Malaria	Enrichment	IKBKG	1.55
200	Type 1 diabetes mellitus	Enrichment	IL6	1.50
201	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.49
202	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.49
203	Ovarian cancer	Enrichment	CTNNB1	1.44
204	Leukemia, acute myeloid	Enrichment	DDX41	1.42
205	Severe combined immunodeficiency	Enrichment	IKBKB	1.39
206	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	1.37
207	Myopathy	Enrichment	TRIM32	1.36
208	Bardet-biedl syndrome	Enrichment	TRIM32	1.34
209	Inflammatory bowel disease 1	Enrichment	IL6	1.32
210	Movement disease	Enrichment	POLR3A	1.29
211	46 xx gonadal dysgenesis	Enrichment	POLR3H	1.26
212	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	POLR3B	1.19
213	Arteriovenous malformations of the brain	Enrichment	IL6	1.01
214	Tooth agenesis	Enrichment	POLR3GL	1.00
215	Kallmann syndrome	Enrichment	POLR2F	0.99
216	Inherited cancer-predisposing syndrome	Enrichment	MRE11	0.92
217	Hirschsprung disease 1	Enrichment	POLR2F	0.89
218	Severe covid-19	Enrichment	CASP10	0.84
219	Optic atrophy plus syndrome	Enrichment	POLR3H	0.73
220	Type 2 diabetes mellitus	Enrichment	IL6	0.69
221	Spastic ataxia	Enrichment	POLR3A	0.65
222	Rare genetic deafness	Enrichment	POLR2F	0.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cytosolic sensors of pathogen-associated DNA

Pathway Network for Cytosolic sensors of pathogen-associated DNA

Pathway network for the Cytosolic sensors of pathogen-associated DNA SuperPath

Member Pathways for Cytosolic sensors of pathogen-associated DNA

Pathways in the Cytosolic sensors of pathogen-associated DNA SuperPath

Gene overlap in member pathways for Cytosolic sensors of pathogen-associated DNA SuperPath

Associated Genes for Cytosolic sensors of pathogen-associated DNA

Associated Disorders for Cytosolic sensors of pathogen-associated DNA

Disorders associated with Cytosolic sensors of pathogen-associated DNA SuperPath

STRING Interaction Network for Cytosolic sensors of pathogen-associated DNA

Sources for Cytosolic sensors of pathogen-associated DNA