D-galactose degradation V (Leloir pathway)

Pathway network for the D-galactose degradation V (Leloir pathway) SuperPath

Sources:

PubChem
WikiPathways
Reactome

Pathways in the D-galactose degradation V (Leloir pathway) SuperPath

#	Name	Source	Genes
1	D-galactose degradation V (Leloir pathway)	PubChem	GALE GALK1 GALM GALT PGM1 PGM2 (see all 6) (see less)
2	Disorders of galactose metabolism	WikiPathways	AKR1B1 GALE GALK1 GALT GBE1 GYG1 GYG2 GYS1 GYS2 PGM1 PYGL SLC2A2 SLC5A1 (see all 13) (see less)
3	Galactose catabolism	Reactome	AKR1B1 GALE GALK1 GALM GALT PGM1 (see all 6) (see less)
4	Glycogen storage disease type IV (GBE1)	Reactome	GBE1 GYG2 GYS2
5	Glycogen storage disease type 0 (liver GYS2)	Reactome	GYG2 GYS2
6	Defective GALM causes GALAC4	Reactome	GALM
7	Defective GALK1 causes GALCT2	Reactome	GALK1
8	Defective GALT can cause GALCT	Reactome	GALT

Gene overlap in member pathways for D-galactose degradation V (Leloir pathway) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GALT	Galactose-1-Phosphate Uridylyltransferase	Protein Coding	4
2	GALK1	Galactokinase 1	Protein Coding	4
3	GALM	Galactose Mutarotase	Protein Coding	3
4	GALE	UDP-Galactose-4-Epimerase	Protein Coding	3
5	PGM1	Phosphoglucomutase 1	Protein Coding	3
6	GYG2	Glycogenin 2	Protein Coding	3
7	GYS2	Glycogen Synthase 2	Protein Coding	3
8	GBE1	1,4-Alpha-Glucan Branching Enzyme 1	Protein Coding	2
9	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	2
10	PGM2	Phosphoglucomutase 2	Protein Coding	1
11	SLC5A1	Solute Carrier Family 5 Member 1	Protein Coding	1
12	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	1
13	PYGL	Glycogen Phosphorylase L	Protein Coding	1
14	GYS1	Glycogen Synthase 1	Protein Coding	1
15	GYG1	Glycogenin 1	Protein Coding	1

Disorders associated with D-galactose degradation V (Leloir pathway) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Glycogen storage disease iv	Direct
2	Glycogen storage disease	Direct
3	Galactosemia iv	Direct
4	Galactosemia ii	Direct
5	Galactosemia	Direct
6	Galactosemia iii	Enrichment	GALE	3.35
7	Thrombocytopenia 13, syndromic	Enrichment	GALE	3.35
8	Galactosemia i	Enrichment	GALT	3.05
9	Congenital disorder of glycosylation, type it	Enrichment	PGM1	3.05
10	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	GALK1	3.05
11	Glycogen storage disease vi	Enrichment	PYGL	3.02
12	Polyglucosan body neuropathy, adult form	Enrichment	GBE1	3.02
13	Glucose/galactose malabsorption	Enrichment	SLC5A1	3.02
14	Adult polyglucosan body disease	Enrichment	GBE1	3.02
15	Fanconi-bickel syndrome	Enrichment	SLC2A2	2.72
16	Glycogen storage disease 0, liver	Enrichment	GYS2	2.72
17	Osteogenesis imperfecta, type xv	Enrichment	GBE1	2.72
18	Glycogen storage disease xv	Enrichment	GYG1	2.72
19	Polyglucosan body myopathy 2	Enrichment	GYG1	2.72
20	Glycogen storage disease 0, muscle	Enrichment	GYS1	2.72
21	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	2.72
22	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	2.72
23	Epidermolysis bullosa simplex 1c, localized	Enrichment	GALK1	2.66
24	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	GALK1	2.58
25	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	GALK1	2.58
26	Junctional epidermolysis bullosa non-herlitz type	Enrichment	GALK1	2.58
27	Cutis laxa, autosomal recessive, type ib	Enrichment	GBE1	2.54
28	Epidermolysis bullosa simplex	Enrichment	GALK1	2.51
29	Renal glucosuria	Enrichment	SLC5A1	2.42
30	Junctional epidermolysis bullosa	Enrichment	GALK1	2.40
31	Congenital disorder of glycosylation, type in	Enrichment	PGM1	2.13
32	Congenital long qt syndrome	Enrichment	SLC2A2	1.94
33	Primary ovarian insufficiency	Enrichment	GALT	1.59
34	Long qt syndrome 1	Enrichment	SLC2A2	1.55
35	Fetal akinesia deformation sequence 1	Enrichment	GBE1	1.46
36	Type 2 diabetes mellitus	Enrichment	SLC2A2	1.40
37	Distal arthrogryposis	Enrichment	GBE1	1.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

D-galactose degradation V (Leloir pathway)

Pathway Network for D-galactose degradation V (Leloir pathway)

Pathway network for the D-galactose degradation V (Leloir pathway) SuperPath

Member Pathways for D-galactose degradation V (Leloir pathway)

Pathways in the D-galactose degradation V (Leloir pathway) SuperPath

Gene overlap in member pathways for D-galactose degradation V (Leloir pathway) SuperPath

Associated Genes for D-galactose degradation V (Leloir pathway)

Associated Disorders for D-galactose degradation V (Leloir pathway)

Disorders associated with D-galactose degradation V (Leloir pathway) SuperPath

STRING Interaction Network for D-galactose degradation V (Leloir pathway)

Sources for D-galactose degradation V (Leloir pathway)