D-myo-inositol (1,4,5)-trisphosphate biosynthesis

No Pathway Network information available for D-myo-inositol (1,4,5)-trisphosphate biosynthesis

#	Name	Source	Genes
1	D-myo-inositol (1,4,5)-trisphosphate biosynthesis	PubChem	CDIPT PI4K2A PI4K2B PI4KA PI4KB PIP4K2A PIP5K1A PIP5K1B PIP5K1C PLCB2 PLCD1 PLCE1 PLCG2 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PI4K2B	Phosphatidylinositol 4-Kinase Type 2 Beta	Protein Coding	1
2	PI4K2A	Phosphatidylinositol 4-Kinase Type 2 Alpha	Protein Coding	1
3	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
4	PI4KA	Phosphatidylinositol 4-Kinase Alpha	Protein Coding	1
5	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	1
6	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	1
7	PI4KB	Phosphatidylinositol 4-Kinase Beta	Protein Coding	1
8	CDIPT	CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase	Protein Coding	1
9	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
10	PLCD1	Phospholipase C Delta 1	Protein Coding	1
11	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
12	PLCB2	Phospholipase C Beta 2	Protein Coding	1
13	PLCG2	Phospholipase C Gamma 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	3.02
2	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	3.02
3	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	3.02
4	Spastic paraplegia 84, autosomal recessive	Enrichment	PI4KA	3.02
5	Deafness, autosomal dominant 87	Enrichment	PI4KB	3.02
6	Gastrointestinal defects and immunodeficiency syndrome 2	Enrichment	PI4KA	3.02
7	Pi4ka-related disorder	Enrichment	PI4KA	3.02
8	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.72
9	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PI4KA	2.72
10	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.72
11	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	2.72
12	Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities	Enrichment	PI4K2A	2.72
13	Combined immunodeficiency-multiple intestinal atresia	Enrichment	PI4KA	2.72
14	Heparin cofactor ii deficiency	Enrichment	PI4KA	2.54
15	Nephrotic syndrome, type 3	Enrichment	PLCE1	2.54
16	Nephrotic syndrome, type 1	Enrichment	PLCE1	2.07
17	Bilateral perisylvian polymicrogyria	Enrichment	PI4KA	2.07
18	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.72
19	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	1.49
20	Nephrotic syndrome	Enrichment	PLCE1	1.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for D-myo-inositol (1,4,5)-trisphosphate biosynthesis