Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 BRAF CYP2C8 CYP3A4
2	Alectinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 ALK CYP3A4

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	2
2	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	2
3	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2
4	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
5	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
6	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	1

Disorders associated with Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neuroblastoma 3	Enrichment	ALK	3.53
2	Colchicine resistance	Enrichment	ABCB1	3.53
3	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.53
4	Encephalopathy, acute transient	Enrichment	ABCB1	3.53
5	Inflammatory bowel disease 13	Enrichment	ABCB1	3.53
6	Blood group, junior system	Enrichment	ABCG2	3.53
7	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.53
8	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	3.53
9	Alk-positive large b-cell lymphoma	Enrichment	ALK	3.53
10	Noonan syndrome 7	Enrichment	BRAF	3.43
11	Leopard syndrome 3	Enrichment	BRAF	3.43
12	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.43
13	Lymphangioma	Enrichment	BRAF	3.43
14	Phace association	Enrichment	BRAF	3.43
15	Syringocystadenoma papilliferum	Enrichment	BRAF	3.43
16	Ganglioglioma	Enrichment	BRAF	3.43
17	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.43
18	Phace syndrome	Enrichment	BRAF	3.43
19	Classic hairy cell leukemia	Enrichment	BRAF	3.43
20	Pulmonic stenosis	Enrichment	BRAF	3.13
21	Ataxia-telangiectasia	Enrichment	BRAF	2.96
22	Langerhans cell histiocytosis	Enrichment	BRAF	2.96
23	Tethered spinal cord syndrome	Enrichment	BRAF	2.96
24	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	2.83
25	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.83
26	Cardiofaciocutaneous syndrome	Enrichment	BRAF	2.83
27	Craniopharyngioma	Enrichment	BRAF	2.83
28	Noonan syndrome with multiple lentigines	Enrichment	BRAF	2.83
29	Newborn respiratory distress syndrome	Enrichment	BRAF	2.83
30	Inflammatory myofibroblastic tumor	Enrichment	ALK	2.75
31	Lung squamous cell carcinoma	Enrichment	ALK	2.75
32	Wilms tumor 5	Enrichment	BRAF	2.66
33	Melanocytic nevus syndrome, congenital	Enrichment	ALK	2.63
34	Neuroblastoma	Enrichment	ALK	2.63
35	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	2.59
36	Gallbladder cancer	Enrichment	BRAF	2.59
37	Pilomyxoid astrocytoma	Enrichment	BRAF	2.59
38	Follicular thyroid carcinoma	Enrichment	BRAF	2.59
39	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	2.53
40	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.49
41	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.48
42	Primary hyperaldosteronism	Enrichment	BRAF	2.48
43	Ventricular septal defect	Enrichment	BRAF	2.48
44	Melanoma	Enrichment	BRAF	2.43
45	Lung non-small cell carcinoma	Enrichment	BRAF	2.39
46	Lip and oral cavity carcinoma	Enrichment	BRAF	2.35
47	Rhabdomyosarcoma	Enrichment	ALK	2.33
48	Lung cancer susceptibility 3	Enrichment	BRAF	2.29
49	Wilms tumor 1	Enrichment	BRAF	2.26
50	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF	2.26
51	Melanoma, cutaneous malignant 1	Enrichment	BRAF	2.20
52	Dandy-walker syndrome	Enrichment	BRAF	2.20
53	Arteriovenous malformations of the brain	Enrichment	BRAF	2.16
54	Diffuse large b-cell lymphoma	Enrichment	BRAF	2.16
55	Noonan syndrome 1	Enrichment	BRAF	2.07
56	Differentiated thyroid carcinoma	Enrichment	ALK	2.07
57	Lung cancer	Enrichment	ALK	2.03
58	Rasopathy	Enrichment	BRAF	2.02
59	Myeloma, multiple	Enrichment	BRAF	1.69
60	Dilated cardiomyopathy	Enrichment	BRAF	1.54
61	Ovarian cancer	Enrichment	ALK	1.53
62	Colorectal cancer	Enrichment	BRAF	1.50
63	Inherited cancer-predisposing syndrome	Enrichment	ALK	1.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Member Pathways for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics

Sources for Dabrafenib Pathway, Pharmacokinetics/Pharmacodynamics