DAP12 interactions

No Pathway Network information available for DAP12 interactions

Pathways in the DAP12 interactions SuperPath

#	Name	Source	Genes
1	DAP12 interactions	Reactome	B2M BTK CD300E CD300LB CLEC5A FYN GRAP2 GRB2 HLA-B HLA-C HLA-E HRAS KIR2DS1 KIR2DS2 KIR2DS4 KIR2DS5 KIR3DS1 KLRC2 KLRD1 KLRK1 KRAS LAT LCK LCP2 NCR2 NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLCG2 RAC1 SHC1 SIGLEC14 SIGLEC15 SIRPB1 SOS1 SYK TREM1 TREM2 TYROBP VAV2 VAV3 (see all 44) (see less)
2	DAP12 signaling	Reactome	B2M BTK FYN GRAP2 GRB2 HLA-E HRAS KLRC2 KLRD1 KLRK1 KRAS LAT LCK LCP2 NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLCG2 RAC1 SHC1 SOS1 SYK TREM2 TYROBP VAV2 VAV3 (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
2	KLRK1	Killer Cell Lectin Like Receptor K1	Protein Coding	2
3	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
4	LAT	Linker For Activation Of T Cells	Protein Coding	2
5	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
6	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	2
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
8	KLRC2	Killer Cell Lectin Like Receptor C2	Protein Coding	2
9	KLRD1	Killer Cell Lectin Like Receptor D1	Protein Coding	2
10	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
11	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
12	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	2
13	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
14	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
15	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
16	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
17	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
18	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
19	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
20	TREM2	Triggering Receptor Expressed On Myeloid Cells 2	Protein Coding	2
21	B2M	Beta-2-Microglobulin	Protein Coding	2
22	RAC1	Rac Family Small GTPase 1	Protein Coding	2
23	SHC1	SHC Adaptor Protein 1	Protein Coding	2
24	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
25	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	2
26	BTK	Bruton Tyrosine Kinase	Protein Coding	2
27	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	2
28	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
29	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	2
30	SIGLEC14	Sialic Acid Binding Ig Like Lectin 14	Protein Coding	1
31	KIR2DS2	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2	Protein Coding	1
32	SIRPB1	Signal Regulatory Protein Beta 1	Protein Coding	1
33	CD300LB	CD300 Molecule Like Family Member B	Protein Coding	1
34	CLEC5A	C-Type Lectin Domain Containing 5A	Protein Coding	1
35	SIGLEC15	Sialic Acid Binding Ig Like Lectin 15	Protein Coding	1
36	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
37	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	1
38	CD300E	CD300e Molecule	Protein Coding	1
39	KIR2DS1	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 1	Protein Coding	1
40	KIR2DS4	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4 (Gene/Pseudogene)	Protein Coding	1
41	KIR2DS5	Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 5	Protein Coding	1
42	KIR3DS1	Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Short Cytoplasmic Tail 1	Protein Coding	1
43	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	1
44	NCR2	Natural Cytotoxicity Triggering Receptor 2	Protein Coding	1

Disorders associated with DAP12 interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.22
2	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.26
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	7.65
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.45
5	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	6.84
6	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	6.61
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	6.51
8	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TREM2, TYROBP	5.36
9	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.36
10	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.88
11	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.88
12	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.58
13	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.58
14	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	4.51
15	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.51
16	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.18
17	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.18
18	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.04
19	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.04
20	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.04
21	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.04
22	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.04
23	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.91
24	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.80
25	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.71
26	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.54
27	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.54
28	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.34
29	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	3.27
30	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1	3.08
31	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.70
32	Lung cancer	Enrichment	KRAS, PIK3CA	2.68
33	Macrodactyly	Enrichment	PIK3CA	2.67
34	Oculoectodermal syndrome	Enrichment	KRAS	2.67
35	Noonan syndrome 4	Enrichment	SOS1	2.67
36	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.67
37	Cowden syndrome 5	Enrichment	PIK3CA	2.67
38	Melanosis, neurocutaneous	Enrichment	NRAS	2.67
39	Noonan syndrome 6	Enrichment	NRAS	2.67
40	Immunodeficiency 43	Enrichment	B2M	2.67
41	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.67
42	Immunodeficiency 81	Enrichment	LCP2	2.67
43	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.67
44	Short syndrome	Enrichment	PIK3R1	2.67
45	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.67
46	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.67
47	Dialysis-related amyloidosis	Enrichment	B2M	2.67
48	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.67
49	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.67
50	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.67
51	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.67
52	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.67
53	Alzheimer disease 17	Enrichment	TREM2	2.67
54	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.67
55	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.67
56	Immunodeficiency 22	Enrichment	LCK	2.67
57	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2	Enrichment	TREM2	2.67
58	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.67
59	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.67
60	Hypospadias	Enrichment	PIK3CA	2.67
61	Colitis	Enrichment	SYK	2.67
62	Congenital pulmonary airway malformation	Enrichment	KRAS	2.67
63	Rare venous malformation	Enrichment	PIK3CA	2.67
64	Diaphragmatic eventration	Enrichment	PIK3CA	2.67
65	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.67
66	Rare combined vascular malformation	Enrichment	PIK3CA	2.67
67	Cavernous lymphangioma	Enrichment	PIK3CA	2.67
68	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.67
69	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.67
70	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.67
71	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.67
72	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.67
73	Macrodactyly of toe	Enrichment	PIK3CA	2.67
74	Neurocutaneous melanocytosis	Enrichment	NRAS	2.67
75	Spondyloarthropathy 1	Enrichment	HLA-B	2.49
76	Psoriasis 1	Enrichment	HLA-C	2.49
77	Ankylosing spondylitis 1	Enrichment	HLA-B	2.49
78	Reactive arthritis	Enrichment	HLA-B	2.49
79	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.49
80	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.49
81	Gastric cancer	Enrichment	KRAS, PIK3CA	2.42
82	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.40
83	Fibromatosis, gingival, 1	Enrichment	SOS1	2.37
84	Costello syndrome	Enrichment	HRAS	2.37
85	Pulmonic stenosis	Enrichment	SOS1	2.37
86	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.37
87	Keratosis, seborrheic	Enrichment	PIK3CA	2.37
88	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.37
89	Noonan syndrome 8	Enrichment	PIK3CA	2.37
90	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.37
91	Agammaglobulinemia, x-linked	Enrichment	BTK	2.37
92	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.37
93	Immunodeficiency 52	Enrichment	LAT	2.37
94	Arthritis	Enrichment	SYK	2.37
95	Wooly hair nevus	Enrichment	HRAS	2.37
96	Myeloma, multiple	Enrichment	KRAS, PIK3R2	2.20
97	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.19
98	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.19
99	Nuchal bleb, familial	Enrichment	SOS1	2.19
100	Langerhans cell histiocytosis	Enrichment	NRAS	2.19
101	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.19
102	Agammaglobulinemia 1	Enrichment	BTK	2.19
103	Immunodeficiency 14	Enrichment	PIK3R1	2.19
104	Spermatocytoma	Enrichment	HRAS	2.19
105	Keratoacanthoma	Enrichment	PIK3CA	2.19
106	Severe cutaneous adverse reaction	Enrichment	HLA-B	2.19
107	Stevens-johnson syndrome	Enrichment	HLA-B	2.19
108	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.07
109	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.07
110	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.07
111	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.07
112	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.07
113	Cerebrovascular disease	Enrichment	PIK3CA	2.07
114	Pilocytic astrocytoma	Enrichment	KRAS	2.07
115	Epidermolytic nevus	Enrichment	HRAS	2.07
116	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.07
117	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M	2.07
118	Gingival fibromatosis	Enrichment	SOS1	2.07
119	Takayasu arteritis	Enrichment	HLA-B	2.01
120	Capillary malformations, congenital	Enrichment	PIK3CA	1.97
121	Amyloidosis, hereditary systemic 2	Enrichment	B2M	1.97
122	Hemimegalencephaly	Enrichment	PIK3CA	1.97
123	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.89
124	Cowden syndrome 1	Enrichment	PIK3CA	1.89
125	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.89
126	Temporal arteritis	Enrichment	HLA-B	1.89
127	Semantic dementia	Enrichment	TREM2	1.83
128	Pilomyxoid astrocytoma	Enrichment	KRAS	1.83
129	Overgrowth syndrome	Enrichment	PIK3R1	1.83
130	Early-onset autosomal dominant alzheimer disease	Enrichment	TREM2	1.83
131	Lymphoma, non-hodgkin, familial	Enrichment	B2M	1.77
132	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.72
133	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.72
134	Progressive non-fluent aphasia	Enrichment	TREM2	1.72
135	Cowden syndrome	Enrichment	PIK3CA	1.72
136	Behavioral variant of frontotemporal dementia	Enrichment	TREM2	1.72
137	Ovarian cancer	Enrichment	KRAS, PIK3CA	1.71
138	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.67
139	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	HLA-C	1.65
140	Immune deficiency disease	Enrichment	SYK	1.63
141	Frontotemporal dementia 1	Enrichment	TREM2	1.63
142	Meningioma	Enrichment	PIK3CA	1.60
143	Aortic valve disease 1	Enrichment	SOS1	1.56
144	Protein-deficiency anemia	Enrichment	NRAS	1.56
145	Nk-cell enteropathy	Enrichment	PIK3CB	1.56
146	Lung cancer susceptibility 3	Enrichment	KRAS	1.53
147	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.53
148	Rhabdomyosarcoma	Enrichment	HRAS	1.47
149	Arteriovenous malformations of the brain	Enrichment	KRAS	1.40
150	Diffuse large b-cell lymphoma	Enrichment	BTK	1.40
151	Endometrial cancer	Enrichment	PIK3CA	1.36
152	Hepatocellular carcinoma	Enrichment	PIK3CA	1.34
153	Pancreatic cancer	Enrichment	KRAS	1.28
154	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.27
155	Human immunodeficiency virus type 1	Enrichment	HLA-C	1.25
156	Behcet syndrome	Enrichment	HLA-B	1.22
157	Prostate cancer	Enrichment	PIK3CA	1.22
158	Severe combined immunodeficiency	Enrichment	LCK	1.17
159	Hypertelorism	Enrichment	PIK3CA	0.98
160	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.95
161	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TREM2	0.93

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DAP12 interactions

Pathway Network for DAP12 interactions

Member Pathways for DAP12 interactions

Pathways in the DAP12 interactions SuperPath

Associated Genes for DAP12 interactions

Associated Disorders for DAP12 interactions

Disorders associated with DAP12 interactions SuperPath

STRING Interaction Network for DAP12 interactions

Sources for DAP12 interactions