DDX58/IFIH1-mediated induction of interferon-alpha/beta

Pathway network for the DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

Sources:

Reactome
WikiPathways

Pathways in the DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

#	Name	Source	Genes
1	DDX58/IFIH1-mediated induction of interferon-alpha/beta	Reactome	AGER APP ATG12 ATG5 CASP10 CASP8 CHUK CREBBP CYLD DHX58 EP300 FADD HERC5 HMGB1 HSP90AA1 HSP90AB1 IFIH1 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNB1 IKBKB IKBKE IKBKG IRF3 IRF7 ISG15 ITCH MAP3K1 MAVS NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 OTUD5 PCBP2 PIN1 RELA RIGI RIPK1 RNF125 RNF135 RNF216 RPS27A S100A12 S100B SAA1 SIKE1 TANK TAX1BP1 TBK1 TKFC TNFAIP3 TOMM70 TRAF2 TRAF3 TRAF6 TRIM25 TRIM4 UBA52 UBA7 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 (see all 82) (see less)
2	Novel intracellular components of RIG-I-like receptor pathway	WikiPathways	ATG12 ATG5 AZI2 CASP10 CASP8 CHUK CXCL10 CXCL12 CXCL8 CYLD DDX17 DDX3X DDX3Y DHX58 FADD IFIH1 IFNA1 IFNB1 IFNE IFNG IFNK IKBKB IKBKE IKBKG IRF3 IRF7 ISG15 MAP3K1 MAP3K7 MAPK10 MAPK9 MAVS NFKB1 NFKBIA NFKBIB NLRX1 OTUD5 PIN1 RELA RIGI RIPK1 RNF125 SIKE1 SNW1 STING1 TANK TBK1 TBKBP1 TKFC TRADD TRAF2 TRAF3 TRAF6 TRIM25 (see all 54) (see less)
3	Negative regulators of DDX58/IFIH1 signaling	Reactome	ATG12 ATG5 CYLD HERC5 IFIH1 IKBKE IRF3 ISG15 ITCH MAVS NLRC5 NLRX1 OTUD5 PCBP2 PIN1 RIGI RNF125 RNF135 RNF216 RPS27A TAX1BP1 TBK1 TNFAIP3 TRAF3 TRIM25 TRIM4 UBA52 UBA7 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L6 (see all 35) (see less)
4	TRAF3-dependent IRF activation pathway	Reactome	CREBBP EP300 IFIH1 IFNB1 IKBKE IRF3 IRF7 MAVS RIGI RNF135 SIKE1 TBK1 TRAF3 TRIM25 TRIM4 (see all 15) (see less)
5	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Reactome	CASP10 CASP8 CHUK FADD IFIH1 IKBKB IKBKG MAVS RIGI RIPK1 RNF135 TRIM25 TRIM4 (see all 13) (see less)
6	SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation	WikiPathways	IFNB1 IKBKE IRF3 MAVS RIGI TBK1 TRAF3 TRAF6 (see all 8) (see less)

Gene overlap in member pathways for DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RIGI	RNA Sensor RIG-I	Protein Coding	6
2	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	6
3	TBK1	TANK Binding Kinase 1	Protein Coding	5
4	IRF3	Interferon Regulatory Factor 3	Protein Coding	5
5	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	5
6	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	5
7	TRIM25	Tripartite Motif Containing 25	Protein Coding	5
8	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	5
9	IFNB1	Interferon Beta 1	Protein Coding	4
10	RNF135	Ring Finger Protein 135	Protein Coding	4
11	TRIM4	Tripartite Motif Containing 4	Protein Coding	4
12	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
13	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	3
14	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
15	IRF7	Interferon Regulatory Factor 7	Protein Coding	3
16	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	3
17	RNF125	Ring Finger Protein 125	Protein Coding	3
18	OTUD5	OTU Deubiquitinase 5	Protein Coding	3
19	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
20	NLRX1	NLR Family Member X1	Protein Coding	3
21	SIKE1	Suppressor Of IKBKE 1	Protein Coding	3
22	CASP8	Caspase 8	Protein Coding	3
23	CASP10	Caspase 10	Protein Coding	3
24	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
25	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	3
26	FADD	Fas Associated Via Death Domain	Protein Coding	3
27	ATG12	Autophagy Related 12	Protein Coding	3
28	ATG5	Autophagy Related 5	Protein Coding	3
29	ISG15	ISG15 Ubiquitin Like Modifier	Protein Coding	3
30	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	2
31	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
32	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
33	TKFC	Triokinase And FMN Cyclase	Protein Coding	2
34	UBE2K	Ubiquitin Conjugating Enzyme E2 K	Protein Coding	2
35	IFNA1	Interferon Alpha 1	Protein Coding	2
36	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
37	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
38	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
39	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
40	PCBP2	Poly(RC) Binding Protein 2	Protein Coding	2
41	HERC5	HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 5	Protein Coding	2
42	RNF216	Ring Finger Protein 216	Protein Coding	2
43	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
44	RPS27A	Ribosomal Protein S27a	Protein Coding	2
45	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	2
46	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
47	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
48	UBB	Ubiquitin B	Protein Coding	2
49	UBC	Ubiquitin C	Protein Coding	2
50	UBA7	Ubiquitin Like Modifier Activating Enzyme 7	Protein Coding	2
51	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
52	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
53	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	2
54	DHX58	DExH-Box Helicase 58	Protein Coding	2
55	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	2
56	NLRC5	NLR Family CARD Domain Containing 5	Protein Coding	2
57	TAX1BP1	Tax1 Binding Protein 1	Protein Coding	2
58	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	2
59	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	1
60	NKIRAS2	NFKB Inhibitor Interacting Ras Like 2	Protein Coding	1
61	NKIRAS1	NFKB Inhibitor Interacting Ras Like 1	Protein Coding	1
62	HMGB1	High Mobility Group Box 1	Protein Coding	1
63	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
64	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
65	IFNA2	Interferon Alpha 2	Protein Coding	1
66	IFNA4	Interferon Alpha 4	Protein Coding	1
67	IFNA5	Interferon Alpha 5	Protein Coding	1
68	IFNA6	Interferon Alpha 6	Protein Coding	1
69	IFNA7	Interferon Alpha 7	Protein Coding	1
70	IFNA8	Interferon Alpha 8	Protein Coding	1
71	IFNA10	Interferon Alpha 10	Protein Coding	1
72	IFNA13	Interferon Alpha 13	Protein Coding	1
73	IFNA14	Interferon Alpha 14	Protein Coding	1
74	IFNA16	Interferon Alpha 16	Protein Coding	1
75	IFNA17	Interferon Alpha 17	Protein Coding	1
76	IFNA21	Interferon Alpha 21	Protein Coding	1
77	APP	Amyloid Beta Precursor Protein	Protein Coding	1
78	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
79	S100A12	S100 Calcium Binding Protein A12	Protein Coding	1
80	S100B	S100 Calcium Binding Protein B	Protein Coding	1
81	SAA1	Serum Amyloid A1	Protein Coding	1
82	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	1
83	TBKBP1	TBK1 Binding Protein 1	Protein Coding	1
84	DDX3Y	DEAD-Box Helicase 3 Y-Linked	Protein Coding	1
85	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
86	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
87	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
88	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
89	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
90	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
91	IFNG	Interferon Gamma	Protein Coding	1
92	STING1	Stimulator Of Interferon Response CGAMP Interactor 1	Protein Coding	1
93	DDX3X	DEAD-Box Helicase 3 X-Linked	Protein Coding	1
94	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
95	DDX17	DEAD-Box Helicase 17	Protein Coding	1
96	AZI2	5-Azacytidine Induced 2	Protein Coding	1
97	IFNK	Interferon Kappa	Protein Coding	1
98	IFNE	Interferon Epsilon	Protein Coding	1
99	SNW1	SNW Domain Containing 1	Protein Coding	1

Disorders associated with DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, IFNA21, IFNA4, IFNA6, IFNB1, IRF3, TRAF3	10.19
2	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	6.07
3	Herpes simplex virus encephalitis	Enrichment	TBK1, TRAF3	5.52
4	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.81
5	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.77
6	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.77
7	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.93
8	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	3.23
9	Immunodeficiency 132a	Enrichment	TRAF3	3.23
10	Immunodeficiency 132b	Enrichment	TRAF3	3.23
11	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	3.23
12	Singleton-merten syndrome 2	Enrichment	RIGI	3.23
13	Corticobasal syndrome	Enrichment	TBK1	3.23
14	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	3.23
15	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.13
16	Incontinentia pigmenti	Enrichment	IKBKG	3.02
17	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	3.02
18	Caspase 8 deficiency	Enrichment	CASP8	3.02
19	Fetal encasement syndrome	Enrichment	CHUK	3.02
20	Singleton-merten syndrome 1	Enrichment	IFIH1	3.02
21	Immunodeficiency 15b	Enrichment	IKBKB	3.02
22	Immunodeficiency 15a	Enrichment	IKBKB	3.02
23	Immunodeficiency 95	Enrichment	IFIH1	3.02
24	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	3.02
25	Type 1 diabetes mellitus 19	Enrichment	IFIH1	3.02
26	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	3.02
27	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.02
28	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.02
29	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	3.02
30	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	3.02
31	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.02
32	Immunodeficiency 39 viral infections	Enrichment	IRF7	2.96
33	Immunodeficiency 39	Enrichment	IRF7	2.96
34	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.96
35	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.96
36	Menke-hennekam syndrome	Enrichment	CREBBP	2.96
37	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.93
38	Immunodeficiency 33	Enrichment	IKBKG	2.72
39	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.72
40	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.72
41	Basal ganglia disease	Enrichment	IFIH1	2.72
42	Oculootodental syndrome	Enrichment	FADD	2.72
43	Thumb deformity	Enrichment	CREBBP	2.66
44	Menke-hennekam syndrome 2	Enrichment	EP300	2.66
45	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.66
46	Human immunodeficiency virus type 1	Enrichment	CXCL12, IFNG	2.64
47	Tenorio syndrome	Enrichment	RNF125	2.59
48	Immunodeficiency 38 with basal ganglia calcification	Enrichment	ISG15	2.59
49	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	2.59
50	Multiple congenital anomalies-neurodevelopmental syndrome, x-linked	Enrichment	OTUD5	2.59
51	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.59
52	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.59
53	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.59
54	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	RNF135	2.54
55	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.53
56	Tethered spinal cord syndrome	Enrichment	CREBBP	2.48
57	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.48
58	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	2.42
59	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.40
60	Sting-associated vasculopathy, infantile-onset	Enrichment	STING1	2.40
61	46,xy sex reversal 6	Enrichment	MAP3K1	2.40
62	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.40
63	Corpus callosum, agenesis of, with facial anomalies and robin sequence	Enrichment	DDX3X	2.40
64	Immunodeficiency 69	Enrichment	IFNG	2.40
65	Intellectual developmental disorder, x-linked, syndromic, snijders blok type	Enrichment	DDX3X	2.40
66	Sting-associated vasculopathy with onset in infancy	Enrichment	STING1	2.40
67	Triokinase and fmn cyclase deficiency syndrome	Enrichment	TKFC	2.40
68	Ddx3x-related neurodevelopmental disorder	Enrichment	DDX3X	2.40
69	Inherited metabolic disorder	Enrichment	TKFC	2.40
70	X-linked intellectual disability-hypotonia-movement disorder syndrome	Enrichment	DDX3X	2.40
71	Motor neuron disease	Enrichment	TBK1	2.38
72	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.32
73	Spastic diplegia	Enrichment	IFIH1	2.32
74	Cylindromatosis, familial	Enrichment	CYLD	2.29
75	Gordon holmes syndrome	Enrichment	RNF216	2.29
76	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	2.29
77	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.29
78	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	2.29
79	Brooke-spiegler syndrome	Enrichment	CYLD	2.29
80	Submucosal cleft palate	Enrichment	UBB	2.29
81	Cleft hard palate	Enrichment	UBB	2.29
82	Progressive non-fluent aphasia	Enrichment	TBK1	2.28
83	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.26
84	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.24
85	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.24
86	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	2.23
87	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.22
88	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.22
89	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.22
90	Serum amyloid a amyloidosis	Enrichment	SAA1	2.22
91	Hypertrichosis	Enrichment	CREBBP	2.18
92	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	2.12
93	Uvula, bifid	Enrichment	UBB	2.11
94	Neurodegeneration with brain iron accumulation 5	Enrichment	OTUD5	2.11
95	Cleft soft palate	Enrichment	UBB	2.11
96	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.10
97	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.10
98	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.10
99	Rela fusion-positive ependymoma	Enrichment	RELA	2.10
100	Common variable immunodeficiency 12	Enrichment	NFKB1	2.10
101	Coronary heart disease 5	Enrichment	IKBKG	2.07
102	Adult hepatocellular carcinoma	Enrichment	CASP8	2.07
103	Aicardi-goutiares syndrome	Enrichment	IFIH1	2.07
104	Aicardi-goutieres syndrome	Enrichment	IFIH1	2.02
105	Charge syndrome	Enrichment	EP300	2.00
106	Immune deficiency disease	Enrichment	RIPK1	1.98
107	Sengers syndrome	Enrichment	TKFC	1.92
108	Tuberous sclerosis 1	Enrichment	IFNG	1.92
109	Hepatitis c virus	Enrichment	IFNG	1.92
110	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.92
111	Tuberous sclerosis 2	Enrichment	IFNG	1.92
112	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.92
113	Familial chilblain lupus	Enrichment	STING1	1.92
114	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.92
115	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.92
116	Diamond-blackfan anemia 12	Enrichment	NKIRAS1	1.92
117	Heart disease	Enrichment	CREBBP	1.81
118	Polydactyly, postaxial, type a1	Enrichment	EP300	1.78
119	Corpus callosum, agenesis of	Enrichment	CREBBP	1.78
120	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.78
121	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.78
122	Idiopathic aplastic anemia	Enrichment	IFNG	1.70
123	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.68
124	Hepatocellular carcinoma	Enrichment	CASP8	1.68
125	Malaria	Enrichment	IKBKG	1.66
126	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.62
127	Scoliosis	Enrichment	CREBBP	1.58
128	Severe covid-19	Enrichment	CASP10	1.56
129	Lung cancer	Enrichment	CASP8	1.52
130	Severe combined immunodeficiency	Enrichment	IKBKB	1.51
131	Lennox-gastaut syndrome	Enrichment	MAPK10	1.50
132	Chromosome y microdeletion syndrome	Enrichment	DDX3Y	1.50
133	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	1.47
134	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	RNF216	1.45
135	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.41
136	Aplastic anemia	Enrichment	IFNG	1.41
137	Gastric cancer	Enrichment	CASP10	1.39
138	Alzheimer's disease 1	Enrichment	APP	1.38
139	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.38
140	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.37
141	Myeloma, multiple	Enrichment	CREBBP, CYLD	1.35
142	Leukodystrophy	Enrichment	RNF216	1.30
143	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.29
144	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.26
145	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DDX3X	1.21
146	Gliosarcoma	Enrichment	NFKBIA	1.21
147	Giant cell glioblastoma	Enrichment	NFKBIA	1.18
148	Breast cancer	Enrichment	CASP8	1.16
149	Alzheimer's disease	Enrichment	APP	1.12
150	Autism	Enrichment	CREBBP	1.11
151	Precursor t-cell acute lymphoblastic leukemia	Enrichment	DDX3X	1.06
152	Colorectal cancer	Enrichment	EP300	1.04
153	Systemic lupus erythematosus	Enrichment	TNFAIP3	1.02
154	Alzheimer disease, familial, 1	Enrichment	APP	1.01
155	Autism spectrum disorder	Enrichment	RNF135	1.00
156	Congenital nervous system abnormality	Enrichment	CREBBP	0.95
157	Nervous system disease	Enrichment	CREBBP	0.95
158	Microcephaly	Enrichment	EP300	0.89
159	Complex neurodevelopmental disorder	Enrichment	OTUD5	0.56
160	Inherited cancer-predisposing syndrome	Enrichment	CYLD	0.54
161	Ovarian cancer	Enrichment	MAP3K1	0.48

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

DDX58/IFIH1-mediated induction of interferon-alpha/beta

Pathway Network for DDX58/IFIH1-mediated induction of interferon-alpha/beta

Pathway network for the DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

Member Pathways for DDX58/IFIH1-mediated induction of interferon-alpha/beta

Pathways in the DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

Gene overlap in member pathways for DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

Associated Genes for DDX58/IFIH1-mediated induction of interferon-alpha/beta

Associated Disorders for DDX58/IFIH1-mediated induction of interferon-alpha/beta

Disorders associated with DDX58/IFIH1-mediated induction of interferon-alpha/beta SuperPath

STRING Interaction Network for DDX58/IFIH1-mediated induction of interferon-alpha/beta

Sources for DDX58/IFIH1-mediated induction of interferon-alpha/beta