Deactivation of the beta-catenin transactivating complex

No Pathway Network information available for Deactivation of the beta-catenin transactivating complex

Pathways in the Deactivation of the beta-catenin transactivating complex SuperPath

#	Name	Source	Genes
1	Deactivation of the beta-catenin transactivating complex	Reactome	AKT1 AKT2 APC ASH2L BCL9 BCL9L BTRC CBY1 CHD8 CTBP1 CTNNB1 CTNNBIP1 HDAC1 KMT2D LEF1 MEN1 PYGO1 PYGO2 RBBP5 RPS27A SOX13 SOX17 SOX2 SOX3 SOX4 SOX6 SOX7 SOX9 SRY TCF7 TCF7L1 TCF7L2 TLE1 TLE2 TLE3 TLE4 UBA52 UBB UBC XPO1 YWHAZ (see all 41) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
2	CTNNB1	Catenin Beta 1	Protein Coding	1
3	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
4	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
5	CBY1	Chibby 1, Beta Catenin Antagonist	Protein Coding	1
6	PYGO1	Pygopus Family PHD Finger 1	Protein Coding	1
7	BCL9L	BCL9 Like	Protein Coding	1
8	HDAC1	Histone Deacetylase 1	Protein Coding	1
9	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
10	MEN1	Menin 1	Protein Coding	1
11	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
12	SOX6	SRY-Box Transcription Factor 6	Protein Coding	1
13	CTNNBIP1	Catenin Beta Interacting Protein 1	Protein Coding	1
14	CHD8	Chromodomain Helicase DNA Binding Protein 8	Protein Coding	1
15	RBBP5	RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	1
16	BCL9	BCL9 Transcription Coactivator	Protein Coding	1
17	RPS27A	Ribosomal Protein S27a	Protein Coding	1
18	SOX17	SRY-Box Transcription Factor 17	Protein Coding	1
19	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
20	SOX3	SRY-Box Transcription Factor 3	Protein Coding	1
21	SOX4	SRY-Box Transcription Factor 4	Protein Coding	1
22	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
23	SRY	Sex Determining Region Y	Protein Coding	1
24	TCF7	Transcription Factor 7	Protein Coding	1
25	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
26	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	1
27	TLE2	TLE Family Member 2, Transcriptional Corepressor	Protein Coding	1
28	TLE3	TLE Family Member 3, Transcriptional Corepressor	Protein Coding	1
29	TLE4	TLE Family Member 4, Transcriptional Corepressor	Protein Coding	1
30	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
31	UBB	Ubiquitin B	Protein Coding	1
32	UBC	Ubiquitin C	Protein Coding	1
33	XPO1	Exportin 1	Protein Coding	1
34	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
35	KMT2D	Lysine Methyltransferase 2D	Protein Coding	1
36	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
37	SOX7	SRY-Box Transcription Factor 7	Protein Coding	1
38	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
39	ASH2L	ASH2 Like, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	1
40	PYGO2	Pygopus Family PHD Finger 2	Protein Coding	1
41	SOX13	SRY-Box Transcription Factor 13	Protein Coding	1

Disorders associated with Deactivation of the beta-catenin transactivating complex SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX3, SOX9, SRY	6.59
2	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	4.57
3	46,xx sex reversal 1	Enrichment	SOX9, SRY	4.57
4	Desmoid tumor	Enrichment	APC, CTNNB1	4.57
5	Craniopharyngioma	Enrichment	APC, CTNNB1	4.27
6	Colorectal cancer	Enrichment	AKT1, APC, CTNNB1, SOX9	3.87
7	46,xy complete gonadal dysgenesis	Enrichment	SOX9, SRY	3.32
8	Septooptic dysplasia	Enrichment	SOX2, SOX3	3.24
9	Medulloblastoma	Enrichment	APC, CTNNB1	3.10
10	46,xy partial gonadal dysgenesis	Enrichment	SOX9, SRY	3.10
11	Autism	Enrichment	CHD8, KMT2D, TCF7L2	2.88
12	Hepatoblastoma	Enrichment	APC, CTNNB1	2.74
13	Hepatocellular carcinoma	Enrichment	APC, CTNNB1	2.70
14	Proteus syndrome	Enrichment	AKT1	2.52
15	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.52
16	Panhypopituitarism, x-linked	Enrichment	SOX3	2.52
17	Branchial cleft anomalies	Enrichment	KMT2D	2.52
18	Vesicoureteral reflux 3	Enrichment	SOX17	2.52
19	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.52
20	Intellectual developmental disorder with speech delay and dysmorphic facies	Enrichment	SOX4	2.52
21	46,xy sex reversal 10	Enrichment	SOX9	2.52
22	Tolchin-le caignec syndrome	Enrichment	SOX6	2.52
23	46,xx sex reversal 2	Enrichment	SOX9	2.52
24	Adrenal cortical adenoma	Enrichment	MEN1	2.52
25	Intellectual developmental disorder, x-linked, with panhypopituitarism	Enrichment	SOX3	2.52
26	Cowden syndrome 6	Enrichment	AKT1	2.52
27	Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome	Enrichment	KMT2D	2.52
28	Adenoid ameloblastoma	Enrichment	CTNNB1	2.52
29	45,x/46,xy mixed gonadal dysgenesis	Enrichment	SRY	2.52
30	Pulmonary hypertension, primary, 7	Enrichment	SOX17	2.52
31	Familial adenomatous polyposis	Enrichment	APC	2.52
32	Adrenal adenoma	Enrichment	MEN1	2.52
33	Gardner syndrome	Enrichment	APC	2.52
34	5q22 microdeletion syndrome	Enrichment	APC	2.52
35	Attenuated familial adenomatous polyposis	Enrichment	APC	2.52
36	Microcystic stromal tumor	Enrichment	CTNNB1	2.52
37	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.52
38	Ovarian cancer	Enrichment	AKT1, APC, CTNNB1	2.46
39	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.22
40	Campomelic dysplasia	Enrichment	SOX9	2.22
41	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.22
42	Hypertrichosis, congenital generalized, 2	Enrichment	SOX3	2.22
43	Hyperparathyroidism 1	Enrichment	MEN1	2.22
44	Complement component c1s deficiency	Enrichment	KMT2D	2.22
45	Choanal atresia, posterior	Enrichment	KMT2D	2.22
46	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.22
47	46,xy sex reversal 1	Enrichment	SRY	2.22
48	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.22
49	Split hand-foot malformation	Enrichment	LEF1	2.22
50	Medullary thyroid carcinoma	Enrichment	MEN1	2.22
51	Periampullary adenoma	Enrichment	APC	2.22
52	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.22
53	Insulinoma	Enrichment	MEN1	2.22
54	14q11.2 microduplication syndrome	Enrichment	CHD8	2.22
55	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.22
56	Teratoma	Enrichment	CTNNB1	2.22
57	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.22
58	Null pituitary adenoma	Enrichment	MEN1	2.22
59	Silent pituitary adenoma	Enrichment	MEN1	2.22
60	Submucosal cleft palate	Enrichment	UBB	2.22
61	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.22
62	Cleft hard palate	Enrichment	UBB	2.22
63	Gigantism	Enrichment	MEN1	2.22
64	Type 2 diabetes mellitus	Enrichment	AKT2, TCF7L2	2.15
65	Hereditary breast carcinoma	Enrichment	AKT1, APC	2.11
66	Uvula, bifid	Enrichment	UBB	2.04
67	Pituitary hormone deficiency, combined, 2	Enrichment	SOX3	2.04
68	Cleft soft palate	Enrichment	UBB	2.04
69	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.04
70	Pituitary adenoma 1, multiple types	Enrichment	MEN1	2.04
71	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.04
72	Anus, imperforate	Enrichment	CTNNB1	2.04
73	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.04
74	Cellular ependymoma	Enrichment	MEN1	2.04
75	Tanycytic ependymoma	Enrichment	MEN1	2.04
76	Papillary ependymoma	Enrichment	MEN1	2.04
77	Familial vesicoureteral reflux	Enrichment	SOX17	2.04
78	Parathyroid adenoma	Enrichment	MEN1	2.04
79	Growth hormone secreting pituitary adenoma	Enrichment	MEN1	2.04
80	Aip familial isolated pituitary adenomas	Enrichment	MEN1	2.04
81	Familial isolated hyperparathyroidism	Enrichment	MEN1	2.04
82	Colon adenocarcinoma	Enrichment	APC	2.04
83	Clear cell ependymoma	Enrichment	MEN1	2.04
84	Apc-associated polyposis conditions	Enrichment	APC	2.04
85	Microphthalmia, syndromic 3	Enrichment	SOX2	1.92
86	Microtia-anotia	Enrichment	KMT2D	1.92
87	Pilomatrixoma	Enrichment	CTNNB1	1.92
88	Alazami syndrome	Enrichment	CTNNB1	1.92
89	Intellectual developmental disorder, autosomal dominant 26	Enrichment	KMT2D	1.92
90	Intellectual developmental disorder with autism and macrocephaly	Enrichment	CHD8	1.92
91	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.92
92	Prolactinoma	Enrichment	MEN1	1.92
93	Primary hyperparathyroidism	Enrichment	MEN1	1.92
94	Benign ependymoma	Enrichment	MEN1	1.92
95	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.82
96	Familial adenomatous polyposis 1	Enrichment	APC	1.82
97	Amblyopia	Enrichment	KMT2D	1.82
98	Lymphoma	Enrichment	KMT2D	1.82
99	Congenital ptosis	Enrichment	CHD8	1.82
100	Kabuki syndrome 1	Enrichment	KMT2D	1.74
101	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.74
102	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.74
103	Split-hand/foot malformation 1	Enrichment	LEF1	1.74
104	Pierre robin syndrome	Enrichment	SOX9	1.74
105	Adrenocortical carcinoma	Enrichment	CTNNB1	1.74
106	Breast adenocarcinoma	Enrichment	AKT1	1.74
107	46,xy disorder of sex development	Enrichment	SRY	1.74
108	Multiple endocrine neoplasia, type i	Enrichment	MEN1	1.68
109	Gastrointestinal stromal tumor	Enrichment	MEN1	1.68
110	Gallbladder cancer	Enrichment	CTNNB1	1.68
111	Overgrowth syndrome	Enrichment	CHD8	1.68
112	Breast cancer	Enrichment	AKT1, APC	1.67
113	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.62
114	Isolated split hand-split foot malformation	Enrichment	BTRC	1.62
115	Charge syndrome	Enrichment	KMT2D	1.57
116	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.57
117	Colonic benign neoplasm	Enrichment	APC	1.57
118	Cowden syndrome	Enrichment	AKT1	1.57
119	Nanophthalmos	Enrichment	SOX2	1.48
120	Diabetes mellitus	Enrichment	MEN1	1.48
121	Heritable pulmonary arterial hypertension	Enrichment	SOX17	1.48
122	Meningioma	Enrichment	AKT1	1.45
123	Pulmonary hypertension, primary, 1	Enrichment	SOX17	1.41
124	Congenital nervous system abnormality	Enrichment	CTNNB1, KMT2D	1.39
125	Nervous system disease	Enrichment	CTNNB1, KMT2D	1.39
126	Coffin-siris syndrome 1	Enrichment	SOX4	1.35
127	Rare genetic intellectual disability	Enrichment	CHD8	1.35
128	Male infertility with spermatogenesis disorder	Enrichment	KMT2D	1.35
129	Hypertension	Enrichment	MEN1	1.33
130	Dandy-walker syndrome	Enrichment	KMT2D	1.30
131	Polycystic liver disease	Enrichment	CTNNB1	1.30
132	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.30
133	Microcephaly	Enrichment	CTNNB1, KMT2D	1.27
134	Macs syndrome	Enrichment	SOX2	1.23
135	Inherited cancer-predisposing syndrome	Enrichment	APC, MEN1	1.22
136	Microphthalmia	Enrichment	SOX2	1.19
137	Strabismus	Enrichment	KMT2D	1.10
138	Bladder cancer	Enrichment	CTNNB1	1.08
139	Isolated joubert syndrome	Enrichment	CBY1	1.06
140	Lung cancer	Enrichment	KMT2D	1.03
141	Connective tissue disease	Enrichment	SOX9	1.03
142	Gastric cancer	Enrichment	APC	0.91
143	Joubert syndrome 1	Enrichment	CBY1	0.85
144	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.85
145	Hereditary breast ovarian cancer syndrome	Enrichment	MEN1	0.81
146	Myeloma, multiple	Enrichment	KMT2D	0.81
147	Autism spectrum disorder	Enrichment	CHD8	0.55
148	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Deactivation of the beta-catenin transactivating complex

Pathway Network for Deactivation of the beta-catenin transactivating complex

Member Pathways for Deactivation of the beta-catenin transactivating complex

Pathways in the Deactivation of the beta-catenin transactivating complex SuperPath

Associated Genes for Deactivation of the beta-catenin transactivating complex

Associated Disorders for Deactivation of the beta-catenin transactivating complex

Disorders associated with Deactivation of the beta-catenin transactivating complex SuperPath

STRING Interaction Network for Deactivation of the beta-catenin transactivating complex

Sources for Deactivation of the beta-catenin transactivating complex