Deadenylation-dependent mRNA decay

Pathway network for the Deadenylation-dependent mRNA decay SuperPath

Sources:

Reactome

Pathways in the Deadenylation-dependent mRNA decay SuperPath

#	Name	Source	Genes
1	Deadenylation-dependent mRNA decay	Reactome	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 DCP1A DCP1B DCP2 DCPS DDX6 DIS3 EDC3 EDC4 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HBS1L LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 NT5C3B PABPC1 PAIP1 PAN2 PAN3 PARN PATL1 SKIC2 SKIC3 SKIC8 TNKS1BP1 TUT4 TUT7 XRN1 (see all 56) (see less)
2	M-decay: degradation of maternal mRNAs by maternally stored factors	Reactome	AGO2 BTG4 CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 DICER1 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 PABPC1 PABPN1L PAIP1 TNKS1BP1 ZFP36L2 (see all 25) (see less)
3	Deadenylation of mRNA	Reactome	CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 PABPC1 PAIP1 PAN2 PAN3 PARN TNKS1BP1 TUT4 TUT7 (see all 25) (see less)
4	mRNA decay by 3' to 5' exoribonuclease	Reactome	DCPS DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 HBS1L NT5C3B SKIC2 SKIC3 SKIC8 (see all 16) (see less)
5	mRNA decay by 5' to 3' exoribonuclease	Reactome	DCP1A DCP1B DCP2 DDX6 EDC3 EDC4 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 PATL1 XRN1 (see all 15) (see less)

Gene overlap in member pathways for Deadenylation-dependent mRNA decay SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PAIP1	Poly(A) Binding Protein Interacting Protein 1	Protein Coding	3
2	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	3
3	EIF4A2	Eukaryotic Translation Initiation Factor 4A2	Protein Coding	3
4	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	3
5	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	3
6	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	3
7	CNOT1	CCR4-NOT Transcription Complex Subunit 1	Protein Coding	3
8	CNOT6L	CCR4-NOT Transcription Complex Subunit 6 Like	Protein Coding	3
9	CNOT10	CCR4-NOT Transcription Complex Subunit 10	Protein Coding	3
10	PABPC1	Poly(A) Binding Protein Cytoplasmic 1	Protein Coding	3
11	CNOT7	CCR4-NOT Transcription Complex Subunit 7	Protein Coding	3
12	CNOT2	CCR4-NOT Transcription Complex Subunit 2	Protein Coding	3
13	CNOT3	CCR4-NOT Transcription Complex Subunit 3	Protein Coding	3
14	CNOT4	CCR4-NOT Transcription Complex Subunit 4	Protein Coding	3
15	CNOT11	CCR4-NOT Transcription Complex Subunit 11	Protein Coding	3
16	CNOT6	CCR4-NOT Transcription Complex Subunit 6	Protein Coding	3
17	TNKS1BP1	Tankyrase 1 Binding Protein 1	Protein Coding	3
18	CNOT9	CCR4-NOT Transcription Complex Subunit 9	Protein Coding	3
19	CNOT8	CCR4-NOT Transcription Complex Subunit 8	Protein Coding	3
20	EIF4A3	Eukaryotic Translation Initiation Factor 4A3	Protein Coding	3
21	HBS1L	HBS1 Like Translational GTPase	Protein Coding	2
22	LSM6	LSM6 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	2
23	EXOSC8	Exosome Component 8	Protein Coding	2
24	NT5C3B	5''-Nucleotidase, Cytosolic IIIB	Protein Coding	2
25	EXOSC6	Exosome Component 6	Protein Coding	2
26	DDX6	DEAD-Box Helicase 6	Protein Coding	2
27	DCP2	Decapping MRNA 2	Protein Coding	2
28	DCP1B	Decapping MRNA 1B	Protein Coding	2
29	PATL1	PAT1 Homolog 1, Processing Body MRNA Decay Factor	Protein Coding	2
30	DIS3	DIS3 Exosome Endoribonuclease And 3''''-5'''' Exoribonuclease	Protein Coding	2
31	EXOSC7	Exosome Component 7	Protein Coding	2
32	TUT4	Terminal Uridylyl Transferase 4	Protein Coding	2
33	EXOSC2	Exosome Component 2	Protein Coding	2
34	EDC4	Enhancer Of MRNA Decapping 4	Protein Coding	2
35	LSM5	LSM5 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	2
36	PAN3	Poly(A) Specific Ribonuclease Subunit PAN3	Protein Coding	2
37	LSM4	LSM4 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	2
38	LSM1	LSM1 Homolog, MRNA Degradation Associated	Protein Coding	2
39	LSM3	LSM3 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	2
40	DCPS	Decapping Enzyme, Scavenger	Protein Coding	2
41	PARN	Poly(A)-Specific Ribonuclease	Protein Coding	2
42	EXOSC3	Exosome Component 3	Protein Coding	2
43	EXOSC1	Exosome Component 1	Protein Coding	2
44	LSM7	LSM7 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	2
45	EXOSC9	Exosome Component 9	Protein Coding	2
46	XRN1	5''-3'' Exoribonuclease 1	Protein Coding	2
47	EXOSC4	Exosome Component 4	Protein Coding	2
48	DCP1A	Decapping MRNA 1A	Protein Coding	2
49	EXOSC5	Exosome Component 5	Protein Coding	2
50	LSM2	LSM2 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	2
51	SKIC2	SKI2 Subunit Of Superkiller Complex	Protein Coding	2
52	TUT7	Terminal Uridylyl Transferase 7	Protein Coding	2
53	EDC3	Enhancer Of MRNA Decapping 3	Protein Coding	2
54	SKIC8	SKI8 Subunit Of Superkiller Complex	Protein Coding	2
55	SKIC3	SKI3 Subunit Of Superkiller Complex	Protein Coding	2
56	PAN2	Poly(A) Specific Ribonuclease Subunit PAN2	Protein Coding	2
57	DICER1	Dicer 1, Ribonuclease III	Protein Coding	1
58	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	1
59	PABPN1L	PABPN1 Like, Cytoplasmic	Protein Coding	1
60	BTG4	BTG Anti-Proliferation Factor 4	Protein Coding	1
61	ZFP36L2	ZFP36 Ring Finger Protein Like 2	Protein Coding	1

Disorders associated with Deadenylation-dependent mRNA decay SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pontocerebellar hypoplasia, type 1e	Enrichment	EXOSC3, EXOSC8, EXOSC9	7.57
2	Trichohepatoenteric syndrome	Enrichment	SKIC2, SKIC3	5.41
3	Trichohepatoenteric syndrome 1	Enrichment	SKIC2, SKIC3	5.11
4	Complex neurodevelopmental disorder	Enrichment	AGO2, CNOT1, CNOT3, EIF4A2	4.14
5	Pontocerebellar hypoplasia	Enrichment	EXOSC3, EXOSC9	3.70
6	Leukodystrophy and cerebellar atrophy	Enrichment	LSM7	2.96
7	Intellectual developmental disorder with impaired language and dysmorphic facies	Enrichment	DDX6	2.96
8	Intellectual developmental disorder, autosomal recessive 50	Enrichment	EDC3	2.96
9	Ficus syndrome	Enrichment	LSM1	2.96
10	Pontocerebellar hypoplasia, type 1f	Enrichment	EXOSC1	2.93
11	Cerebellar ataxia, brain abnormalities, and cardiac conduction defects	Enrichment	EXOSC5	2.93
12	Pontocerebellar hypoplasia, type 1c	Enrichment	EXOSC8	2.93
13	Pontocerebellar hypoplasia, type 1d	Enrichment	EXOSC9	2.93
14	Short stature, hearing loss, retinitis pigmentosa, and distinctive facies	Enrichment	EXOSC2	2.93
15	Robin sequence with cleft mandible and limb anomalies	Enrichment	EIF4A3	2.73
16	Rhabdomyosarcoma, embryonal, 2	Enrichment	DICER1	2.73
17	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	2.73
18	Holoprosencephaly 12 with or without pancreatic agenesis	Enrichment	CNOT1	2.73
19	Oocyte/zygote/embryo maturation arrest 13	Enrichment	ZFP36L2	2.73
20	Autism 19	Enrichment	EIF4E	2.73
21	Dicer1 syndrome	Enrichment	DICER1	2.73
22	Pleuropulmonary blastoma	Enrichment	DICER1	2.73
23	Global developmental delay, lung cysts, overgrowth, and wilms tumor	Enrichment	DICER1	2.73
24	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	Enrichment	EIF4A2	2.73
25	Vissers-bodmer syndrome	Enrichment	CNOT1	2.73
26	Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies	Enrichment	CNOT2	2.73
27	Oocyte/zygote/embryo maturation arrest 8	Enrichment	BTG4	2.73
28	Malignant sertoli-leydig cell tumor of ovary	Enrichment	DICER1	2.73
29	Supratentorial primitive neuroectodermal tumor	Enrichment	DICER1	2.73
30	Gynandroblastoma	Enrichment	DICER1	2.73
31	Dicer1 tumor predisposition	Enrichment	DICER1	2.73
32	Female infertility due to an implantation defect of genetic origin	Enrichment	ZFP36L2	2.73
33	Pancreatic agenesis-holoprosencephaly syndrome	Enrichment	CNOT1	2.73
34	Dyskeratosis congenita, autosomal recessive 6	Enrichment	PARN	2.73
35	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4	Enrichment	PARN	2.73
36	Trichohepatoenteric syndrome 2	Enrichment	SKIC2	2.63
37	Immunodeficiency 57 with autoinflammation	Enrichment	SKIC2	2.63
38	Congenital pontocerebellar hypoplasia type 1	Enrichment	EXOSC3	2.63
39	Pontocerebellar hypoplasia, type 1b	Enrichment	EXOSC3	2.45
40	Cerebellar disease	Enrichment	EXOSC3	2.45
41	Al-raqad syndrome	Enrichment	DCPS	2.45
42	Premature ovarian failure 3	Enrichment	AGO2	2.43
43	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	DICER1	2.43
44	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	DICER1	2.43
45	Alopecia-intellectual disability syndrome 4	Enrichment	CNOT1	2.43
46	Pineoblastoma	Enrichment	DICER1	2.43
47	Malignant granulosa cell tumor of the ovary	Enrichment	DICER1	2.43
48	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.26
49	Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	Enrichment	CNOT3	2.13
50	Embryonal rhabdomyosarcoma	Enrichment	DICER1	2.13
51	Histiocytoid hemangioma	Enrichment	ZFP36L2	2.04
52	Pulmonary fibrosis	Enrichment	PARN	1.96
53	Hoyeraal-hreidarsson syndrome	Enrichment	PARN	1.96
54	Leukodystrophy	Enrichment	LSM7	1.66
55	Congenital myopathy	Enrichment	EXOSC3	1.65
56	Autosomal recessive non-syndromic intellectual disability	Enrichment	DCPS, EDC3	1.62
57	Lissencephaly	Enrichment	EXOSC3	1.61
58	Rhabdomyosarcoma	Enrichment	DICER1	1.54
59	Interstitial lung disease 2	Enrichment	PARN	1.51
60	Dyskeratosis congenita	Enrichment	PARN	1.46
61	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CNOT3	1.38
62	Fetal akinesia deformation sequence 1	Enrichment	EXOSC3	1.37
63	Parkinson disease, late-onset	Enrichment	EIF4G1	1.36
64	Spastic ataxia	Enrichment	EXOSC8	1.22
65	Myeloma, multiple	Enrichment	DIS3	1.19
66	Congenital nervous system abnormality	Enrichment	EXOSC3	0.93
67	Nervous system disease	Enrichment	EXOSC3	0.93
68	Microcephaly	Enrichment	EXOSC3	0.87
69	Ovarian cancer	Enrichment	DICER1	0.77
70	Inherited cancer-predisposing syndrome	Enrichment	DICER1	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Deadenylation-dependent mRNA decay

Pathway Network for Deadenylation-dependent mRNA decay

Pathway network for the Deadenylation-dependent mRNA decay SuperPath

Member Pathways for Deadenylation-dependent mRNA decay

Pathways in the Deadenylation-dependent mRNA decay SuperPath

Gene overlap in member pathways for Deadenylation-dependent mRNA decay SuperPath

Associated Genes for Deadenylation-dependent mRNA decay

Associated Disorders for Deadenylation-dependent mRNA decay

Disorders associated with Deadenylation-dependent mRNA decay SuperPath

STRING Interaction Network for Deadenylation-dependent mRNA decay

Sources for Deadenylation-dependent mRNA decay