Death Receptor Signaling Pathway

Pathway network for the Death Receptor Signaling Pathway SuperPath

Sources:

Sino Biological
R&D Systems
GeneGo (Thomson Reuters)
Reactome

Pathways in the Death Receptor Signaling Pathway SuperPath

#	Name	Source	Genes
1	Death Receptor Signaling Pathway	Sino Biological	BAX BCL2 BCL2L1 BID BIRC2 BIRC3 BIRC5 BIRC7 BIRC8 CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 CRADD DAPK1 DAPK2 DAPK3 DIABLO FADD FAS FASLG GCK HSPA1A IKBKB IKBKE MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP3K11 MAP3K13 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK6 MAPK7 NFKBIA NFKBIB NGF NGFR RELA RIPK1 RIPK2 RIPK3 TNF TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF1A TNFRSF21 TNFRSF25 TNFRSF6B TNFSF10 TNFSF12 TNFSF15 TP53 TRADD TRAF1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ (see all 71) (see less)
2	Apoptosis Signaling Pathway	R&D Systems	AIFM1 APAF1 AXIN1 AXIN2 BAD BAG4 BAK1 BAX BBC3 BCL2 BCL2L1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CDKN1A CRADD CYCS DAXX DIABLO ENDOG FADD FAS FASLG HIPK2 HSP90AA1 HSP90AB1 HSPA1A HSPB1 HTRA2 NAIP NOL3 PIDD1 RIPK1 SFN TNF TNFRSF10A TNFRSF10B TNFRSF12A TNFRSF1A TNFRSF25 TNFSF10 TNFSF12 TNFSF15 TP53 TRADD TRAF2 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 64) (see less)
3	TNF Signaling Pathway	Sino Biological	AKT1 AKT2 AKT3 ATF2 BAD BAX BCL2 BID BIRC2 BIRC3 BIRC5 BIRC7 BIRC8 CASP10 CASP3 CASP6 CASP7 CASP8 CASP9 DIABLO ELK1 FADD FOS IKBKB IKBKE JUN MAP2K3 MAP3K1 MAPK1 MAPK12 MAPK14 MAPK15 MAPK3 MAPK6 MAPK7 NFKBIA NFKBIB RELA RIPK1 RIPK2 RIPK3 TNFRSF1A TRADD XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ (see all 49) (see less)
4	Apoptosis and survival Apoptotic TNF-family pathways	GeneGo (Thomson Reuters)	BAX BCL2 BCL2L1 BEX3 BID BIRC2 CASP10 CASP2 CASP3 CASP7 CASP8 CASP9 CD27 CD70 CRADD DIABLO FADD FAS FASLG LTBR NGF NGFR RIPK1 SIVA1 TNF TNFRSF10A TNFRSF10B TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF21 TNFRSF25 TNFSF10 TNFSF12 TNFSF14 TNFSF18 TRADD TRAF2 TRAF3 XIAP (see all 40) (see less)
5	SARS-CoV-1-mediated effects on programmed cell death	Reactome	BCL2L1 RIPK1 RIPK3

Gene overlap in member pathways for Death Receptor Signaling Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	5
2	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	4
3	BCL2	BCL2 Apoptosis Regulator	Protein Coding	4
4	BCL2L1	BCL2 Like 1	Protein Coding	4
5	BID	BH3 Interacting Domain Death Agonist	Protein Coding	4
6	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	4
7	CASP10	Caspase 10	Protein Coding	4
8	CASP3	Caspase 3	Protein Coding	4
9	CASP7	Caspase 7	Protein Coding	4
10	CASP8	Caspase 8	Protein Coding	4
11	CASP9	Caspase 9	Protein Coding	4
12	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	4
13	FADD	Fas Associated Via Death Domain	Protein Coding	4
14	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	4
15	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	4
16	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	4
17	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	3
18	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	3
19	BIRC7	Baculoviral IAP Repeat Containing 7	Protein Coding	3
20	BIRC8	Baculoviral IAP Repeat Containing 8	Pseudogene	3
21	CASP6	Caspase 6	Protein Coding	3
22	CRADD	CARD And Death Domain Containing Adaptor Protein	Protein Coding	3
23	FAS	Fas Cell Surface Death Receptor	Protein Coding	3
24	FASLG	Fas Ligand	Protein Coding	3
25	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	3
26	TNF	Tumor Necrosis Factor	Protein Coding	3
27	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	3
28	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	3
29	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	3
30	TNFSF10	TNF Superfamily Member 10	Protein Coding	3
31	TNFSF12	TNF Superfamily Member 12	Protein Coding	3
32	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	3
33	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	3
34	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	3
35	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	3
36	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	3
37	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	2
38	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
39	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	2
40	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
41	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
42	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	2
43	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
44	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
45	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
46	NGF	Nerve Growth Factor	Protein Coding	2
47	NGFR	Nerve Growth Factor Receptor	Protein Coding	2
48	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
49	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
50	TNFRSF21	TNF Receptor Superfamily Member 21	Protein Coding	2
51	TNFSF15	TNF Superfamily Member 15	Protein Coding	2
52	TP53	Tumor Protein P53	Protein Coding	2
53	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
54	CASP2	Caspase 2	Protein Coding	2
55	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	2
56	DAPK1	Death Associated Protein Kinase 1	Protein Coding	1
57	DAPK2	Death Associated Protein Kinase 2	Protein Coding	1
58	DAPK3	Death Associated Protein Kinase 3	Protein Coding	1
59	GCK	Glucokinase	Protein Coding	1
60	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
61	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
62	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
63	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
64	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
65	MAP3K13	Mitogen-Activated Protein Kinase Kinase Kinase 13	Protein Coding	1
66	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
67	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
68	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
69	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
70	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
71	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	1
72	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
73	TNFRSF6B	TNF Receptor Superfamily Member 6b	Protein Coding	1
74	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
75	BAG4	BAG Cochaperone 4	Protein Coding	1
76	DAXX	Death Domain Associated Protein	Protein Coding	1
77	TNFRSF12A	TNF Receptor Superfamily Member 12A	Protein Coding	1
78	AXIN1	Axin 1	Protein Coding	1
79	AXIN2	Axin 2	Protein Coding	1
80	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	1
81	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	1
82	NOL3	Nucleolar Protein 3	Protein Coding	1
83	CYCS	Cytochrome C, Somatic	Protein Coding	1
84	SFN	Stratifin	Protein Coding	1
85	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
86	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
87	HTRA2	HtrA Serine Peptidase 2	Protein Coding	1
88	ENDOG	Endonuclease G	Protein Coding	1
89	AIFM1	Apoptosis Inducing Factor Mitochondria Associated 1	Protein Coding	1
90	BIRC6	Baculoviral IAP Repeat Containing 6	Protein Coding	1
91	NAIP	NLR Family Apoptosis Inhibitory Protein	Protein Coding	1
92	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
93	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
94	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
95	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
96	BBC3	BCL2 Binding Component 3	Protein Coding	1
97	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
98	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
99	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
100	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
101	ATF2	Activating Transcription Factor 2	Protein Coding	1
102	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
103	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
104	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
105	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
106	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
107	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
108	MAPK15	Mitogen-Activated Protein Kinase 15	Protein Coding	1
109	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
110	CD27	CD27 Molecule	Protein Coding	1
111	CD70	CD70 Molecule	Protein Coding	1
112	LTBR	Lymphotoxin Beta Receptor	Protein Coding	1
113	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
114	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
115	TNFSF14	TNF Superfamily Member 14	Protein Coding	1
116	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	1
117	TNFSF18	TNF Superfamily Member 18	Protein Coding	1
118	SIVA1	SIVA1 Apoptosis Inducing Factor	Protein Coding	1
119	BEX3	Brain Expressed X-Linked 3	Protein Coding	1

Disorders associated with Death Receptor Signaling Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe acute respiratory syndrome	Direct
2	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	7.02
3	Adult hepatocellular carcinoma	Enrichment	AXIN1, CASP8, TP53	5.08
4	Lung cancer	Enrichment	CASP8, FAS, FASLG, MAP3K8	4.65
5	Lymphoproliferative syndrome 2	Enrichment	CD27, XIAP	4.30
6	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.09
7	Hepatocellular carcinoma	Enrichment	AXIN1, CASP8, TP53	3.84
8	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.79
9	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.79
10	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B, TP53	3.34
11	Immune deficiency disease	Enrichment	CD27, RIPK1	3.34
12	Lymphoma, non-hodgkin, familial	Enrichment	CASP10, TP53	3.22
13	Specific learning disability	Enrichment	MAPK1, YWHAG	3.16
14	Behcet syndrome	Enrichment	FAS, TNFRSF1A	2.85
15	Autoinflammatory disease	Enrichment	TNFRSF1A, XIAP	2.65
16	Breast cancer	Enrichment	AKT1, CASP8, JUN	2.60
17	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	2.57
18	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.53
19	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.53
20	Caspase 8 deficiency	Enrichment	CASP8	2.53
21	Lymphoproliferative syndrome 3	Enrichment	CD70	2.53
22	Immunodeficiency 132a	Enrichment	TRAF3	2.53
23	Immunodeficiency 132b	Enrichment	TRAF3	2.53
24	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.53
25	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	Enrichment	CRADD	2.53
26	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.53
27	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.53
28	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.53
29	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.53
30	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	2.53
31	Common variable immunodeficiency phenotype due to tweak deficiency	Enrichment	TNFSF12	2.53
32	Gliosarcoma	Enrichment	NFKBIA, TP53	2.51
33	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.46
34	Proteus syndrome	Enrichment	AKT1	2.44
35	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.44
36	46,xy sex reversal 6	Enrichment	MAP3K1	2.44
37	Immunodeficiency 15b	Enrichment	IKBKB	2.44
38	Noonan syndrome 13	Enrichment	MAPK1	2.44
39	Immunodeficiency 15a	Enrichment	IKBKB	2.44
40	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.44
41	Cowden syndrome 6	Enrichment	AKT1	2.44
42	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.44
43	Capillary hemangioma	Enrichment	AKT3	2.44
44	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.44
45	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.44
46	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	2.33
47	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.33
48	Caudal duplication anomaly	Enrichment	AXIN1	2.33
49	Myoclonus, familial, 1	Enrichment	NOL3	2.33
50	Bone marrow failure syndrome 5	Enrichment	TP53	2.33
51	Papilloma of choroid plexus	Enrichment	TP53	2.33
52	Basal cell carcinoma 7	Enrichment	TP53	2.33
53	Anaplastic thyroid carcinoma	Enrichment	TP53	2.33
54	Thrombocytopenia 4	Enrichment	CYCS	2.33
55	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.33
56	Ductal carcinoma in situ	Enrichment	TP53	2.33
57	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.33
58	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.33
59	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.33
60	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.33
61	Choroid plexus cancer	Enrichment	TP53	2.33
62	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.33
63	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	2.33
64	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.28
65	Melorheostosis, isolated	Enrichment	MAP2K1	2.28
66	Maturity-onset diabetes of the young, type 2	Enrichment	GCK	2.28
67	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.28
68	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.28
69	Hyperinsulinemic hypoglycemia, familial, 3	Enrichment	GCK	2.28
70	Melorheostosis	Enrichment	MAP2K1	2.28
71	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.28
72	Immunodeficiency 112	Enrichment	MAP3K14	2.28
73	Gestational diabetes	Enrichment	GCK	2.28
74	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.28
75	Verrucous hemangioma	Enrichment	MAP3K3	2.28
76	Nik deficiency	Enrichment	MAP3K14	2.28
77	Deafness, autosomal dominant 64	Enrichment	DIABLO	2.23
78	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.23
79	Immunodeficiency 127	Enrichment	TNF	2.23
80	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.23
81	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.23
82	Oculootodental syndrome	Enrichment	FADD	2.23
83	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	2.20
84	Scoliosis, isolated 1	Enrichment	MAPK7	2.14
85	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.14
86	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.14
87	Rela fusion-positive ependymoma	Enrichment	RELA	2.14
88	Senior-loken syndrome 7	Enrichment	AKT3	2.14
89	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.14
90	Bardet-biedl syndrome 16	Enrichment	AKT3	2.14
91	Colorectal cancer	Enrichment	AXIN2, BAX, TP53	2.10
92	Rasopathy	Enrichment	MAP2K1, MAP2K2	2.09
93	Bladder cancer	Enrichment	CDKN1A, TP53	2.09
94	Mycosis fungoides	Enrichment	TNFRSF1B	2.05
95	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.05
96	Psoriatic arthritis	Enrichment	TNF	2.05
97	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.05
98	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.05
99	Migraine without aura	Enrichment	TNF	2.05
100	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	2.05
101	Vogt-koyanagi-harada disease	Enrichment	FAS	2.05
102	Saczary syndrome	Enrichment	TNFRSF1B	2.05
103	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.03
104	Spondyloepimetaphyseal dysplasia, x-linked, with hypomyelinating leukodystrophy	Enrichment	AIFM1	2.03
105	Charcot-marie-tooth disease, x-linked recessive, 4, with or without cerebellar ataxia	Enrichment	AIFM1	2.03
106	Combined oxidative phosphorylation deficiency 6	Enrichment	AIFM1	2.03
107	Cervical cancer	Enrichment	TP53	2.03
108	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.03
109	Lymphoma, hodgkin, classic	Enrichment	TP53	2.03
110	Congenital fibrosarcoma	Enrichment	TP53	2.03
111	Li-fraumeni syndrome 1	Enrichment	TP53	2.03
112	Sarcoma	Enrichment	TP53	2.03
113	Cervix carcinoma	Enrichment	TP53	2.03
114	Hodgkin's lymphoma	Enrichment	TP53	2.03
115	Charcot-marie-tooth disease x-linked recessive 4	Enrichment	AIFM1	2.03
116	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.03
117	Maturity-onset diabetes of the young, type 1	Enrichment	GCK	1.98
118	Diabetes mellitus, permanent neonatal, 1	Enrichment	GCK	1.98
119	Bone marrow failure syndrome 2	Enrichment	GCK	1.98
120	Tafro syndrome	Enrichment	MAP2K2	1.98
121	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.97
122	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.97
123	Cerebral malaria	Enrichment	TNF	1.93
124	Spinal muscular atrophy, type iii	Enrichment	NAIP	1.85
125	Spinal muscular atrophy, type i	Enrichment	NAIP	1.85
126	Spinal muscular atrophy, type ii	Enrichment	NAIP	1.85
127	Osteogenic sarcoma	Enrichment	TP53	1.85
128	Deafness, x-linked 5, with peripheral neuropathy	Enrichment	AIFM1	1.85
129	X-linked deafness 5	Enrichment	AIFM1	1.85
130	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.85
131	Anaplastic astrocytoma	Enrichment	TP53	1.85
132	Squamous cell carcinoma	Enrichment	TP53	1.85
133	Adenocarcinoma	Enrichment	TP53	1.85
134	Combined oxidative phosphorylation deficiency	Enrichment	AIFM1	1.85
135	Bone osteosarcoma	Enrichment	TP53	1.85
136	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.84
137	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.84
138	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.84
139	Congenital generalized lipodystrophy	Enrichment	FOS	1.84
140	Follicular lymphoma	Enrichment	BCL2	1.83
141	Vascular dementia	Enrichment	TNF	1.83
142	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.83
143	Nijmegen breakage syndrome	Enrichment	GCK	1.81
144	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.81
145	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.81
146	Gastric cancer	Enrichment	CASP10, TP53	1.76
147	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.76
148	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.76
149	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.75
150	Histiocytoid hemangioma	Enrichment	FOS	1.75
151	Hemimegalencephaly	Enrichment	AKT3	1.75
152	Endometrial stromal sarcoma	Enrichment	YWHAE	1.75
153	Small cell cancer of the lung	Enrichment	TP53	1.73
154	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.73
155	Lung sarcomatoid carcinoma	Enrichment	TP53	1.73
156	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.73
157	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.73
158	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	1.73
159	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF	1.69
160	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.68
161	Maturity-onset diabetes of the young, type 3	Enrichment	GCK	1.68
162	Breast adenocarcinoma	Enrichment	AKT1	1.67
163	Kidney clear cell sarcoma	Enrichment	YWHAE	1.67
164	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.63
165	Rhabdomyosarcoma 2	Enrichment	TP53	1.63
166	Lymphoma	Enrichment	TP53	1.63
167	Acute megakaryocytic leukemia	Enrichment	TP53	1.63
168	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.63
169	Megacolon	Enrichment	AKT3	1.60
170	Charge syndrome	Enrichment	TNFRSF1A	1.58
171	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	CRADD	1.58
172	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1, TP53	1.56
173	Li-fraumeni syndrome	Enrichment	TP53	1.55
174	Adrenocortical carcinoma	Enrichment	TP53	1.55
175	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GCK	1.51
176	Nonsyndromic genetic hyperinsulinism	Enrichment	GCK	1.51
177	Asthma	Enrichment	TNF	1.50
178	Combined immunodeficiency	Enrichment	CD27	1.50
179	Combined t cell and b cell immunodeficiency	Enrichment	CD27	1.50
180	Combined t and b cell immunodeficiency	Enrichment	CD27	1.50
181	Cowden syndrome	Enrichment	AKT1	1.49
182	Esophageal cancer	Enrichment	TP53	1.49
183	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.49
184	Essential thrombocythemia	Enrichment	TP53	1.49
185	Gallbladder cancer	Enrichment	TP53	1.49
186	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.49
187	Polymicrogyria	Enrichment	AKT3	1.45
188	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.44
189	Glioma susceptibility 1	Enrichment	TP53	1.43
190	Alzheimer's disease	Enrichment	TNF	1.42
191	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.41
192	Multiple sclerosis	Enrichment	TNFRSF1A	1.39
193	Permanent neonatal diabetes mellitus	Enrichment	GCK	1.39
194	Tooth agenesis, selective, 1	Enrichment	AXIN2	1.38
195	Primary hyperaldosteronism	Enrichment	TP53	1.38
196	Primary biliary cholangitis	Enrichment	TNFSF15	1.38
197	Meningioma	Enrichment	AKT1	1.37
198	Arteriovenous malformation	Enrichment	MAP2K1	1.34
199	Leukemia, chronic lymphocytic	Enrichment	TP53	1.34
200	Familial colorectal cancer	Enrichment	TP53	1.34
201	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.31
202	Myelodysplastic syndrome	Enrichment	TP53	1.29
203	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.29
204	Ovarian cancer	Enrichment	AKT1, MAP3K1	1.29
205	Early-onset parkinson's disease	Enrichment	HTRA2	1.26
206	Lip and oral cavity carcinoma	Enrichment	TP53	1.26
207	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.25
208	Diabetes mellitus	Enrichment	GCK	1.25
209	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.20
210	Heart, malformation of	Enrichment	MAPK1	1.20
211	Lung cancer susceptibility 3	Enrichment	TP53	1.19
212	Malaria	Enrichment	TNF	1.18
213	Microcephaly	Enrichment	MAPK1, YWHAG	1.14
214	Rhabdomyosarcoma	Enrichment	TP53	1.14
215	Severe covid-19	Enrichment	CASP10	1.09
216	Diffuse large b-cell lymphoma	Enrichment	TP53	1.07
217	Peripheral nervous system disease	Enrichment	NGF	1.04
218	Neuropathy	Enrichment	NGF	1.04
219	Leukodystrophy	Enrichment	AIFM1	1.04
220	Hepatoblastoma	Enrichment	TP53	1.02
221	Tooth agenesis	Enrichment	AXIN2	1.00
222	Maturity-onset diabetes of the young	Enrichment	GCK	1.00
223	Diamond-blackfan anemia 1	Enrichment	TP53	0.99
224	Ear malformation	Enrichment	AIFM1	0.97
225	Systemic lupus erythematosus	Enrichment	TNF	0.96
226	Pancreatic cancer	Enrichment	TP53	0.95
227	Severe combined immunodeficiency	Enrichment	IKBKB	0.95
228	Auditory neuropathy	Enrichment	AIFM1	0.94
229	Hirschsprung disease 1	Enrichment	AXIN2	0.89
230	Prostate cancer	Enrichment	TP53	0.89
231	Inherited cancer-predisposing syndrome	Enrichment	AXIN2, TP53	0.89
232	Type 2 diabetes mellitus	Enrichment	AKT2	0.85
233	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIABLO	0.85
234	Hereditary breast carcinoma	Enrichment	AKT1	0.83
235	Diamond-blackfan anemia	Enrichment	TP53	0.80
236	Autosomal recessive non-syndromic intellectual disability	Enrichment	CRADD	0.80
237	Leukemia, acute myeloid	Enrichment	TP53	0.76
238	Charcot-marie-tooth disease	Enrichment	HSPB1	0.75
239	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	0.74
240	Sensorineural hearing loss	Enrichment	AIFM1	0.69
241	Thrombocytopenia	Enrichment	CYCS	0.69
242	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.68
243	Myeloma, multiple	Enrichment	TP53	0.63
244	Schizophrenia	Enrichment	BIRC6	0.61
245	Autism spectrum disorder	Enrichment	MAP2K1	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Death Receptor Signaling Pathway

Pathway Network for Death Receptor Signaling Pathway

Pathway network for the Death Receptor Signaling Pathway SuperPath

Member Pathways for Death Receptor Signaling Pathway

Pathways in the Death Receptor Signaling Pathway SuperPath

Gene overlap in member pathways for Death Receptor Signaling Pathway SuperPath

Associated Genes for Death Receptor Signaling Pathway

Associated Disorders for Death Receptor Signaling Pathway

Disorders associated with Death Receptor Signaling Pathway SuperPath

STRING Interaction Network for Death Receptor Signaling Pathway

Sources for Death Receptor Signaling Pathway