Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations

Sources:

#	Name	Source	Genes
1	Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Reactome	ATRX DAXX
2	Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations	Reactome	ATRX DAXX
3	Alternative Lengthening of Telomeres (ALT)	Reactome	ATRX DAXX
4	Diseases of Telomere Maintenance	Reactome	ATRX DAXX
5	Defective Inhibition of DNA Recombination at Telomere	Reactome	ATRX DAXX

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DAXX	Death Domain Associated Protein	Protein Coding	5
2	ATRX	ATRX Chromatin Remodeler	Protein Coding	5

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Intellectual disability-hypotonic facies syndrome, x-linked, 1	Enrichment	ATRX	3.83
2	Gastric neuroendocrine neoplasm	Enrichment	ATRX	3.83
3	Alpha-thalassemia myelodysplasia syndrome	Enrichment	ATRX	3.53
4	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ATRX	3.53
5	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ATRX	3.53
6	Alpha thalassemia-intellectual disability syndrome type 1	Enrichment	ATRX	3.35
7	Atypical teratoid rhabdoid tumor	Enrichment	ATRX	3.35
8	Anaplastic astrocytoma	Enrichment	ATRX	3.35
9	Primary hyperaldosteronism	Enrichment	ATRX	2.88
10	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	ATRX	2.08
11	Congenital nervous system abnormality	Enrichment	ATRX	1.81
12	Nervous system disease	Enrichment	ATRX	1.81
13	Microcephaly	Enrichment	ATRX	1.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations