Defective Intrinsic Pathway for Apoptosis

Pathway network for the Defective Intrinsic Pathway for Apoptosis SuperPath

Sources:

Reactome

Pathways in the Defective Intrinsic Pathway for Apoptosis SuperPath

#	Name	Source	Genes
1	Defective Intrinsic Pathway for Apoptosis	Reactome	APP BCL2L11 C1QBP CAPN1 CAPN2 CAPNS1 CAPNS2 CAST CDC25A CDC25B CDC25C CDK5 CDK5R1 CDKN2A FOXO3 GOLGA2 JUN LMNA LMNB1 PRDX1 PRDX2 SOD2 TP53 YWHAE (see all 24) (see less)
2	Neurodegenerative Diseases	Reactome	APP BCL2L11 CAPN1 CAPN2 CAPNS1 CAPNS2 CAST CDC25A CDC25B CDC25C CDK5 CDK5R1 FOXO3 GOLGA2 JUN LMNA LMNB1 PRDX1 PRDX2 SOD2 YWHAE (see all 21) (see less)
3	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Reactome	APP BCL2L11 CAPN1 CAPN2 CAPNS1 CAPNS2 CAST CDC25A CDC25B CDC25C CDK5 CDK5R1 FOXO3 GOLGA2 JUN LMNA LMNB1 PRDX1 PRDX2 SOD2 YWHAE (see all 21) (see less)

Gene overlap in member pathways for Defective Intrinsic Pathway for Apoptosis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL2L11	BCL2 Like 11	Protein Coding	3
2	CDK5	Cyclin Dependent Kinase 5	Protein Coding	3
3	FOXO3	Forkhead Box O3	Protein Coding	3
4	GOLGA2	Golgin A2	Protein Coding	3
5	APP	Amyloid Beta Precursor Protein	Protein Coding	3
6	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
7	LMNA	Lamin A/C	Protein Coding	3
8	LMNB1	Lamin B1	Protein Coding	3
9	PRDX1	Peroxiredoxin 1	Protein Coding	3
10	SOD2	Superoxide Dismutase 2	Protein Coding	3
11	PRDX2	Peroxiredoxin 2	Protein Coding	3
12	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	3
13	CAPN1	Calpain 1	Protein Coding	3
14	CAPN2	Calpain 2	Protein Coding	3
15	CAPNS1	Calpain Small Subunit 1	Protein Coding	3
16	CAST	Calpastatin	Protein Coding	3
17	CAPNS2	Calpain Small Subunit 2	Protein Coding	3
18	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	3
19	CDC25A	Cell Division Cycle 25A	Protein Coding	3
20	CDC25B	Cell Division Cycle 25B	Protein Coding	3
21	CDC25C	Cell Division Cycle 25C	Protein Coding	3
22	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
23	C1QBP	Complement C1q Binding Protein	Protein Coding	1
24	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with Defective Intrinsic Pathway for Apoptosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer's disease	Direct
2	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	4.35
3	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	4.35
4	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	4.20
5	Lip and oral cavity carcinoma	Enrichment	CDKN2A, TP53	3.71
6	Neuromuscular disease	Enrichment	GOLGA2, LMNA	3.46
7	Pancreatic cancer	Enrichment	CDKN2A, TP53	3.06
8	Bladder cancer	Enrichment	CDKN2A, TP53	2.93
9	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.81
10	Microvascular complications of diabetes 6	Enrichment	SOD2	2.81
11	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.81
12	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.81
13	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.81
14	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.81
15	Developmental delay with hypotonia, myopathy, and brain abnormalities	Enrichment	GOLGA2	2.81
16	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.81
17	Atypical werner syndrome	Enrichment	LMNA	2.81
18	Mandibuloacral dysplasia	Enrichment	LMNA	2.81
19	Atrioventricular block	Enrichment	LMNA	2.81
20	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.81
21	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.81
22	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.81
23	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.81
24	Laminopathy	Enrichment	LMNA	2.81
25	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.75
26	Bone marrow failure syndrome 5	Enrichment	TP53	2.75
27	Papilloma of choroid plexus	Enrichment	TP53	2.75
28	Basal cell carcinoma 7	Enrichment	TP53	2.75
29	Anaplastic thyroid carcinoma	Enrichment	TP53	2.75
30	Ductal carcinoma in situ	Enrichment	TP53	2.75
31	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.75
32	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.75
33	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.75
34	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.75
35	Choroid plexus cancer	Enrichment	TP53	2.75
36	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.75
37	Gastric cancer	Enrichment	CDKN2A, TP53	2.59
38	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.51
39	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.51
40	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.51
41	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.51
42	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	Enrichment	CAST	2.51
43	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.51
44	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	2.51
45	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.51
46	Restrictive dermopathy 2	Enrichment	LMNA	2.51
47	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.51
48	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.51
49	Autosomal dominant primary microcephaly	Enrichment	LMNB1	2.51
50	Familial partial lipodystrophy	Enrichment	LMNA	2.51
51	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.51
52	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.45
53	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.45
54	Cervical cancer	Enrichment	TP53	2.45
55	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.45
56	Lymphoma, hodgkin, classic	Enrichment	TP53	2.45
57	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.45
58	Congenital fibrosarcoma	Enrichment	TP53	2.45
59	Li-fraumeni syndrome 1	Enrichment	TP53	2.45
60	Sarcoma	Enrichment	TP53	2.45
61	Cervix carcinoma	Enrichment	TP53	2.45
62	Hodgkin's lymphoma	Enrichment	TP53	2.45
63	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.45
64	Restrictive dermopathy 1	Enrichment	LMNA	2.33
65	Body mass index quantitative trait locus 12	Enrichment	CAST	2.33
66	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	2.33
67	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	2.33
68	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	2.33
69	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	2.33
70	Proprotein convertase 1/3 deficiency	Enrichment	CAST	2.33
71	Restrictive dermopathy	Enrichment	LMNA	2.33
72	Osteogenic sarcoma	Enrichment	TP53	2.28
73	Nasopharyngeal carcinoma	Enrichment	TP53	2.28
74	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.28
75	Anaplastic astrocytoma	Enrichment	TP53	2.28
76	Squamous cell carcinoma	Enrichment	TP53	2.28
77	Adenocarcinoma	Enrichment	TP53	2.28
78	Bone osteosarcoma	Enrichment	TP53	2.28
79	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	2.21
80	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	2.21
81	Microtia-anotia	Enrichment	LMNA	2.21
82	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	2.21
83	Sick sinus syndrome	Enrichment	LMNA	2.21
84	Small cell cancer of the lung	Enrichment	TP53	2.15
85	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.15
86	Lung sarcomatoid carcinoma	Enrichment	TP53	2.15
87	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.15
88	Breast cancer	Enrichment	JUN, TP53	2.11
89	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	2.11
90	Histiocytoid hemangioma	Enrichment	LMNA	2.11
91	Endometrial stromal sarcoma	Enrichment	YWHAE	2.11
92	Rhabdomyosarcoma 2	Enrichment	TP53	2.05
93	Lymphoma	Enrichment	TP53	2.05
94	Acute megakaryocytic leukemia	Enrichment	TP53	2.05
95	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	2.03
96	Kidney clear cell sarcoma	Enrichment	YWHAE	2.03
97	Breast adenocarcinoma	Enrichment	TP53	1.98
98	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.98
99	Bethlem myopathy 1a	Enrichment	LMNA	1.97
100	Alzheimer's disease 1	Enrichment	APP	1.97
101	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.97
102	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	PRDX1	1.91
103	Congenital muscular dystrophy	Enrichment	LMNA	1.91
104	Myocarditis	Enrichment	LMNA	1.91
105	Esophageal cancer	Enrichment	TP53	1.91
106	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.91
107	Essential thrombocythemia	Enrichment	TP53	1.91
108	Gallbladder cancer	Enrichment	TP53	1.91
109	Ovarian cancer	Enrichment	CDKN2A, TP53	1.87
110	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.86
111	Glioma susceptibility 1	Enrichment	TP53	1.85
112	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.85
113	Adult hepatocellular carcinoma	Enrichment	TP53	1.80
114	Primary hyperaldosteronism	Enrichment	TP53	1.80
115	Leukemia, chronic lymphocytic	Enrichment	TP53	1.76
116	Melanoma	Enrichment	CDKN2A	1.76
117	Familial colorectal cancer	Enrichment	TP53	1.76
118	Cardiac conduction defect	Enrichment	LMNA	1.73
119	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.73
120	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.73
121	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.73
122	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.71
123	Myelodysplastic syndrome	Enrichment	TP53	1.71
124	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.67
125	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, TP53	1.65
126	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.61
127	Lung cancer susceptibility 3	Enrichment	TP53	1.61
128	Alzheimer disease, familial, 1	Enrichment	APP	1.58
129	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.58
130	Polycystic liver disease	Enrichment	CDC25A	1.58
131	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.58
132	Rhabdomyosarcoma	Enrichment	TP53	1.55
133	Gliosarcoma	Enrichment	TP53	1.55
134	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.54
135	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.53
136	Giant cell glioblastoma	Enrichment	TP53	1.53
137	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.49
138	Diffuse large b-cell lymphoma	Enrichment	TP53	1.48
139	Hepatoblastoma	Enrichment	TP53	1.44
140	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	1.44
141	Muscular dystrophy	Enrichment	LMNA	1.44
142	Hepatocellular carcinoma	Enrichment	TP53	1.42
143	Brugada syndrome	Enrichment	LMNA	1.40
144	Diamond-blackfan anemia 1	Enrichment	TP53	1.40
145	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	1.40
146	Long qt syndrome	Enrichment	LMNA	1.33
147	Peripheral nervous system disease	Enrichment	LMNA	1.31
148	Neuropathy	Enrichment	LMNA	1.31
149	Prostate cancer	Enrichment	TP53	1.30
150	Left ventricular noncompaction	Enrichment	LMNA	1.28
151	Charcot-marie-tooth disease	Enrichment	LMNA	1.21
152	Diamond-blackfan anemia	Enrichment	TP53	1.21
153	Leukemia, acute myeloid	Enrichment	TP53	1.16
154	Body mass index quantitative trait locus 11	Enrichment	CAST	1.13
155	Hereditary breast carcinoma	Enrichment	TP53	1.12
156	Familial isolated dilated cardiomyopathy	Enrichment	LMNA	1.10
157	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.03
158	Myeloma, multiple	Enrichment	TP53	1.02
159	Dilated cardiomyopathy	Enrichment	LMNA	0.93
160	Colorectal cancer	Enrichment	TP53	0.84
161	Mitochondrial disease	Enrichment	C1QBP	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Defective Intrinsic Pathway for Apoptosis

Pathway Network for Defective Intrinsic Pathway for Apoptosis

Pathway network for the Defective Intrinsic Pathway for Apoptosis SuperPath

Member Pathways for Defective Intrinsic Pathway for Apoptosis

Pathways in the Defective Intrinsic Pathway for Apoptosis SuperPath

Gene overlap in member pathways for Defective Intrinsic Pathway for Apoptosis SuperPath

Associated Genes for Defective Intrinsic Pathway for Apoptosis

Associated Disorders for Defective Intrinsic Pathway for Apoptosis

Disorders associated with Defective Intrinsic Pathway for Apoptosis SuperPath

STRING Interaction Network for Defective Intrinsic Pathway for Apoptosis

Sources for Defective Intrinsic Pathway for Apoptosis