Defective Mismatch Repair Associated With MLH1

No Pathway Network information available for Defective Mismatch Repair Associated With MLH1

#	Name	Source	Genes
1	Defective Mismatch Repair Associated With MLH1	Reactome	MLH1 PMS2
2	Defective Mismatch Repair Associated With PMS2	Reactome	MLH1 PMS2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MLH1	MutL Homolog 1	Protein Coding	2
2	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mismatch repair cancer syndrome 1	Enrichment	MLH1, PMS2	7.19
2	Lynch syndrome 1	Enrichment	MLH1, PMS2	6.31
3	Lynch syndrome	Enrichment	MLH1, PMS2	5.94
4	Endometrial cancer	Enrichment	MLH1, PMS2	5.64
5	Gastric cancer	Enrichment	MLH1, PMS2	5.01
6	Hereditary breast ovarian cancer syndrome	Enrichment	MLH1, PMS2	4.79
7	Breast cancer	Enrichment	MLH1, PMS2	4.52
8	Colorectal cancer	Enrichment	MLH1, PMS2	4.39
9	Inherited cancer-predisposing syndrome	Enrichment	MLH1, PMS2	4.03
10	Lynch syndrome 2	Enrichment	MLH1	3.83
11	Mismatch repair cancer syndrome 4	Enrichment	PMS2	3.83
12	Pituitary cancer	Enrichment	PMS2	3.83
13	Burkitt lymphoma	Enrichment	PMS2	3.53
14	Muir-torre syndrome	Enrichment	MLH1	3.53
15	Lynch syndrome 4	Enrichment	PMS2	3.23
16	Breast-ovarian cancer, familial 2	Enrichment	PMS2	3.13
17	Lymphoma	Enrichment	PMS2	3.13
18	Colonic benign neoplasm	Enrichment	MLH1	2.88
19	Familial colorectal cancer	Enrichment	MLH1	2.83
20	Cardiomyopathy, familial hypertrophic, 9	Enrichment	PMS2	2.79
21	Rhabdomyosarcoma	Enrichment	PMS2	2.63
22	Diffuse large b-cell lymphoma	Enrichment	PMS2	2.55
23	Hepatocellular carcinoma	Enrichment	PMS2	2.49
24	Cardiomyopathy, dilated, 1g	Enrichment	PMS2	2.49
25	Lung cancer	Enrichment	MLH1	2.33
26	Hereditary breast carcinoma	Enrichment	MLH1	2.19
27	Ovarian cancer	Enrichment	PMS2	1.83

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Defective Mismatch Repair Associated With MLH1