Defensins

Pathway network for the Defensins SuperPath

Sources:

Reactome

Pathways in the Defensins SuperPath

#	Name	Source	Genes
1	Defensins	Reactome	ART1 CCR2 CCR6 CD4 DEFA1 DEFA1B DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB109B DEFB110 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130A DEFB130B DEFB131A DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B PRSS2 PRSS3 TLR1 TLR2 (see all 51) (see less)
2	Antimicrobial peptides	Reactome	ART1 ATOX1 ATP7A BPI BPIFA1 BPIFA2 BPIFB1 BPIFB2 BPIFB4 BPIFB6 CAMP CCR2 CCR6 CD4 CHGA CLU CTSG DCD DEFA1 DEFA1B DEFA3 DEFA4 DEFA5 DEFA6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB109B DEFB110 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130A DEFB130B DEFB131A DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B ELANE EPPIN GNLY HTN1 HTN3 ITLN1 LCN2 LEAP2 LTF LYZ PDZD11 PGLYRP1 PGLYRP2 PGLYRP3 PGLYRP4 PI3 PLA2G2A PRSS2 PRSS3 PRTN3 REG3A REG3G RNASE3 RNASE6 RNASE7 RNASE8 S100A7 S100A7A S100A8 S100A9 SEMG1 SLC11A1 TLR1 TLR2 (see all 95) (see less)
3	Beta defensins	Reactome	CCR2 CCR6 DEFB1 DEFB103A DEFB103B DEFB104A DEFB104B DEFB105A DEFB105B DEFB106A DEFB106B DEFB107A DEFB107B DEFB108B DEFB109B DEFB110 DEFB113 DEFB114 DEFB115 DEFB116 DEFB118 DEFB119 DEFB121 DEFB123 DEFB124 DEFB125 DEFB126 DEFB127 DEFB128 DEFB129 DEFB130A DEFB130B DEFB131A DEFB132 DEFB134 DEFB135 DEFB136 DEFB4A DEFB4B TLR1 TLR2 (see all 41) (see less)
4	Alpha-defensins	Reactome	ART1 CD4 DEFA1 DEFA1B DEFA3 DEFA4 DEFA5 DEFA6 PRSS2 PRSS3 (see all 10) (see less)
5	Metal sequestration by antimicrobial proteins	Reactome	LCN2 LTF S100A7 S100A7A S100A8 S100A9 (see all 6) (see less)
6	Ion influx/efflux at host-pathogen interface	Reactome	ATOX1 ATP7A PDZD11 SLC11A1

Gene overlap in member pathways for Defensins SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DEFB130B	Defensin Beta 130B	Protein Coding	3
2	DEFB4B	Defensin Beta 4B	Protein Coding	3
3	DEFB118	Defensin Beta 118	Protein Coding	3
4	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	3
5	DEFB104A	Defensin Beta 104A	Protein Coding	3
6	DEFB127	Defensin Beta 127	Protein Coding	3
7	DEFB129	Defensin Beta 129	Protein Coding	3
8	DEFA1	Defensin Alpha 1	Protein Coding	3
9	DEFA3	Defensin Alpha 3	Protein Coding	3
10	DEFA4	Defensin Alpha 4	Protein Coding	3
11	DEFA5	Defensin Alpha 5	Protein Coding	3
12	DEFA6	Defensin Alpha 6	Protein Coding	3
13	DEFB1	Defensin Beta 1	Protein Coding	3
14	DEFB4A	Defensin Beta 4A	Protein Coding	3
15	DEFB105A	Defensin Beta 105A	Protein Coding	3
16	DEFB106A	Defensin Beta 106A	Protein Coding	3
17	DEFB107A	Defensin Beta 107A	Protein Coding	3
18	DEFB108B	Defensin Beta 108B	Protein Coding	3
19	DEFB110	Defensin Beta 110	Protein Coding	3
20	DEFB113	Defensin Beta 113	Protein Coding	3
21	DEFB114	Defensin Beta 114	Protein Coding	3
22	DEFB115	Defensin Beta 115	Protein Coding	3
23	DEFB116	Defensin Beta 116	Protein Coding	3
24	DEFB119	Defensin Beta 119	Protein Coding	3
25	DEFB121	Defensin Beta 121	Protein Coding	3
26	DEFB123	Defensin Beta 123	Protein Coding	3
27	DEFB124	Defensin Beta 124	Protein Coding	3
28	DEFB125	Defensin Beta 125	Protein Coding	3
29	DEFB128	Defensin Beta 128	Protein Coding	3
30	DEFB130A	Defensin Beta 130A	Protein Coding	3
31	DEFB132	Defensin Beta 132	Protein Coding	3
32	DEFB103A	Defensin Beta 103A	Protein Coding	3
33	ART1	ADP-Ribosyltransferase 1	Protein Coding	3
34	DEFB107B	Defensin Beta 107B	Protein Coding	3
35	DEFB104B	Defensin Beta 104B	Protein Coding	3
36	DEFB106B	Defensin Beta 106B	Protein Coding	3
37	DEFB105B	Defensin Beta 105B	Protein Coding	3
38	DEFB103B	Defensin Beta 103B	Protein Coding	3
39	PRSS2	Serine Protease 2	Protein Coding	3
40	PRSS3	Serine Protease 3	Protein Coding	3
41	DEFB135	Defensin Beta 135	Protein Coding	3
42	DEFB136	Defensin Beta 136	Protein Coding	3
43	DEFB134	Defensin Beta 134	Protein Coding	3
44	DEFB109B	Defensin Beta 109B	Protein Coding	3
45	DEFB131A	Defensin Beta 131A	Protein Coding	3
46	TLR1	Toll Like Receptor 1	Protein Coding	3
47	TLR2	Toll Like Receptor 2	Protein Coding	3
48	DEFA1B	Defensin Alpha 1B	Protein Coding	3
49	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	3
50	DEFB126	Defensin Beta 126	Protein Coding	3
51	CD4	CD4 Molecule	Protein Coding	3
52	S100A7A	S100 Calcium Binding Protein A7A	Protein Coding	2
53	LCN2	Lipocalin 2	Protein Coding	2
54	LTF	Lactotransferrin	Protein Coding	2
55	ATOX1	Antioxidant 1 Copper Chaperone	Protein Coding	2
56	PDZD11	PDZ Domain Containing 11	Protein Coding	2
57	ATP7A	ATPase Copper Transporting Alpha	Protein Coding	2
58	S100A7	S100 Calcium Binding Protein A7	Protein Coding	2
59	S100A8	S100 Calcium Binding Protein A8	Protein Coding	2
60	S100A9	S100 Calcium Binding Protein A9	Protein Coding	2
61	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	2
62	GNLY	Granulysin	Protein Coding	1
63	CHGA	Chromogranin A	Protein Coding	1
64	PGLYRP2	Peptidoglycan Recognition Protein 2	Protein Coding	1
65	PGLYRP3	Peptidoglycan Recognition Protein 3	Protein Coding	1
66	LEAP2	Liver Enriched Antimicrobial Peptide 2	Protein Coding	1
67	DCD	Dermcidin	Protein Coding	1
68	CLU	Clusterin	Protein Coding	1
69	RNASE8	Ribonuclease A Family Member 8	Protein Coding	1
70	BPIFB6	BPI Fold Containing Family B Member 6	Protein Coding	1
71	REG3G	Regenerating Family Member 3 Gamma	Protein Coding	1
72	BPIFA2	BPI Fold Containing Family A Member 2	Protein Coding	1
73	BPIFB4	BPI Fold Containing Family B Member 4	Protein Coding	1
74	CTSG	Cathepsin G	Protein Coding	1
75	ELANE	Elastase, Neutrophil Expressed	Protein Coding	1
76	HTN1	Histatin 1	Protein Coding	1
77	HTN3	Histatin 3	Protein Coding	1
78	LYZ	Lysozyme	Protein Coding	1
79	REG3A	Regenerating Family Member 3 Alpha	Protein Coding	1
80	BPIFA1	BPI Fold Containing Family A Member 1	Protein Coding	1
81	PI3	Peptidase Inhibitor 3	Protein Coding	1
82	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1
83	ITLN1	Intelectin 1	Protein Coding	1
84	PRTN3	Proteinase 3	Protein Coding	1
85	PGLYRP4	Peptidoglycan Recognition Protein 4	Protein Coding	1
86	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	1
87	RNASE3	Ribonuclease A Family Member 3	Protein Coding	1
88	RNASE6	Ribonuclease A Family Member 6	Protein Coding	1
89	SEMG1	Semenogelin 1	Protein Coding	1
90	BPI	Bactericidal Permeability Increasing Protein	Protein Coding	1
91	BPIFB2	BPI Fold Containing Family B Member 2	Protein Coding	1
92	CAMP	Cathelicidin Antimicrobial Peptide	Protein Coding	1
93	RNASE7	Ribonuclease A Family Member 7	Protein Coding	1
94	PGLYRP1	Peptidoglycan Recognition Protein 1	Protein Coding	1
95	BPIFB1	BPI Fold Containing Family B Member 1	Protein Coding	1

Disorders associated with Defensins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neuronopathy, distal hereditary motor, x-linked	Enrichment	ATP7A	3.53
2	Buruli ulcer	Enrichment	SLC11A1	3.53
3	Occipital horn syndrome	Enrichment	ATP7A	3.53
4	Okt4 epitope deficiency	Enrichment	CD4	3.13
5	Immunodeficiency 79	Enrichment	CD4	3.13
6	Menkes disease	Enrichment	ATP7A	3.05
7	Tuberculosis	Enrichment	SLC11A1	2.93
8	Leprosy 3	Enrichment	TLR2	2.52
9	Polycystic lung disease	Enrichment	CCR2	2.52
10	Leprosy 5	Enrichment	TLR1	2.52
11	Immunoglobulin light chain amyloidosis	Enrichment	LYZ	2.15
12	Amyloidosis, hereditary systemic 5	Enrichment	LYZ	2.15
13	Hirschsprung disease 1	Enrichment	ATP7A	2.07
14	Cystic fibrosis	Enrichment	SLC11A1	2.03
15	Pancreatitis, hereditary	Enrichment	PRSS2	1.90
16	Cyclic neutropenia	Enrichment	ELANE	1.86
17	Neutropenia, severe congenital, x-linked	Enrichment	ELANE	1.86
18	Diffuse cutaneous systemic sclerosis	Enrichment	CCR6	1.82
19	Limited scleroderma	Enrichment	CCR6	1.74
20	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	ELANE	1.68
21	Rheumatoid arthritis	Enrichment	TLR1	1.57
22	Amyloidosis, hereditary systemic 2	Enrichment	LYZ	1.46
23	Autosomal dominant severe congenital neutropenia	Enrichment	ELANE	1.46
24	Granulomatosis with polyangiitis	Enrichment	PRTN3	1.38
25	Neutropenia	Enrichment	ELANE	1.32
26	Human immunodeficiency virus type 1	Enrichment	CCR2	1.28
27	Familial colorectal cancer	Enrichment	PLA2G2A	1.17
28	Colorectal cancer	Enrichment	PLA2G2A, TLR2	0.91
29	Autoinflammatory disease	Enrichment	ELANE	0.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Defensins

Pathway network for the Defensins SuperPath

Member Pathways for Defensins

Pathways in the Defensins SuperPath

Gene overlap in member pathways for Defensins SuperPath

Associated Genes for Defensins

Associated Disorders for Defensins

Disorders associated with Defensins SuperPath

STRING Interaction Network for Defensins

Sources for Defensins