Degradation of beta catenin

Pathway network for the Degradation of beta catenin SuperPath

Sources:

PubChem
Reactome

Pathways in the Degradation of beta catenin SuperPath

#	Name	Source	Genes
1	Degradation of beta catenin	PubChem	APC AXIN1 AXIN2 BTRC CTNNB1 CUL1 DVL2 FZD5 LRP6 SKP1 WNT3A (see all 11) (see less)
2	Canonical Wnt signaling pathway	PubChem	APC AXIN1 CAV1 CSNK1G1 CTNNB1 CUL3 DVL2 FZD5 GRK5 KLHL12 LRP6 NKD2 PI4K2A PIP5K1B PPP2R5A RANBP3 WNT3A (see all 17) (see less)
3	APC truncation mutants are not K63 polyubiquitinated	Reactome	APC

Gene overlap in member pathways for Degradation of beta catenin SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	3
2	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	2
3	LRP6	LDL Receptor Related Protein 6	Protein Coding	2
4	FZD5	Frizzled Class Receptor 5	Protein Coding	2
5	WNT3A	Wnt Family Member 3A	Protein Coding	2
6	AXIN1	Axin 1	Protein Coding	2
7	CTNNB1	Catenin Beta 1	Protein Coding	2
8	AXIN2	Axin 2	Protein Coding	1
9	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
10	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	1
11	CUL1	Cullin 1	Protein Coding	1
12	NKD2	NKD Inhibitor Of Wnt Signaling Pathway 2	Protein Coding	1
13	RANBP3	RAN Binding Protein 3	Protein Coding	1
14	CSNK1G1	Casein Kinase 1 Gamma 1	Protein Coding	1
15	PI4K2A	Phosphatidylinositol 4-Kinase Type 2 Alpha	Protein Coding	1
16	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
17	KLHL12	Kelch Like Family Member 12	Protein Coding	1
18	CUL3	Cullin 3	Protein Coding	1
19	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	1
20	GRK5	G Protein-Coupled Receptor Kinase 5	Protein Coding	1
21	CAV1	Caveolin 1	Protein Coding	1

Disorders associated with Degradation of beta catenin SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	6.22
2	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	5.75
3	Desmoid tumor	Enrichment	APC, CTNNB1	5.75
4	Craniopharyngioma	Enrichment	APC, CTNNB1	5.45
5	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	4.67
6	Colorectal cancer	Enrichment	APC, AXIN2, CTNNB1	4.39
7	Medulloblastoma	Enrichment	APC, CTNNB1	4.27
8	Ovarian cancer	Enrichment	APC, AXIN2, CTNNB1	4.20
9	Familial adenomatous polyposis	Enrichment	APC	4.13
10	Gardner syndrome	Enrichment	APC	4.13
11	5q22 microdeletion syndrome	Enrichment	APC	4.13
12	Attenuated familial adenomatous polyposis	Enrichment	APC	4.13
13	Polycystic liver disease	Enrichment	CTNNB1, LRP6	4.09
14	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP6	4.09
15	Hepatoblastoma	Enrichment	APC, CTNNB1	3.90
16	Tooth agenesis	Enrichment	AXIN2, LRP6	3.86
17	Periampullary adenoma	Enrichment	APC	3.83
18	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	3.83
19	Cenani-lenz syndactyly syndrome	Enrichment	APC	3.66
20	Colon adenocarcinoma	Enrichment	APC	3.66
21	Apc-associated polyposis conditions	Enrichment	APC	3.66
22	Familial adenomatous polyposis 1	Enrichment	APC	3.43
23	Colonic benign neoplasm	Enrichment	APC	3.18
24	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	3.09
25	Tooth agenesis, selective, 7	Enrichment	LRP6	3.09
26	Caudal duplication anomaly	Enrichment	AXIN1	3.09
27	Exudative vitreoretinopathy 8	Enrichment	LRP6	3.09
28	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	3.09
29	Microphthalmia/coloboma 11	Enrichment	FZD5	3.09
30	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	3.09
31	Adenoid ameloblastoma	Enrichment	CTNNB1	3.09
32	Microcystic stromal tumor	Enrichment	CTNNB1	3.09
33	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.90
34	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.90
35	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.90
36	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.90
37	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.90
38	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.79
39	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.79
40	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.79
41	Teratoma	Enrichment	CTNNB1	2.79
42	Osteoporosis, juvenile	Enrichment	WNT3A	2.61
43	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.61
44	Anus, imperforate	Enrichment	CTNNB1	2.61
45	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.61
46	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	2.60
47	Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities	Enrichment	PI4K2A	2.60
48	Gastric cancer	Enrichment	APC	2.50
49	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	2.49
50	Pilomatrixoma	Enrichment	CTNNB1	2.49
51	Alazami syndrome	Enrichment	CTNNB1	2.49
52	Orofacial cleft	Enrichment	LRP6	2.49
53	Eyelid coloboma	Enrichment	FZD5	2.49
54	Orofacial clefting syndrome	Enrichment	LRP6	2.49
55	Lens coloboma	Enrichment	FZD5	2.49
56	Hereditary breast carcinoma	Enrichment	APC	2.49
57	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	2.43
58	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.39
59	Coloboma of choroid and retina	Enrichment	FZD5	2.39
60	Coloboma of optic nerve	Enrichment	FZD5	2.31
61	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.31
62	Adrenocortical carcinoma	Enrichment	CTNNB1	2.31
63	Inherited cancer-predisposing syndrome	Enrichment	APC, AXIN2	2.31
64	Breast cancer	Enrichment	APC	2.26
65	Gallbladder cancer	Enrichment	CTNNB1	2.25
66	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	2.20
67	Exudative vitreoretinopathy	Enrichment	CTNNB1	2.19
68	Isolated split hand-split foot malformation	Enrichment	BTRC	2.19
69	Tooth agenesis, selective, 1	Enrichment	AXIN2	2.14
70	Limited scleroderma	Enrichment	CAV1	2.13
71	Cat eye syndrome	Enrichment	FZD5	2.09
72	Microphthalmia/coloboma 12	Enrichment	FZD5	1.98
73	Coloboma of macula	Enrichment	FZD5	1.92
74	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.86
75	Nk-cell enteropathy	Enrichment	CUL3	1.79
76	Bladder cancer	Enrichment	CTNNB1	1.63
77	Hirschsprung disease 1	Enrichment	AXIN2	1.63
78	Congenital nervous system abnormality	Enrichment	CTNNB1	1.08
79	Nervous system disease	Enrichment	CTNNB1	1.08
80	Microcephaly	Enrichment	CTNNB1	1.02
81	Autism spectrum disorder	Enrichment	CUL3	0.89
82	Complex neurodevelopmental disorder	Enrichment	CUL3	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Degradation of beta catenin

Pathway Network for Degradation of beta catenin

Pathway network for the Degradation of beta catenin SuperPath

Member Pathways for Degradation of beta catenin

Pathways in the Degradation of beta catenin SuperPath

Gene overlap in member pathways for Degradation of beta catenin SuperPath

Associated Genes for Degradation of beta catenin

Associated Disorders for Degradation of beta catenin

Disorders associated with Degradation of beta catenin SuperPath

STRING Interaction Network for Degradation of beta catenin

Sources for Degradation of beta catenin