Dendritic Cells Developmental Lineage Pathway

No Pathway Network information available for Dendritic Cells Developmental Lineage Pathway

Pathways in the Dendritic Cells Developmental Lineage Pathway SuperPath

#	Name	Source	Genes
1	Dendritic Cells Developmental Lineage Pathway	R&D Systems	ADGRE1 BATF3 CD14 CD163 CD19 CD1A CD1C CD1D CD207 CD209 CD244 CD34 CD38 CD3E CD4 CD48 CD83 CD8A CDH1 CLEC4C CLEC9A CSF1 CSF1R CSF2 CX3CR1 EPCAM FLT3 FLT3LG GFI1 ID2 IFNA2 IFNB1 IFNG IKZF1 IL10 IL12A IL17RA IL1B IL2 IL23A IL3RA IL6 IL7R IRF2 IRF4 IRF8 ITGAE ITGAM ITGAX KIT KLF4 LAMP2 LY75 MME MS4A1 NCAM1 NRP1 PTPRC RELB RUNX2 RUNX3 SELL SIRPA SLAMF1 SPI1 SPIB SPN TGFB1 THBD THY1 TLR7 TLR9 TNF XCR1 (see all 74) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD34	CD34 Molecule	Protein Coding	1
2	CD38	CD38 Molecule	Protein Coding	1
3	SPN	Sialophorin	Protein Coding	1
4	THY1	Thy-1 Cell Surface Antigen	Protein Coding	1
5	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
6	MME	Membrane Metalloendopeptidase	Protein Coding	1
7	IL7R	Interleukin 7 Receptor	Protein Coding	1
8	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	1
9	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
10	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
11	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
12	CX3CR1	C-X3-C Motif Chemokine Receptor 1	Protein Coding	1
13	SPIB	Spi-B Transcription Factor	Protein Coding	1
14	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
15	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
16	CLEC4C	C-Type Lectin Domain Family 4 Member C	Protein Coding	1
17	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
18	NRP1	Neuropilin 1	Protein Coding	1
19	TLR7	Toll Like Receptor 7	Protein Coding	1
20	TLR9	Toll Like Receptor 9	Protein Coding	1
21	IFNA2	Interferon Alpha 2	Protein Coding	1
22	IFNB1	Interferon Beta 1	Protein Coding	1
23	IL6	Interleukin 6	Protein Coding	1
24	TNF	Tumor Necrosis Factor	Protein Coding	1
25	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	1
26	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
27	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
28	CD14	CD14 Molecule	Protein Coding	1
29	CD19	CD19 Molecule	Protein Coding	1
30	MS4A1	Membrane Spanning 4-Domains A1	Protein Coding	1
31	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	1
32	CD1C	CD1c Molecule	Protein Coding	1
33	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
34	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1
35	IL1B	Interleukin 1 Beta	Protein Coding	1
36	IL10	Interleukin 10	Protein Coding	1
37	BATF3	Basic Leucine Zipper ATF-Like Transcription Factor 3	Protein Coding	1
38	CD1A	CD1a Molecule	Protein Coding	1
39	CLEC9A	C-Type Lectin Domain Containing 9A	Protein Coding	1
40	THBD	Thrombomodulin	Protein Coding	1
41	XCR1	X-C Motif Chemokine Receptor 1	Protein Coding	1
42	IL12A	Interleukin 12A	Protein Coding	1
43	CD209	CD209 Molecule	Protein Coding	1
44	GFI1	Growth Factor Independent 1 Transcriptional Repressor	Protein Coding	1
45	SELL	Selectin L	Protein Coding	1
46	CD163	CD163 Molecule	Protein Coding	1
47	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	1
48	CSF1	Colony Stimulating Factor 1	Protein Coding	1
49	CD83	CD83 Molecule	Protein Coding	1
50	CDH1	Cadherin 1	Protein Coding	1
51	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	1
52	CD207	CD207 Molecule	Protein Coding	1
53	SLAMF1	Signaling Lymphocytic Activation Molecule Family Member 1	Protein Coding	1
54	CD244	CD244 Molecule	Protein Coding	1
55	CD48	CD48 Molecule	Protein Coding	1
56	KLF4	KLF Transcription Factor 4	Protein Coding	1
57	LAMP2	Lysosomal Associated Membrane Protein 2	Protein Coding	1
58	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	1
59	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
60	IL17RA	Interleukin 17 Receptor A	Protein Coding	1
61	CD4	CD4 Molecule	Protein Coding	1
62	CD8A	CD8 Subunit Alpha	Protein Coding	1
63	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
64	CD1D	CD1d Molecule	Protein Coding	1
65	LY75	Lymphocyte Antigen 75	Protein Coding	1
66	ITGAE	Integrin Subunit Alpha E	Protein Coding	1
67	IKZF1	IKAROS Family Zinc Finger 1	Protein Coding	1
68	IRF2	Interferon Regulatory Factor 2	Protein Coding	1
69	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
70	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
71	CSF2	Colony Stimulating Factor 2	Protein Coding	1
72	IFNG	Interferon Gamma	Protein Coding	1
73	IL2	Interleukin 2	Protein Coding	1
74	ADGRE1	Adhesion G Protein-Coupled Receptor E1	Protein Coding	1

Disorders associated with Dendritic Cells Developmental Lineage Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus type 1	Enrichment	CD209, CX3CR1, IFNG, IL10	5.63
2	Immunodeficiency 104, severe combined	Enrichment	IL7R, PTPRC	4.53
3	Systemic lupus erythematosus	Enrichment	IL10, ITGAM, TLR7, TNF	4.24
4	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	3.76
5	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	3.54
6	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	3.54
7	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, TGFB1	3.36
8	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3, IKZF1	3.22
9	Breast cancer	Enrichment	CDH1, EPCAM, IL2, IL7R	3.13
10	Severe combined immunodeficiency	Enrichment	CD3E, IL7R, PTPRC	3.12
11	Rheumatoid arthritis	Enrichment	CD244, IL10	2.99
12	Primary biliary cholangitis	Enrichment	IL12A, SPIB	2.99
13	Leukemia, acute lymphoblastic	Enrichment	FLT3, IKZF1	2.81
14	Gastric cancer	Enrichment	CDH1, EPCAM, IL1B	2.78
15	Alzheimer's disease	Enrichment	CSF1R, TNF	2.66
16	Behcet syndrome	Enrichment	IL10, IL12A	2.33
17	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.26
18	Birbeck granule deficiency	Enrichment	CD207	2.26
19	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.26
20	Mastocytosis, cutaneous	Enrichment	KIT	2.26
21	Hemolytic uremic syndrome, atypical 6	Enrichment	THBD	2.26
22	Spinocerebellar ataxia 43	Enrichment	MME	2.26
23	Immunodeficiency 116	Enrichment	CD8A	2.26
24	Immunodeficiency 32a	Enrichment	IRF8	2.26
25	Immunodeficiency 69	Enrichment	IFNG	2.26
26	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.26
27	Immunodeficiency 131	Enrichment	IRF4	2.26
28	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.26
29	Okt4 epitope deficiency	Enrichment	CD4	2.26
30	Graft-versus-host disease	Enrichment	IL10	2.26
31	X-linked immunodeficiency 74	Enrichment	TLR7	2.26
32	Danon disease	Enrichment	LAMP2	2.26
33	Systemic lupus erythematosus 17	Enrichment	TLR7	2.26
34	Immunodeficiency 18	Enrichment	CD3E	2.26
35	Thrombophilia due to thrombomodulin defect	Enrichment	THBD	2.26
36	Dengue virus	Enrichment	CD209	2.26
37	Lynch syndrome 8	Enrichment	EPCAM	2.26
38	Immunodeficiency, common variable, 3	Enrichment	CD19	2.26
39	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.26
40	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.26
41	Macular degeneration, age-related, 12	Enrichment	CX3CR1	2.26
42	Immunodeficiency, common variable, 5	Enrichment	MS4A1	2.26
43	Psoriasis	Enrichment	IL17RA	2.26
44	Immunodeficiency, common variable, 13	Enrichment	IKZF1	2.26
45	Immunodeficiency 53	Enrichment	RELB	2.26
46	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.26
47	Immunodeficiency 79	Enrichment	CD4	2.26
48	Cd45 deficiency	Enrichment	PTPRC	2.26
49	Chronic mast cell leukemia	Enrichment	KIT	2.26
50	Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization	Enrichment	MME	2.26
51	Csf1r-related disorder	Enrichment	CSF1R	2.26
52	Combined immunodeficiency due to dimerization defective ikaros mutation	Enrichment	IKZF1	2.26
53	Immunodeficiency 125	Enrichment	FLT3LG	2.26
54	Charcot-marie-tooth disease type 2t	Enrichment	MME	2.26
55	Mme-related autosomal dominant charcot marie tooth disease type 2	Enrichment	MME	2.26
56	Breast lobular carcinoma	Enrichment	CDH1	2.26
57	Agammaglobulinemia	Enrichment	SPI1	2.26
58	Isolated bone marrow mastocytosis	Enrichment	KIT	2.26
59	Smoldering systemic mastocytosis	Enrichment	KIT	2.26
60	Mastocytosis	Enrichment	KIT	2.26
61	Early-onset combined immunodeficiency with low ig due to dominant negative ikaros mutation	Enrichment	IKZF1	2.26
62	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.26
63	Whipple disease	Enrichment	IRF4	2.26
64	Cutaneous mastocytoma	Enrichment	KIT	2.26
65	Typical urticaria pigmentosa	Enrichment	KIT	2.26
66	T-b+ severe combined immunodeficiency due to il-7ralpha deficiency	Enrichment	IL7R	2.26
67	Nodular urticaria pigmentosa	Enrichment	KIT	2.26
68	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.26
69	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.26
70	Acute mast cell leukemia	Enrichment	KIT	2.26
71	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.26
72	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.26
73	Testis seminoma	Enrichment	KIT	2.26
74	Multisystem inflammatory syndrome in children	Enrichment	CD163, IFNB1	2.20
75	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.96
76	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	1.96
77	Camurati-engelmann disease 1	Enrichment	TGFB1	1.96
78	Immunodeficiency 32b	Enrichment	IRF8	1.96
79	Neutropenia, nonimmune chronic idiopathic, of adults	Enrichment	GFI1	1.96
80	Piebald trait	Enrichment	KIT	1.96
81	Neutropenia, severe congenital, 2, autosomal dominant	Enrichment	GFI1	1.96
82	Diarrhea 5, with tufting enteropathy, congenital	Enrichment	EPCAM	1.96
83	Immunodeficiency 51	Enrichment	IL17RA	1.96
84	Diamond-blackfan anemia-like	Enrichment	IKZF1	1.96
85	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.96
86	Immunodeficiency 127	Enrichment	TNF	1.96
87	Stevens-johnson syndrome	Enrichment	IKZF1	1.96
88	Camurati-engelmann disease	Enrichment	TGFB1	1.96
89	Multiple sclerosis 3	Enrichment	IL7R	1.96
90	Charcot-marie-tooth disease, axonal, type 2t	Enrichment	MME	1.96
91	Acute myeloid leukemia without maturation	Enrichment	FLT3	1.96
92	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19	1.96
93	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.96
94	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.96
95	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.79
96	Tuberous sclerosis 1	Enrichment	IFNG	1.79
97	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.79
98	Psoriatic arthritis	Enrichment	TNF	1.79
99	Hepatitis c virus	Enrichment	IFNG	1.79
100	Tuberous sclerosis 2	Enrichment	IFNG	1.79
101	Testicular germ cell cancer	Enrichment	KIT	1.79
102	Cleidocranial dysplasia	Enrichment	RUNX2	1.79
103	Migraine without aura	Enrichment	TNF	1.79
104	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.79
105	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3E	1.79
106	Leukemia, acute myeloid	Enrichment	FLT3, KIT	1.70
107	Kaposi sarcoma	Enrichment	IL6	1.66
108	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.66
109	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.66
110	Cerebral malaria	Enrichment	TNF	1.66
111	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.66
112	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.66
113	Hereditary breast carcinoma	Enrichment	CDH1, EPCAM	1.62
114	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.57
115	Vascular dementia	Enrichment	TNF	1.57
116	Autosomal dominant severe congenital neutropenia	Enrichment	GFI1	1.57
117	Idiopathic aplastic anemia	Enrichment	IFNG	1.57
118	Type 1 diabetes mellitus	Enrichment	IL6	1.49
119	Testicular germ cell tumor	Enrichment	KIT	1.49
120	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.49
121	Chronic mucocutaneous candidiasis	Enrichment	IL17RA	1.49
122	Cleft lip with or without cleft palate	Enrichment	CDH1	1.49
123	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	THBD	1.49
124	Inherited cancer-predisposing syndrome	Enrichment	CDH1, EPCAM, KIT	1.45
125	Myeloma, multiple	Enrichment	FLT3, IL7R	1.43
126	Gastrointestinal stromal tumor	Enrichment	KIT	1.43
127	Inflammatory bowel disease 1	Enrichment	IL6	1.32
128	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.32
129	Colonic benign neoplasm	Enrichment	EPCAM	1.32
130	Lynch syndrome 1	Enrichment	EPCAM	1.27
131	Omenn syndrome	Enrichment	IL7R	1.27
132	Aplastic anemia	Enrichment	IFNG	1.27
133	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.27
134	Immune deficiency disease	Enrichment	IKZF1	1.23
135	Asthma	Enrichment	TNF	1.23
136	Frontotemporal dementia 1	Enrichment	CSF1R	1.23
137	Lip and oral cavity carcinoma	Enrichment	KIT	1.20
138	Cleft lip/palate	Enrichment	CDH1	1.13
139	Lynch syndrome	Enrichment	EPCAM	1.10
140	Colorectal cancer	Enrichment	CDH1, EPCAM	1.09
141	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.05
142	Arteriovenous malformations of the brain	Enrichment	IL6	1.01
143	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MME	1.01
144	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	1.01
145	Ovarian cancer	Enrichment	CDH1, KIT	0.98
146	Endometrial cancer	Enrichment	CDH1	0.96
147	Malaria	Enrichment	TNF	0.93
148	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	0.93
149	Prostate cancer	Enrichment	CDH1	0.83
150	Cystic fibrosis	Enrichment	TGFB1	0.79
151	Peripheral nervous system disease	Enrichment	MME	0.79
152	Neuropathy	Enrichment	MME	0.79
153	Familial hypertrophic cardiomyopathy	Enrichment	LAMP2	0.78
154	Left ventricular noncompaction	Enrichment	LAMP2	0.76
155	Type 2 diabetes mellitus	Enrichment	IL6	0.69
156	Nephrotic syndrome	Enrichment	RUNX2	0.68
157	Hypertrophic cardiomyopathy	Enrichment	LAMP2	0.68
158	Thrombocytopenia	Enrichment	THBD	0.64
159	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.56
160	Dilated cardiomyopathy	Enrichment	LAMP2	0.45

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Dendritic Cells Developmental Lineage Pathway

Pathway Network for Dendritic Cells Developmental Lineage Pathway

Member Pathways for Dendritic Cells Developmental Lineage Pathway

Pathways in the Dendritic Cells Developmental Lineage Pathway SuperPath

Associated Genes for Dendritic Cells Developmental Lineage Pathway

Associated Disorders for Dendritic Cells Developmental Lineage Pathway

Disorders associated with Dendritic Cells Developmental Lineage Pathway SuperPath

STRING Interaction Network for Dendritic Cells Developmental Lineage Pathway

Sources for Dendritic Cells Developmental Lineage Pathway