Detoxification of Reactive Oxygen Species

Pathway network for the Detoxification of Reactive Oxygen Species SuperPath

Sources:

Reactome
PubChem
PharmGKB

Pathways in the Detoxification of Reactive Oxygen Species SuperPath

#	Name	Source	Genes
1	Detoxification of Reactive Oxygen Species	Reactome	AQP8 ATOX1 ATP7A CAT CCS CYBA CYBB ERO1A GPX1 GPX2 GPX3 GPX5 GPX6 GPX7 GPX8 GSR GSTP1 NCF1 NCF2 NCF4 NOX4 NOX5 NUDT2 P4HB PRDX1 PRDX2 PRDX3 PRDX5 PRDX6 SOD1 SOD2 SOD3 TXN TXN2 TXNRD1 TXNRD2 (see all 36) (see less)
2	reactive oxygen species degradation	PubChem	CAT GPX1 GPX2 GPX3 SOD1 SOD2 SOD3 (see all 7) (see less)
3	Oxidative Stress Regulatory Pathway (Erythrocyte)	PharmGKB	CAT GPX1 GSR PRDX2 SOD1 TXN TXNRD1 (see all 7) (see less)

Gene overlap in member pathways for Detoxification of Reactive Oxygen Species SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GPX1	Glutathione Peroxidase 1	Protein Coding	3
2	SOD1	Superoxide Dismutase 1	Protein Coding	3
3	CAT	Catalase	Protein Coding	3
4	GPX2	Glutathione Peroxidase 2	Protein Coding	2
5	GPX3	Glutathione Peroxidase 3	Protein Coding	2
6	GSR	Glutathione-Disulfide Reductase	Protein Coding	2
7	SOD2	Superoxide Dismutase 2	Protein Coding	2
8	SOD3	Superoxide Dismutase 3	Protein Coding	2
9	PRDX2	Peroxiredoxin 2	Protein Coding	2
10	TXN	Thioredoxin	Protein Coding	2
11	TXNRD1	Thioredoxin Reductase 1	Protein Coding	2
12	TXNRD2	Thioredoxin Reductase 2	Protein Coding	1
13	PRDX3	Peroxiredoxin 3	Protein Coding	1
14	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	1
15	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
16	GPX6	Glutathione Peroxidase 6	Protein Coding	1
17	PRDX5	Peroxiredoxin 5	Protein Coding	1
18	TXN2	Thioredoxin 2	Protein Coding	1
19	GPX5	Glutathione Peroxidase 5	Protein Coding	1
20	GPX7	Glutathione Peroxidase 7	Protein Coding	1
21	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
22	ERO1A	Endoplasmic Reticulum Oxidoreductase 1 Alpha	Protein Coding	1
23	NUDT2	Nudix Hydrolase 2	Protein Coding	1
24	AQP8	Aquaporin 8	Protein Coding	1
25	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	1
26	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	1
27	ATOX1	Antioxidant 1 Copper Chaperone	Protein Coding	1
28	GPX8	Glutathione Peroxidase 8 (Putative)	Protein Coding	1
29	P4HB	Prolyl 4-Hydroxylase Subunit Beta	Protein Coding	1
30	NOX4	NADPH Oxidase 4	Protein Coding	1
31	PRDX1	Peroxiredoxin 1	Protein Coding	1
32	ATP7A	ATPase Copper Transporting Alpha	Protein Coding	1
33	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1
34	NOX5	NADPH Oxidase 5	Protein Coding	1
35	PRDX6	Peroxiredoxin 6	Protein Coding	1
36	CCS	Copper Chaperone For Superoxide Dismutase	Protein Coding	1

Disorders associated with Detoxification of Reactive Oxygen Species SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	10.49
2	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	4.69
3	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	4.39
4	Microvascular complications of diabetes 6	Enrichment	SOD2	3.29
5	Acatalasemia	Enrichment	CAT	3.29
6	Glutathione peroxidase deficiency	Enrichment	GPX1	3.29
7	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	3.29
8	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.99
9	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	2.59
10	Cole-carpenter syndrome 1	Enrichment	P4HB	2.58
11	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.58
12	Neuronopathy, distal hereditary motor, x-linked	Enrichment	ATP7A	2.58
13	Immunodeficiency 34	Enrichment	CYBB	2.58
14	Spinocerebellar ataxia, autosomal recessive 32	Enrichment	PRDX3	2.58
15	Combined oxidative phosphorylation deficiency 29	Enrichment	TXN2	2.58
16	Occipital horn syndrome	Enrichment	ATP7A	2.58
17	Glucocorticoid deficiency 5	Enrichment	TXNRD2	2.58
18	Corneal dystrophy, punctiform and polychromatic pre-descemet	Enrichment	PRDX3	2.58
19	Intellectual developmental disorder with or without peripheral neuropathy	Enrichment	NUDT2	2.58
20	Motor neuron disease	Enrichment	SOD1	2.44
21	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	2.29
22	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	2.28
23	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	2.28
24	Albinism, oculocutaneous, type ia	Enrichment	NOX4	2.28
25	Kala-azar 2	Enrichment	GSTP1	2.28
26	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	2.10
27	Menkes disease	Enrichment	ATP7A	2.10
28	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	2.10
29	Cole-carpenter syndrome	Enrichment	P4HB	2.10
30	Autosomal recessive cerebellar ataxia	Enrichment	PRDX3	1.88
31	Familial glucocorticoid deficiency	Enrichment	TXNRD2	1.88
32	Osteogenesis imperfecta, type i	Enrichment	P4HB	1.80
33	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	PRDX1	1.68
34	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.63
35	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	1.53
36	Williams-beuren syndrome	Enrichment	NCF1	1.29
37	Hirschsprung disease 1	Enrichment	ATP7A	1.13
38	Familial isolated dilated cardiomyopathy	Enrichment	TXNRD2	0.88

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Detoxification of Reactive Oxygen Species

Pathway Network for Detoxification of Reactive Oxygen Species

Pathway network for the Detoxification of Reactive Oxygen Species SuperPath

Member Pathways for Detoxification of Reactive Oxygen Species

Pathways in the Detoxification of Reactive Oxygen Species SuperPath

Gene overlap in member pathways for Detoxification of Reactive Oxygen Species SuperPath

Associated Genes for Detoxification of Reactive Oxygen Species

Associated Disorders for Detoxification of Reactive Oxygen Species

Disorders associated with Detoxification of Reactive Oxygen Species SuperPath

STRING Interaction Network for Detoxification of Reactive Oxygen Species

Sources for Detoxification of Reactive Oxygen Species