Deubiquitination

No Pathway Network information available for Deubiquitination

Pathways in the Deubiquitination SuperPath

#	Name	Source	Genes
1	Deubiquitination	Reactome	ABRAXAS1 ABRAXAS2 ACTB ACTL6A ACTR5 ACTR8 ADRB2 ADRM1 APC AR ARRB1 ARRB2 ASXL1 ASXL2 ATXN3 ATXN3L ATXN7 AXIN1 AXIN2 BABAM1 BABAM2 BAP1 BARD1 BECN1 BIRC2 BIRC3 BRCA1 BRCC3 CCNA1 CCNA2 CCP110 CDC20 CDC25A CDK1 CFTR CLSPN CYLD DDB2 EP300 ESR1 FKBP8 FOXK1 FOXK2 FOXO4 GATA3 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 HCFC1 HGS HIF1A IDE IFIH1 IKBKG IL33 INO80 INO80B INO80C INO80D INO80E JOSD1 JOSD2 KAT2A KAT2B KDM1B KEAP1 MAP3K7 MAT2B MAVS MBD5 MBD6 MCRS1 MDM2 MDM4 MUL1 MYC MYSM1 NEDD8 NFKBIA NFRKB NLRP3 NOD1 NOD2 OTUB1 OTUB2 OTUD3 OTUD5 OTUD7A POLB PRKN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTEN PTRH2 RAD23A RAD23B RCE1 RHOA RHOT1 RIGI RIPK1 RIPK2 RNF123 RNF128 RNF135 RNF146 RPS27A RUVBL1 SEM1 SENP8 SIAH2 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNX3 STAM STAM2 STAMBP STAMBPL1 SUDS3 TAB1 TADA2B TADA3 TAF10 TAF9B TFPT TGFB1 TGFBR1 TGFBR2 TNFAIP3 TNIP1 TNIP2 TNIP3 TNKS TNKS2 TOMM20 TOMM70 TP53 TRAF2 TRAF3 TRAF6 TRIM25 TRIM4 TRRAP UBA52 UBB UBC UBE2D1 UCHL1 UCHL3 UCHL5 UFD1 UIMC1 USP10 USP12 USP13 USP14 USP15 USP16 USP17L1 USP17L10 USP17L11 USP17L12 USP17L13 USP17L15 USP17L17 USP17L18 USP17L19 USP17L2 USP17L20 USP17L21 USP17L22 USP17L24 USP17L25 USP17L26 USP17L27 USP17L28 USP17L29 USP17L3 USP17L30 USP17L4 USP17L5 USP17L8 USP18 USP19 USP20 USP22 USP24 USP25 USP26 USP28 USP3 USP30 USP33 USP34 USP37 USP42 USP44 USP47 USP48 USP49 USP5 USP7 USP8 USP9X VCP VCPIP1 VDAC1 VDAC2 VDAC3 WDR20 WDR48 YOD1 YY1 ZRANB1 (see all 279) (see less)
2	Ub-specific processing proteases	Reactome	ADRB2 ADRM1 AR ARRB1 ARRB2 ATXN7 AXIN1 AXIN2 BECN1 BIRC2 BIRC3 CCNA1 CCNA2 CCP110 CDC20 CDC25A CFTR CLSPN CYLD DDB2 FKBP8 FOXO4 GATA3 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 HGS HIF1A IDE IFIH1 IKBKG IL33 KAT2A KEAP1 MAP3K7 MAT2B MDM2 MDM4 MUL1 MYC NFKBIA OTUB1 POLB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTEN PTRH2 RCE1 RHOT1 RIGI RIPK1 RNF123 RNF128 RNF146 RPS27A RUVBL1 SEM1 SIAH2 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMURF2 SNX3 STAM2 SUDS3 TAB1 TADA2B TADA3 TAF10 TAF9B TGFBR1 TNKS TNKS2 TOMM20 TOMM70 TP53 TRAF2 TRAF6 TRRAP UBA52 UBB UBC UFD1 USP10 USP12 USP13 USP14 USP15 USP16 USP17L1 USP17L10 USP17L11 USP17L12 USP17L13 USP17L15 USP17L17 USP17L18 USP17L19 USP17L2 USP17L20 USP17L21 USP17L22 USP17L24 USP17L25 USP17L26 USP17L27 USP17L28 USP17L29 USP17L3 USP17L30 USP17L4 USP17L5 USP17L8 USP18 USP19 USP20 USP22 USP24 USP25 USP26 USP28 USP3 USP30 USP33 USP34 USP37 USP42 USP44 USP47 USP48 USP49 USP5 USP7 USP8 USP9X VDAC1 VDAC2 VDAC3 WDR20 WDR48 (see all 203) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	USP17L10	Ubiquitin Specific Peptidase 17 Like Family Member 10	Protein Coding	2
2	USP17L11	Ubiquitin Specific Peptidase 17 Like Family Member 11	Protein Coding	2
3	USP17L12	Ubiquitin Specific Peptidase 17 Like Family Member 12	Protein Coding	2
4	USP17L13	Ubiquitin Specific Peptidase 17 Like Family Member 13	Protein Coding	2
5	USP17L17	Ubiquitin Specific Peptidase 17 Like Family Member 17	Protein Coding	2
6	USP17L18	Ubiquitin Specific Peptidase 17 Like Family Member 18	Protein Coding	2
7	USP17L19	Ubiquitin Specific Peptidase 17 Like Family Member 19	Protein Coding	2
8	USP17L20	Ubiquitin Specific Peptidase 17 Like Family Member 20	Protein Coding	2
9	USP17L21	Ubiquitin Specific Peptidase 17 Like Family Member 21	Protein Coding	2
10	USP17L22	Ubiquitin Specific Peptidase 17 Like Family Member 22	Protein Coding	2
11	USP17L15	Ubiquitin Specific Peptidase 17 Like Family Member 15	Protein Coding	2
12	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
13	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	2
14	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
15	TADA3	Transcriptional Adaptor 3	Protein Coding	2
16	USP16	Ubiquitin Specific Peptidase 16	Protein Coding	2
17	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	2
18	USP20	Ubiquitin Specific Peptidase 20	Protein Coding	2
19	USP19	Ubiquitin Specific Peptidase 19	Protein Coding	2
20	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
21	USP18	Ubiquitin Specific Peptidase 18	Protein Coding	2
22	H2BC26	H2B Clustered Histone 26	Protein Coding	2
23	ADRB2	Adrenoceptor Beta 2	Protein Coding	2
24	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	2
25	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	2
26	USP12	Ubiquitin Specific Peptidase 12	Protein Coding	2
27	H2AC1	H2A Clustered Histone 1	Protein Coding	2
28	USP33	Ubiquitin Specific Peptidase 33	Protein Coding	2
29	USP22	Ubiquitin Specific Peptidase 22	Protein Coding	2
30	USP24	Ubiquitin Specific Peptidase 24	Protein Coding	2
31	RIGI	RNA Sensor RIG-I	Protein Coding	2
32	FKBP8	FKBP Prolyl Isomerase 8	Protein Coding	2
33	H2BC1	H2B Clustered Histone 1	Protein Coding	2
34	USP49	Ubiquitin Specific Peptidase 49	Protein Coding	2
35	GATA3	GATA Binding Protein 3	Protein Coding	2
36	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	2
37	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	2
38	USP25	Ubiquitin Specific Peptidase 25	Protein Coding	2
39	H2AC8	H2A Clustered Histone 8	Protein Coding	2
40	H2AC7	H2A Clustered Histone 7	Protein Coding	2
41	H2BC5	H2B Clustered Histone 5	Protein Coding	2
42	H2BC3	H2B Clustered Histone 3	Protein Coding	2
43	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	2
44	H2AC21	H2A Clustered Histone 21	Protein Coding	2
45	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	2
46	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	2
47	IDE	Insulin Degrading Enzyme	Protein Coding	2
48	AR	Androgen Receptor	Protein Coding	2
49	USP17L2	Ubiquitin Specific Peptidase 17 Like Family Member 2	Protein Coding	2
50	USP17L8	Ubiquitin Specific Peptidase 17 Like Family Member 8	Protein Coding	2
51	USP17L1	Ubiquitin Specific Peptidase 17 Like Family Member 1	Protein Coding	2
52	ARRB1	Arrestin Beta 1	Protein Coding	2
53	SMAD1	SMAD Family Member 1	Protein Coding	2
54	SMAD2	SMAD Family Member 2	Protein Coding	2
55	SMAD3	SMAD Family Member 3	Protein Coding	2
56	SMAD4	SMAD Family Member 4	Protein Coding	2
57	ARRB2	Arrestin Beta 2	Protein Coding	2
58	SMAD7	SMAD Family Member 7	Protein Coding	2
59	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
60	MDM4	MDM4 Regulator Of P53	Protein Coding	2
61	FOXO4	Forkhead Box O4	Protein Coding	2
62	H2BC18	H2B Clustered Histone 18	Protein Coding	2
63	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
64	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
65	TAF9B	TATA-Box Binding Protein Associated Factor 9b	Protein Coding	2
66	PTRH2	Peptidyl-TRNA Hydrolase 2	Protein Coding	2
67	POLB	DNA Polymerase Beta	Protein Coding	2
68	USP47	Ubiquitin Specific Peptidase 47	Protein Coding	2
69	RHOT1	Ras Homolog Family Member T1	Protein Coding	2
70	OTUB1	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1	Protein Coding	2
71	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
72	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
73	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
74	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
75	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
76	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
77	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
78	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
79	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
80	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
81	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
82	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
83	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
84	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
85	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
86	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
87	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
88	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
89	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
90	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
91	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
92	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
93	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
94	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
95	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
96	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
97	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
98	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
99	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
100	WDR48	WD Repeat Domain 48	Protein Coding	2
101	USP28	Ubiquitin Specific Peptidase 28	Protein Coding	2
102	USP37	Ubiquitin Specific Peptidase 37	Protein Coding	2
103	RPS27A	Ribosomal Protein S27a	Protein Coding	2
104	ATXN7	Ataxin 7	Protein Coding	2
105	RNF123	Ring Finger Protein 123	Protein Coding	2
106	CLSPN	Claspin	Protein Coding	2
107	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	2
108	SUDS3	SIN3A Corepressor Complex Component SDS3	Protein Coding	2
109	USP17L4	Ubiquitin Specific Peptidase 17 Like Family Member 4	Protein Coding	2
110	USP17L3	Ubiquitin Specific Peptidase 17 Like Family Member 3	Protein Coding	2
111	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	2
112	SIAH2	Siah E3 Ubiquitin Protein Ligase 2	Protein Coding	2
113	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	2
114	TAF10	TATA-Box Binding Protein Associated Factor 10	Protein Coding	2
115	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
116	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	2
117	TP53	Tumor Protein P53	Protein Coding	2
118	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
119	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
120	H2AC19	H2A Clustered Histone 19	Protein Coding	2
121	USP17L24	Ubiquitin Specific Peptidase 17 Like Family Member 24	Protein Coding	2
122	USP17L25	Ubiquitin Specific Peptidase 17 Like Family Member 25	Protein Coding	2
123	USP17L26	Ubiquitin Specific Peptidase 17 Like Family Member 26	Protein Coding	2
124	USP17L5	Ubiquitin Specific Peptidase 17 Like Family Member 5	Protein Coding	2
125	USP17L27	Ubiquitin Specific Peptidase 17 Like Family Member 27	Protein Coding	2
126	USP17L28	Ubiquitin Specific Peptidase 17 Like Family Member 28	Protein Coding	2
127	USP17L29	Ubiquitin Specific Peptidase 17 Like Family Member 29	Protein Coding	2
128	USP17L30	Ubiquitin Specific Peptidase 17 Like Family Member 30	Protein Coding	2
129	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
130	UBB	Ubiquitin B	Protein Coding	2
131	UBC	Ubiquitin C	Protein Coding	2
132	UFD1	Ubiquitin Recognition Factor In ER Associated Degradation 1	Protein Coding	2
133	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	2
134	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	2
135	VDAC3	Voltage Dependent Anion Channel 3	Protein Coding	2
136	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	2
137	RNF128	Ring Finger Protein 128	Protein Coding	2
138	MUL1	Mitochondrial E3 Ubiquitin Protein Ligase 1	Protein Coding	2
139	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
140	TNKS2	Tankyrase 2	Protein Coding	2
141	USP5	Ubiquitin Specific Peptidase 5	Protein Coding	2
142	RNF146	Ring Finger Protein 146	Protein Coding	2
143	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	2
144	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	2
145	AXIN1	Axin 1	Protein Coding	2
146	AXIN2	Axin 2	Protein Coding	2
147	H2AC13	H2A Clustered Histone 13	Protein Coding	2
148	H2AC15	H2A Clustered Histone 15	Protein Coding	2
149	H2AC14	H2A Clustered Histone 14	Protein Coding	2
150	H2AC16	H2A Clustered Histone 16	Protein Coding	2
151	H2AC6	H2A Clustered Histone 6	Protein Coding	2
152	H2AC4	H2A Clustered Histone 4	Protein Coding	2
153	H2AC17	H2A Clustered Histone 17	Protein Coding	2
154	H2AC18	H2A Clustered Histone 18	Protein Coding	2
155	H2AC20	H2A Clustered Histone 20	Protein Coding	2
156	H2BC8	H2B Clustered Histone 8	Protein Coding	2
157	H2BC13	H2B Clustered Histone 13	Protein Coding	2
158	H2BC15	H2B Clustered Histone 15	Protein Coding	2
159	H2BC14	H2B Clustered Histone 14	Protein Coding	2
160	H2BC7	H2B Clustered Histone 7	Protein Coding	2
161	H2BC6	H2B Clustered Histone 6	Protein Coding	2
162	H2BC9	H2B Clustered Histone 9	Protein Coding	2
163	H2BC10	H2B Clustered Histone 10	Protein Coding	2
164	H2BC4	H2B Clustered Histone 4	Protein Coding	2
165	H2BC17	H2B Clustered Histone 17	Protein Coding	2
166	H2BC21	H2B Clustered Histone 21	Protein Coding	2
167	USP26	Ubiquitin Specific Peptidase 26	Protein Coding	2
168	USP44	Ubiquitin Specific Peptidase 44	Protein Coding	2
169	USP42	Ubiquitin Specific Peptidase 42	Protein Coding	2
170	USP48	Ubiquitin Specific Peptidase 48	Protein Coding	2
171	USP30	Ubiquitin Specific Peptidase 30	Protein Coding	2
172	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
173	H2AC12	H2A Clustered Histone 12	Protein Coding	2
174	H2BC12	H2B Clustered Histone 12	Protein Coding	2
175	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	2
176	TNKS	Tankyrase	Protein Coding	2
177	BECN1	Beclin 1	Protein Coding	2
178	SNX3	Sorting Nexin 3	Protein Coding	2
179	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	2
180	CCNA2	Cyclin A2	Protein Coding	2
181	CCNA1	Cyclin A1	Protein Coding	2
182	H2AC11	H2A Clustered Histone 11	Protein Coding	2
183	H2BC11	H2B Clustered Histone 11	Protein Coding	2
184	USP13	Ubiquitin Specific Peptidase 13	Protein Coding	2
185	IL33	Interleukin 33	Protein Coding	2
186	USP14	Ubiquitin Specific Peptidase 14	Protein Coding	2
187	USP10	Ubiquitin Specific Peptidase 10	Protein Coding	2
188	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	2
189	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	2
190	WDR20	WD Repeat Domain 20	Protein Coding	2
191	H2AC25	H2A Clustered Histone 25	Protein Coding	2
192	TADA2B	Transcriptional Adaptor 2B	Protein Coding	2
193	USP34	Ubiquitin Specific Peptidase 34	Protein Coding	2
194	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	2
195	TOMM20	Translocase Of Outer Mitochondrial Membrane 20	Protein Coding	2
196	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	2
197	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
198	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	2
199	CDC20	Cell Division Cycle 20	Protein Coding	2
200	CDC25A	Cell Division Cycle 25A	Protein Coding	2
201	USP15	Ubiquitin Specific Peptidase 15	Protein Coding	2
202	USP3	Ubiquitin Specific Peptidase 3	Protein Coding	2
203	RCE1	Ras Converting CAAX Endopeptidase 1	Protein Coding	2
204	TNIP1	TNFAIP3 Interacting Protein 1	Protein Coding	1
205	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	1
206	MCRS1	Microspherule Protein 1	Protein Coding	1
207	STAMBP	STAM Binding Protein	Protein Coding	1
208	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
209	MBD6	Methyl-CpG Binding Domain Protein 6	Protein Coding	1
210	MYSM1	Myb Like, SWIRM And MPN Domains 1	Protein Coding	1
211	SENP8	SUMO Peptidase Family Member, NEDD8 Specific	Protein Coding	1
212	INO80C	INO80 Complex Subunit C	Protein Coding	1
213	JOSD2	Josephin Domain Containing 2	Protein Coding	1
214	OTUD7A	OTU Deubiquitinase 7A	Protein Coding	1
215	ASXL1	ASXL Transcriptional Regulator 1	Protein Coding	1
216	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
217	ESR1	Estrogen Receptor 1	Protein Coding	1
218	KDM1B	Lysine Demethylase 1B	Protein Coding	1
219	FOXK1	Forkhead Box K1	Protein Coding	1
220	ABRAXAS2	Abraxas 2, BRISC Complex Subunit	Protein Coding	1
221	OTUD3	OTU Deubiquitinase 3	Protein Coding	1
222	INO80E	INO80 Complex Subunit E	Protein Coding	1
223	BABAM1	BRISC And BRCA1 A Complex Member 1	Protein Coding	1
224	TFPT	TCF3 Fusion Partner	Protein Coding	1
225	HCFC1	Host Cell Factor C1	Protein Coding	1
226	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
227	FOXK2	Forkhead Box K2	Protein Coding	1
228	RHOA	Ras Homolog Family Member A	Protein Coding	1
229	ATXN3	Ataxin 3	Protein Coding	1
230	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	1
231	NFRKB	Nuclear Factor Related To KappaB Binding Protein	Protein Coding	1
232	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
233	UCHL5	Ubiquitin C-Terminal Hydrolase L5	Protein Coding	1
234	UIMC1	Ubiquitin Interaction Motif Containing 1	Protein Coding	1
235	INO80	INO80 Complex ATPase Subunit	Protein Coding	1
236	ZRANB1	Zinc Finger RANBP2-Type Containing 1	Protein Coding	1
237	INO80D	INO80 Complex Subunit D	Protein Coding	1
238	ASXL2	ASXL Transcriptional Regulator 2	Protein Coding	1
239	YOD1	YOD1 Deubiquitinase	Protein Coding	1
240	OTUD5	OTU Deubiquitinase 5	Protein Coding	1
241	MBD5	Methyl-CpG Binding Domain Protein 5	Protein Coding	1
242	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
243	STAMBPL1	STAM Binding Protein Like 1	Protein Coding	1
244	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	1
245	RAD23A	RAD23 Nucleotide Excision Repair Protein A	Protein Coding	1
246	RAD23B	RAD23 Nucleotide Excision Repair Protein B	Protein Coding	1
247	ACTB	Actin Beta	Protein Coding	1
248	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	1
249	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
250	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
251	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
252	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
253	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
254	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
255	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	1
256	UCHL3	Ubiquitin C-Terminal Hydrolase L3	Protein Coding	1
257	VCP	Valosin Containing Protein	Protein Coding	1
258	YY1	YY1 Transcription Factor	Protein Coding	1
259	TRIM25	Tripartite Motif Containing 25	Protein Coding	1
260	OTUB2	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2	Protein Coding	1
261	TNIP2	TNFAIP3 Interacting Protein 2	Protein Coding	1
262	BRCC3	BRCA1/BRCA2-Containing Complex Subunit 3	Protein Coding	1
263	ACTR5	Actin Related Protein 5	Protein Coding	1
264	TNIP3	TNFAIP3 Interacting Protein 3	Protein Coding	1
265	VCPIP1	Valosin Containing Protein Interacting Protein 1	Protein Coding	1
266	STAM	Signal Transducing Adaptor Molecule	Protein Coding	1
267	BAP1	BRCA1 Associated Deubiquitinase 1	Protein Coding	1
268	INO80B	INO80 Complex Subunit B	Protein Coding	1
269	ABRAXAS1	Abraxas 1, BRCA1 A Complex Subunit	Protein Coding	1
270	RNF135	Ring Finger Protein 135	Protein Coding	1
271	ACTL6A	Actin Like 6A	Protein Coding	1
272	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
273	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
274	TRIM4	Tripartite Motif Containing 4	Protein Coding	1
275	ATXN3L	Ataxin 3 Like	Protein Coding	1
276	ACTR8	Actin Related Protein 8	Protein Coding	1
277	BABAM2	BRISC And BRCA1 A Complex Member 2	Protein Coding	1
278	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
279	JOSD1	Josephin Domain Containing 1	Protein Coding	1

Disorders associated with Deubiquitination SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	5.07
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFBR1, TGFBR2	4.69
3	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	3.65
4	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	3.65
5	Gastric cancer	Enrichment	APC, BARD1, BRCA1, PTEN, SMAD4, TP53	3.64
6	Primary hyperaldosteronism	Enrichment	TP53, USP48, USP8	3.59
7	Hereditary breast carcinoma	Enrichment	APC, BARD1, BRCA1, ESR1, PTEN, TP53	3.58
8	Inherited cancer-predisposing syndrome	Enrichment	ABRAXAS1, APC, AXIN2, BAP1, BARD1, BRCA1, CYLD, PTEN, SMAD4, TP53	3.40
9	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.38
10	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	3.18
11	Breast cancer	Enrichment	ABRAXAS1, APC, BARD1, BRCA1, ESR1, PTEN, TP53	3.06
12	Myeloma, multiple	Enrichment	BAP1, BARD1, CYLD, H2AC16, H2AC17, TP53	3.01
13	Ovarian cancer	Enrichment	APC, AR, AXIN2, BARD1, BRCA1, PRKN, PTEN, TP53	2.95
14	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	2.88
15	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFBR1, TGFBR2	2.70
16	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	2.66
17	Prostate cancer	Enrichment	AR, BRCA1, PTEN, TP53	2.56
18	Li-fraumeni syndrome	Enrichment	MDM2, TP53	2.49
19	Rhabdomyosarcoma	Enrichment	BRCA1, PTEN, TP53	2.40
20	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	2.35
21	Gallbladder cancer	Enrichment	SMAD4, TP53	2.35
22	Hereditary breast ovarian cancer syndrome	Enrichment	BARD1, BRCA1, PTEN, RIPK1, TP53	2.27
23	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1, TGFB1	2.22
24	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1, TGFB1	2.22
25	Adult hepatocellular carcinoma	Enrichment	AXIN1, TP53	2.13
26	Esophageal cancer	Enrichment	TGFBR2, TP53	2.08
27	Endometrial cancer	Enrichment	BARD1, BRCA1, PTEN	2.06
28	Hepatoblastoma	Enrichment	APC, BARD1, TP53	2.06
29	Colorectal cancer	Enrichment	APC, AXIN2, BRCA1, EP300, SMAD4, TP53	2.04
30	Hepatocellular carcinoma	Enrichment	APC, AXIN1, TP53	2.00
31	Glioma susceptibility 1	Enrichment	BAP1, TP53	1.96
32	Male infertility	Enrichment	AR, CFTR, USP26	1.85
33	Pancreatic cancer	Enrichment	BRCA1, SMAD4, TP53	1.85
34	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	1.82
35	Spermatogenic failure, x-linked, 6	Enrichment	USP26	1.82
36	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	1.82
37	Vacterl association with hydrocephalus	Enrichment	PTEN	1.82
38	Androgen insensitivity, partial	Enrichment	AR	1.82
39	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	1.82
40	Incontinentia pigmenti	Enrichment	IKBKG	1.82
41	Microphthalmia, syndromic 8	Enrichment	SNX3	1.82
42	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	1.82
43	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.82
44	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.82
45	Caudal duplication anomaly	Enrichment	AXIN1	1.82
46	Singleton-merten syndrome 1	Enrichment	IFIH1	1.82
47	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	1.82
48	Accelerated tumor formation	Enrichment	MDM2	1.82
49	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	1.82
50	Immunodeficiency 95	Enrichment	IFIH1	1.82
51	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	1.82
52	Lessel-kubisch syndrome	Enrichment	MDM2	1.82
53	Bone marrow failure syndrome 6	Enrichment	MDM4	1.82
54	Bone marrow failure syndrome 5	Enrichment	TP53	1.82
55	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.82
56	Stankiewicz-isidor syndrome	Enrichment	PSMD12	1.82
57	Papilloma of choroid plexus	Enrichment	TP53	1.82
58	Basal cell carcinoma 7	Enrichment	TP53	1.82
59	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	1.82
60	Type 1 diabetes mellitus 19	Enrichment	IFIH1	1.82
61	Anaplastic thyroid carcinoma	Enrichment	TP53	1.82
62	Papillary tumor of the pineal region	Enrichment	PTEN	1.82
63	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	1.82
64	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.82
65	Colorectal cancer 3	Enrichment	SMAD7	1.82
66	Glioma susceptibility 2	Enrichment	PTEN	1.82
67	Deafness, autosomal dominant 85	Enrichment	USP48	1.82
68	Ductal carcinoma in situ	Enrichment	TP53	1.82
69	Deafness, autosomal dominant 75	Enrichment	TRRAP	1.82
70	Singleton-merten syndrome 2	Enrichment	RIGI	1.82
71	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	1.82
72	Pseudo-torch syndrome 2	Enrichment	USP18	1.82
73	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	1.82
74	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.82
75	Autosomal recessive spastic paraplegia type 60	Enrichment	WDR48	1.82
76	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	1.82
77	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.82
78	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	1.82
79	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.82
80	Heritable thoracic aortic disease	Enrichment	SMAD4	1.82
81	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	1.82
82	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	1.82
83	Epilepsy, idiopathic generalized 19	Enrichment	USP25	1.82
84	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.82
85	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	1.82
86	Choroid plexus cancer	Enrichment	TP53	1.82
87	Complete androgen insensitivity syndrome	Enrichment	AR	1.82
88	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.82
89	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	1.82
90	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	1.77
91	Myelodysplastic syndrome	Enrichment	ASXL1, TP53	1.69
92	Uterine corpus cancer	Enrichment	BRCA1, PTEN	1.69
93	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	1.69
94	Torticollis	Enrichment	ACTL6A	1.69
95	Baraitser-winter syndrome 1	Enrichment	ACTB	1.69
96	Cinca syndrome	Enrichment	NLRP3	1.69
97	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	1.69
98	Melanoma, uveal 2	Enrichment	BAP1	1.69
99	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	1.69
100	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	1.69
101	Leprosy 2	Enrichment	PRKN	1.69
102	Blau syndrome	Enrichment	NOD2	1.69
103	Muckle-wells syndrome	Enrichment	NLRP3	1.69
104	Shashi-pena syndrome	Enrichment	ASXL2	1.69
105	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	1.69
106	Bone marrow failure syndrome 4	Enrichment	MYSM1	1.69
107	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.69
108	Immunodeficiency 132a	Enrichment	TRAF3	1.69
109	Immunodeficiency 132b	Enrichment	TRAF3	1.69
110	Multiple congenital anomalies-neurodevelopmental syndrome, x-linked	Enrichment	OTUD5	1.69
111	Infant-type hemispheric glioma	Enrichment	BRCA1	1.69
112	Becker nevus syndrome	Enrichment	ACTB	1.69
113	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.69
114	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.69
115	Parkinson disease 5, autosomal dominant	Enrichment	UCHL1	1.69
116	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	1.69
117	Mbd5 haploinsufficiency	Enrichment	MBD5	1.69
118	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.69
119	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.69
120	Neurodevelopmental disorder with hypotonia and seizures	Enrichment	OTUD7A	1.69
121	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.69
122	Multisystem proteinopathy	Enrichment	VCP	1.69
123	Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome	Enrichment	BRCC3	1.69
124	Baraitser-winter syndrome	Enrichment	ACTB	1.69
125	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	1.69
126	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	1.69
127	Congenital progressive bone marrow failure-b-cell immunodeficiency-skeletal dysplasia syndrome	Enrichment	MYSM1	1.69
128	Familial adenomatous polyposis	Enrichment	APC	1.69
129	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.69
130	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.69
131	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	1.69
132	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	1.69
133	Gardner syndrome	Enrichment	APC	1.69
134	5q22 microdeletion syndrome	Enrichment	APC	1.69
135	Attenuated familial adenomatous polyposis	Enrichment	APC	1.69
136	Primary peritoneal carcinoma	Enrichment	BRCA1	1.69
137	Bladder cancer	Enrichment	BRCA1, PTEN, TP53	1.67
138	Gliosarcoma	Enrichment	NFKBIA, TP53	1.63
139	Early-onset parkinson's disease	Enrichment	PRKN, UCHL1	1.61
140	Meningioma	Enrichment	BAP1, PTEN	1.61
141	Autism spectrum disorder	Enrichment	ASXL1, ASXL2, MBD5, PRKN, PTEN, RNF135	1.60
142	Polycystic liver disease	Enrichment	CDC25A, RUVBL1	1.58
143	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	1.58
144	Autosomal dominant polycystic liver disease	Enrichment	CDC25A, RUVBL1	1.58
145	Spinocerebellar ataxia 7	Enrichment	ATXN7	1.53
146	Burkitt lymphoma	Enrichment	MYC	1.53
147	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.53
148	Cylindromatosis, familial	Enrichment	CYLD	1.53
149	Myhre syndrome	Enrichment	SMAD4	1.53
150	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.53
151	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	1.53
152	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	1.53
153	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	1.53
154	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	1.53
155	Cervical cancer	Enrichment	TP53	1.53
156	Immunodeficiency 33	Enrichment	IKBKG	1.53
157	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	1.53
158	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.53
159	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.53
160	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	KEAP1	1.53
161	Lymphoma, hodgkin, classic	Enrichment	TP53	1.53
162	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.53
163	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	1.53
164	Birk-aharoni syndrome	Enrichment	PSMC1	1.53
165	46,xy sex reversal 1	Enrichment	AR	1.53
166	Androgen insensitivity syndrome	Enrichment	AR	1.53
167	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	1.53
168	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.53
169	Brooke-spiegler syndrome	Enrichment	CYLD	1.53
170	Hypospadias 1, x-linked	Enrichment	AR	1.53
171	Congenital fibrosarcoma	Enrichment	TP53	1.53
172	Li-fraumeni syndrome 1	Enrichment	TP53	1.53
173	Sarcoma	Enrichment	TP53	1.53
174	Cervix carcinoma	Enrichment	TP53	1.53
175	Hodgkin's lymphoma	Enrichment	TP53	1.53
176	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.53
177	Hao-fountain syndrome	Enrichment	USP7	1.53
178	Chromosome 2p16.1-p15 deletion syndrome	Enrichment	USP34	1.53
179	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.53
180	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.53
181	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.53
182	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.53
183	Basal ganglia disease	Enrichment	IFIH1	1.53
184	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.53
185	Vacterl with hydrocephalus	Enrichment	PTEN	1.53
186	Posterior hypospadias	Enrichment	AR	1.53
187	Juvenile polyposis of infancy	Enrichment	PTEN	1.53
188	Xeroderma pigmentosum group e	Enrichment	DDB2	1.53
189	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.53
190	Submucosal cleft palate	Enrichment	UBB	1.53
191	Cleft hard palate	Enrichment	UBB	1.53
192	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	1.49
193	Lung cancer susceptibility 3	Enrichment	PRKN, TP53	1.49
194	Lynch syndrome	Enrichment	CFTR, TGFBR2	1.43
195	Camurati-engelmann disease 1	Enrichment	TGFB1	1.39
196	Moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism	Enrichment	BRCC3	1.39
197	Parkinson disease 12	Enrichment	PRKN	1.39
198	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	1.39
199	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.39
200	Yao syndrome	Enrichment	NOD2	1.39
201	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	1.39
202	Spastic paraplegia 79b, autosomal recessive	Enrichment	UCHL1	1.39
203	Gabriele-de vries syndrome	Enrichment	YY1	1.39
204	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.39
205	Menke-hennekam syndrome 2	Enrichment	EP300	1.39
206	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.39
207	Bohring-opitz syndrome	Enrichment	ASXL1	1.39
208	Pancreatic cancer 4	Enrichment	BRCA1	1.39
209	Hereditary spastic paraplegia 79a	Enrichment	UCHL1	1.39
210	Camurati-engelmann disease	Enrichment	TGFB1	1.39
211	Ocular melanoma	Enrichment	BAP1	1.39
212	Pericardial effusion	Enrichment	NLRP3	1.39
213	Spastic paraplegia 79a, autosomal dominant, with ataxia	Enrichment	UCHL1	1.39
214	Microcephaly-capillary malformation syndrome	Enrichment	STAMBP	1.39
215	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.39
216	Periampullary adenoma	Enrichment	APC	1.39
217	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.39
218	Insulinoma	Enrichment	YY1	1.39
219	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	1.39
220	Inflammatory breast carcinoma	Enrichment	BRCA1	1.39
221	Kury-isidor syndrome	Enrichment	BAP1	1.39
222	Peritoneum cancer	Enrichment	BRCA1	1.39
223	Bilateral breast cancer	Enrichment	BRCA1	1.39
224	Crohn's disease	Enrichment	NOD2	1.39
225	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	1.39
226	Juvenile polyposis syndrome	Enrichment	SMAD4	1.35
227	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.35
228	Uvula, bifid	Enrichment	UBB	1.35
229	Nuchal bleb, familial	Enrichment	CFTR	1.35
230	Osteogenic sarcoma	Enrichment	TP53	1.35
231	Cleft soft palate	Enrichment	UBB	1.35
232	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	1.35
233	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12	1.35
234	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.35
235	Dedifferentiated liposarcoma	Enrichment	MDM2	1.35
236	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.35
237	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.35
238	Anaplastic astrocytoma	Enrichment	TP53	1.35
239	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.35
240	Squamous cell carcinoma	Enrichment	TP53	1.35
241	Adenocarcinoma	Enrichment	TP53	1.35
242	End stage renal disease	Enrichment	GATA3	1.35
243	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.35
244	Bone osteosarcoma	Enrichment	TP53	1.35
245	Well-differentiated liposarcoma	Enrichment	MDM2	1.35
246	Enchondromatosis	Enrichment	HIF1A	1.35
247	Thyroid hemiagenesis	Enrichment	PSMD3	1.35
248	Hyperpigmentation of the skin	Enrichment	USP9X	1.35
249	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	1.24
250	Parkinson's disease	Enrichment	ATXN3, PRKN	1.24
251	Small cell cancer of the lung	Enrichment	TP53	1.23
252	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.23
253	Lung sarcomatoid carcinoma	Enrichment	TP53	1.23
254	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	PTRH2	1.23
255	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.23
256	Idiopathic bronchiectasis	Enrichment	CFTR	1.23
257	Glioma	Enrichment	PTEN	1.23
258	Desmoid disease, hereditary	Enrichment	APC	1.22
259	Mesothelioma, malignant	Enrichment	BAP1	1.22
260	Combined cellular and humoral immune defects with granulomas	Enrichment	INO80	1.22
261	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	HCFC1	1.22
262	Neurodegeneration with brain iron accumulation 5	Enrichment	OTUD5	1.22
263	Estrogen resistance	Enrichment	ESR1	1.22
264	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.22
265	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	RNF135	1.22
266	Tumor predisposition syndrome 1	Enrichment	BAP1	1.22
267	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	1.22
268	Umbilical hernia	Enrichment	ACTL6A	1.22
269	Desmoid tumor	Enrichment	APC	1.22
270	Migraine without aura	Enrichment	ESR1	1.22
271	Bap1 tumor predisposition syndrome	Enrichment	BAP1	1.22
272	Colon adenocarcinoma	Enrichment	APC	1.22
273	Apc-associated polyposis conditions	Enrichment	APC	1.22
274	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.14
275	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.14
276	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.14
277	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.14
278	Rhabdomyosarcoma 2	Enrichment	TP53	1.14
279	Macrocephaly/autism syndrome	Enrichment	PTEN	1.14
280	Spastic diplegia	Enrichment	IFIH1	1.14
281	Lymphoma	Enrichment	TP53	1.14
282	Hemangioma	Enrichment	PTEN	1.14
283	Hemimegalencephaly	Enrichment	PTEN	1.14
284	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.14
285	Myocardial infarction	Enrichment	ESR1, PSMA6	1.13
286	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, TRAF3	1.13
287	Intellectual developmental disorder, autosomal dominant 1	Enrichment	MBD5	1.10
288	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.10
289	Cholangiocarcinoma	Enrichment	BRCA1	1.10
290	Aminoacylase 1 deficiency	Enrichment	ACTB	1.10
291	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.10
292	Chronic myelomonocytic leukemia	Enrichment	ASXL1	1.10
293	Craniopharyngioma	Enrichment	APC	1.10
294	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	ASXL1	1.10
295	Complex hereditary spastic paraplegia	Enrichment	PRKN	1.10
296	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.10
297	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.06
298	Cowden syndrome 1	Enrichment	PTEN	1.06
299	Patent ductus arteriosus	Enrichment	PSMC3	1.06
300	Adrenocortical carcinoma	Enrichment	TP53	1.06
301	Breast adenocarcinoma	Enrichment	TP53	1.06
302	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.06
303	Parkinson disease, late-onset	Enrichment	ATXN3, PRKN	1.06
304	Autoinflammatory disease	Enrichment	NLRP3, NOD2	1.06
305	Dementia, lewy body	Enrichment	VCP	1.01
306	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.01
307	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.01
308	Familial adenomatous polyposis 1	Enrichment	APC	1.01
309	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.01
310	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.01
311	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.01
312	2q23.1 microduplication syndrome	Enrichment	MBD5	1.01
313	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.01
314	Aggressive systemic mastocytosis	Enrichment	ASXL1	1.01
315	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.00
316	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.00
317	Essential thrombocythemia	Enrichment	TP53	1.00
318	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.00
319	Follicular thyroid carcinoma	Enrichment	PTEN	1.00
320	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.00
321	Lymphoma, non-hodgkin, familial	Enrichment	TP53	0.94
322	Isolated split hand-split foot malformation	Enrichment	SEM1	0.94
323	Difference of sex development	Enrichment	AR	0.94
324	Melanoma, uveal	Enrichment	BAP1	0.93
325	Machado-joseph disease	Enrichment	ATXN3	0.93
326	Rubinstein-taybi syndrome 1	Enrichment	EP300	0.93
327	Hemihyperplasia, isolated	Enrichment	RHOA	0.93
328	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	0.93
329	Inguinal hernia	Enrichment	ACTL6A	0.93
330	Clear cell renal cell carcinoma	Enrichment	BAP1	0.93
331	Hypertrichosis	Enrichment	ASXL1	0.93
332	Tooth agenesis, selective, 1	Enrichment	AXIN2	0.90
333	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	0.90
334	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	0.90
335	Coronary heart disease 5	Enrichment	IKBKG	0.90
336	Cowden syndrome	Enrichment	PTEN	0.90
337	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	0.90
338	Aicardi-goutiares syndrome	Enrichment	IFIH1	0.90
339	Leukemia, chronic lymphocytic	Enrichment	TP53	0.85
340	Aicardi-goutieres syndrome	Enrichment	IFIH1	0.85
341	Polymicrogyria	Enrichment	PSMC3	0.85
342	Melanoma	Enrichment	PTEN	0.85
343	Familial colorectal cancer	Enrichment	TP53	0.85
344	Lung cancer	Enrichment	BRCA1, PRKN	0.85
345	Cystic fibrosis	Enrichment	CFTR, TGFB1	0.85
346	Connective tissue disease	Enrichment	SMAD3, TGFBR2	0.85
347	Pectus excavatum	Enrichment	TGFBR1	0.82
348	Immune deficiency disease	Enrichment	RIPK1	0.82
349	Xeroderma pigmentosum, variant type	Enrichment	DDB2	0.82
350	Meningioma, familial	Enrichment	PTEN	0.82
351	46,xy complete gonadal dysgenesis	Enrichment	AR	0.82
352	Gastroesophageal reflux	Enrichment	ACTL6A	0.81
353	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	0.81
354	Ewing sarcoma	Enrichment	BAP1	0.81
355	Digeorge syndrome	Enrichment	UFD1	0.78
356	Lip and oral cavity carcinoma	Enrichment	TP53	0.78
357	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1, USP9X	0.77
358	Charge syndrome	Enrichment	EP300	0.77
359	Inflammatory bowel disease 1	Enrichment	NOD2	0.77
360	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	ASXL1	0.77
361	Progressive non-fluent aphasia	Enrichment	VCP	0.77
362	Colonic benign neoplasm	Enrichment	APC	0.77
363	Behavioral variant of frontotemporal dementia	Enrichment	VCP	0.77
364	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TRRAP, USP48	0.74
365	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	0.73
366	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.72
367	Hereditary chronic pancreatitis	Enrichment	CFTR	0.72
368	Systemic lupus erythematosus	Enrichment	TNFAIP3, TNIP1	0.72
369	Leukemia, acute myeloid	Enrichment	ASXL1, TP53	0.70
370	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR, CFTR	0.69
371	Migraine with or without aura 1	Enrichment	ESR1	0.69
372	Atrial heart septal defect	Enrichment	ACTL6A	0.69
373	Interatrial communication	Enrichment	ACTL6A	0.69
374	Juvenile myelomonocytic leukemia	Enrichment	ASXL1	0.66
375	Pancreatitis, hereditary	Enrichment	CFTR	0.65
376	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	0.63
377	Alzheimer's disease	Enrichment	VCP	0.63
378	Patent foramen ovale	Enrichment	PSMC3	0.62
379	Microcephaly	Enrichment	ACTB, ASXL1, EP300, PSMC3	0.61
380	Complex neurodevelopmental disorder	Enrichment	ACTL6A, BAP1, OTUD5, PSMD12	0.60
381	Medulloblastoma	Enrichment	APC	0.60
382	Periventricular nodular heterotopia	Enrichment	BRCA1	0.60
383	Renal cell carcinoma, nonpapillary	Enrichment	BAP1	0.57
384	Polydactyly, postaxial, type a1	Enrichment	EP300	0.57
385	Rare genetic intellectual disability	Enrichment	EP300	0.57
386	Tooth agenesis	Enrichment	AXIN2	0.55
387	Isolated congenital microcephaly	Enrichment	INO80	0.55
388	Diamond-blackfan anemia 1	Enrichment	TP53	0.53
389	Malaria	Enrichment	IKBKG	0.53
390	Non-syndromic male infertility due to sperm motility disorder	Enrichment	USP26	0.53
391	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.53
392	Alzheimer disease, familial, 1	Enrichment	VCP	0.53
393	Melanoma, cutaneous malignant 1	Enrichment	BAP1	0.53
394	Arteriovenous malformations of the brain	Enrichment	NLRP3	0.49
395	Behcet syndrome	Enrichment	NOD2	0.49
396	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	0.49
397	Schizophrenia	Enrichment	MBD5, PRKN	0.46
398	Hirschsprung disease 1	Enrichment	AXIN2	0.45
399	Cakut	Enrichment	GATA3	0.40
400	Diamond-blackfan anemia	Enrichment	TP53	0.38
401	Autism	Enrichment	MBD5, PRKN	0.36
402	Thrombocytopenia	Enrichment	SMAD4	0.29
403	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.29
404	Autosomal dominant non-syndromic intellectual disability	Enrichment	MBD5	0.19
405	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	0.15
406	Congenital nervous system abnormality	Enrichment	PTEN	0.10
407	Nervous system disease	Enrichment	PTEN	0.10
408	Retinitis pigmentosa	Enrichment	TFPT	0.01

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Deubiquitination

Pathway Network for Deubiquitination

Member Pathways for Deubiquitination

Pathways in the Deubiquitination SuperPath

Associated Genes for Deubiquitination

Associated Disorders for Deubiquitination

Disorders associated with Deubiquitination SuperPath

STRING Interaction Network for Deubiquitination

Sources for Deubiquitination