Development A2B receptor- action via G-protein alpha s

No Pathway Network information available for Development A2B receptor- action via G-protein alpha s

Pathways in the Development A2B receptor- action via G-protein alpha s SuperPath

#	Name	Source	Genes
1	Development A2B receptor- action via G-protein alpha s	GeneGo (Thomson Reuters)	ADCY1 ADORA2B AKT1 AKT2 AKT3 ARHGEF7 BRAF CDC42 CEBPB CREB1 CTNNB1 ELK1 GNA11 GNAQ GNAS GRB2 GSK3B HRAS IL6 ITPR1 ITPR2 ITPR3 MAP2K1 MAP2K2 MAP2K3 MAP3K4 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 NFKB1 NFKB2 NOS3 PIK3CA PIK3CB PIK3CD PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCE PTK2B RAP1A RAPGEF2 RAPGEF3 REL RELA RELB SHC1 SOS1 SOS2 TCF7L2 VAV1 (see all 62) (see less)
2	Development A2A receptor signaling	GeneGo (Thomson Reuters)	ADCY6 ADORA2A AKT1 AKT2 AKT3 ARHGEF7 ATF2 BAD BRAF CDC42 CHUK CREB1 ELK1 GNAS HRAS IKBKB JUN MAP2K1 MAP2K2 MAP2K6 MAP2K7 MAP3K1 MAP3K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PAK1 PARD6A PARD6B PARD6G PDPK1 PIK3CA PIK3CB PIK3CD PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCZ RAP1A RAPGEF2 RAPGEF3 REL RELA RELB RPS6KA1 RPS6KA2 RPS6KA3 (see all 62) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
4	CDC42	Cell Division Cycle 42	Protein Coding	2
5	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
6	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
7	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
8	GNAS	GNAS Complex Locus	Protein Coding	2
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
10	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
11	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
12	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
13	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
14	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
15	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
16	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
17	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
18	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
19	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	2
20	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	2
21	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	2
22	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	2
23	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
24	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
25	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
26	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
27	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
28	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
29	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
30	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	2
31	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
32	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	2
33	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
34	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
35	RAPGEF2	Rap Guanine Nucleotide Exchange Factor 2	Protein Coding	2
36	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
37	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	2
38	ADCY1	Adenylate Cyclase 1	Protein Coding	1
39	ADORA2B	Adenosine A2b Receptor	Protein Coding	1
40	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
41	CTNNB1	Catenin Beta 1	Protein Coding	1
42	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
43	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
44	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
45	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
46	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
47	IL6	Interleukin 6	Protein Coding	1
48	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
49	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
50	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
51	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
52	PLCB2	Phospholipase C Beta 2	Protein Coding	1
53	PLCB3	Phospholipase C Beta 3	Protein Coding	1
54	PLCB4	Phospholipase C Beta 4	Protein Coding	1
55	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
56	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
57	SHC1	SHC Adaptor Protein 1	Protein Coding	1
58	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
59	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
60	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
61	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
62	PLCB1	Phospholipase C Beta 1	Protein Coding	1
63	ADCY6	Adenylate Cyclase 6	Protein Coding	1
64	ADORA2A	Adenosine A2a Receptor	Protein Coding	1
65	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
66	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
67	ATF2	Activating Transcription Factor 2	Protein Coding	1
68	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
69	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
70	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
71	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
72	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
73	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
74	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
75	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
76	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
77	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
78	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
79	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
80	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
81	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
82	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
83	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
84	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
85	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
86	PARD6G	Par-6 Family Cell Polarity Regulator Gamma	Protein Coding	1
87	PARD6B	Par-6 Family Cell Polarity Regulator Beta	Protein Coding	1

Disorders associated with Development A2B receptor- action via G-protein alpha s SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	BRAF, HRAS, MAP2K1, MAP2K2, SOS1, SOS2	9.15
2	Rasopathy	Enrichment	BRAF, HRAS, MAP2K1, MAP2K2, SOS1, SOS2	8.81
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, MAP2K1, MAP2K2, SOS1	8.31
4	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, MAP2K1, PIK3CA	6.89
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2	6.44
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1, MAP2K2	6.44
7	Capillary malformations, congenital	Enrichment	GNA11, GNAQ, PIK3CA	6.04
8	Melanoma, uveal	Enrichment	GNA11, GNAQ, PLCB4	5.74
9	Gallbladder cancer	Enrichment	BRAF, CTNNB1, PIK3CA	5.50
10	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.13
11	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.97
12	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	4.71
13	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.69
14	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.69
15	Immune system disease	Enrichment	CDC42, PIK3CD	4.69
16	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.69
17	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	4.21
18	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3CA	4.21
19	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	4.21
20	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	3.91
21	Craniopharyngioma	Enrichment	BRAF, CTNNB1	3.91
22	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.69
23	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	3.52
24	Adrenocortical carcinoma	Enrichment	CTNNB1, PRKAR1A	3.52
25	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.52
26	Bladder cancer	Enrichment	CTNNB1, HRAS, PIK3CA	3.52
27	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.37
28	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS	3.37
29	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.37
30	Noonan syndrome 3	Enrichment	HRAS, SOS1	3.37
31	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.37
32	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS	3.37
33	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS	3.25
34	Colorectal cancer	Enrichment	AKT1, BRAF, CTNNB1, PIK3CA	3.18
35	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.14
36	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.14
37	Primary hyperaldosteronism	Enrichment	BRAF, GNAS	3.14
38	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.14
39	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	3.14
40	Type 2 diabetes mellitus	Enrichment	AKT2, IL6, TCF7L2	3.04
41	Specific learning disability	Enrichment	MAPK1, RPS6KA3	2.96
42	Meningioma	Enrichment	AKT1, PIK3CA	2.88
43	Arteriovenous malformations of the brain	Enrichment	BRAF, IL6	2.48
44	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.35
45	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.34
46	Macrodactyly	Enrichment	PIK3CA	2.34
47	Proteus syndrome	Enrichment	AKT1	2.34
48	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.34
49	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.34
50	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.34
51	Noonan syndrome 4	Enrichment	SOS1	2.34
52	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.34
53	Carney complex, type 1	Enrichment	PRKAR1A	2.34
54	Melorheostosis, isolated	Enrichment	MAP2K1	2.34
55	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.34
56	Osseous heteroplasia, progressive	Enrichment	GNAS	2.34
57	Noonan syndrome 7	Enrichment	BRAF	2.34
58	Leopard syndrome 3	Enrichment	BRAF	2.34
59	Cowden syndrome 5	Enrichment	PIK3CA	2.34
60	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.34
61	Noonan syndrome 9	Enrichment	SOS2	2.34
62	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.34
63	Sturge-weber syndrome	Enrichment	GNAQ	2.34
64	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.34
65	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.34
66	Noonan syndrome 13	Enrichment	MAPK1	2.34
67	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.34
68	Immunodeficiency 92	Enrichment	REL	2.34
69	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.34
70	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.34
71	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.34
72	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.34
73	Myxoma, intracardiac	Enrichment	PRKAR1A	2.34
74	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.34
75	Lymphangioma	Enrichment	BRAF	2.34
76	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.34
77	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.34
78	Phace association	Enrichment	BRAF	2.34
79	Melorheostosis	Enrichment	MAP2K1	2.34
80	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.34
81	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.34
82	Cowden syndrome 6	Enrichment	AKT1	2.34
83	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.34
84	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.34
85	Disorders of gnas inactivation	Enrichment	GNAS	2.34
86	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.34
87	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.34
88	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.34
89	Immunodeficiency 53	Enrichment	RELB	2.34
90	Epilepsy, familial adult myoclonic, 7	Enrichment	RAPGEF2	2.34
91	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.34
92	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.34
93	Adenoid ameloblastoma	Enrichment	CTNNB1	2.34
94	Hypospadias	Enrichment	PIK3CA	2.34
95	Capillary hemangioma	Enrichment	AKT3	2.34
96	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.34
97	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.34
98	Rare venous malformation	Enrichment	PIK3CA	2.34
99	Diaphragmatic eventration	Enrichment	PIK3CA	2.34
100	Nocarh syndrome	Enrichment	CDC42	2.34
101	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.34
102	Syringocystadenoma papilliferum	Enrichment	BRAF	2.34
103	Rare combined vascular malformation	Enrichment	PIK3CA	2.34
104	Ganglioglioma	Enrichment	BRAF	2.34
105	Cavernous lymphangioma	Enrichment	PIK3CA	2.34
106	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.34
107	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.34
108	Monostotic fibrous dysplasia	Enrichment	GNAS	2.34
109	Phace syndrome	Enrichment	BRAF	2.34
110	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.34
111	Classic hairy cell leukemia	Enrichment	BRAF	2.34
112	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.34
113	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.34
114	Mazabraud syndrome	Enrichment	GNAS	2.34
115	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.34
116	Macrodactyly of toe	Enrichment	PIK3CA	2.34
117	Microcystic stromal tumor	Enrichment	CTNNB1	2.34
118	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.34
119	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.34
120	Fetal encasement syndrome	Enrichment	CHUK	2.34
121	46,xy sex reversal 6	Enrichment	MAP3K1	2.34
122	Immunodeficiency 15b	Enrichment	IKBKB	2.34
123	Immunodeficiency 15a	Enrichment	IKBKB	2.34
124	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.34
125	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.34
126	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.34
127	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.34
128	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	2.34
129	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.34
130	Breast cancer	Enrichment	AKT1, PIK3CA, SHC1	2.31
131	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS	2.11
132	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.04
133	Fibromatosis, gingival, 1	Enrichment	SOS1	2.04
134	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.04
135	Costello syndrome	Enrichment	HRAS	2.04
136	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.04
137	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.04
138	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.04
139	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.04
140	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.04
141	Keratosis, seborrheic	Enrichment	PIK3CA	2.04
142	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.04
143	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.04
144	Noonan syndrome 8	Enrichment	PIK3CA	2.04
145	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.04
146	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.04
147	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.04
148	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.04
149	Usher syndrome, type iv	Enrichment	PRKAR1A	2.04
150	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.04
151	Rela fusion-positive ependymoma	Enrichment	RELA	2.04
152	Senior-loken syndrome 7	Enrichment	AKT3	2.04
153	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.04
154	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.04
155	Acrodysostosis	Enrichment	PRKAR1A	2.04
156	Pseudohypoparathyroidism	Enrichment	GNAS	2.04
157	Fibrolamellar carcinoma	Enrichment	PRKACA	2.04
158	Ocular melanoma	Enrichment	PLCB4	2.04
159	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.04
160	Bardet-biedl syndrome 16	Enrichment	AKT3	2.04
161	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.04
162	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.04
163	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.04
164	Teratoma	Enrichment	CTNNB1	2.04
165	Common variable immunodeficiency 12	Enrichment	NFKB1	2.04
166	Tafro syndrome	Enrichment	MAP2K2	2.04
167	Wooly hair nevus	Enrichment	HRAS	2.04
168	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.04
169	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.04
170	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.04
171	Lung cancer	Enrichment	BRAF, PIK3CA	2.03
172	Ovarian cancer	Enrichment	AKT1, CTNNB1, PIK3CA	1.96
173	Desmoid disease, hereditary	Enrichment	CTNNB1	1.86
174	Mccune-albright syndrome	Enrichment	GNAS	1.86
175	Ataxia-telangiectasia	Enrichment	BRAF	1.86
176	Gillespie syndrome	Enrichment	ITPR1	1.86
177	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.86
178	Nuchal bleb, familial	Enrichment	SOS1	1.86
179	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.86
180	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	1.86
181	Anus, imperforate	Enrichment	CTNNB1	1.86
182	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.86
183	Tethered spinal cord syndrome	Enrichment	BRAF	1.86
184	Large congenital melanocytic nevus	Enrichment	HRAS	1.86
185	Desmoid tumor	Enrichment	CTNNB1	1.86
186	Immunodeficiency 14	Enrichment	PIK3CD	1.86
187	Spermatocytoma	Enrichment	HRAS	1.86
188	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.86
189	Melanoma of soft tissue	Enrichment	CREB1	1.86
190	Keratoacanthoma	Enrichment	PIK3CA	1.86
191	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.86
192	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.86
193	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.76
194	Kaposi sarcoma	Enrichment	IL6	1.74
195	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.74
196	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.74
197	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.74
198	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.74
199	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.74
200	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.74
201	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.74
202	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.74
203	Pilomatrixoma	Enrichment	CTNNB1	1.74
204	Carney complex variant	Enrichment	PRKAR1A	1.74
205	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.74
206	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.74
207	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.74
208	Alazami syndrome	Enrichment	CTNNB1	1.74
209	Cerebrovascular disease	Enrichment	PIK3CA	1.74
210	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.74
211	Noonan syndrome with multiple lentigines	Enrichment	BRAF	1.74
212	Newborn respiratory distress syndrome	Enrichment	BRAF	1.74
213	Epidermolytic nevus	Enrichment	HRAS	1.74
214	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.74
215	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.74
216	Gingival fibromatosis	Enrichment	SOS1	1.74
217	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.74
218	Alzheimer disease 2	Enrichment	NOS3	1.64
219	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.64
220	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.64
221	Pre-eclampsia	Enrichment	NOS3	1.64
222	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	1.63
223	Cowden syndrome 1	Enrichment	PIK3CA	1.57
224	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.57
225	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.57
226	Type 1 diabetes mellitus	Enrichment	IL6	1.57
227	Wilms tumor 5	Enrichment	BRAF	1.57
228	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.57
229	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.57
230	Brachydactyly	Enrichment	GNAS	1.50
231	Pilomyxoid astrocytoma	Enrichment	BRAF	1.50
232	Megacolon	Enrichment	AKT3	1.50
233	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.44
234	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.44
235	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.44
236	Gastroesophageal reflux	Enrichment	RPS6KA3	1.44
237	Orthostatic intolerance	Enrichment	RPS6KA3	1.44
238	Lennox-gastaut syndrome	Enrichment	MAPK10	1.44
239	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.39
240	Inflammatory bowel disease 1	Enrichment	IL6	1.39
241	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.39
242	Stroke, ischemic	Enrichment	NOS3	1.35
243	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.35
244	Polymicrogyria	Enrichment	AKT3	1.35
245	Melanoma	Enrichment	BRAF	1.35
246	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.35
247	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.31
248	Congenital long qt syndrome	Enrichment	ITPR3	1.27
249	Aortic valve disease 1	Enrichment	SOS1	1.24
250	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.24
251	Nk-cell enteropathy	Enrichment	PIK3CB	1.24
252	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.24
253	Multiple sclerosis	Enrichment	ITPR1	1.21
254	Medulloblastoma	Enrichment	CTNNB1	1.21
255	Lung cancer susceptibility 3	Enrichment	BRAF	1.21
256	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.21
257	Wilms tumor 1	Enrichment	BRAF	1.18
258	Anterior segment dysgenesis	Enrichment	ITPR1	1.18
259	Lynch syndrome	Enrichment	PIK3CA	1.18
260	Rhabdomyosarcoma	Enrichment	HRAS	1.15
261	Gliosarcoma	Enrichment	NFKBIA	1.15
262	Alzheimer disease, familial, 1	Enrichment	NOS3	1.13
263	Hypertension, essential	Enrichment	NOS3	1.13
264	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.13
265	Dandy-walker syndrome	Enrichment	BRAF	1.13
266	Polycystic liver disease	Enrichment	CTNNB1	1.13
267	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.13
268	Giant cell glioblastoma	Enrichment	NFKBIA	1.13
269	Heart, malformation of	Enrichment	MAPK1	1.10
270	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.08
271	Endometrial cancer	Enrichment	PIK3CA	1.04
272	Hepatoblastoma	Enrichment	CTNNB1	1.04
273	Microcephaly	Enrichment	CTNNB1, MAPK1	0.96
274	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.95
275	Prostate cancer	Enrichment	PIK3CA	0.90
276	Long qt syndrome 1	Enrichment	ITPR3	0.89
277	Non-immune hydrops fetalis	Enrichment	HRAS	0.88
278	Severe combined immunodeficiency	Enrichment	IKBKB	0.85
279	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.82
280	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.77
281	Centralopathic epilepsy	Enrichment	PLCB1	0.75
282	Gastric cancer	Enrichment	PIK3CA	0.75
283	West syndrome	Enrichment	PLCB1	0.74
284	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.69
285	Spastic ataxia	Enrichment	ITPR1	0.67
286	Myeloma, multiple	Enrichment	BRAF	0.64
287	Primary ovarian insufficiency	Enrichment	NOS3	0.62
288	Autism	Enrichment	TCF7L2	0.55
289	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.53
290	Dilated cardiomyopathy	Enrichment	BRAF	0.51
291	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.47
292	Congenital nervous system abnormality	Enrichment	CTNNB1	0.41
293	Nervous system disease	Enrichment	CTNNB1	0.41
294	Autism spectrum disorder	Enrichment	MAP2K1	0.40
295	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.36
296	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development A2B receptor- action via G-protein alpha s

Pathway Network for Development A2B receptor- action via G-protein alpha s

Member Pathways for Development A2B receptor- action via G-protein alpha s

Pathways in the Development A2B receptor- action via G-protein alpha s SuperPath

Associated Genes for Development A2B receptor- action via G-protein alpha s

Associated Disorders for Development A2B receptor- action via G-protein alpha s

Disorders associated with Development A2B receptor- action via G-protein alpha s SuperPath

STRING Interaction Network for Development A2B receptor- action via G-protein alpha s

Sources for Development A2B receptor- action via G-protein alpha s