Development A3 receptor signaling

Pathway network for the Development A3 receptor signaling SuperPath

Sources:

GeneGo (Thomson Reuters)

Pathways in the Development A3 receptor signaling SuperPath

#	Name	Source	Genes
1	Development A3 receptor signaling	GeneGo (Thomson Reuters)	ADCY1 ADORA3 AKT1 AKT2 AKT3 CCND1 CHUK CREB1 CTNNB1 ELK1 GNA11 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GSK3B HRAS IKBKB ITPR1 ITPR2 ITPR3 MAP2K1 MAP2K2 MAPK3 MYC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PDPK1 PIK3CG PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCE PTK2B RAF1 RASGRF1 REL RELA RELB SHC1 SOS1 SOS2 STAT3 TCF7L2 (see all 76) (see less)
2	Development A1 receptor signaling	GeneGo (Thomson Reuters)	ADCY1 ADORA1 AKT1 AKT2 AKT3 ATF2 CHUK CREB1 ELK1 GNA15 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HRAS IKBKB ITPR1 ITPR2 ITPR3 MAP2K1 MAP2K2 MAP2K3 MAP3K4 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PIK3CG PIK3R5 PLA2G4A PLCB3 PREX1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKD1 RAC1 RAF1 REL RELA RELB SHC1 SOS1 SOS2 SRC (see all 77) (see less)
3	G-protein signaling G-Protein alpha-q signaling cascades	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ARHGEF12 BTK CHUK GNA11 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GRK2 HRAS IKBKB ITPR1 ITPR2 ITPR3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PDPK1 PIK3CA PIK3CB PIK3CD PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PRKCE PTK2B REL RELA RELB RGS2 RGS3 RHOA ROCK1 ROCK2 SHC1 SOS1 SOS2 (see all 60) (see less)

Gene overlap in member pathways for Development A3 receptor signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
3	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
4	GNB1	G Protein Subunit Beta 1	Protein Coding	3
5	GNB2	G Protein Subunit Beta 2	Protein Coding	3
6	GNB3	G Protein Subunit Beta 3	Protein Coding	3
7	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
8	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
9	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
10	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
11	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
12	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
13	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
14	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
15	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
16	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
17	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
18	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
19	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
20	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
21	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
22	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
23	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
24	NFKBIB	NFKB Inhibitor Beta	Protein Coding	3
25	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	3
26	PLCB3	Phospholipase C Beta 3	Protein Coding	3
27	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3
28	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
29	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	3
30	SHC1	SHC Adaptor Protein 1	Protein Coding	3
31	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
32	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	3
33	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
34	GNB5	G Protein Subunit Beta 5	Protein Coding	3
35	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
36	GNG2	G Protein Subunit Gamma 2	Protein Coding	3
37	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
38	GNB4	G Protein Subunit Beta 4	Protein Coding	3
39	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
40	ADCY1	Adenylate Cyclase 1	Protein Coding	2
41	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
42	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
43	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
44	GNA11	G Protein Subunit Alpha 11	Protein Coding	2
45	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
46	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
47	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
48	GNAO1	G Protein Subunit Alpha O1	Protein Coding	2
49	GNAQ	G Protein Subunit Alpha Q	Protein Coding	2
50	GNAZ	G Protein Subunit Alpha Z	Protein Coding	2
51	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
52	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
53	PLCB2	Phospholipase C Beta 2	Protein Coding	2
54	PLCB4	Phospholipase C Beta 4	Protein Coding	2
55	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
56	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
57	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
58	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	2
59	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	2
60	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	2
61	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	2
62	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
63	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
64	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
65	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
66	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
67	PLCB1	Phospholipase C Beta 1	Protein Coding	2
68	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
69	ADORA3	Adenosine A3 Receptor	Protein Coding	1
70	CCND1	Cyclin D1	Protein Coding	1
71	CTNNB1	Catenin Beta 1	Protein Coding	1
72	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
73	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
74	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
75	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
76	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
77	ADORA1	Adenosine A1 Receptor	Protein Coding	1
78	ATF2	Activating Transcription Factor 2	Protein Coding	1
79	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
80	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
81	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
82	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
83	PRKCA	Protein Kinase C Alpha	Protein Coding	1
84	PRKCD	Protein Kinase C Delta	Protein Coding	1
85	PRKD1	Protein Kinase D1	Protein Coding	1
86	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
87	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
88	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
89	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
90	RAC1	Rac Family Small GTPase 1	Protein Coding	1
91	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
92	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
93	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	1
94	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
95	RHOA	Ras Homolog Family Member A	Protein Coding	1
96	BTK	Bruton Tyrosine Kinase	Protein Coding	1
97	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
98	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
99	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
100	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
101	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
102	RGS2	Regulator Of G Protein Signaling 2	Protein Coding	1
103	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	1
104	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
105	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
106	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1

Disorders associated with Development A3 receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.62
2	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.27
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	7.86
4	Capillary malformations, congenital	Enrichment	GNA11, GNAQ, PIK3CA	6.09
5	Melanoma, uveal	Enrichment	GNA11, GNAQ, PLCB4	5.79
6	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.24
7	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.72
8	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3CA	4.24
9	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	4.24
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	3.94
11	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.73
12	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.73
13	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.73
14	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.72
15	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	3.54
16	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.54
17	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.54
18	Breast cancer	Enrichment	AKT1, GNG3, PIK3CA, SHC1	3.48
19	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.40
20	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.40
21	Adrenocortical carcinoma	Enrichment	CTNNB1, PRKAR1A	3.34
22	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.17
23	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.17
24	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.07
25	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.07
26	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	2.99
27	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.96
28	Meningioma	Enrichment	AKT1, PIK3CA	2.91
29	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.91
30	Acute promyelocytic leukemia	Enrichment	PRKAR1A, STAT3	2.63
31	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.35
32	Macrodactyly	Enrichment	PIK3CA	2.35
33	Proteus syndrome	Enrichment	AKT1	2.35
34	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.35
35	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.35
36	Noonan syndrome 4	Enrichment	SOS1	2.35
37	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.35
38	Cowden syndrome 5	Enrichment	PIK3CA	2.35
39	Noonan syndrome 9	Enrichment	SOS2	2.35
40	Fetal encasement syndrome	Enrichment	CHUK	2.35
41	Sturge-weber syndrome	Enrichment	GNAQ	2.35
42	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.35
43	Immunodeficiency 15b	Enrichment	IKBKB	2.35
44	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.35
45	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.35
46	Immunodeficiency 15a	Enrichment	IKBKB	2.35
47	Immunodeficiency 92	Enrichment	REL	2.35
48	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.35
49	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.35
50	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.35
51	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.35
52	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.35
53	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.35
54	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.35
55	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.35
56	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.35
57	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.35
58	Cowden syndrome 6	Enrichment	AKT1	2.35
59	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.35
60	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.35
61	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.35
62	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.35
63	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.35
64	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.35
65	Immunodeficiency 53	Enrichment	RELB	2.35
66	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.35
67	Sick sinus syndrome 4	Enrichment	GNB2	2.35
68	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.35
69	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.35
70	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.35
71	Hypospadias	Enrichment	PIK3CA	2.35
72	Capillary hemangioma	Enrichment	AKT3	2.35
73	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.35
74	Rare venous malformation	Enrichment	PIK3CA	2.35
75	Diaphragmatic eventration	Enrichment	PIK3CA	2.35
76	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.35
77	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.35
78	Rare combined vascular malformation	Enrichment	PIK3CA	2.35
79	Cavernous lymphangioma	Enrichment	PIK3CA	2.35
80	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.35
81	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.35
82	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.35
83	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.35
84	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.35
85	Macrodactyly of toe	Enrichment	PIK3CA	2.35
86	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.35
87	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.25
88	Noonan syndrome 5	Enrichment	RAF1	2.25
89	Carney complex, type 1	Enrichment	PRKAR1A	2.25
90	Melorheostosis, isolated	Enrichment	MAP2K1	2.25
91	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.25
92	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.25
93	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.25
94	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.25
95	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.25
96	Ventricular tachycardia, familial	Enrichment	GNAI2	2.25
97	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.25
98	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.25
99	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.25
100	Myxoma, intracardiac	Enrichment	PRKAR1A	2.25
101	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.25
102	Melorheostosis	Enrichment	MAP2K1	2.25
103	Leopard syndrome 2	Enrichment	RAF1	2.25
104	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.25
105	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.25
106	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.25
107	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.25
108	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.25
109	Trigonitis	Enrichment	RAF1	2.25
110	Adenoid ameloblastoma	Enrichment	CTNNB1	2.25
111	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.25
112	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.25
113	Gnao1-related disorder	Enrichment	GNAO1	2.25
114	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.25
115	Microcystic stromal tumor	Enrichment	CTNNB1	2.25
116	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.25
117	Noonan syndrome 13	Enrichment	MAPK1	2.25
118	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.25
119	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.25
120	Thrombocytopenia 6	Enrichment	SRC	2.25
121	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.25
122	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.25
123	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.25
124	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.25
125	Bladder cancer	Enrichment	HRAS, PIK3CA	2.14
126	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.05
127	Fibromatosis, gingival, 1	Enrichment	SOS1	2.05
128	Costello syndrome	Enrichment	HRAS	2.05
129	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.05
130	Pulmonic stenosis	Enrichment	SOS1	2.05
131	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.05
132	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.05
133	Keratosis, seborrheic	Enrichment	PIK3CA	2.05
134	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.05
135	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.05
136	Noonan syndrome 8	Enrichment	PIK3CA	2.05
137	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.05
138	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.05
139	Agammaglobulinemia, x-linked	Enrichment	BTK	2.05
140	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.05
141	Rela fusion-positive ependymoma	Enrichment	RELA	2.05
142	Senior-loken syndrome 7	Enrichment	AKT3	2.05
143	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.05
144	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.05
145	Ocular melanoma	Enrichment	PLCB4	2.05
146	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.05
147	Immune system disease	Enrichment	PIK3CD	2.05
148	Bardet-biedl syndrome 16	Enrichment	AKT3	2.05
149	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.05
150	Common variable immunodeficiency 12	Enrichment	NFKB1	2.05
151	Cerebral visual impairment	Enrichment	GNB1	2.05
152	Wooly hair nevus	Enrichment	HRAS	2.05
153	Burkitt lymphoma	Enrichment	MYC	1.95
154	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.95
155	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.95
156	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.95
157	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.95
158	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.95
159	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.95
160	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.95
161	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.95
162	Usher syndrome, type iv	Enrichment	PRKAR1A	1.95
163	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.95
164	Acrodysostosis	Enrichment	PRKAR1A	1.95
165	Fibrolamellar carcinoma	Enrichment	PRKACA	1.95
166	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.95
167	Hypopituitarism	Enrichment	GNAI2	1.95
168	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.95
169	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.95
170	Teratoma	Enrichment	CTNNB1	1.95
171	Tafro syndrome	Enrichment	MAP2K2	1.95
172	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.95
173	Colorectal cancer	Enrichment	AKT1, CCND1, CTNNB1	1.89
174	Gillespie syndrome	Enrichment	ITPR1	1.88
175	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.88
176	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.88
177	Nuchal bleb, familial	Enrichment	SOS1	1.88
178	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.88
179	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	1.88
180	Agammaglobulinemia 1	Enrichment	BTK	1.88
181	Large congenital melanocytic nevus	Enrichment	HRAS	1.88
182	Immunodeficiency 14	Enrichment	PIK3CD	1.88
183	Spermatocytoma	Enrichment	HRAS	1.88
184	Keratoacanthoma	Enrichment	PIK3CA	1.88
185	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.79
186	Desmoid disease, hereditary	Enrichment	CTNNB1	1.78
187	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.78
188	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.78
189	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.78
190	Anus, imperforate	Enrichment	CTNNB1	1.78
191	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.78
192	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.78
193	Desmoid tumor	Enrichment	CTNNB1	1.78
194	Hyper ige syndrome	Enrichment	STAT3	1.78
195	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.78
196	Melanoma of soft tissue	Enrichment	CREB1	1.78
197	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.76
198	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.76
199	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.76
200	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.76
201	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.76
202	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.76
203	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.76
204	Cerebrovascular disease	Enrichment	PIK3CA	1.76
205	Epidermolytic nevus	Enrichment	HRAS	1.76
206	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.76
207	Gingival fibromatosis	Enrichment	SOS1	1.76
208	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.76
209	Familial sick sinus syndrome	Enrichment	GNB2	1.76
210	Congenital nervous system abnormality	Enrichment	CTNNB1, GNAO1, GNB5	1.67
211	Nervous system disease	Enrichment	CTNNB1, GNAO1, GNB5	1.67
212	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.65
213	Pilomatrixoma	Enrichment	CTNNB1	1.65
214	Carney complex variant	Enrichment	PRKAR1A	1.65
215	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.65
216	Achromatopsia 4	Enrichment	GNAI3	1.65
217	Alazami syndrome	Enrichment	CTNNB1	1.65
218	Mantle cell lymphoma	Enrichment	CCND1	1.65
219	Craniopharyngioma	Enrichment	CTNNB1	1.65
220	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.65
221	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.65
222	Type 2 diabetes mellitus	Enrichment	AKT2, TCF7L2	1.64
223	West syndrome	Enrichment	GNAO1, PLCB1	1.60
224	Cowden syndrome 1	Enrichment	PIK3CA	1.58
225	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.58
226	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.58
227	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.56
228	Von hippel-lindau syndrome	Enrichment	CCND1	1.56
229	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.51
230	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.51
231	Gallbladder cancer	Enrichment	PIK3CA	1.51
232	Megacolon	Enrichment	AKT3	1.51
233	Follicular thyroid carcinoma	Enrichment	HRAS	1.51
234	Microcephaly	Enrichment	CTNNB1, GNAO1, GNB1	1.50
235	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.48
236	Hypothyroidism	Enrichment	GNB1	1.46
237	Pilomyxoid astrocytoma	Enrichment	RAF1	1.41
238	Myelofibrosis	Enrichment	SRC	1.41
239	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.41
240	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.41
241	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.36
242	Polymicrogyria	Enrichment	AKT3	1.36
243	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.36
244	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.36
245	Choreatic disease	Enrichment	GNAO1	1.36
246	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.36
247	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.32
248	Myelodysplastic syndrome	Enrichment	GNB1	1.32
249	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.30
250	Congenital long qt syndrome	Enrichment	ITPR3	1.29
251	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.26
252	Aortic valve disease 1	Enrichment	SOS1	1.25
253	Nk-cell enteropathy	Enrichment	PIK3CB	1.25
254	Movement disease	Enrichment	GNAO1	1.22
255	Multiple sclerosis	Enrichment	ITPR1	1.22
256	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.22
257	Specific learning disability	Enrichment	MAPK1	1.22
258	Anterior segment dysgenesis	Enrichment	ITPR1	1.19
259	Lynch syndrome	Enrichment	PIK3CA	1.19
260	Rhabdomyosarcoma	Enrichment	HRAS	1.16
261	Gliosarcoma	Enrichment	NFKBIA	1.16
262	Hypertension, essential	Enrichment	GNB3	1.14
263	Cleft palate, isolated	Enrichment	GNB1	1.14
264	Giant cell glioblastoma	Enrichment	NFKBIA	1.14
265	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.13
266	Medulloblastoma	Enrichment	CTNNB1	1.12
267	Osteoporosis	Enrichment	SRC	1.12
268	Diffuse large b-cell lymphoma	Enrichment	BTK	1.09
269	Rare genetic intellectual disability	Enrichment	GNAO1	1.09
270	Endometrial cancer	Enrichment	PIK3CA	1.05
271	Polycystic liver disease	Enrichment	CTNNB1	1.04
272	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.04
273	Hepatocellular carcinoma	Enrichment	PIK3CA	1.03
274	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.03
275	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.02
276	Congenital stationary night blindness	Enrichment	GNB3	1.01
277	Heart, malformation of	Enrichment	MAPK1	1.01
278	Jeune thoracic dystrophy	Enrichment	GRK2	0.98
279	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.96
280	Hepatoblastoma	Enrichment	CTNNB1	0.95
281	Strabismus	Enrichment	GNB1	0.95
282	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.93
283	Prostate cancer	Enrichment	PIK3CA	0.92
284	Differentiated thyroid carcinoma	Enrichment	HRAS	0.92
285	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.92
286	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	0.90
287	Long qt syndrome 1	Enrichment	ITPR3	0.90
288	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.90
289	Non-immune hydrops fetalis	Enrichment	HRAS	0.89
290	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.88
291	Lung cancer	Enrichment	PIK3CA	0.88
292	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.87
293	Severe combined immunodeficiency	Enrichment	IKBKB	0.87
294	Dystonia	Enrichment	GNB1	0.84
295	Complex neurodevelopmental disorder	Enrichment	GNB2, TCF7L2	0.81
296	Cerebral palsy	Enrichment	GNB1	0.80
297	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.78
298	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.77
299	Centralopathic epilepsy	Enrichment	PLCB1	0.76
300	Gastric cancer	Enrichment	PIK3CA	0.76
301	Left ventricular noncompaction	Enrichment	RAF1	0.75
302	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.74
303	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.70
304	Hypertelorism	Enrichment	PIK3CA	0.69
305	Spastic ataxia	Enrichment	ITPR1	0.68
306	Thrombocytopenia	Enrichment	SRC	0.62
307	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.59
308	Myeloma, multiple	Enrichment	CCND1	0.57
309	Autism	Enrichment	TCF7L2	0.48
310	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.46
311	Dilated cardiomyopathy	Enrichment	RAF1	0.44
312	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.40
313	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development A3 receptor signaling

Pathway Network for Development A3 receptor signaling

Pathway network for the Development A3 receptor signaling SuperPath

Member Pathways for Development A3 receptor signaling

Pathways in the Development A3 receptor signaling SuperPath

Gene overlap in member pathways for Development A3 receptor signaling SuperPath

Associated Genes for Development A3 receptor signaling

Associated Disorders for Development A3 receptor signaling

Disorders associated with Development A3 receptor signaling SuperPath

STRING Interaction Network for Development A3 receptor signaling

Sources for Development A3 receptor signaling