Development Dopamine D2 receptor transactivation of EGFR

Pathway network for the Development Dopamine D2 receptor transactivation of EGFR SuperPath

Sources:

GeneGo (Thomson Reuters)
Reactome

Pathways in the Development Dopamine D2 receptor transactivation of EGFR SuperPath

#	Name	Source	Genes
1	Development Dopamine D2 receptor transactivation of EGFR	GeneGo (Thomson Reuters)	ADAM12 AKT1 AKT2 AKT3 DRD2 EGFR GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HBEGF HRAS MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAF1 SHC1 SOS1 SOS2 SRC (see all 47) (see less)
2	Extra-nuclear estrogen signaling	Reactome	AKT1 AKT2 AKT3 AREG BCL2 BTC CALM1 CALM2 CALM3 CAV1 CAV2 CCND1 CDKN1B CREB1 EGF EGFR ELK1 EPGN EREG ESR1 ESR2 FOS FOXO3 GNAI1 GNAI2 GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HBEGF HRAS HSP90AA1 HSPB1 IGF1R KRAS MAPK1 MAPK3 MMP2 MMP3 MMP7 MMP9 NOS3 NRAS PDPK1 PIK3CA PIK3R1 PIK3R2 PIK3R3 PRKCZ PRMT1 PTK2 S1PR3 SHC1 SPHK1 SRC SRF STRN TGFA UHMK1 XPO1 ZDHHC21 ZDHHC7 (see all 77) (see less)
3	Development Alpha-2 adrenergic receptor activation of ERK	GeneGo (Thomson Reuters)	ADAM12 ADRA2A ADRA2B ADRA2C AKT1 AKT2 AKT3 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CYP2C8 DAGLA DAGLB EGFR GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HBEGF HRAS ITPR1 ITPR2 ITPR3 JUN MAP2K1 MAP2K2 MAPK1 MAPK3 MGLL PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLA2G4A PLA2G4C PLCB2 PLCB3 PTK2B RAF1 SHC1 SOS1 SOS2 SRC (see all 69) (see less)
4	Chemotaxis CXCR4 signaling pathway	GeneGo (Thomson Reuters)	BCAR1 CBL CDC42 CRK CRKL CXCL12 CXCR4 DOK1 ELK1 FYN GNAI1 GNAI2 GNAI3 GNAO1 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 HRAS JAK2 LCK MAP2K1 MAP2K2 MAPK1 MAPK3 PTK2 PTK2B PTPN11 PTPRC PXN RAC1 RAF1 RASA1 RHOA SHC1 SOS1 SOS2 SRC STAT3 VAV1 (see all 55) (see less)

Gene overlap in member pathways for Development Dopamine D2 receptor transactivation of EGFR SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GNAI1	G Protein Subunit Alpha I1	Protein Coding	4
2	GNAI2	G Protein Subunit Alpha I2	Protein Coding	4
3	GNAI3	G Protein Subunit Alpha I3	Protein Coding	4
4	GNB1	G Protein Subunit Beta 1	Protein Coding	4
5	GNB2	G Protein Subunit Beta 2	Protein Coding	4
6	GNB3	G Protein Subunit Beta 3	Protein Coding	4
7	GNG3	G Protein Subunit Gamma 3	Protein Coding	4
8	GNG4	G Protein Subunit Gamma 4	Protein Coding	4
9	GNG5	G Protein Subunit Gamma 5	Protein Coding	4
10	GNG7	G Protein Subunit Gamma 7	Protein Coding	4
11	GNG10	G Protein Subunit Gamma 10	Protein Coding	4
12	GNG11	G Protein Subunit Gamma 11	Protein Coding	4
13	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	4
14	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	4
15	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
16	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
17	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	4
18	SHC1	SHC Adaptor Protein 1	Protein Coding	4
19	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
20	GNB5	G Protein Subunit Beta 5	Protein Coding	4
21	GNG13	G Protein Subunit Gamma 13	Protein Coding	4
22	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
23	GNG12	G Protein Subunit Gamma 12	Protein Coding	4
24	GNB4	G Protein Subunit Beta 4	Protein Coding	4
25	GNG8	G Protein Subunit Gamma 8	Protein Coding	4
26	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
27	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
28	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
29	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
30	GNAO1	G Protein Subunit Alpha O1	Protein Coding	3
31	GNAZ	G Protein Subunit Alpha Z	Protein Coding	3
32	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
33	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	3
34	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
35	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
36	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
37	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
38	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
39	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
40	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
41	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	3
42	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
43	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
44	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
45	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
46	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	2
47	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
48	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
49	CALM1	Calmodulin 1	Protein Coding	2
50	CALM2	Calmodulin 2	Protein Coding	2
51	CALM3	Calmodulin 3	Protein Coding	2
52	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
53	DRD2	Dopamine Receptor D2	Protein Coding	1
54	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
55	UHMK1	U2AF Homology Motif Kinase 1	Protein Coding	1
56	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
57	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	1
58	EGF	Epidermal Growth Factor	Protein Coding	1
59	EREG	Epiregulin	Protein Coding	1
60	ESR1	Estrogen Receptor 1	Protein Coding	1
61	ESR2	Estrogen Receptor 2	Protein Coding	1
62	FOXO3	Forkhead Box O3	Protein Coding	1
63	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
64	EPGN	Epithelial Mitogen	Protein Coding	1
65	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	1
66	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
67	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
68	ZDHHC21	ZDHHC Palmitoyltransferase 21	Protein Coding	1
69	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	1
70	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
71	AREG	Amphiregulin	Protein Coding	1
72	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
73	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
74	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
75	MMP7	Matrix Metallopeptidase 7	Protein Coding	1
76	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
77	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
78	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
79	ZDHHC7	ZDHHC Palmitoyltransferase 7	Protein Coding	1
80	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
81	CCND1	Cyclin D1	Protein Coding	1
82	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
83	SRF	Serum Response Factor	Protein Coding	1
84	STRN	Striatin	Protein Coding	1
85	BTC	Betacellulin	Protein Coding	1
86	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
87	XPO1	Exportin 1	Protein Coding	1
88	CAV1	Caveolin 1	Protein Coding	1
89	CAV2	Caveolin 2	Protein Coding	1
90	SPHK1	Sphingosine Kinase 1	Protein Coding	1
91	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
92	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	1
93	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	1
94	DAGLA	Diacylglycerol Lipase Alpha	Protein Coding	1
95	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
96	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
97	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
98	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
99	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	1
100	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
101	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
102	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
103	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
104	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
105	PLCB2	Phospholipase C Beta 2	Protein Coding	1
106	PLCB3	Phospholipase C Beta 3	Protein Coding	1
107	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
108	MGLL	Monoglyceride Lipase	Protein Coding	1
109	DAGLB	Diacylglycerol Lipase Beta	Protein Coding	1
110	RHOA	Ras Homolog Family Member A	Protein Coding	1
111	CBL	Cbl Proto-Oncogene	Protein Coding	1
112	CDC42	Cell Division Cycle 42	Protein Coding	1
113	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
114	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
115	DOK1	Docking Protein 1	Protein Coding	1
116	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
117	JAK2	Janus Kinase 2	Protein Coding	1
118	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
119	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
120	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
121	PXN	Paxillin	Protein Coding	1
122	RAC1	Rac Family Small GTPase 1	Protein Coding	1
123	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
124	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
125	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
126	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
127	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
128	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1

Disorders associated with Development Dopamine D2 receptor transactivation of EGFR SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	11.03
3	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	10.67
4	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, NRAS, PIK3CA	8.63
5	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.08
6	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.48
7	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.81
8	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42, PTPN11	6.60
9	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.15
10	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.49
11	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	5.46
12	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	5.46
13	Breast cancer	Enrichment	AKT1, ESR1, GNG3, KRAS, PIK3CA, SHC1	5.39
14	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.34
15	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.16
16	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	5.08
17	Colorectal cancer	Enrichment	AKT1, CCND1, NRAS, PIK3CA, PIK3R1, SRC	5.02
18	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.82
19	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, PIK3CA	4.69
20	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.50
21	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.45
22	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.45
23	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.45
24	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.32
25	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.15
26	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.15
27	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.15
28	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.02
29	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	4.02
30	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.02
31	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, KRAS, PIK3CA	3.96
32	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.93
33	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	3.80
34	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.76
35	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.72
36	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.61
37	Ovarian cancer	Enrichment	AKT1, CDKN1B, EGFR, KRAS, PIK3CA	3.57
38	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.49
39	Myelofibrosis	Enrichment	JAK2, SRC	3.48
40	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.38
41	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.28
42	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.24
43	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.18
44	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.18
45	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.18
46	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.18
47	Meningioma	Enrichment	AKT1, PIK3CA	3.12
48	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	3.11
49	Specific learning disability	Enrichment	MAPK1, PTPN11	3.06
50	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	2.98
51	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	2.95
52	Microcephaly	Enrichment	GNAO1, GNB1, MAPK1, PTPN11	2.81
53	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.73
54	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GNB1	2.68
55	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	2.56
56	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.50
57	Macrodactyly	Enrichment	PIK3CA	2.46
58	Proteus syndrome	Enrichment	AKT1	2.46
59	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.46
60	Noonan syndrome 5	Enrichment	RAF1	2.46
61	Noonan syndrome 4	Enrichment	SOS1	2.46
62	Melorheostosis, isolated	Enrichment	MAP2K1	2.46
63	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.46
64	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.46
65	Cowden syndrome 5	Enrichment	PIK3CA	2.46
66	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.46
67	Noonan syndrome 9	Enrichment	SOS2	2.46
68	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.46
69	Ventricular tachycardia, familial	Enrichment	GNAI2	2.46
70	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.46
71	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.46
72	Noonan syndrome 13	Enrichment	MAPK1	2.46
73	Short syndrome	Enrichment	PIK3R1	2.46
74	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.46
75	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.46
76	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.46
77	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.46
78	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.46
79	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.46
80	Melorheostosis	Enrichment	MAP2K1	2.46
81	Leopard syndrome 2	Enrichment	RAF1	2.46
82	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.46
83	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.46
84	Cowden syndrome 6	Enrichment	AKT1	2.46
85	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.46
86	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.46
87	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.46
88	Thrombocytopenia 6	Enrichment	SRC	2.46
89	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.46
90	Sick sinus syndrome 4	Enrichment	GNB2	2.46
91	Trigonitis	Enrichment	RAF1	2.46
92	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.46
93	Hypospadias	Enrichment	PIK3CA	2.46
94	Capillary hemangioma	Enrichment	AKT3	2.46
95	Rare venous malformation	Enrichment	PIK3CA	2.46
96	Diaphragmatic eventration	Enrichment	PIK3CA	2.46
97	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.46
98	Rare combined vascular malformation	Enrichment	PIK3CA	2.46
99	Cavernous lymphangioma	Enrichment	PIK3CA	2.46
100	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.46
101	Gnao1-related disorder	Enrichment	GNAO1	2.46
102	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.46
103	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.46
104	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.46
105	Macrodactyly of toe	Enrichment	PIK3CA	2.46
106	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.46
107	Myeloma, multiple	Enrichment	CCND1, KRAS, PIK3R2	2.41
108	Metachondromatosis	Enrichment	PTPN11	2.39
109	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.39
110	Leopard syndrome 1	Enrichment	PTPN11	2.39
111	Whim syndrome 1	Enrichment	CXCR4	2.39
112	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.39
113	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.39
114	Immunodeficiency 22	Enrichment	LCK	2.39
115	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.39
116	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.39
117	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.39
118	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.39
119	Cd45 deficiency	Enrichment	PTPRC	2.39
120	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.39
121	Gorham's disease	Enrichment	RASA1	2.39
122	Nocarh syndrome	Enrichment	CDC42	2.39
123	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.39
124	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.39
125	Malignant astrocytoma	Enrichment	PTPN11	2.39
126	Hypertension, essential	Enrichment	GNB3, NOS3	2.39
127	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.31
128	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.29
129	Neuroocular syndrome 2, paroxysmal type	Enrichment	DAGLA	2.29
130	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.29
131	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	2.29
132	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.29
133	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.29
134	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.29
135	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.29
136	Long qt syndrome 16	Enrichment	CALM3	2.29
137	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.29
138	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.29
139	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.29
140	Long qt syndrome 15	Enrichment	CALM2	2.29
141	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.29
142	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.29
143	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.29
144	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.29
145	Strabismus	Enrichment	GNB1, PTPN11	2.27
146	Oculoectodermal syndrome	Enrichment	KRAS	2.25
147	Hypomagnesemia 4, renal	Enrichment	EGF	2.25
148	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.25
149	Melanosis, neurocutaneous	Enrichment	NRAS	2.25
150	Noonan syndrome 6	Enrichment	NRAS	2.25
151	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.25
152	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.25
153	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.25
154	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.25
155	Ovarian dysgenesis 8	Enrichment	ESR2	2.25
156	Neuroendocrine tumor	Enrichment	CDKN1B	2.25
157	Coronary heart disease 6	Enrichment	MMP3	2.25
158	Congenital pulmonary airway malformation	Enrichment	KRAS	2.25
159	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.25
160	Neurocutaneous melanocytosis	Enrichment	NRAS	2.25
161	Fibromatosis, gingival, 1	Enrichment	SOS1	2.16
162	Costello syndrome	Enrichment	HRAS	2.16
163	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.16
164	Pulmonic stenosis	Enrichment	SOS1	2.16
165	Keratosis, seborrheic	Enrichment	PIK3CA	2.16
166	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.16
167	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.16
168	Noonan syndrome 8	Enrichment	PIK3CA	2.16
169	Senior-loken syndrome 7	Enrichment	AKT3	2.16
170	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.16
171	Immune system disease	Enrichment	PIK3CD	2.16
172	Bardet-biedl syndrome 16	Enrichment	AKT3	2.16
173	Hypopituitarism	Enrichment	GNAI2	2.16
174	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.16
175	Tafro syndrome	Enrichment	MAP2K2	2.16
176	Cerebral visual impairment	Enrichment	GNB1	2.16
177	Wooly hair nevus	Enrichment	HRAS	2.16
178	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.16
179	Severe combined immunodeficiency	Enrichment	LCK, PTPRC	2.10
180	Ovarian germ cell cancer	Enrichment	CBL	2.09
181	Thrombocythemia 3	Enrichment	JAK2	2.09
182	Myopia 28, autosomal recessive	Enrichment	DOK1	2.09
183	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.09
184	Werner syndrome	Enrichment	PTPN11	2.09
185	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.09
186	Polycythemia	Enrichment	JAK2	2.09
187	Hypereosinophilic syndrome	Enrichment	JAK2	2.09
188	Malignant germ cell tumor of ovary	Enrichment	CBL	2.09
189	Autism spectrum disorder	Enrichment	GNB1, MAP2K1, PTPN11	2.01
190	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.99
191	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.99
192	Long qt syndrome 14	Enrichment	CALM1	1.99
193	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.98
194	Nuchal bleb, familial	Enrichment	SOS1	1.98
195	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.98
196	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.98
197	Spermatocytoma	Enrichment	HRAS	1.98
198	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.98
199	Keratoacanthoma	Enrichment	PIK3CA	1.98
200	Long qt syndrome	Enrichment	CALM1, CALM2	1.97
201	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.95
202	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.95
203	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.95
204	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.95
205	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.95
206	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.95
207	Metaphyseal anadysplasia	Enrichment	MMP9	1.95
208	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.95
209	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.92
210	Polycythemia vera	Enrichment	JAK2	1.92
211	Hyper ige syndrome	Enrichment	STAT3	1.92
212	Wieacker-wolff syndrome	Enrichment	RASA1	1.92
213	Tricuspid valve insufficiency	Enrichment	PTPN11	1.92
214	Dystonia	Enrichment	CAMK2B, GNB1	1.87
215	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.86
216	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.86
217	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.86
218	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.86
219	Achromatopsia 4	Enrichment	GNAI3	1.86
220	Cerebrovascular disease	Enrichment	PIK3CA	1.86
221	Epidermolytic nevus	Enrichment	HRAS	1.86
222	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.86
223	Gingival fibromatosis	Enrichment	SOS1	1.86
224	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.86
225	Familial sick sinus syndrome	Enrichment	GNB2	1.86
226	Gillespie syndrome	Enrichment	ITPR1	1.82
227	Erythrocytosis, familial, 1	Enrichment	JAK2	1.79
228	Budd-chiari syndrome	Enrichment	JAK2	1.79
229	Thrombocytopenia	Enrichment	PTPN11, SRC	1.79
230	Congenital nervous system abnormality	Enrichment	CAMK2B, GNAO1, GNB5	1.78
231	Nervous system disease	Enrichment	CAMK2B, GNAO1, GNB5	1.78
232	Thyroid carcinoma, familial medullary	Enrichment	ESR2	1.77
233	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.77
234	Estrogen resistance	Enrichment	ESR1	1.77
235	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.77
236	Migraine without aura	Enrichment	ESR1	1.77
237	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.77
238	Melanoma of soft tissue	Enrichment	CREB1	1.77
239	Capillary malformations, congenital	Enrichment	PIK3CA	1.76
240	Lymphoma	Enrichment	PTPN11	1.70
241	Aggressive systemic mastocytosis	Enrichment	CBL	1.70
242	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.69
243	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.69
244	Dystonia 11, myoclonic	Enrichment	DRD2	1.69
245	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.69
246	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.67
247	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.65
248	Congenital generalized lipodystrophy	Enrichment	FOS	1.65
249	Mantle cell lymphoma	Enrichment	CCND1	1.65
250	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.65
251	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.65
252	Pilocytic astrocytoma	Enrichment	KRAS	1.65
253	Primary hyperparathyroidism	Enrichment	CDKN1B	1.65
254	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.62
255	Pilomyxoid astrocytoma	Enrichment	RAF1	1.62
256	Megacolon	Enrichment	AKT3	1.62
257	Overgrowth syndrome	Enrichment	PIK3R1	1.62
258	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.62
259	Hemangioma, capillary infantile	Enrichment	RASA1	1.62
260	Basal cell carcinoma 1	Enrichment	RASA1	1.62
261	Patent ductus arteriosus	Enrichment	PTPN11	1.62
262	Gastric cancer	Enrichment	KRAS, PIK3CA	1.61
263	Hypothyroidism	Enrichment	GNB1	1.56
264	Choreatic disease	Enrichment	GNAO1	1.56
265	Essential thrombocythemia	Enrichment	JAK2	1.55
266	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.55
267	Alzheimer disease 2	Enrichment	NOS3	1.55
268	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.55
269	Von hippel-lindau syndrome	Enrichment	CCND1	1.55
270	Insulin-like growth factor i	Enrichment	IGF1R	1.55
271	Pre-eclampsia	Enrichment	NOS3	1.55
272	Follicular lymphoma	Enrichment	BCL2	1.55
273	Histiocytoid hemangioma	Enrichment	FOS	1.55
274	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.55
275	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.52
276	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.52
277	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	1.52
278	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.50
279	Limited scleroderma	Enrichment	CAV1	1.47
280	Polymicrogyria	Enrichment	AKT3	1.47
281	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.44
282	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.44
283	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.43
284	Myelodysplastic syndrome	Enrichment	GNB1	1.43
285	Movement disease	Enrichment	GNAO1	1.43
286	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.41
287	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.40
288	Pectus excavatum	Enrichment	PTPN11	1.36
289	Aortic valve disease 1	Enrichment	SOS1	1.36
290	Nk-cell enteropathy	Enrichment	PIK3CB	1.36
291	Autosomal dominant cerebellar ataxia	Enrichment	DAGLA	1.35
292	Osteoporosis	Enrichment	SRC	1.32
293	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.32
294	Epicanthus	Enrichment	PTPN11	1.32
295	Congenital long qt syndrome	Enrichment	PTPN11	1.32
296	Rare genetic intellectual disability	Enrichment	GNAO1	1.29
297	Acute promyelocytic leukemia	Enrichment	STAT3	1.29
298	Gliosarcoma	Enrichment	EGFR	1.27
299	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.26
300	Stroke, ischemic	Enrichment	NOS3	1.26
301	Cleft palate, isolated	Enrichment	GNB1	1.24
302	Giant cell glioblastoma	Enrichment	EGFR	1.24
303	Heart, malformation of	Enrichment	MAPK1	1.22
304	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.22
305	Migraine with or without aura 1	Enrichment	ESR1	1.22
306	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.22
307	Multiple sclerosis	Enrichment	ITPR1	1.16
308	Endometrial cancer	Enrichment	PIK3CA	1.15
309	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.15
310	Patent foramen ovale	Enrichment	PTPN11	1.15
311	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.15
312	Protein-deficiency anemia	Enrichment	NRAS	1.15
313	Hepatocellular carcinoma	Enrichment	PIK3CA	1.13
314	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.13
315	Anterior segment dysgenesis	Enrichment	ITPR1	1.13
316	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.13
317	Congenital stationary night blindness	Enrichment	GNB3	1.11
318	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.10
319	Sudden infant death syndrome	Enrichment	CALM2	1.08
320	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	1.08
321	Alzheimer disease, familial, 1	Enrichment	NOS3	1.03
322	Scoliosis	Enrichment	PTPN11	1.03
323	Prostate cancer	Enrichment	PIK3CA	1.02
324	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.97
325	Left ventricular noncompaction	Enrichment	RAF1	0.94
326	Developmental and epileptic encephalopathy	Enrichment	GNAO1	0.93
327	Myocardial infarction	Enrichment	ESR1	0.93
328	Tooth agenesis	Enrichment	TGFA	0.93
329	Cerebral palsy	Enrichment	GNB1	0.90
330	Pancreatic cancer	Enrichment	KRAS	0.88
331	Type 2 diabetes mellitus	Enrichment	AKT2	0.87
332	West syndrome	Enrichment	GNAO1	0.85
333	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.79
334	Hypertelorism	Enrichment	PIK3CA	0.78
335	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.77
336	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, EGFR	0.76
337	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.70
338	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.69
339	Charcot-marie-tooth disease	Enrichment	HSPB1	0.68
340	Primary ovarian insufficiency	Enrichment	JAK2	0.67
341	Spastic ataxia	Enrichment	ITPR1	0.62
342	Dilated cardiomyopathy	Enrichment	RAF1	0.61
343	Autism	Enrichment	CAMK2G	0.51
344	Complex neurodevelopmental disorder	Enrichment	GNB2	0.45

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development Dopamine D2 receptor transactivation of EGFR

Pathway Network for Development Dopamine D2 receptor transactivation of EGFR

Pathway network for the Development Dopamine D2 receptor transactivation of EGFR SuperPath

Member Pathways for Development Dopamine D2 receptor transactivation of EGFR

Pathways in the Development Dopamine D2 receptor transactivation of EGFR SuperPath

Gene overlap in member pathways for Development Dopamine D2 receptor transactivation of EGFR SuperPath

Associated Genes for Development Dopamine D2 receptor transactivation of EGFR

Associated Disorders for Development Dopamine D2 receptor transactivation of EGFR

Disorders associated with Development Dopamine D2 receptor transactivation of EGFR SuperPath

STRING Interaction Network for Development Dopamine D2 receptor transactivation of EGFR

Sources for Development Dopamine D2 receptor transactivation of EGFR