Development EGFR signaling via small GTPases

Pathway network for the Development EGFR signaling via small GTPases SuperPath

Sources:

GeneGo (Thomson Reuters)

Pathways in the Development EGFR signaling via small GTPases SuperPath

#	Name	Source	Genes
1	Development EGFR signaling via small GTPases	GeneGo (Thomson Reuters)	ABI1 CBL DOK2 EGF EGFR ELK1 EPS8 ERBB2 FOS GRB2 HRAS KRAS MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K10 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MYC NRAS PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAB5A RAC1 RAF1 RASA1 SHC1 SOS1 SOS2 USP6NL VAV2 (see all 39) (see less)
2	Development PDGF signaling via MAPK cascades	GeneGo (Thomson Reuters)	ADCY3 ELK1 GNAS GRB2 HRAS ITPR1 ITPR2 ITPR3 JUN MAP2K1 MAP2K2 MAP2K4 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCE PTGIR RAC1 RAF1 SHC1 SOS1 SOS2 SRF VAV2 (see all 46) (see less)
3	Development EGFR signaling via PIP3	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CBL EGF EGFR ERBB2 GAB1 GRB2 IRS1 IRS2 MAP2K4 MAP2K7 MAP3K10 MAPK10 MAPK8 MAPK9 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN RAC1 VAV2 (see all 27) (see less)

Gene overlap in member pathways for Development EGFR signaling via small GTPases SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
3	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
4	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
5	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
6	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
7	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
8	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
9	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	3
10	RAC1	Rac Family Small GTPase 1	Protein Coding	3
11	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
12	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	3
13	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
14	CBL	Cbl Proto-Oncogene	Protein Coding	2
15	EGF	Epidermal Growth Factor	Protein Coding	2
16	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2
17	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
18	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	2
19	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
20	MAP3K10	Mitogen-Activated Protein Kinase Kinase Kinase 10	Protein Coding	2
21	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
22	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
23	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
24	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
25	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
26	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
27	SHC1	SHC Adaptor Protein 1	Protein Coding	2
28	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
29	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
30	EPS8	EGFR Pathway Substrate 8, Signaling Adaptor	Protein Coding	1
31	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
32	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
33	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
34	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
35	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
36	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
37	DOK2	Docking Protein 2	Protein Coding	1
38	USP6NL	USP6 N-Terminal Like	Protein Coding	1
39	ABI1	Abl Interactor 1	Protein Coding	1
40	ADCY3	Adenylate Cyclase 3	Protein Coding	1
41	GNAS	GNAS Complex Locus	Protein Coding	1
42	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
43	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
44	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
45	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
46	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
47	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
48	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
49	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
50	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
51	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
52	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
53	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
54	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
55	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
56	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
57	PRKCA	Protein Kinase C Alpha	Protein Coding	1
58	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
59	PTGIR	Prostaglandin I2 Receptor	Protein Coding	1
60	SRF	Serum Response Factor	Protein Coding	1
61	PDGFC	Platelet Derived Growth Factor C	Protein Coding	1
62	PDGFD	Platelet Derived Growth Factor D	Protein Coding	1
63	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
64	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
65	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
66	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
67	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
68	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
69	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
70	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1

Disorders associated with Development EGFR signaling via small GTPases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	16.00
2	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	11.65
3	Noonan syndrome 1	Enrichment	CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	11.32
4	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.80
5	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.69
6	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA, RASA1	8.69
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	8.69
8	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	8.14
9	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.92
10	Bladder cancer	Enrichment	EGFR, ERBB2, HRAS, KRAS, PIK3CA	7.77
11	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	7.55
12	Hemimegalencephaly	Enrichment	AKT3, PIK3CA, PTEN	7.15
13	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.06
14	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	7.06
15	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	7.06
16	Cowden syndrome 1	Enrichment	EGFR, PIK3CA, PTEN	6.85
17	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	6.36
18	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	6.23
19	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	5.91
20	Ovarian cancer	Enrichment	AKT1, EGFR, ERBB2, PIK3CA, PTEN	5.83
21	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	5.82
22	Lung cancer	Enrichment	EGFR, ERBB2, KRAS, PIK3CA	5.70
23	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS	5.32
24	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	5.32
25	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, KRAS	5.11
26	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.09
27	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.95
28	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.94
29	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.94
30	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.94
31	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.64
32	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	4.62
33	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.62
34	Colorectal cancer	Enrichment	AKT1, ERBB2, PIK3CA, PIK3R1	4.61
35	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.32
36	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.24
37	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.12
38	Type 2 diabetes mellitus	Enrichment	AKT2, IRS1, IRS2	4.12
39	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN	4.10
40	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.10
41	Gastric cancer	Enrichment	ERBB2, PIK3CA, PTEN	4.08
42	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN	4.05
43	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	3.95
44	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.92
45	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.87
46	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.78
47	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.78
48	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.78
49	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	3.78
50	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.78
51	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.77
52	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.51
53	Breast cancer	Enrichment	AKT1, PIK3CA, PTEN	3.36
54	Rhabdomyosarcoma	Enrichment	CBL, PTEN	3.35
55	Endometrial cancer	Enrichment	PIK3CA, PTEN	3.11
56	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.08
57	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	3.00
58	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.87
59	Prostate cancer	Enrichment	PIK3CA, PTEN	2.82
60	Macrodactyly	Enrichment	PIK3CA	2.70
61	Proteus syndrome	Enrichment	AKT1	2.70
62	Paget disease, extramammary	Enrichment	ERBB2	2.70
63	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.70
64	Vacterl association with hydrocephalus	Enrichment	PTEN	2.70
65	Deafness, autosomal recessive 26	Enrichment	GAB1	2.70
66	Hypomagnesemia 4, renal	Enrichment	EGF	2.70
67	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.70
68	Cowden syndrome 5	Enrichment	PIK3CA	2.70
69	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.70
70	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.70
71	Short syndrome	Enrichment	PIK3R1	2.70
72	Papillary tumor of the pineal region	Enrichment	PTEN	2.70
73	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.70
74	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.70
75	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.70
76	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.70
77	Cowden syndrome 6	Enrichment	AKT1	2.70
78	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.70
79	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.70
80	Glioma susceptibility 2	Enrichment	PTEN	2.70
81	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.70
82	Hypospadias	Enrichment	PIK3CA	2.70
83	Capillary hemangioma	Enrichment	AKT3	2.70
84	Rare venous malformation	Enrichment	PIK3CA	2.70
85	Diaphragmatic eventration	Enrichment	PIK3CA	2.70
86	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.70
87	Rare combined vascular malformation	Enrichment	PIK3CA	2.70
88	Cavernous lymphangioma	Enrichment	PIK3CA	2.70
89	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.70
90	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.70
91	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.70
92	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.70
93	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.70
94	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.70
95	Macrodactyly of toe	Enrichment	PIK3CA	2.70
96	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.70
97	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.70
98	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.54
99	Oculoectodermal syndrome	Enrichment	KRAS	2.54
100	Noonan syndrome 5	Enrichment	RAF1	2.54
101	Noonan syndrome 4	Enrichment	SOS1	2.54
102	Melorheostosis, isolated	Enrichment	MAP2K1	2.54
103	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.54
104	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.54
105	Melanosis, neurocutaneous	Enrichment	NRAS	2.54
106	Noonan syndrome 9	Enrichment	SOS2	2.54
107	Noonan syndrome 6	Enrichment	NRAS	2.54
108	Noonan syndrome 13	Enrichment	MAPK1	2.54
109	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.54
110	Melorheostosis	Enrichment	MAP2K1	2.54
111	Leopard syndrome 2	Enrichment	RAF1	2.54
112	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.54
113	Deafness, autosomal recessive 102	Enrichment	EPS8	2.54
114	Trigonitis	Enrichment	RAF1	2.54
115	Congenital pulmonary airway malformation	Enrichment	KRAS	2.54
116	Gorham's disease	Enrichment	RASA1	2.54
117	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.54
118	Neurocutaneous melanocytosis	Enrichment	NRAS	2.54
119	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.47
120	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.47
121	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.47
122	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.47
123	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.47
124	Carney complex, type 1	Enrichment	PRKAR1A	2.47
125	Osseous heteroplasia, progressive	Enrichment	GNAS	2.47
126	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.47
127	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.47
128	46,xy sex reversal 6	Enrichment	MAP3K1	2.47
129	Gist-plus syndrome	Enrichment	PDGFRA	2.47
130	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.47
131	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.47
132	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.47
133	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.47
134	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.47
135	Myxoma, intracardiac	Enrichment	PRKAR1A	2.47
136	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.47
137	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.47
138	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.47
139	Disorders of gnas inactivation	Enrichment	GNAS	2.47
140	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.47
141	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.47
142	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.47
143	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.47
144	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.47
145	Monostotic fibrous dysplasia	Enrichment	GNAS	2.47
146	Mazabraud syndrome	Enrichment	GNAS	2.47
147	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.45
148	Ovarian germ cell cancer	Enrichment	CBL	2.40
149	Keratosis, seborrheic	Enrichment	PIK3CA	2.40
150	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.40
151	Noonan syndrome 8	Enrichment	PIK3CA	2.40
152	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.40
153	Senior-loken syndrome 7	Enrichment	AKT3	2.40
154	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.40
155	Immune system disease	Enrichment	PIK3CD	2.40
156	Bardet-biedl syndrome 16	Enrichment	AKT3	2.40
157	Vacterl with hydrocephalus	Enrichment	PTEN	2.40
158	Malignant germ cell tumor of ovary	Enrichment	CBL	2.40
159	Juvenile polyposis of infancy	Enrichment	PTEN	2.40
160	Burkitt lymphoma	Enrichment	MYC	2.24
161	Fibromatosis, gingival, 1	Enrichment	SOS1	2.24
162	Costello syndrome	Enrichment	HRAS	2.24
163	Pulmonic stenosis	Enrichment	SOS1	2.24
164	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.24
165	Tafro syndrome	Enrichment	MAP2K2	2.24
166	Wooly hair nevus	Enrichment	HRAS	2.24
167	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.23
168	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.22
169	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.22
170	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.22
171	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.22
172	Keratoacanthoma	Enrichment	PIK3CA	2.22
173	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.17
174	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.17
175	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.17
176	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.17
177	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.17
178	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.17
179	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.17
180	Usher syndrome, type iv	Enrichment	PRKAR1A	2.17
181	Infantile myofibromatosis	Enrichment	PDGFRB	2.17
182	Acrodysostosis	Enrichment	PRKAR1A	2.17
183	Pseudohypoparathyroidism	Enrichment	GNAS	2.17
184	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.17
185	Fibrolamellar carcinoma	Enrichment	PRKACA	2.17
186	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.17
187	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.17
188	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.17
189	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.17
190	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.17
191	Barrett esophagus	Enrichment	ERBB2	2.10
192	Cerebrovascular disease	Enrichment	PIK3CA	2.10
193	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.10
194	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.10
195	Glioma	Enrichment	PTEN	2.10
196	Nuchal bleb, familial	Enrichment	SOS1	2.07
197	Wieacker-wolff syndrome	Enrichment	RASA1	2.07
198	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.07
199	Spermatocytoma	Enrichment	HRAS	2.07
200	Macrocephaly/autism syndrome	Enrichment	PTEN	2.00
201	Myeloproliferative neoplasm	Enrichment	CBL	2.00
202	Hemangioma	Enrichment	PTEN	2.00
203	Acute megakaryocytic leukemia	Enrichment	PTEN	2.00
204	Aggressive systemic mastocytosis	Enrichment	CBL	2.00
205	Mccune-albright syndrome	Enrichment	GNAS	1.99
206	Gillespie syndrome	Enrichment	ITPR1	1.99
207	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.99
208	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.95
209	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.94
210	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.94
211	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.94
212	Congenital generalized lipodystrophy	Enrichment	FOS	1.94
213	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.94
214	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.94
215	Pilocytic astrocytoma	Enrichment	KRAS	1.94
216	Epidermolytic nevus	Enrichment	HRAS	1.94
217	Gingival fibromatosis	Enrichment	SOS1	1.94
218	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.94
219	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.92
220	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.91
221	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.87
222	Carney complex variant	Enrichment	PRKAR1A	1.87
223	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.87
224	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.87
225	Megacolon	Enrichment	AKT3	1.86
226	Overgrowth syndrome	Enrichment	PIK3R1	1.86
227	Histiocytoid hemangioma	Enrichment	FOS	1.84
228	Glioma susceptibility 1	Enrichment	ERBB2	1.80
229	Lennox-gastaut syndrome	Enrichment	MAPK10	1.80
230	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.77
231	Hemangioma, capillary infantile	Enrichment	RASA1	1.77
232	Basal cell carcinoma 1	Enrichment	RASA1	1.77
233	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.75
234	Polymicrogyria	Enrichment	AKT3	1.70
235	Melanoma	Enrichment	PTEN	1.70
236	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.70
237	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.70
238	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.70
239	Meningioma, familial	Enrichment	PTEN	1.66
240	Uterine corpus cancer	Enrichment	PTEN	1.66
241	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.63
242	Brachydactyly	Enrichment	GNAS	1.63
243	Nk-cell enteropathy	Enrichment	PIK3CB	1.59
244	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.57
245	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PTEN	1.55
246	Ellis-van creveld syndrome	Enrichment	PRKACA	1.52
247	Primary hyperaldosteronism	Enrichment	GNAS	1.52
248	Specific learning disability	Enrichment	MAPK1	1.51
249	Gliosarcoma	Enrichment	EGFR	1.50
250	Giant cell glioblastoma	Enrichment	EGFR	1.48
251	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.44
252	Aortic valve disease 1	Enrichment	SOS1	1.43
253	Protein-deficiency anemia	Enrichment	NRAS	1.43
254	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.43
255	Congenital long qt syndrome	Enrichment	ITPR3	1.40
256	Hepatocellular carcinoma	Enrichment	PIK3CA	1.37
257	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.36
258	Multiple sclerosis	Enrichment	ITPR1	1.33
259	Cleft lip/palate	Enrichment	PDGFRA	1.33
260	Hydrocephalus	Enrichment	PDGFRB	1.30
261	Anterior segment dysgenesis	Enrichment	ITPR1	1.30
262	Heart, malformation of	Enrichment	MAPK1	1.30
263	Dandy-walker syndrome	Enrichment	PDGFRB	1.25
264	Hirschsprung disease 1	Enrichment	ERBB2	1.25
265	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.19
266	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.18
267	Pancreatic cancer	Enrichment	KRAS	1.16
268	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.14
269	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.04
270	Left ventricular noncompaction	Enrichment	RAF1	1.02
271	Long qt syndrome 1	Enrichment	ITPR3	1.01
272	Hypertelorism	Enrichment	PIK3CA	1.01
273	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.98
274	Cerebral palsy	Enrichment	PDGFRB	0.91
275	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.85
276	Spastic ataxia	Enrichment	ITPR1	0.78
277	Deafness, autosomal recessive	Enrichment	EPS8	0.78
278	Autosomal recessive nonsyndromic deafness	Enrichment	EPS8	0.77
279	Congenital nervous system abnormality	Enrichment	PTEN	0.72
280	Nervous system disease	Enrichment	PTEN	0.72
281	Autism spectrum disorder	Enrichment	PTEN	0.71
282	Dilated cardiomyopathy	Enrichment	RAF1	0.69
283	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EPS8	0.64
284	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.64
285	Microcephaly	Enrichment	MAPK1	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development EGFR signaling via small GTPases

Pathway Network for Development EGFR signaling via small GTPases

Pathway network for the Development EGFR signaling via small GTPases SuperPath

Member Pathways for Development EGFR signaling via small GTPases

Pathways in the Development EGFR signaling via small GTPases SuperPath

Gene overlap in member pathways for Development EGFR signaling via small GTPases SuperPath

Associated Genes for Development EGFR signaling via small GTPases

Associated Disorders for Development EGFR signaling via small GTPases

Disorders associated with Development EGFR signaling via small GTPases SuperPath

STRING Interaction Network for Development EGFR signaling via small GTPases

Sources for Development EGFR signaling via small GTPases