Development FGFR signaling pathway

Pathway network for the Development FGFR signaling pathway SuperPath

Sources:

GeneGo (Thomson Reuters)
QIAGEN

Pathways in the Development FGFR signaling pathway SuperPath

#	Name	Source	Genes
1	Development FGFR signaling pathway	GeneGo (Thomson Reuters)	ABI1 AKT1 AKT2 AKT3 ATF2 CBL CREB1 CRK DOCK1 ELK1 EPS8 FGF2 FGFR1 FRS2 GAB1 GRB2 HRAS HSPG2 ITPR1 ITPR2 ITPR3 JUN MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP3K1 MAP3K11 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 PAK1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKCD PTPN11 RAC1 RAF1 SDC1 SDC2 SDC4 SHB SHC1 SOS1 SOS2 UBA52 UBB UBC (see all 61) (see less)
2	FGF Pathway	QIAGEN	ATF2 CDC42 ELK1 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GPLD1 GRB2 HRAS ITPR1 ITPR2 ITPR3 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PLD1 PLD2 PLD3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAC1 RAF1 RALA RALB RALBP1 RALGDS RASA1 RRAS RRAS2 SOS1 SOS2 (see all 90) (see less)
3	Development FGF-family signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 FGF1 FGF10 FGF16 FGF19 FGF2 FGF3 FGF4 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 GAB1 GRB2 HRAS HSPG2 ITPR1 ITPR2 ITPR3 MAP2K1 MAP2K2 MAP2K6 MAP3K11 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKCA PRKCB PRKCD PRKCE PTPN11 RAC1 RAF1 SHC1 SOS1 SOS2 (see all 54) (see less)
4	Development Flt3 signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ATF2 BAD BCL2L1 CBL CDC42 CRK CRKL FLT3 FLT3LG FYN GAB1 GAB2 GRB2 HRAS INPP5D JUN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K4 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 PAK1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PTPN11 RAC1 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 SHC1 SOS1 SOS2 SRC STAT5A VAV1 (see all 53) (see less)

Gene overlap in member pathways for Development FGFR signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	4
2	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	4
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
4	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	4
5	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	4
6	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
7	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	4
8	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	4
9	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	4
10	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	4
11	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	4
12	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	4
13	RAC1	Rac Family Small GTPase 1	Protein Coding	4
14	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	4
15	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	4
16	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	4
17	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	4
18	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
19	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
20	ATF2	Activating Transcription Factor 2	Protein Coding	3
21	FGF2	Fibroblast Growth Factor 2	Protein Coding	3
22	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	3
23	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	3
24	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
25	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
26	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
27	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	3
28	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
29	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
30	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
31	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
32	PRKCD	Protein Kinase C Delta	Protein Coding	3
33	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
34	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
35	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
36	SHC1	SHC Adaptor Protein 1	Protein Coding	3
37	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
38	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
39	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	3
40	CBL	Cbl Proto-Oncogene	Protein Coding	2
41	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
42	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
43	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	2
44	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
45	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
46	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	2
47	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
48	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
49	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
50	CDC42	Cell Division Cycle 42	Protein Coding	2
51	FGF1	Fibroblast Growth Factor 1	Protein Coding	2
52	FGF10	Fibroblast Growth Factor 10	Protein Coding	2
53	FGF16	Fibroblast Growth Factor 16	Protein Coding	2
54	FGF19	Fibroblast Growth Factor 19	Protein Coding	2
55	FGF3	Fibroblast Growth Factor 3	Protein Coding	2
56	FGF4	Fibroblast Growth Factor 4	Protein Coding	2
57	FGF6	Fibroblast Growth Factor 6	Protein Coding	2
58	FGF7	Fibroblast Growth Factor 7	Protein Coding	2
59	FGF8	Fibroblast Growth Factor 8	Protein Coding	2
60	FGF9	Fibroblast Growth Factor 9	Protein Coding	2
61	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	2
62	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	2
63	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	2
64	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
65	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
66	PRKCA	Protein Kinase C Alpha	Protein Coding	2
67	PRKCB	Protein Kinase C Beta	Protein Coding	2
68	PRKCE	Protein Kinase C Epsilon	Protein Coding	2
69	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
70	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
71	EPS8	EGFR Pathway Substrate 8, Signaling Adaptor	Protein Coding	1
72	SDC1	Syndecan 1	Protein Coding	1
73	SDC2	Syndecan 2	Protein Coding	1
74	SDC4	Syndecan 4	Protein Coding	1
75	SHB	SH2 Domain Containing Adaptor Protein B	Protein Coding	1
76	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
77	UBB	Ubiquitin B	Protein Coding	1
78	UBC	Ubiquitin C	Protein Coding	1
79	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
80	ABI1	Abl Interactor 1	Protein Coding	1
81	FGF11	Fibroblast Growth Factor 11	Protein Coding	1
82	FGF12	Fibroblast Growth Factor 12	Protein Coding	1
83	FGF13	Fibroblast Growth Factor 13	Protein Coding	1
84	FGF14	Fibroblast Growth Factor 14	Protein Coding	1
85	FGF17	Fibroblast Growth Factor 17	Protein Coding	1
86	FGF18	Fibroblast Growth Factor 18	Protein Coding	1
87	FGF20	Fibroblast Growth Factor 20	Protein Coding	1
88	FGF21	Fibroblast Growth Factor 21	Protein Coding	1
89	FGF22	Fibroblast Growth Factor 22	Protein Coding	1
90	FGF23	Fibroblast Growth Factor 23	Protein Coding	1
91	FGF5	Fibroblast Growth Factor 5	Protein Coding	1
92	GPLD1	Glycosylphosphatidylinositol Specific Phospholipase D1	Protein Coding	1
93	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
94	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
95	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
96	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
97	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
98	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
99	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
100	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
101	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
102	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
103	PLD1	Phospholipase D1	Protein Coding	1
104	PLD2	Phospholipase D2	Protein Coding	1
105	PLD3	Phospholipase D Family Member 3	Protein Coding	1
106	PRKCG	Protein Kinase C Gamma	Protein Coding	1
107	PRKCH	Protein Kinase C Eta	Protein Coding	1
108	PRKCI	Protein Kinase C Iota	Protein Coding	1
109	PRKD1	Protein Kinase D1	Protein Coding	1
110	PRKD3	Protein Kinase D3	Protein Coding	1
111	PRKCQ	Protein Kinase C Theta	Protein Coding	1
112	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
113	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
114	RALB	RAS Like Proto-Oncogene B	Protein Coding	1
115	RALBP1	RalA Binding Protein 1	Protein Coding	1
116	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
117	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
118	RRAS	RAS Related	Protein Coding	1
119	RRAS2	RAS Related 2	Protein Coding	1
120	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
121	BCL2L1	BCL2 Like 1	Protein Coding	1
122	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
123	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
124	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	1
125	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
126	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	1
127	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
128	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
129	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
130	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
131	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
132	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
133	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
134	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1

Disorders associated with Development FGFR signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	16.00
3	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	11.63
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.14
5	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	7.22
6	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS	7.20
7	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.65
8	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42, PTPN11	6.65
9	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS	6.24
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.95
11	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.95
12	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.95
13	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.33
14	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.18
15	Specific learning disability	Enrichment	MAPK1, PTPN11, RPS6KA3	5.04
16	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, RASA1	5.01
17	Pilomyxoid astrocytoma	Enrichment	FGFR1, KRAS, RAF1	5.01
18	Immune system disease	Enrichment	CDC42, PIK3CD	4.82
19	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.81
20	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.81
21	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.81
22	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.81
23	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.81
24	Colorectal cancer	Enrichment	AKT1, FGFR2, FGFR3, PIK3CA, PIK3R1	4.62
25	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.36
26	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.36
27	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.35
28	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.35
29	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.35
30	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.33
31	Spermatocytoma	Enrichment	FGFR3, HRAS	4.33
32	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.23
33	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	4.05
34	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.05
35	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.05
36	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.03
37	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.89
38	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.89
39	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.83
40	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.81
41	Holoprosencephaly	Enrichment	FGF8, FGFR1	3.81
42	Bladder cancer	Enrichment	FGFR3, HRAS, PIK3CA	3.69
43	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, SHC1	3.69
44	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	3.67
45	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.65
46	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	3.64
47	Lung squamous cell carcinoma	Enrichment	FGFR3, PIK3CA	3.64
48	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.59
49	Kallmann syndrome	Enrichment	FGF17, FGF8, FGFR1	3.34
50	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.28
51	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.18
52	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.05
53	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.05
54	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.05
55	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.04
56	Meningioma	Enrichment	AKT1, PIK3CA	3.02
57	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.02
58	Congenital long qt syndrome	Enrichment	ITPR3, PTPN11	3.00
59	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.88
60	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.76
61	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.74
62	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	2.74
63	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	2.74
64	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.69
65	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	2.64
66	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.55
67	Endometrial cancer	Enrichment	FGFR2, PIK3CA	2.51
68	Lung cancer susceptibility 3	Enrichment	FGF10, KRAS	2.42
69	Macrodactyly	Enrichment	PIK3CA	2.41
70	Proteus syndrome	Enrichment	AKT1	2.41
71	Metachondromatosis	Enrichment	PTPN11	2.41
72	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.41
73	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.41
74	Deafness, autosomal recessive 26	Enrichment	GAB1	2.41
75	Noonan syndrome 5	Enrichment	RAF1	2.41
76	Noonan syndrome 4	Enrichment	SOS1	2.41
77	Melorheostosis, isolated	Enrichment	MAP2K1	2.41
78	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.41
79	Leopard syndrome 1	Enrichment	PTPN11	2.41
80	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.41
81	Cowden syndrome 5	Enrichment	PIK3CA	2.41
82	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.41
83	Noonan syndrome 9	Enrichment	SOS2	2.41
84	46,xy sex reversal 6	Enrichment	MAP3K1	2.41
85	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.41
86	Noonan syndrome 13	Enrichment	MAPK1	2.41
87	Short syndrome	Enrichment	PIK3R1	2.41
88	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.41
89	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.41
90	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.41
91	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.41
92	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.41
93	Melorheostosis	Enrichment	MAP2K1	2.41
94	Leopard syndrome 2	Enrichment	RAF1	2.41
95	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.41
96	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.41
97	Cowden syndrome 6	Enrichment	AKT1	2.41
98	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.41
99	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.41
100	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.41
101	Thrombocytopenia 6	Enrichment	SRC	2.41
102	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.41
103	Trigonitis	Enrichment	RAF1	2.41
104	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.41
105	Immunodeficiency 125	Enrichment	FLT3LG	2.41
106	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.41
107	Hypospadias	Enrichment	PIK3CA	2.41
108	Capillary hemangioma	Enrichment	AKT3	2.41
109	Rare venous malformation	Enrichment	PIK3CA	2.41
110	Diaphragmatic eventration	Enrichment	PIK3CA	2.41
111	Nocarh syndrome	Enrichment	CDC42	2.41
112	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.41
113	Rare combined vascular malformation	Enrichment	PIK3CA	2.41
114	Cavernous lymphangioma	Enrichment	PIK3CA	2.41
115	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.41
116	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.41
117	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.41
118	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.41
119	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.41
120	Macrodactyly of toe	Enrichment	PIK3CA	2.41
121	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.41
122	Malignant astrocytoma	Enrichment	PTPN11	2.41
123	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.40
124	Hypochondroplasia	Enrichment	FGFR3	2.40
125	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.40
126	Osteoglophonic dysplasia	Enrichment	FGFR1	2.40
127	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.40
128	Trigonocephaly 1	Enrichment	FGFR1	2.40
129	Muenke syndrome	Enrichment	FGFR3	2.40
130	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.40
131	Apert syndrome	Enrichment	FGFR2	2.40
132	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.40
133	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.40
134	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	2.40
135	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.40
136	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.40
137	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.40
138	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.40
139	Metacarpal 4-5 fusion	Enrichment	FGF16	2.40
140	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	2.40
141	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.40
142	Multiple synostoses syndrome 3	Enrichment	FGF9	2.40
143	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	2.40
144	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.40
145	Hartsfield syndrome	Enrichment	FGFR1	2.40
146	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.40
147	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	2.40
148	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.40
149	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.40
150	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.40
151	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.40
152	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.40
153	Interstitial lung disease specific to childhood	Enrichment	FGF10	2.40
154	Deafness, autosomal recessive 102	Enrichment	EPS8	2.35
155	Temporomandibular joint anomaly	Enrichment	DOCK1	2.35
156	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.34
157	Myeloma, multiple	Enrichment	FGFR3, KRAS, PIK3R2	2.22
158	Long qt syndrome 1	Enrichment	ITPR3, PTPN11	2.20
159	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.19
160	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.18
161	Spinocerebellar ataxia 27a	Enrichment	FGF14	2.18
162	Oculoectodermal syndrome	Enrichment	KRAS	2.18
163	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.18
164	Melanosis, neurocutaneous	Enrichment	NRAS	2.18
165	Noonan syndrome 6	Enrichment	NRAS	2.18
166	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	2.18
167	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.18
168	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	2.18
169	Noonan syndrome 11	Enrichment	MRAS	2.18
170	Intellectual developmental disorder, x-linked 110	Enrichment	FGF13	2.18
171	Spinocerebellar ataxia 27b, late-onset	Enrichment	FGF14	2.18
172	Developmental and epileptic encephalopathy 90	Enrichment	FGF13	2.18
173	Familial isolated trichomegaly	Enrichment	FGF5	2.18
174	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.18
175	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.18
176	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.18
177	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.18
178	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.18
179	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	2.18
180	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	2.18
181	Developmental and epileptic encephalopathy 47	Enrichment	FGF12	2.18
182	Congenital pulmonary airway malformation	Enrichment	KRAS	2.18
183	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.18
184	Gorham's disease	Enrichment	RASA1	2.18
185	Spinocerebellar ataxia type 27b	Enrichment	FGF14	2.18
186	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.18
187	Verrucous hemangioma	Enrichment	MAP3K3	2.18
188	Neurocutaneous melanocytosis	Enrichment	NRAS	2.18
189	Ovarian cancer	Enrichment	AKT1, MAP3K1, PIK3CA	2.14
190	Fibromatosis, gingival, 1	Enrichment	SOS1	2.11
191	Costello syndrome	Enrichment	HRAS	2.11
192	Ovarian germ cell cancer	Enrichment	CBL	2.11
193	Pulmonic stenosis	Enrichment	SOS1	2.11
194	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.11
195	Noonan syndrome 8	Enrichment	PIK3CA	2.11
196	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.11
197	Werner syndrome	Enrichment	PTPN11	2.11
198	Senior-loken syndrome 7	Enrichment	AKT3	2.11
199	Bardet-biedl syndrome 16	Enrichment	AKT3	2.11
200	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.11
201	Malignant germ cell tumor of ovary	Enrichment	CBL	2.11
202	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.11
203	Tafro syndrome	Enrichment	MAP2K2	2.11
204	Wooly hair nevus	Enrichment	HRAS	2.11
205	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.10
206	Otodental dysplasia	Enrichment	FGF3	2.10
207	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.10
208	Cervical cancer	Enrichment	FGFR3	2.10
209	Aural atresia, congenital	Enrichment	FGFR2	2.10
210	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	2.10
211	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	2.10
212	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.10
213	Split hand-foot malformation	Enrichment	FGFR2	2.10
214	Cervix carcinoma	Enrichment	FGFR3	2.10
215	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.10
216	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.10
217	Oculootodental syndrome	Enrichment	FGF3	2.10
218	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.05
219	Submucosal cleft palate	Enrichment	UBB	2.05
220	Cleft hard palate	Enrichment	UBB	2.05
221	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.93
222	Nuchal bleb, familial	Enrichment	SOS1	1.93
223	Tricuspid valve insufficiency	Enrichment	PTPN11	1.93
224	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.93
225	Keratoacanthoma	Enrichment	PIK3CA	1.93
226	Achondroplasia	Enrichment	FGFR3	1.92
227	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.92
228	Larsen syndrome	Enrichment	FGFR3	1.92
229	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	1.92
230	Gillespie syndrome	Enrichment	ITPR1	1.92
231	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.92
232	Hamartoma	Enrichment	FGFR3	1.92
233	Testicular germ cell cancer	Enrichment	FGFR3	1.92
234	Testicular cancer	Enrichment	FGFR3	1.92
235	Gastric cancer	Enrichment	FGFR2, PIK3CA	1.90
236	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.89
237	Trichomegaly	Enrichment	FGF5	1.88
238	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.88
239	Charcot-marie-tooth disease, demyelinating, type 4f	Enrichment	PLD3	1.88
240	Noonan syndrome 12	Enrichment	RRAS2	1.88
241	Spinocerebellar ataxia 46	Enrichment	PLD3	1.88
242	Charcot-marie-tooth disease type 4f	Enrichment	PLD3	1.88
243	Uvula, bifid	Enrichment	UBB	1.87
244	Cleft soft palate	Enrichment	UBB	1.87
245	Melanoma of soft tissue	Enrichment	CREB1	1.87
246	Thrombocytopenia	Enrichment	PTPN11, SRC	1.82
247	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.81
248	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.81
249	Cerebrovascular disease	Enrichment	PIK3CA	1.81
250	Epidermolytic nevus	Enrichment	HRAS	1.81
251	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.81
252	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3	1.81
253	Gingival fibromatosis	Enrichment	SOS1	1.81
254	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.81
255	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.80
256	Multiple synostoses syndrome	Enrichment	FGF9	1.80
257	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.80
258	Glioma	Enrichment	FGFR2	1.80
259	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	1.76
260	Capillary malformations, congenital	Enrichment	PIK3CA	1.71
261	Lymphoma	Enrichment	PTPN11	1.71
262	Acute myeloid leukemia with maturation	Enrichment	FLT3	1.71
263	Myeloproliferative neoplasm	Enrichment	CBL	1.71
264	Aggressive systemic mastocytosis	Enrichment	CBL	1.71
265	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3	1.71
266	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.70
267	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23	1.70
268	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.70
269	Succinic semialdehyde dehydrogenase deficiency	Enrichment	GPLD1	1.70
270	Wieacker-wolff syndrome	Enrichment	RASA1	1.70
271	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, PTPN11	1.68
272	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.63
273	Cowden syndrome 1	Enrichment	PIK3CA	1.63
274	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.63
275	Patent ductus arteriosus	Enrichment	PTPN11	1.63
276	Split-hand/foot malformation 1	Enrichment	FGFR2	1.63
277	Testicular germ cell tumor	Enrichment	FGFR3	1.63
278	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.63
279	46,xy disorder of sex development	Enrichment	FGFR3	1.63
280	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.58
281	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.58
282	Hereditary ataxia	Enrichment	PRKCG	1.58
283	Pilocytic astrocytoma	Enrichment	KRAS	1.58
284	Myelofibrosis	Enrichment	SRC	1.57
285	Gallbladder cancer	Enrichment	PIK3CA	1.57
286	Megacolon	Enrichment	AKT3	1.57
287	Overgrowth syndrome	Enrichment	PIK3R1	1.57
288	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.57
289	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.54
290	Gastroesophageal reflux	Enrichment	RPS6KA3	1.51
291	Orthostatic intolerance	Enrichment	RPS6KA3	1.51
292	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.46
293	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.46
294	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.46
295	Ventricular septal defect	Enrichment	RPS6KA3	1.46
296	Orofacial cleft 1	Enrichment	FGF10	1.45
297	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.45
298	Lennox-gastaut syndrome	Enrichment	MAPK10	1.45
299	Polymicrogyria	Enrichment	AKT3	1.42
300	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.41
301	Primary bone dysplasia	Enrichment	FGFR3	1.41
302	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.41
303	Hemangioma, capillary infantile	Enrichment	RASA1	1.41
304	Basal cell carcinoma 1	Enrichment	RASA1	1.41
305	Pectus excavatum	Enrichment	PTPN11	1.38
306	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.38
307	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.38
308	Osteochondrodysplasia	Enrichment	FGFR3	1.37
309	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.34
310	Hypophosphatemic rickets	Enrichment	FGF23	1.34
311	Epicanthus	Enrichment	PTPN11	1.34
312	Septooptic dysplasia	Enrichment	FGFR1	1.33
313	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.33
314	Aortic valve disease 1	Enrichment	SOS1	1.30
315	Nk-cell enteropathy	Enrichment	PIK3CB	1.30
316	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	1.30
317	Osteoporosis	Enrichment	SRC	1.27
318	Multiple sclerosis	Enrichment	ITPR1	1.26
319	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.26
320	Lynch syndrome	Enrichment	PIK3CA	1.24
321	Hydrocephalus	Enrichment	FGFR2	1.24
322	Anterior segment dysgenesis	Enrichment	ITPR1	1.24
323	Septopreoptic holoprosencephaly	Enrichment	FGF8	1.24
324	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	1.24
325	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.24
326	Renal agenesis, bilateral	Enrichment	FGF20	1.24
327	Stroke, ischemic	Enrichment	PRKCH	1.19
328	Alobar holoprosencephaly	Enrichment	FGF8	1.18
329	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.17
330	Heart, malformation of	Enrichment	MAPK1	1.17
331	Patent foramen ovale	Enrichment	PTPN11	1.17
332	Hepatoblastoma	Enrichment	FGFR3	1.09
333	Hepatocellular carcinoma	Enrichment	PIK3CA	1.08
334	Protein-deficiency anemia	Enrichment	NRAS	1.08
335	Microcephaly	Enrichment	MAPK1, PTPN11	1.08
336	Tooth agenesis	Enrichment	FGFR1	1.08
337	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.06
338	Generalized epilepsy with febrile seizures plus	Enrichment	FGF13	1.05
339	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.05
340	Scoliosis	Enrichment	PTPN11	1.05
341	Strabismus	Enrichment	PTPN11	1.00
342	Prostate cancer	Enrichment	PIK3CA	0.97
343	Charcot-marie-tooth disease type 4	Enrichment	PLD3	0.95
344	Lung cancer	Enrichment	PIK3CA	0.93
345	Arteriovenous malformations of the brain	Enrichment	KRAS	0.92
346	Connective tissue disease	Enrichment	FGFR3	0.92
347	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.92
348	Left ventricular noncompaction	Enrichment	RAF1	0.89
349	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.88
350	Type 2 diabetes mellitus	Enrichment	AKT2	0.82
351	Pancreatic cancer	Enrichment	KRAS	0.81
352	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.81
353	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.73
354	Spastic ataxia	Enrichment	ITPR1	0.72
355	Charcot-marie-tooth disease	Enrichment	PLD3	0.62
356	Deafness, autosomal recessive	Enrichment	EPS8	0.61
357	Autosomal recessive nonsyndromic deafness	Enrichment	EPS8	0.60
358	Dilated cardiomyopathy	Enrichment	RAF1	0.57
359	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.51
360	Undetermined early-onset epileptic encephalopathy	Enrichment	FGF12	0.51
361	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EPS8	0.48
362	Congenital nervous system abnormality	Enrichment	FGFR3	0.46
363	Nervous system disease	Enrichment	FGFR3	0.46
364	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.39
365	Complex neurodevelopmental disorder	Enrichment	RALA	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development FGFR signaling pathway

Pathway Network for Development FGFR signaling pathway

Pathway network for the Development FGFR signaling pathway SuperPath

Member Pathways for Development FGFR signaling pathway

Pathways in the Development FGFR signaling pathway SuperPath

Gene overlap in member pathways for Development FGFR signaling pathway SuperPath

Associated Genes for Development FGFR signaling pathway

Associated Disorders for Development FGFR signaling pathway

Disorders associated with Development FGFR signaling pathway SuperPath

STRING Interaction Network for Development FGFR signaling pathway

Sources for Development FGFR signaling pathway