Development IGF-1 receptor signaling

Pathway network for the Development IGF-1 receptor signaling SuperPath

Sources:

GeneGo (Thomson Reuters)

Pathways in the Development IGF-1 receptor signaling SuperPath

#	Name	Source	Genes
1	Development IGF-1 receptor signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BAD BCL2L1 CASP9 CCND1 CCND2 CCND3 CHUK CREB1 EIF4EBP1 ELK1 FOXO3 GRB2 GSK3A GSK3B GYS1 HRAS IGF1 IGF1R IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IKBKB IRS1 IRS2 MAP2K1 MAP2K2 MAP3K5 MAPK1 MAPK3 MTOR MYC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTEN RAF1 REL RELA RELB RHEB RPS6 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KB1 SHC1 SOS1 SOS2 TSC1 TSC2 YWHAB YWHAE YWHAZ (see all 69) (see less)
2	Immune response IL-4 signaling pathway	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CCL11 CHUK ELK1 FCER2 FES GATA3 GRB2 GSK3B HRAS IGH IGHE IGHG1 IGHG4 IGHV3-23 IGK IGKC IGKJ IGKV@ IGL IGLJ IGLV@ IKBKB IL2RG IL4 IL4R INPP5D IRS1 IRS2 JAK1 JAK3 MAP2K1 MAP2K2 MAPK1 MAPK3 MTOR NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAF1 REL RELA RELB RPS6KB1 SHC1 SOCS1 SOCS5 SOS1 SOS2 STAT6 (see all 61) (see less)
3	Signal transduction AKT signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BAD BAX BCL2L1 BCL2L11 CASP9 CCND1 CCND2 CCND3 CDKN1A CDKN1B CHUK EIF4EBP1 FASLG FOXO3 GAB1 GSK3A GSK3B GYS1 HSP90AA1 HSP90AB1 HSP90B1 IGF1R IKBKB IRS1 MDM2 MET MTOR MYC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PCNA PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP2CA PPP2CB PTEN REL RELA RELB RHEB RPS6 RPS6KB1 TP53 TRAP1 TSC1 TSC2 (see all 57) (see less)

Gene overlap in member pathways for Development IGF-1 receptor signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
3	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
4	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	3
5	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	3
6	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
7	IRS1	Insulin Receptor Substrate 1	Protein Coding	3
8	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
9	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
10	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
11	NFKBIB	NFKB Inhibitor Beta	Protein Coding	3
12	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	3
13	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	3
14	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
15	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
16	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
17	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
18	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
19	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	3
20	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
21	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	3
22	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	3
23	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
24	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
25	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	2
26	CCND1	Cyclin D1	Protein Coding	2
27	BCL2L1	BCL2 Like 1	Protein Coding	2
28	CASP9	Caspase 9	Protein Coding	2
29	CCND2	Cyclin D2	Protein Coding	2
30	CCND3	Cyclin D3	Protein Coding	2
31	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	2
32	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
33	FOXO3	Forkhead Box O3	Protein Coding	2
34	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
35	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	2
36	GYS1	Glycogen Synthase 1	Protein Coding	2
37	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
38	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	2
39	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
40	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
41	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
42	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
43	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
44	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
45	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
46	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	2
47	RPS6	Ribosomal Protein S6	Protein Coding	2
48	SHC1	SHC Adaptor Protein 1	Protein Coding	2
49	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
50	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
51	TSC1	TSC Complex Subunit 1	Protein Coding	2
52	TSC2	TSC Complex Subunit 2	Protein Coding	2
53	IRS2	Insulin Receptor Substrate 2	Protein Coding	2
54	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
55	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
56	IGF2	Insulin Like Growth Factor 2	Protein Coding	1
57	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	1
58	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Protein Coding	1
59	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
60	IGFBP4	Insulin Like Growth Factor Binding Protein 4	Protein Coding	1
61	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	1
62	IGFBP6	Insulin Like Growth Factor Binding Protein 6	Protein Coding	1
63	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
64	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
65	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
66	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
67	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
68	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
69	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
70	FCER2	Fc Epsilon Receptor II	Protein Coding	1
71	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
72	GATA3	GATA Binding Protein 3	Protein Coding	1
73	IGH	Immunoglobulin Heavy Locus	Protein Coding	1
74	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	1
75	IGHG1	Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)	Protein Coding	1
76	IGHG4	Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)	Protein Coding	1
77	IGKC	Immunoglobulin Kappa Constant	Protein Coding	1
78	IGKV@	Immunoglobulin Kappa Variable Cluster	Gene Cluster	1
79	IGL	Immunoglobulin Lambda Locus	Protein Coding	1
80	IGLV@	Immunoglobulin Lambda Variable Cluster	Gene Cluster	1
81	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
82	IL4	Interleukin 4	Protein Coding	1
83	IL4R	Interleukin 4 Receptor	Protein Coding	1
84	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	1
85	JAK1	Janus Kinase 1	Protein Coding	1
86	JAK3	Janus Kinase 3	Protein Coding	1
87	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
88	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
89	IGKJ	Immunoglobulin Kappa Joining Cluster	Genetic Locus	1
90	IGLJ	Immunoglobulin Lambda Joining Cluster	Genetic Locus	1
91	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
92	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	1
93	IGHV3-23	Immunoglobulin Heavy Variable 3-23	Protein Coding	1
94	IGK	Immunoglobulin Kappa Locus	Protein Coding	1
95	FASLG	Fas Ligand	Protein Coding	1
96	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
97	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
98	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
99	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
100	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
101	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
102	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
103	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
104	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
105	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
106	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
107	TP53	Tumor Protein P53	Protein Coding	1
108	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
109	BCL2L11	BCL2 Like 11	Protein Coding	1
110	TRAP1	TNF Receptor Associated Protein 1	Protein Coding	1

Disorders associated with Development IGF-1 receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, PTEN, RHEB	11.23
2	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.49
3	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.49
4	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	9.20
5	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.87
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	8.35
7	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TP53, TSC1, TSC2	7.46
8	Colorectal cancer	Enrichment	AKT1, BAX, CCND1, MET, PIK3CA, PIK3R1, TP53	7.15
9	Bladder cancer	Enrichment	CDKN1A, PIK3CA, PTEN, TP53, TSC1	6.92
10	Ovarian cancer	Enrichment	AKT1, CDKN1B, MET, PIK3CA, PTEN, TP53, TSC2	6.70
11	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.55
12	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, CCND2, PIK3R2	6.55
13	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA, TP53	5.86
14	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.52
15	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	5.24
16	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.15
17	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.99
18	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	4.86
19	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	4.82
20	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.76
21	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, MET, PTEN, TP53, TSC1, TSC2	4.74
22	Immunoglobulin kappa light chain deficiency	Enrichment	IGK, IGKC	4.70
23	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN, TP53	4.47
24	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.28
25	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.28
26	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.28
27	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.28
28	Hamartoma	Enrichment	TSC1, TSC2	4.28
29	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.28
30	Recurrent infections associated with rare immunoglobulin isotypes deficiency	Enrichment	IGK, IGKC	4.23
31	Hepatocellular carcinoma	Enrichment	MET, PIK3CA, TP53	3.99
32	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.98
33	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.93
34	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.93
35	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.76
36	Prostate cancer	Enrichment	PIK3CA, PTEN, TP53	3.62
37	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	3.60
38	Li-fraumeni syndrome	Enrichment	MDM2, TP53	3.59
39	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.59
40	Breast cancer	Enrichment	AKT1, PIK3CA, PTEN, TP53	3.56
41	Lung cancer	Enrichment	FASLG, MET, PIK3CA	3.49
42	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	3.44
43	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TP53	3.44
44	Renal cell carcinoma, papillary, 1	Enrichment	MET, MTOR	3.44
45	Gallbladder cancer	Enrichment	PIK3CA, TP53	3.44
46	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.44
47	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.44
48	Hemihyperplasia, isolated	Enrichment	IGF2, PIK3CA	3.42
49	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.39
50	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.39
51	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, PTEN	3.28
52	Follicular thyroid carcinoma	Enrichment	HRAS, PTEN	3.28
53	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.26
54	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	3.12
55	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.12
56	Gastric cancer	Enrichment	PIK3CA, PTEN, TP53	3.11
57	Type 2 diabetes mellitus	Enrichment	AKT2, IRS1, IRS2	3.06
58	Lip and oral cavity carcinoma	Enrichment	PIK3CA, TP53	2.95
59	Nk-cell enteropathy	Enrichment	IGF1R, PIK3CB	2.88
60	Specific learning disability	Enrichment	MAPK1, RPS6KA3	2.87
61	Myeloma, multiple	Enrichment	CCND1, PIK3R2, TP53	2.78
62	Renal cell carcinoma, nonpapillary	Enrichment	MET, MTOR	2.75
63	Rhabdomyosarcoma	Enrichment	PTEN, TP53	2.70
64	Gliosarcoma	Enrichment	NFKBIA, TP53	2.70
65	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.64
66	Diffuse large b-cell lymphoma	Enrichment	PTEN, TP53	2.55
67	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.46
68	Macrodactyly	Enrichment	PIK3CA	2.38
69	Proteus syndrome	Enrichment	AKT1	2.38
70	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.38
71	Vacterl association with hydrocephalus	Enrichment	PTEN	2.38
72	Deafness, autosomal recessive 26	Enrichment	GAB1	2.38
73	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.38
74	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.38
75	Cowden syndrome 5	Enrichment	PIK3CA	2.38
76	Fetal encasement syndrome	Enrichment	CHUK	2.38
77	Accelerated tumor formation	Enrichment	MDM2	2.38
78	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.38
79	Immunodeficiency 15b	Enrichment	IKBKB	2.38
80	Immunodeficiency 15a	Enrichment	IKBKB	2.38
81	Immunodeficiency 92	Enrichment	REL	2.38
82	Lessel-kubisch syndrome	Enrichment	MDM2	2.38
83	Short syndrome	Enrichment	PIK3R1	2.38
84	Bone marrow failure syndrome 5	Enrichment	TP53	2.38
85	Osteofibrous dysplasia	Enrichment	MET	2.38
86	Papilloma of choroid plexus	Enrichment	TP53	2.38
87	Basal cell carcinoma 7	Enrichment	TP53	2.38
88	Anaplastic thyroid carcinoma	Enrichment	TP53	2.38
89	Papillary tumor of the pineal region	Enrichment	PTEN	2.38
90	Deafness, autosomal recessive 97	Enrichment	MET	2.38
91	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.38
92	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.38
93	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.38
94	Neuroendocrine tumor	Enrichment	CDKN1B	2.38
95	Autism 9	Enrichment	MET	2.38
96	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.38
97	Cowden syndrome 6	Enrichment	AKT1	2.38
98	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.38
99	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.38
100	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.38
101	Glioma susceptibility 2	Enrichment	PTEN	2.38
102	Ductal carcinoma in situ	Enrichment	TP53	2.38
103	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.38
104	Immunodeficiency 53	Enrichment	RELB	2.38
105	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.38
106	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.38
107	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.38
108	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.38
109	Arthrogryposis, distal, type 11	Enrichment	MET	2.38
110	Hypospadias	Enrichment	PIK3CA	2.38
111	Capillary hemangioma	Enrichment	AKT3	2.38
112	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.38
113	Choroid plexus cancer	Enrichment	TP53	2.38
114	Rare venous malformation	Enrichment	PIK3CA	2.38
115	Diaphragmatic eventration	Enrichment	PIK3CA	2.38
116	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.38
117	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.38
118	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.38
119	Rare combined vascular malformation	Enrichment	PIK3CA	2.38
120	Cavernous lymphangioma	Enrichment	PIK3CA	2.38
121	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.38
122	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.38
123	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.38
124	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.38
125	Macrodactyly of toe	Enrichment	PIK3CA	2.38
126	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.38
127	Noonan syndrome 5	Enrichment	RAF1	2.35
128	Noonan syndrome 4	Enrichment	SOS1	2.35
129	Melorheostosis, isolated	Enrichment	MAP2K1	2.35
130	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.35
131	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.35
132	Noonan syndrome 9	Enrichment	SOS2	2.35
133	Noonan syndrome 13	Enrichment	MAPK1	2.35
134	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.35
135	Melorheostosis	Enrichment	MAP2K1	2.35
136	Leopard syndrome 2	Enrichment	RAF1	2.35
137	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.35
138	Trigonitis	Enrichment	RAF1	2.35
139	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.35
140	B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3)	Enrichment	IGH	2.35
141	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.35
142	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.35
143	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.29
144	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.29
145	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.29
146	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.29
147	Burkitt lymphoma	Enrichment	MYC	2.08
148	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.08
149	Cervical cancer	Enrichment	TP53	2.08
150	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.08
151	Keratosis, seborrheic	Enrichment	PIK3CA	2.08
152	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.08
153	Noonan syndrome 8	Enrichment	PIK3CA	2.08
154	Lymphoma, hodgkin, classic	Enrichment	TP53	2.08
155	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.08
156	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.08
157	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.08
158	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.08
159	Cebalid syndrome	Enrichment	MTOR	2.08
160	Childhood hepatocellular carcinoma	Enrichment	MET	2.08
161	Rela fusion-positive ependymoma	Enrichment	RELA	2.08
162	Glycogen storage disease 0, muscle	Enrichment	GYS1	2.08
163	Senior-loken syndrome 7	Enrichment	AKT3	2.08
164	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.08
165	Papillary renal cell carcinoma	Enrichment	MET	2.08
166	Congenital fibrosarcoma	Enrichment	TP53	2.08
167	Li-fraumeni syndrome 1	Enrichment	TP53	2.08
168	Sarcoma	Enrichment	TP53	2.08
169	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.08
170	Cervix carcinoma	Enrichment	TP53	2.08
171	Immune system disease	Enrichment	PIK3CD	2.08
172	Hodgkin's lymphoma	Enrichment	TP53	2.08
173	Bardet-biedl syndrome 16	Enrichment	AKT3	2.08
174	Smith-kingsmore syndrome	Enrichment	MTOR	2.08
175	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.08
176	Vacterl with hydrocephalus	Enrichment	PTEN	2.08
177	Glycogen storage disease due to muscle and heart glycogen synthase deficiency	Enrichment	GYS1	2.08
178	Common variable immunodeficiency 12	Enrichment	NFKB1	2.08
179	Juvenile polyposis of infancy	Enrichment	PTEN	2.08
180	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.08
181	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	2.05
182	Fibromatosis, gingival, 1	Enrichment	SOS1	2.05
183	Costello syndrome	Enrichment	HRAS	2.05
184	Hemangiopericytoma, malignant	Enrichment	STAT6	2.05
185	Pulmonic stenosis	Enrichment	SOS1	2.05
186	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.05
187	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	2.05
188	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	2.05
189	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	2.05
190	Tafro syndrome	Enrichment	MAP2K2	2.05
191	Wooly hair nevus	Enrichment	HRAS	2.05
192	Severe combined immunodeficiency	Enrichment	IKBKB, JAK3	2.02
193	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.99
194	Silver-russell syndrome 3	Enrichment	IGF2	1.99
195	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.99
196	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	1.99
197	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	1.99
198	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.90
199	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.90
200	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.90
201	Osteogenic sarcoma	Enrichment	TP53	1.90
202	Tuberous sclerosis 2	Enrichment	TSC2	1.90
203	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.90
204	Dedifferentiated liposarcoma	Enrichment	MDM2	1.90
205	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.90
206	Anaplastic astrocytoma	Enrichment	TP53	1.90
207	Xanthinuria, type ii	Enrichment	TSC2	1.90
208	Squamous cell carcinoma	Enrichment	TP53	1.90
209	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.90
210	Adenocarcinoma	Enrichment	TP53	1.90
211	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.90
212	Bone osteosarcoma	Enrichment	TP53	1.90
213	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.90
214	Well-differentiated liposarcoma	Enrichment	MDM2	1.90
215	Renal cell carcinoma	Enrichment	MET	1.90
216	Keratoacanthoma	Enrichment	PIK3CA	1.90
217	Systemic lupus erythematosus	Enrichment	IGHG1, SOCS1	1.88
218	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.87
219	Immune thrombocytopenia	Enrichment	SOCS1	1.87
220	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.87
221	Agammaglobulinemia 1, autosomal recessive	Enrichment	IGH	1.87
222	Nuchal bleb, familial	Enrichment	SOS1	1.87
223	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.87
224	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.87
225	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.87
226	Agammaglobulinemia 1	Enrichment	IGH	1.87
227	Large congenital melanocytic nevus	Enrichment	HRAS	1.87
228	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1	1.87
229	End stage renal disease	Enrichment	GATA3	1.87
230	Spermatocytoma	Enrichment	HRAS	1.87
231	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.82
232	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.82
233	Melanoma of soft tissue	Enrichment	CREB1	1.82
234	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	1.82
235	Small cell cancer of the lung	Enrichment	TP53	1.78
236	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.78
237	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.78
238	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.78
239	Mantle cell lymphoma	Enrichment	CCND1	1.78
240	Lung sarcomatoid carcinoma	Enrichment	TP53	1.78
241	Cerebrovascular disease	Enrichment	PIK3CA	1.78
242	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.78
243	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.78
244	Primary hyperparathyroidism	Enrichment	CDKN1B	1.78
245	Glioma	Enrichment	PTEN	1.78
246	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.75
247	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.75
248	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.75
249	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.75
250	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.75
251	Epidermolytic nevus	Enrichment	HRAS	1.75
252	Adenosine deaminase deficiency	Enrichment	JAK3	1.75
253	Gingival fibromatosis	Enrichment	SOS1	1.75
254	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.75
255	Autism spectrum disorder	Enrichment	MAP2K1, PTEN, TSC2	1.74
256	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.69
257	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	1.69
258	Capillary malformations, congenital	Enrichment	PIK3CA	1.68
259	Von hippel-lindau syndrome	Enrichment	CCND1	1.68
260	Rhabdomyosarcoma 2	Enrichment	TP53	1.68
261	Macrocephaly/autism syndrome	Enrichment	PTEN	1.68
262	Lymphoma	Enrichment	TP53	1.68
263	Hemangioma	Enrichment	PTEN	1.68
264	Lymphoma, mucosa-associated lymphoid type	Enrichment	IGH	1.65
265	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.65
266	Follicular lymphoma	Enrichment	IGH	1.65
267	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN, TP53	1.65
268	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.60
269	Congenital anomalies of kidney and urinary tract 1	Enrichment	TRAP1	1.60
270	Keratoconus	Enrichment	TSC1	1.60
271	Adrenocortical carcinoma	Enrichment	TP53	1.60
272	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.60
273	Endometrial stromal sarcoma	Enrichment	YWHAE	1.60
274	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	1.54
275	Esophageal cancer	Enrichment	TP53	1.54
276	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.54
277	Polycystic kidney disease 1	Enrichment	TSC2	1.54
278	Essential thrombocythemia	Enrichment	TP53	1.54
279	Megacolon	Enrichment	AKT3	1.54
280	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.54
281	Kidney clear cell sarcoma	Enrichment	YWHAE	1.52
282	Pilomyxoid astrocytoma	Enrichment	RAF1	1.51
283	Arthrogryposis, distal, type 1a	Enrichment	MET	1.48
284	Glioma susceptibility 1	Enrichment	TP53	1.48
285	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.48
286	Silver-russell syndrome 1	Enrichment	IGF2	1.45
287	Primary hyperaldosteronism	Enrichment	TP53	1.43
288	Gastroesophageal reflux	Enrichment	RPS6KA3	1.40
289	Orthostatic intolerance	Enrichment	RPS6KA3	1.40
290	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.38
291	Polymicrogyria	Enrichment	AKT3	1.38
292	Melanoma	Enrichment	PTEN	1.38
293	Familial colorectal cancer	Enrichment	TP53	1.38
294	Omenn syndrome	Enrichment	IL2RG	1.36
295	Ventricular septal defect	Enrichment	RPS6KA3	1.35
296	Meningioma, familial	Enrichment	PTEN	1.34
297	Myelodysplastic syndrome	Enrichment	TP53	1.34
298	Glycogen storage disease	Enrichment	GYS1	1.34
299	Uterine corpus cancer	Enrichment	PTEN	1.34
300	Asthma	Enrichment	CCL11	1.32
301	Combined immunodeficiency	Enrichment	IL2RG	1.32
302	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.32
303	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.32
304	Aortic valve disease 1	Enrichment	SOS1	1.24
305	Lung cancer susceptibility 3	Enrichment	TP53	1.24
306	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.21
307	Lynch syndrome	Enrichment	PIK3CA	1.21
308	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.21
309	Kidney disease	Enrichment	TSC1	1.21
310	Rare genetic intellectual disability	Enrichment	MTOR	1.21
311	Congenital nervous system abnormality	Enrichment	PTEN, TSC2	1.14
312	Nervous system disease	Enrichment	PTEN, TSC2	1.14
313	Wilms tumor 1	Enrichment	IGF2	1.13
314	Heart, malformation of	Enrichment	MAPK1	1.11
315	Human immunodeficiency virus type 1	Enrichment	CCL11	1.11
316	Hepatoblastoma	Enrichment	TP53	1.07
317	Beckwith-wiedemann syndrome	Enrichment	IGF2	1.06
318	Diamond-blackfan anemia 1	Enrichment	TP53	1.03
319	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.03
320	Pancreatic cancer	Enrichment	TP53	1.00
321	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.99
322	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.96
323	Severe covid-19	Enrichment	JAK3	0.91
324	Differentiated thyroid carcinoma	Enrichment	HRAS	0.91
325	Microcephaly	Enrichment	IGF1R, MAPK1	0.89
326	Non-immune hydrops fetalis	Enrichment	HRAS	0.88
327	Cakut	Enrichment	TRAP1	0.87
328	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.86
329	Diamond-blackfan anemia	Enrichment	TP53	0.85
330	Left ventricular noncompaction	Enrichment	RAF1	0.84
331	Leukemia, acute myeloid	Enrichment	TP53	0.81
332	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.77
333	West syndrome	Enrichment	TSC2	0.77
334	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.67
335	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.65
336	Dilated cardiomyopathy	Enrichment	RAF1	0.52
337	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.50
338	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development IGF-1 receptor signaling

Pathway Network for Development IGF-1 receptor signaling

Pathway network for the Development IGF-1 receptor signaling SuperPath

Member Pathways for Development IGF-1 receptor signaling

Pathways in the Development IGF-1 receptor signaling SuperPath

Gene overlap in member pathways for Development IGF-1 receptor signaling SuperPath

Associated Genes for Development IGF-1 receptor signaling

Associated Disorders for Development IGF-1 receptor signaling

Disorders associated with Development IGF-1 receptor signaling SuperPath

STRING Interaction Network for Development IGF-1 receptor signaling

Sources for Development IGF-1 receptor signaling