Development_Leptin signaling via JAK/STAT and MAPK cascades

No Pathway Network information available for Development_Leptin signaling via JAK/STAT and MAPK cascades

Pathways in the Development_Leptin signaling via JAK/STAT and MAPK cascades SuperPath

#	Name	Source	Genes
1	Development_Leptin signaling via JAK/STAT and MAPK cascades	GeneGo (Thomson Reuters)	CRP CYCS EDN1 EGR1 FOS GRB2 HIF1A HRAS JAK2 LEP LEPR MAP2K1 MAPK1 MAPK3 PIAS3 PLA2G4A PLA2G4C POMC PTPN1 PTPN11 RAF1 SOCS3 SOS1 SOS2 STAT3 TIMP1 TRH VEGFA (see all 28) (see less)
2	phospho-PLA2 pathway	Reactome	MAPK1 PLA2G4A

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
2	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
3	CRP	C-Reactive Protein	Protein Coding	1
4	EDN1	Endothelin 1	Protein Coding	1
5	EGR1	Early Growth Response 1	Protein Coding	1
6	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
7	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
8	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
10	JAK2	Janus Kinase 2	Protein Coding	1
11	LEP	Leptin	Protein Coding	1
12	LEPR	Leptin Receptor	Protein Coding	1
13	POMC	Proopiomelanocortin	Protein Coding	1
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
15	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
16	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
17	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
18	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
19	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
20	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
21	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
22	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
23	TRH	Thyrotropin Releasing Hormone	Protein Coding	1
24	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
25	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
26	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
27	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
28	CYCS	Cytochrome C, Somatic	Protein Coding	1

Disorders associated with Development_Leptin signaling via JAK/STAT and MAPK cascades SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, MAP2K1, PTPN11, RAF1, SOS1, SOS2	11.23
2	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, PTPN11, RAF1, SOS1, SOS2	10.45
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, PTPN11, RAF1, SOS1	10.02
4	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	9.28
5	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.91
6	Leptin deficiency or dysfunction	Enrichment	LEP, LEPR	4.61
7	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.61
8	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.94
9	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.83
10	Noonan syndrome 13	Enrichment	MAPK1	3.83
11	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	3.83
12	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	3.83
13	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	3.83
14	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.74
15	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1	3.65
16	Specific learning disability	Enrichment	MAPK1, PTPN11	3.65
17	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	3.23
18	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.89
19	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.73
20	Metachondromatosis	Enrichment	PTPN11	2.69
21	Thyrotropin-releasing hormone deficiency	Enrichment	TRH	2.69
22	Noonan syndrome 5	Enrichment	RAF1	2.69
23	Noonan syndrome 4	Enrichment	SOS1	2.69
24	Melorheostosis, isolated	Enrichment	MAP2K1	2.69
25	Dermatitis, atopic, 4	Enrichment	SOCS3	2.69
26	Leopard syndrome 1	Enrichment	PTPN11	2.69
27	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.69
28	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.69
29	Noonan syndrome 9	Enrichment	SOS2	2.69
30	Auriculocondylar syndrome 3	Enrichment	EDN1	2.69
31	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.69
32	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.69
33	Thrombocytopenia 4	Enrichment	CYCS	2.69
34	Question mark ears, isolated	Enrichment	EDN1	2.69
35	Melorheostosis	Enrichment	MAP2K1	2.69
36	Leopard syndrome 2	Enrichment	RAF1	2.69
37	Leptin receptor deficiency	Enrichment	LEPR	2.69
38	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.69
39	Trigonitis	Enrichment	RAF1	2.69
40	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.69
41	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.69
42	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.69
43	Malignant astrocytoma	Enrichment	PTPN11	2.69
44	Heart, malformation of	Enrichment	MAPK1	2.58
45	Fibromatosis, gingival, 1	Enrichment	SOS1	2.38
46	Costello syndrome	Enrichment	HRAS	2.38
47	Pulmonic stenosis	Enrichment	SOS1	2.38
48	Thrombocythemia 3	Enrichment	JAK2	2.38
49	Werner syndrome	Enrichment	PTPN11	2.38
50	Polycythemia	Enrichment	JAK2	2.38
51	Hypereosinophilic syndrome	Enrichment	JAK2	2.38
52	Wooly hair nevus	Enrichment	HRAS	2.38
53	Thrombocytopenia	Enrichment	CYCS, PTPN11	2.36
54	Body mass index quantitative trait locus 11	Enrichment	LEPR, POMC	2.32
55	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.21
56	Polycythemia vera	Enrichment	JAK2	2.21
57	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	2.21
58	Nuchal bleb, familial	Enrichment	SOS1	2.21
59	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.21
60	Large congenital melanocytic nevus	Enrichment	HRAS	2.21
61	Hyper ige syndrome	Enrichment	STAT3	2.21
62	Spermatocytoma	Enrichment	HRAS	2.21
63	Tricuspid valve insufficiency	Enrichment	PTPN11	2.21
64	Enchondromatosis	Enrichment	HIF1A	2.21
65	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	2.21
66	Erythrocytosis, familial, 1	Enrichment	JAK2	2.08
67	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.08
68	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.08
69	Budd-chiari syndrome	Enrichment	JAK2	2.08
70	Auriculocondylar syndrome 1	Enrichment	EDN1	2.08
71	Congenital generalized lipodystrophy	Enrichment	FOS	2.08
72	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.08
73	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.08
74	Epidermolytic nevus	Enrichment	HRAS	2.08
75	Gingival fibromatosis	Enrichment	SOS1	2.08
76	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.08
77	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.99
78	Lymphoma	Enrichment	PTPN11	1.99
79	Myeloproliferative neoplasm	Enrichment	JAK2	1.99
80	Histiocytoid hemangioma	Enrichment	FOS	1.99
81	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.99
82	Patent ductus arteriosus	Enrichment	PTPN11	1.91
83	Nevus, epidermal	Enrichment	HRAS	1.84
84	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.84
85	Myelofibrosis	Enrichment	JAK2	1.84
86	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.84
87	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.84
88	Essential thrombocythemia	Enrichment	JAK2	1.84
89	Pilomyxoid astrocytoma	Enrichment	RAF1	1.84
90	Follicular thyroid carcinoma	Enrichment	HRAS	1.84
91	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.79
92	Microcephaly	Enrichment	MAPK1	1.74
93	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.73
94	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.68
95	Pectus excavatum	Enrichment	PTPN11	1.65
96	Epicanthus	Enrichment	PTPN11	1.61
97	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.61
98	Lip and oral cavity carcinoma	Enrichment	HRAS	1.61
99	Congenital long qt syndrome	Enrichment	PTPN11	1.61
100	Aortic valve disease 1	Enrichment	SOS1	1.58
101	Acute promyelocytic leukemia	Enrichment	STAT3	1.58
102	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.54
103	Rhabdomyosarcoma	Enrichment	HRAS	1.49
104	Patent foramen ovale	Enrichment	PTPN11	1.44
105	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.41
106	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.31
107	Scoliosis	Enrichment	PTPN11	1.31
108	Strabismus	Enrichment	PTPN11	1.27
109	Bladder cancer	Enrichment	HRAS	1.23
110	Differentiated thyroid carcinoma	Enrichment	HRAS	1.23
111	Long qt syndrome 1	Enrichment	PTPN11	1.22
112	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.18
113	Left ventricular noncompaction	Enrichment	RAF1	1.16
114	Leukemia, acute myeloid	Enrichment	JAK2	1.10
115	Type 2 diabetes mellitus	Enrichment	PTPN1	1.08
116	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.07
117	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.98
118	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.96
119	Primary ovarian insufficiency	Enrichment	JAK2	0.94
120	Dilated cardiomyopathy	Enrichment	RAF1	0.82
121	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development_Leptin signaling via JAK/STAT and MAPK cascades

Pathway Network for Development_Leptin signaling via JAK/STAT and MAPK cascades

Member Pathways for Development_Leptin signaling via JAK/STAT and MAPK cascades

Pathways in the Development_Leptin signaling via JAK/STAT and MAPK cascades SuperPath

Associated Genes for Development_Leptin signaling via JAK/STAT and MAPK cascades

Associated Disorders for Development_Leptin signaling via JAK/STAT and MAPK cascades

Disorders associated with Development_Leptin signaling via JAK/STAT and MAPK cascades SuperPath

STRING Interaction Network for Development_Leptin signaling via JAK/STAT and MAPK cascades

Sources for Development_Leptin signaling via JAK/STAT and MAPK cascades