Development_Leptin signaling via PI3K-dependent pathway

No Pathway Network information available for Development_Leptin signaling via PI3K-dependent pathway

Pathways in the Development_Leptin signaling via PI3K-dependent pathway SuperPath

#	Name	Source	Genes
1	Development_Leptin signaling via PI3K-dependent pathway	GeneGo (Thomson Reuters)	ABCC8 ACACA ACACB AKT1 AKT2 AKT3 ATP1A1 CEBPA CHUK CPT1A CPT1B CREB1 GSK3A GSK3B GYS2 IKBKB IRS1 IRS2 JAK2 KCNJ11 LEP LEPR NFKB1 NFKBIA NFKBIB NFKBIE PDE3B PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKACG PRKAG1 PRKAG2 PRKAG3 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN1 RELA SLC2A4 STK11 (see all 52) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	1
2	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	1
3	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
4	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
5	ATP1A1	ATPase Na+/K+ Transporting Subunit Alpha 1	Protein Coding	1
6	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
7	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
8	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	1
9	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	1
10	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
11	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
12	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
13	GYS2	Glycogen Synthase 2	Protein Coding	1
14	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
15	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
16	JAK2	Janus Kinase 2	Protein Coding	1
17	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	1
18	LEP	Leptin	Protein Coding	1
19	LEPR	Leptin Receptor	Protein Coding	1
20	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
21	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
22	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
23	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
24	PDE3B	Phosphodiesterase 3B	Protein Coding	1
25	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
26	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
27	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
28	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
29	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
30	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
31	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
32	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
33	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
34	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
35	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
36	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
37	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
38	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
39	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
40	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
41	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
42	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
43	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
44	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
45	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
46	STK11	Serine/Threonine Kinase 11	Protein Coding	1
47	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	1
48	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
49	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
50	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
51	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
52	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1

Disorders associated with Development_Leptin signaling via PI3K-dependent pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 2 diabetes mellitus	Enrichment	ABCC8, AKT2, IRS1, IRS2, KCNJ11, PTPN1, SLC2A4	9.67
2	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.67
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.37
4	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.37
5	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.37
6	Dend syndrome	Enrichment	ABCC8, KCNJ11	4.37
7	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.07
8	Leptin deficiency or dysfunction	Enrichment	LEP, LEPR	4.07
9	Neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	4.07
10	Transient neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	3.84
11	Hypoglycemia	Enrichment	ABCC8, KCNJ11	3.84
12	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.84
13	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	ABCC8, KCNJ11	3.67
14	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.67
15	Nonsyndromic genetic hyperinsulinism	Enrichment	ABCC8, KCNJ11	3.67
16	Permanent neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	3.40
17	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.29
18	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.29
19	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.20
20	Meningioma	Enrichment	AKT1, PIK3CA	3.03
21	Lip and oral cavity carcinoma	Enrichment	PIK3CA, STK11	3.03
22	Maturity-onset diabetes of the young	Enrichment	ABCC8, KCNJ11	2.58
23	Macrodactyly	Enrichment	PIK3CA	2.42
24	Proteus syndrome	Enrichment	AKT1	2.42
25	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.42
26	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.42
27	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.42
28	Carney complex, type 1	Enrichment	PRKAR1A	2.42
29	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.42
30	Cowden syndrome 5	Enrichment	PIK3CA	2.42
31	Fetal encasement syndrome	Enrichment	CHUK	2.42
32	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.42
33	Immunodeficiency 15b	Enrichment	IKBKB	2.42
34	Immunodeficiency 15a	Enrichment	IKBKB	2.42
35	Maturity-onset diabetes of the young, type 12	Enrichment	ABCC8	2.42
36	Short syndrome	Enrichment	PIK3R1	2.42
37	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	2.42
38	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.42
39	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.42
40	Myxoma, intracardiac	Enrichment	PRKAR1A	2.42
41	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.42
42	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.42
43	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.42
44	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.42
45	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.42
46	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.42
47	Cowden syndrome 6	Enrichment	AKT1	2.42
48	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.42
49	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.42
50	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.42
51	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.42
52	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.42
53	Leptin receptor deficiency	Enrichment	LEPR	2.42
54	Autosomal dominant hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.42
55	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.42
56	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.42
57	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.42
58	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.42
59	Hypospadias	Enrichment	PIK3CA	2.42
60	Capillary hemangioma	Enrichment	AKT3	2.42
61	Diazoxide-resistant focal hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.42
62	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.42
63	Rare venous malformation	Enrichment	PIK3CA	2.42
64	Diaphragmatic eventration	Enrichment	PIK3CA	2.42
65	Congestive heart failure	Enrichment	ABCC8	2.42
66	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.42
67	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.42
68	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.42
69	Rare combined vascular malformation	Enrichment	PIK3CA	2.42
70	Cavernous lymphangioma	Enrichment	PIK3CA	2.42
71	Intermediate dend syndrome	Enrichment	KCNJ11	2.42
72	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.42
73	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.42
74	Intestinal polyposis syndrome	Enrichment	STK11	2.42
75	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.42
76	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.42
77	Autosomal recessive hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	2.42
78	Macrodactyly of toe	Enrichment	PIK3CA	2.42
79	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.42
80	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.42
81	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.42
82	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	2.35
83	Peutz-jeghers syndrome	Enrichment	STK11	2.12
84	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.12
85	Glycogen storage disease 0, liver	Enrichment	GYS2	2.12
86	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	2.12
87	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.12
88	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.12
89	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.12
90	Keratosis, seborrheic	Enrichment	PIK3CA	2.12
91	Diabetes mellitus, permanent neonatal, 1	Enrichment	KCNJ11	2.12
92	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.12
93	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.12
94	Hypoglycemia, leucine-induced	Enrichment	ABCC8	2.12
95	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.12
96	Noonan syndrome 8	Enrichment	PIK3CA	2.12
97	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.12
98	Thrombocythemia 3	Enrichment	JAK2	2.12
99	Diabetes mellitus, transient neonatal, 2	Enrichment	ABCC8	2.12
100	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.12
101	Charcot-marie-tooth disease, axonal, type 2dd	Enrichment	ATP1A1	2.12
102	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.12
103	Usher syndrome, type iv	Enrichment	PRKAR1A	2.12
104	Rela fusion-positive ependymoma	Enrichment	RELA	2.12
105	Senior-loken syndrome 7	Enrichment	AKT3	2.12
106	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.12
107	Acrodysostosis	Enrichment	PRKAR1A	2.12
108	Hypomagnesemia, seizures, and impaired intellectual development 2	Enrichment	ATP1A1	2.12
109	Fibrolamellar carcinoma	Enrichment	PRKACA	2.12
110	Diabetes mellitus, permanent neonatal, 3	Enrichment	ABCC8	2.12
111	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.12
112	Immune system disease	Enrichment	PIK3CD	2.12
113	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.12
114	Bardet-biedl syndrome 16	Enrichment	AKT3	2.12
115	Polycythemia	Enrichment	JAK2	2.12
116	Glycogen storage disorder due to hepatic glycogen synthase deficiency	Enrichment	GYS2	2.12
117	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.12
118	Hypereosinophilic syndrome	Enrichment	JAK2	2.12
119	Hyperinsulinism	Enrichment	KCNJ11	2.12
120	Common variable immunodeficiency 12	Enrichment	NFKB1	2.12
121	Leukemia, acute myeloid	Enrichment	CEBPA, JAK2	1.99
122	Polycythemia vera	Enrichment	JAK2	1.94
123	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.94
124	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	1.94
125	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.94
126	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.94
127	Hyperinsulinemic hypoglycemia	Enrichment	ABCC8	1.94
128	Testicular germ cell cancer	Enrichment	STK11	1.94
129	Melanoma of soft tissue	Enrichment	CREB1	1.94
130	Testicular cancer	Enrichment	STK11	1.94
131	Keratoacanthoma	Enrichment	PIK3CA	1.94
132	Apc-associated polyposis conditions	Enrichment	STK11	1.94
133	Gastric cancer	Enrichment	PIK3CA, STK11	1.93
134	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.91
135	Inherited cancer-predisposing syndrome	Enrichment	CEBPA, PRKAR1A, STK11	1.85
136	Erythrocytosis, familial, 1	Enrichment	JAK2	1.82
137	Dermatitis, atopic	Enrichment	KCNJ11	1.82
138	Budd-chiari syndrome	Enrichment	JAK2	1.82
139	Carney complex variant	Enrichment	PRKAR1A	1.82
140	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.82
141	Cerebrovascular disease	Enrichment	PIK3CA	1.82
142	Newborn respiratory distress syndrome	Enrichment	ABCC8	1.82
143	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.82
144	Capillary malformations, congenital	Enrichment	PIK3CA	1.72
145	Familial adenomatous polyposis 1	Enrichment	STK11	1.72
146	Myeloproliferative neoplasm	Enrichment	JAK2	1.72
147	Polyhydramnios	Enrichment	ABCC8	1.72
148	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.72
149	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.72
150	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.72
151	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.64
152	Cowden syndrome 1	Enrichment	PIK3CA	1.64
153	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.64
154	Testicular germ cell tumor	Enrichment	STK11	1.64
155	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.64
156	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.64
157	Hypertrichosis	Enrichment	KCNJ11	1.64
158	Nevus, epidermal	Enrichment	PIK3CA	1.58
159	Myelofibrosis	Enrichment	JAK2	1.58
160	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.58
161	Essential thrombocythemia	Enrichment	JAK2	1.58
162	Gallbladder cancer	Enrichment	PIK3CA	1.58
163	Megacolon	Enrichment	AKT3	1.58
164	Common variable immunodeficiency	Enrichment	NFKB1	1.58
165	Overgrowth syndrome	Enrichment	PIK3R1	1.58
166	Gastroesophageal reflux	Enrichment	ABCC8	1.52
167	Breast cancer	Enrichment	AKT1, PIK3CA	1.48
168	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.47
169	Arteriovenous malformation	Enrichment	PIK3CA	1.47
170	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.47
171	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.42
172	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.42
173	Polymicrogyria	Enrichment	AKT3	1.42
174	Melanoma	Enrichment	STK11	1.42
175	Atrial heart septal defect	Enrichment	ABCC8	1.38
176	Glycogen storage disease	Enrichment	GYS2	1.38
177	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.38
178	Diabetes mellitus	Enrichment	KCNJ11	1.38
179	Interatrial communication	Enrichment	ABCC8	1.38
180	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	1.31
181	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.31
182	Nk-cell enteropathy	Enrichment	PIK3CB	1.31
183	Lynch syndrome	Enrichment	PIK3CA	1.25
184	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.24
185	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.22
186	Gliosarcoma	Enrichment	NFKBIA	1.22
187	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.20
188	Giant cell glioblastoma	Enrichment	NFKBIA	1.20
189	Endometrial cancer	Enrichment	PIK3CA	1.11
190	Hepatocellular carcinoma	Enrichment	PIK3CA	1.09
191	Pancreatic cancer	Enrichment	STK11	1.04
192	Bladder cancer	Enrichment	PIK3CA	0.98
193	Prostate cancer	Enrichment	PIK3CA	0.98
194	Lung cancer	Enrichment	PIK3CA	0.94
195	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.92
196	Severe combined immunodeficiency	Enrichment	IKBKB	0.92
197	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.82
198	Body mass index quantitative trait locus 11	Enrichment	LEPR	0.76
199	Hypertelorism	Enrichment	PIK3CA	0.74
200	Myeloma, multiple	Enrichment	PIK3R2	0.71
201	Primary ovarian insufficiency	Enrichment	JAK2	0.69
202	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.60

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development_Leptin signaling via PI3K-dependent pathway

Pathway Network for Development_Leptin signaling via PI3K-dependent pathway

Member Pathways for Development_Leptin signaling via PI3K-dependent pathway

Pathways in the Development_Leptin signaling via PI3K-dependent pathway SuperPath

Associated Genes for Development_Leptin signaling via PI3K-dependent pathway

Associated Disorders for Development_Leptin signaling via PI3K-dependent pathway

Disorders associated with Development_Leptin signaling via PI3K-dependent pathway SuperPath

STRING Interaction Network for Development_Leptin signaling via PI3K-dependent pathway

Sources for Development_Leptin signaling via PI3K-dependent pathway