Development NOTCH1-mediated pathway for NF-KB activity modulation

Pathway network for the Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

Sources:

GeneGo (Thomson Reuters)
Reactome

Pathways in the Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

#	Name	Source	Genes
1	Development NOTCH1-mediated pathway for NF-KB activity modulation	GeneGo (Thomson Reuters)	ADAM17 APH1A APH1B CHUK CIRSR DLL1 EP300 H3-3A H3-3B H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 IKBKB IL1A IL1R1 IRAK1 IRAK2 JAG1 KAT2B MAML1 MAP3K1 MAP3K14 NCOR1 NCOR2 NCSTN NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NOTCH1 PSEN1 PSEN2 PSENEN RBBP4 RBBP7 RBPJ REL RELA RELB SAP30 SNW1 TRAF6 (see all 57) (see less)
2	Development Notch Signaling Pathway	GeneGo (Thomson Reuters)	ADAM17 APH1A APH1B CIRSR CUL1 DLL1 DLL4 EP300 FBXW7 FURIN H3-3A H3-3B H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 HES1 HEY1 HEY2 JAG1 JAG2 KAT2A KAT2B LFNG MAML1 MFNG MYOD1 NCOR1 NCOR2 NCSTN NFKBIA NOTCH1 PSEN1 PSEN2 PSENEN RBBP4 RBBP7 RBPJ REL RFNG SAP30 SNW1 TLE1 TLE2 TLE3 TLE4 TP63 TP73 (see all 61) (see less)
3	Regulated proteolysis of p75NTR	Reactome	ADAM17 APH1A APH1B NCSTN NFKB1 PSEN1 PSEN2 PSENEN RELA TRAF6 (see all 10) (see less)

Gene overlap in member pathways for Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PSEN1	Presenilin 1	Protein Coding	3
2	PSEN2	Presenilin 2	Protein Coding	3
3	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	3
4	NCSTN	Nicastrin	Protein Coding	3
5	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	3
6	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	3
7	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	3
8	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	2
9	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
10	H3-3A	H3.3 Histone A	Protein Coding	2
11	H3-3B	H3.3 Histone B	Protein Coding	2
12	HDAC1	Histone Deacetylase 1	Protein Coding	2
13	HDAC2	Histone Deacetylase 2	Protein Coding	2
14	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	2
15	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
16	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
17	NOTCH1	Notch Receptor 1	Protein Coding	2
18	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
19	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
20	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	2
21	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
22	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
23	H3-4	H3.4 Histone, Cluster Member	Protein Coding	2
24	H4C9	H4 Clustered Histone 9	Protein Coding	2
25	H4C1	H4 Clustered Histone 1	Protein Coding	2
26	H4C4	H4 Clustered Histone 4	Protein Coding	2
27	H4C6	H4 Clustered Histone 6	Protein Coding	2
28	H4C12	H4 Clustered Histone 12	Protein Coding	2
29	H4C11	H4 Clustered Histone 11	Protein Coding	2
30	H4C3	H4 Clustered Histone 3	Protein Coding	2
31	H4C8	H4 Clustered Histone 8	Protein Coding	2
32	H4C2	H4 Clustered Histone 2	Protein Coding	2
33	H4C5	H4 Clustered Histone 5	Protein Coding	2
34	H4C13	H4 Clustered Histone 13	Protein Coding	2
35	H4C14	H4 Clustered Histone 14	Protein Coding	2
36	SAP30	Sin3A Associated Protein 30	Protein Coding	2
37	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	2
38	CIRSR	Corepressor Of RBPJ And Splicing Regulator	Protein Coding	2
39	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	2
40	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	2
41	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	2
42	SNW1	SNW Domain Containing 1	Protein Coding	2
43	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	2
44	H4C16	H4 Histone 16	Protein Coding	2
45	H4C15	H4 Clustered Histone 15	Protein Coding	2
46	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
47	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
48	IL1A	Interleukin 1 Alpha	Protein Coding	1
49	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
50	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
51	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
52	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
53	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
54	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
55	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
56	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
57	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
58	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
59	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
60	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
61	LFNG	LFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
62	MFNG	MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
63	MYOD1	Myogenic Differentiation 1	Protein Coding	1
64	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
65	RFNG	RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
66	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	1
67	TLE2	TLE Family Member 2, Transcriptional Corepressor	Protein Coding	1
68	TLE3	TLE Family Member 3, Transcriptional Corepressor	Protein Coding	1
69	TLE4	TLE Family Member 4, Transcriptional Corepressor	Protein Coding	1
70	TP73	Tumor Protein P73	Protein Coding	1
71	CUL1	Cullin 1	Protein Coding	1
72	TP63	Tumor Protein P63	Protein Coding	1
73	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
74	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	1
75	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
76	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1

Disorders associated with Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	5.83
2	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	5.52
3	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	4.99
4	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.76
5	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.76
6	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.76
7	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H4C1, H4C9	4.28
8	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.28
9	Tetralogy of fallot	Enrichment	HEY2, JAG1, NOTCH1	3.68
10	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.44
11	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	3.18
12	Acne inversa, familial, 1	Enrichment	NCSTN	3.13
13	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	3.13
14	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	3.13
15	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	3.13
16	Acne inversa, familial, 3	Enrichment	PSEN1	3.13
17	Pash syndrome	Enrichment	NCSTN	3.13
18	Huntington's disease-like	Enrichment	PSEN2	3.13
19	Alzheimer disease 3	Enrichment	PSEN1	2.83
20	Pick disease of brain	Enrichment	PSEN1	2.83
21	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.83
22	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.83
23	Rela fusion-positive ependymoma	Enrichment	RELA	2.83
24	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.83
25	Common variable immunodeficiency 12	Enrichment	NFKB1	2.83
26	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.66
27	Dowling-degos disease	Enrichment	PSENEN	2.53
28	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.43
29	Dementia	Enrichment	PSEN1	2.43
30	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.38
31	Fetal encasement syndrome	Enrichment	CHUK	2.38
32	46,xy sex reversal 6	Enrichment	MAP3K1	2.38
33	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.38
34	Immunodeficiency 15b	Enrichment	IKBKB	2.38
35	Immunodeficiency 15a	Enrichment	IKBKB	2.38
36	Immunodeficiency 92	Enrichment	REL	2.38
37	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.38
38	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.38
39	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.38
40	Immunodeficiency 53	Enrichment	RELB	2.38
41	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.38
42	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.38
43	Immunodeficiency 112	Enrichment	MAP3K14	2.38
44	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.38
45	Nik deficiency	Enrichment	MAP3K14	2.38
46	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	2.35
47	Rapp-hodgkin syndrome	Enrichment	TP63	2.35
48	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.35
49	Spondylocostal dysostosis 3, autosomal recessive	Enrichment	LFNG	2.35
50	Split-hand/foot malformation 4	Enrichment	TP63	2.35
51	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.35
52	Adult syndrome	Enrichment	TP63	2.35
53	Ciliary dyskinesia, primary, 47, and lissencephaly	Enrichment	TP73	2.35
54	Adams-oliver syndrome 6	Enrichment	DLL4	2.35
55	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.35
56	Limb-mammary syndrome	Enrichment	TP63	2.35
57	Premature ovarian failure 21	Enrichment	TP63	2.35
58	Congenital myopathy 17	Enrichment	MYOD1	2.35
59	Orofacial cleft 8	Enrichment	TP63	2.35
60	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.35
61	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.35
62	Tp63-related disorders	Enrichment	TP63	2.35
63	Semantic dementia	Enrichment	PSEN1	2.29
64	Progressive non-fluent aphasia	Enrichment	PSEN1	2.18
65	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	2.18
66	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.13
67	Frontotemporal dementia 1	Enrichment	PSEN1	2.09
68	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.08
69	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.08
70	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.08
71	Adams-oliver syndrome 3	Enrichment	RBPJ	2.08
72	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.08
73	Menke-hennekam syndrome 2	Enrichment	EP300	2.08
74	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.08
75	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	2.05
76	Bladder exstrophy	Enrichment	TP63	2.05
77	Fissured tongue	Enrichment	TP63	2.05
78	Alzheimer's disease	Enrichment	PSEN1	2.02
79	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.90
80	Alagille syndrome 1	Enrichment	JAG1	1.90
81	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.90
82	Keratoacanthoma	Enrichment	NOTCH1	1.90
83	Respiratory failure	Enrichment	TP73	1.87
84	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9	1.82
85	Skin disease	Enrichment	NCSTN	1.79
86	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	HEY2, NOTCH1	1.78
87	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.78
88	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.78
89	Middle aortic syndrome	Enrichment	JAG1	1.78
90	Small cell cancer of the lung	Enrichment	TP73	1.75
91	Cleft lip and alveolus	Enrichment	TP63	1.75
92	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.68
93	Pervasive developmental disorder	Enrichment	FBXW7	1.65
94	Aplasia cutis congenita	Enrichment	DLL4	1.65
95	Cleft upper lip	Enrichment	TP63	1.65
96	Rare pervasive developmental disorder	Enrichment	FBXW7	1.65
97	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.60
98	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.60
99	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.57
100	Spondylocostal dysostosis, autosomal recessive	Enrichment	LFNG	1.57
101	Glioma susceptibility 1	Enrichment	H3-3A	1.48
102	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.48
103	Isolated split hand-split foot malformation	Enrichment	TP63	1.45
104	Charge syndrome	Enrichment	EP300	1.43
105	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	1.38
106	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.34
107	Aortic valve disease 1	Enrichment	NOTCH1	1.27
108	Premature menopause	Enrichment	TP63	1.24
109	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.24
110	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.24
111	Colorectal cancer	Enrichment	EP300, FBXW7	1.23
112	Cleft lip/palate	Enrichment	TP63	1.21
113	Polydactyly, postaxial, type a1	Enrichment	EP300	1.21
114	Rare genetic intellectual disability	Enrichment	EP300	1.21
115	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.21
116	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.21
117	Gliosarcoma	Enrichment	NFKBIA	1.19
118	Microform holoprosencephaly	Enrichment	DLL1	1.19
119	Lobar holoprosencephaly	Enrichment	DLL1	1.19
120	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.18
121	Giant cell glioblastoma	Enrichment	NFKBIA	1.16
122	Alobar holoprosencephaly	Enrichment	DLL1	1.16
123	Heart, malformation of	Enrichment	JAG1	1.14
124	Semilobar holoprosencephaly	Enrichment	DLL1	1.14
125	Congenital nervous system abnormality	Enrichment	PSEN1	1.12
126	Nervous system disease	Enrichment	PSEN1	1.12
127	Hepatoblastoma	Enrichment	JAG1	1.07
128	Connective tissue disease	Enrichment	NOTCH1	0.90
129	Severe combined immunodeficiency	Enrichment	IKBKB	0.89
130	Systemic lupus erythematosus	Enrichment	IRAK1	0.82
131	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	0.81
132	Type 2 diabetes mellitus	Enrichment	RBPJ	0.79
133	Distal arthrogryposis	Enrichment	MYOD1	0.76
134	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.72
135	Myeloma, multiple	Enrichment	NCOR2	0.68
136	Primary ovarian insufficiency	Enrichment	TP63	0.63
137	Ovarian cancer	Enrichment	MAP3K1	0.46
138	Microcephaly	Enrichment	EP300	0.39
139	Hereditary retinal dystrophy	Enrichment	JAG1	0.15
140	Fundus dystrophy	Enrichment	JAG1	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development NOTCH1-mediated pathway for NF-KB activity modulation

Pathway Network for Development NOTCH1-mediated pathway for NF-KB activity modulation

Pathway network for the Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

Member Pathways for Development NOTCH1-mediated pathway for NF-KB activity modulation

Pathways in the Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

Gene overlap in member pathways for Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

Associated Genes for Development NOTCH1-mediated pathway for NF-KB activity modulation

Associated Disorders for Development NOTCH1-mediated pathway for NF-KB activity modulation

Disorders associated with Development NOTCH1-mediated pathway for NF-KB activity modulation SuperPath

STRING Interaction Network for Development NOTCH1-mediated pathway for NF-KB activity modulation

Sources for Development NOTCH1-mediated pathway for NF-KB activity modulation