Development of ureteric collection system

No Pathway Network information available for Development of ureteric collection system

Pathways in the Development of ureteric collection system SuperPath

#	Name	Source	Genes
1	Development of ureteric collection system	WikiPathways	ANOS1 BMP2 BMP4 BMP5 BMP7 BMPER BMPR1A BMPR2 CCND1 CRIM1 CTDNEP1 EYA1 FOXC1 FRAS1 FREM1 FST GDF11 GDNF GFRA1 GLI1 GLI2 GLI3 GPC3 GREB1L HOXA11 HOXD11 ITGA8 MYCN PAX2 PBX1 RARA RARB RARG RET SALL1 SHH SIX1 SIX2 SLIT2 SMAD1 SMO SPRY1 TGFB2 WNT11 WT1 (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
2	ITGA8	Integrin Subunit Alpha 8	Protein Coding	1
3	FRAS1	Fraser Extracellular Matrix Complex Subunit 1	Protein Coding	1
4	WT1	WT1 Transcription Factor	Protein Coding	1
5	WNT11	Wnt Family Member 11	Protein Coding	1
6	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
7	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
8	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	1
9	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	1
10	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
11	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
12	BMP2	Bone Morphogenetic Protein 2	Protein Coding	1
13	SIX1	SIX Homeobox 1	Protein Coding	1
14	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
15	SALL1	Spalt Like Transcription Factor 1	Protein Coding	1
16	RET	Ret Proto-Oncogene	Protein Coding	1
17	CCND1	Cyclin D1	Protein Coding	1
18	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
19	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
20	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
21	PBX1	PBX Homeobox 1	Protein Coding	1
22	PAX2	Paired Box 2	Protein Coding	1
23	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
24	SMAD1	SMAD Family Member 1	Protein Coding	1
25	ANOS1	Anosmin 1	Protein Coding	1
26	HOXD11	Homeobox D11	Protein Coding	1
27	HOXA11	Homeobox A11	Protein Coding	1
28	GLI3	GLI Family Zinc Finger 3	Protein Coding	1
29	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
30	GLI1	GLI Family Zinc Finger 1	Protein Coding	1
31	GPC3	Glypican 3	Protein Coding	1
32	GFRA1	GDNF Family Receptor Alpha 1	Protein Coding	1
33	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	1
34	FOXC1	Forkhead Box C1	Protein Coding	1
35	EYA1	EYA Transcriptional Coactivator And Phosphatase 1	Protein Coding	1
36	BMPER	BMP Binding Endothelial Regulator	Protein Coding	1
37	FREM1	FRAS1 Related Extracellular Matrix 1	Protein Coding	1
38	SIX2	SIX Homeobox 2	Protein Coding	1
39	FST	Follistatin	Protein Coding	1
40	SPRY1	Sprouty RTK Signaling Antagonist 1	Protein Coding	1
41	GDF11	Growth Differentiation Factor 11	Protein Coding	1
42	GREB1L	GREB1 Like Retinoic Acid Receptor Coactivator	Protein Coding	1
43	BMP5	Bone Morphogenetic Protein 5	Protein Coding	1
44	CRIM1	Cysteine Rich Transmembrane BMP Regulator 1	Protein Coding	1
45	CTDNEP1	CTD Nuclear Envelope Phosphatase 1	Protein Coding	1

Disorders associated with Development of ureteric collection system SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Renal agenesis, bilateral	Enrichment	EYA1, GFRA1, GREB1L, ITGA8, RET	10.24
2	Renal hypodysplasia/aplasia 3	Enrichment	BMP4, FRAS1, FREM1, GREB1L, RET	9.60
3	Cakut	Enrichment	FOXC1, FRAS1, GREB1L, PAX2, SALL1, SLIT2	8.93
4	Renal hypodysplasia/aplasia 1	Enrichment	FRAS1, ITGA8, RET	5.72
5	Hirschsprung disease 1	Enrichment	GDNF, GLI3, RET, SMO	5.63
6	Branchiootic syndrome	Enrichment	EYA1, SIX1	4.97
7	Branchiootic syndrome 1	Enrichment	EYA1, SIX1	4.97
8	Postaxial polydactyly type b	Enrichment	GLI1, GLI3	4.97
9	Renal hypoplasia, bilateral	Enrichment	PAX2, PBX1	4.97
10	Focal segmental glomerulosclerosis	Enrichment	EYA1, PAX2, WT1	4.43
11	Orofacial cleft	Enrichment	FST, GDF11	4.19
12	Orofacial clefting syndrome	Enrichment	FST, GDF11	4.19
13	Ventricular septal defect 1	Enrichment	BMP2, BMP7	3.97
14	Atrial septal defect 1	Enrichment	BMP2, TGFB2	3.80
15	Branchiootorenal syndrome 1	Enrichment	EYA1, SIX1	3.80
16	Branchiootorenal syndrome	Enrichment	EYA1, SIX1	3.65
17	Congenital central hypoventilation syndrome	Enrichment	GDNF, RET	3.42
18	Peters-plus syndrome	Enrichment	BMP4, FOXC1	3.32
19	Microphthalmia/coloboma 12	Enrichment	PAX2, RARB	3.09
20	Diaphragmatic hernia, congenital	Enrichment	FRAS1, GLI3	3.09
21	Coloboma of macula	Enrichment	PAX2, RARB	2.96
22	Polydactyly, postaxial, type a1	Enrichment	GLI1, GLI3	2.96
23	Wilms tumor 1	Enrichment	GPC3, WT1	2.96
24	Septopreoptic holoprosencephaly	Enrichment	GLI2, SHH	2.96
25	Midline interhemispheric variant of holoprosencephaly	Enrichment	GLI2, SHH	2.96
26	Microform holoprosencephaly	Enrichment	GLI2, SHH	2.90
27	Lobar holoprosencephaly	Enrichment	GLI2, SHH	2.90
28	Alobar holoprosencephaly	Enrichment	GLI2, SHH	2.85
29	Semilobar holoprosencephaly	Enrichment	GLI2, SHH	2.80
30	Craniosynostosis	Enrichment	GLI2, GLI3	2.71
31	Holoprosencephaly 3	Enrichment	SHH	2.48
32	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.48
33	Pallister-hall syndrome	Enrichment	GLI3	2.48
34	Greig cephalopolysyndactyly syndrome	Enrichment	GLI3	2.48
35	Hypertelorism and tetralogy of fallot	Enrichment	FOXC1	2.48
36	Curry-jones syndrome	Enrichment	SMO	2.48
37	Diaphanospondylodysostosis	Enrichment	BMPER	2.48
38	Polydactyly, preaxial iv	Enrichment	GLI3	2.48
39	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	2.48
40	Townes-brocks syndrome 1	Enrichment	SALL1	2.48
41	Microphthalmia/coloboma 5	Enrichment	SHH	2.48
42	Otofaciocervical syndrome 1	Enrichment	EYA1	2.48
43	Polydactyly, preaxial i	Enrichment	GLI1	2.48
44	Culler-jones syndrome	Enrichment	GLI2	2.48
45	Mayer-rokitansky-kuster-hauser syndrome	Enrichment	GREB1L	2.48
46	Polydactyly, postaxial, type a8	Enrichment	GLI1	2.48
47	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Enrichment	PBX1	2.48
48	Vertebral hypersegmentation and orofacial anomalies	Enrichment	GDF11	2.48
49	Microphthalmia, syndromic 6	Enrichment	BMP4	2.48
50	Orofacial cleft 11	Enrichment	BMP4	2.48
51	Renal hypodysplasia/aplasia 4	Enrichment	GFRA1	2.48
52	Deafness, autosomal dominant 23	Enrichment	SIX1	2.48
53	Radioulnar synostosis with amegakaryocytic thrombocytopenia 1	Enrichment	HOXA11	2.48
54	Camurati-engelmann disease 2	Enrichment	TGFB2	2.48
55	Meacham syndrome	Enrichment	WT1	2.48
56	Holoprosencephaly 9	Enrichment	GLI2	2.48
57	Microphthalmia, syndromic 12	Enrichment	RARB	2.48
58	Hirschsprung disease 3	Enrichment	GDNF	2.48
59	20p12.3 microdeletion syndrome	Enrichment	BMP2	2.48
60	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1	Enrichment	BMP2	2.48
61	Mayer-rokitansky-kuster-hauser syndrome type 1	Enrichment	GREB1L	2.48
62	Primary pulmonary hypertension	Enrichment	BMPR2	2.48
63	Thyroid cancer	Enrichment	RET	2.48
64	Pulmonary hypertension	Enrichment	BMPR2	2.48
65	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	2.48
66	Pax2-related disorder	Enrichment	PAX2	2.48
67	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.48
68	Autosomal dominant nonsyndromic hearing loss 23	Enrichment	SIX1	2.48
69	Six2-related frontonasal dysplasia	Enrichment	SIX2	2.48
70	Gastrointestinal system disease	Enrichment	RET	2.48
71	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.48
72	Multiple endocrine neoplasia	Enrichment	RET	2.48
73	Ovarian cancer	Enrichment	BMPR1A, RET, WT1	2.34
74	Genetic steroid-resistant nephrotic syndrome	Enrichment	PAX2, WT1	2.25
75	Papillorenal syndrome	Enrichment	PAX2	2.18
76	Deafness, unilateral	Enrichment	SIX1	2.18
77	Manitoba oculotrichoanal syndrome	Enrichment	FREM1	2.18
78	Pallister-hall-like syndrome	Enrichment	SMO	2.18
79	Denys-drash syndrome	Enrichment	WT1	2.18
80	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	2.18
81	Axenfeld-rieger syndrome, type 3	Enrichment	FOXC1	2.18
82	Nephrotic syndrome, type 4	Enrichment	WT1	2.18
83	Genitourinary tract anomalies	Enrichment	HOXA11	2.18
84	Macrophthalmia, colobomatous, with microcornea	Enrichment	CRIM1	2.18
85	Bifid nose with or without anorectal and renal anomalies	Enrichment	FREM1	2.18
86	Axenfeld-rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities	Enrichment	FOXC1	2.18
87	Branchiootic syndrome 3	Enrichment	SIX1	2.18
88	Solitary median maxillary central incisor	Enrichment	SHH	2.18
89	Fibrodysplasia ossificans progressiva	Enrichment	BMPR2	2.18
90	Frasier syndrome	Enrichment	WT1	2.18
91	White-sutton syndrome	Enrichment	GLI2	2.18
92	Anterior segment dysgenesis 3	Enrichment	FOXC1	2.18
93	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.18
94	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	2.18
95	Tibial hemimelia	Enrichment	GLI3	2.18
96	Deafness, autosomal dominant 80	Enrichment	GREB1L	2.18
97	Townes-brocks syndrome	Enrichment	SALL1	2.18
98	Focal segmental glomerulosclerosis 7	Enrichment	PAX2	2.18
99	Synpolydactyly	Enrichment	GLI3	2.18
100	Medullary thyroid carcinoma	Enrichment	RET	2.18
101	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.18
102	Trigonocephaly 2	Enrichment	FREM1	2.18
103	Megalencephaly-polydactyly syndrome	Enrichment	MYCN	2.18
104	Craniosynostosis 7	Enrichment	BMP2	2.18
105	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A	2.18
106	Interfrontal craniofaciosynostosis	Enrichment	FREM1	2.18
107	Otofaciocervical syndrome	Enrichment	EYA1	2.18
108	Axenfeld-rieger syndrome	Enrichment	FOXC1	2.18
109	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	PBX1	2.18
110	Pulmonary venoocclusive disease	Enrichment	BMPR2	2.18
111	Familial retinoblastoma	Enrichment	MYCN	2.18
112	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.18
113	Isolated radial hemimelia	Enrichment	SHH	2.18
114	Desmoplastic small round cell tumor	Enrichment	WT1	2.18
115	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.18
116	Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome	Enrichment	HOXA11	2.18
117	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A, RET, WT1	2.02
118	Retinoblastoma	Enrichment	MYCN	2.00
119	Thyroid carcinoma, familial medullary	Enrichment	RET	2.00
120	Mesothelioma, malignant	Enrichment	WT1	2.00
121	Juvenile polyposis syndrome	Enrichment	BMPR1A	2.00
122	Acrocallosal syndrome	Enrichment	GLI3	2.00
123	Syndactyly, type iv	Enrichment	SHH	2.00
124	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3	2.00
125	Aarskog-scott syndrome	Enrichment	GLI3	2.00
126	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	GREB1L	2.00
127	Transposition of the great arteries, dextro-looped	Enrichment	BMP2	2.00
128	Umbilical hernia	Enrichment	GLI3	2.00
129	Gingival overgrowth	Enrichment	RET	2.00
130	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	2.00
131	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2	2.00
132	Aniridia 1	Enrichment	WT1	1.88
133	Branchiooculofacial syndrome	Enrichment	EYA1	1.88
134	Brachydactyly, type a2	Enrichment	BMP2	1.88
135	Polydactyly, preaxial ii	Enrichment	SHH	1.88
136	Schizencephaly	Enrichment	SHH	1.88
137	Microtia-anotia	Enrichment	BMP5	1.88
138	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	1.88
139	Mantle cell lymphoma	Enrichment	CCND1	1.88
140	Haddad syndrome	Enrichment	RET	1.88
141	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2, GREB1L	1.83
142	Feingold syndrome 1	Enrichment	MYCN	1.78
143	Multiple endocrine neoplasia, type iia	Enrichment	RET	1.78
144	Martsolf syndrome 1	Enrichment	ANOS1	1.78
145	Von hippel-lindau syndrome	Enrichment	CCND1	1.78
146	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	ANOS1	1.78
147	Pseudovaginal perineoscrotal hypospadias	Enrichment	ANOS1	1.78
148	Atrioventricular septal defect	Enrichment	BMP5	1.78
149	Leber congenital amaurosis 10	Enrichment	WT1	1.78
150	Congenital heart defects, multiple types, 4	Enrichment	BMP7	1.78
151	Juvenile glaucoma	Enrichment	FOXC1	1.78
152	Aniridia	Enrichment	FOXC1	1.78
153	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A	1.78
154	Fraser syndrome 1	Enrichment	FRAS1	1.70
155	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	WT1	1.70
156	Wilms tumor 5	Enrichment	WT1	1.70
157	Anterior segment dysgenesis 5	Enrichment	BMP4	1.70
158	Congenital anomalies of kidney and urinary tract 1	Enrichment	PAX2	1.70
159	Renal hypoplasia	Enrichment	PAX2	1.70
160	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.70
161	Hemochromatosis, type 1	Enrichment	BMP2	1.58
162	Hypothyroidism	Enrichment	RET	1.58
163	Neuroblastoma	Enrichment	MYCN	1.58
164	Difference of sex development	Enrichment	WT1	1.58
165	Combined pituitary hormone deficiency	Enrichment	GLI2	1.58
166	Tooth agenesis, selective, 1	Enrichment	BMPR2	1.53
167	Ellis-van creveld syndrome	Enrichment	GLI1	1.53
168	Leukemia, acute lymphoblastic 3	Enrichment	WT1	1.53
169	Loeys-dietz syndrome	Enrichment	TGFB2	1.53
170	Hypogonadotropic hypogonadism	Enrichment	ANOS1	1.53
171	Cystic kidney disease	Enrichment	PAX2	1.53
172	Marfan syndrome	Enrichment	TGFB2	1.49
173	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.49
174	Stickler syndrome	Enrichment	BMP4	1.49
175	Colorectal cancer	Enrichment	CCND1, RET	1.47
176	46,xy complete gonadal dysgenesis	Enrichment	WT1	1.44
177	Heritable pulmonary arterial hypertension	Enrichment	BMPR2	1.44
178	Familial colorectal cancer type x	Enrichment	BMPR1A	1.44
179	Septooptic dysplasia	Enrichment	SHH	1.41
180	Meningioma	Enrichment	SMO	1.41
181	Pulmonary hypertension, primary, 1	Enrichment	BMPR2	1.37
182	Acute promyelocytic leukemia	Enrichment	RARA	1.37
183	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	ANOS1	1.34
184	Pheochromocytoma	Enrichment	RET	1.34
185	Cleft lip/palate	Enrichment	BMP4	1.34
186	46,xy partial gonadal dysgenesis	Enrichment	WT1	1.34
187	Anterior segment dysgenesis	Enrichment	FOXC1	1.31
188	Kidney disease	Enrichment	WT1	1.31
189	Ehlers-danlos syndrome	Enrichment	TGFB2	1.21
190	Macs syndrome	Enrichment	SHH	1.19
191	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.17
192	Hepatocellular carcinoma	Enrichment	RET	1.15
193	Microphthalmia	Enrichment	RARB	1.15
194	Kallmann syndrome	Enrichment	ANOS1	1.13
195	Tetralogy of fallot	Enrichment	RET	1.08
196	Differentiated thyroid carcinoma	Enrichment	RET	1.04
197	Nephrotic syndrome	Enrichment	PAX2	0.88
198	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2	0.87
199	Hereditary breast carcinoma	Enrichment	RET	0.87
200	Sensorineural hearing loss	Enrichment	RET	0.83
201	Hypertelorism	Enrichment	RET	0.80
202	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	SIX1	0.80
203	Myeloma, multiple	Enrichment	CCND1	0.77
204	Primary ovarian insufficiency	Enrichment	WT1	0.75
205	Autism	Enrichment	SHH	0.67
206	Breast cancer	Enrichment	RET	0.66
207	Rare genetic deafness	Enrichment	EYA1	0.64
208	Autism spectrum disorder	Enrichment	PBX1	0.52
209	Hereditary retinal dystrophy	Enrichment	PAX2	0.21
210	Fundus dystrophy	Enrichment	PAX2	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development of ureteric collection system

Pathway Network for Development of ureteric collection system

Member Pathways for Development of ureteric collection system

Pathways in the Development of ureteric collection system SuperPath

Associated Genes for Development of ureteric collection system

Associated Disorders for Development of ureteric collection system

Disorders associated with Development of ureteric collection system SuperPath

STRING Interaction Network for Development of ureteric collection system

Sources for Development of ureteric collection system