Development Slit-Robo signaling

Pathway network for the Development Slit-Robo signaling SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways

Pathways in the Development Slit-Robo signaling SuperPath

#	Name	Source	Genes
1	Development Slit-Robo signaling	GeneGo (Thomson Reuters)	ABL1 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 ACTR2 ACTR3 ACTR3B ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDK5 CFL1 CFL2 CTTN DPYSL2 ENAH FYN LIMK1 MAPT PFN1 PTK2 RHOA ROBO1 ROBO2 ROBO3 ROBO4 ROCK1 ROCK2 SLIT1 SLIT2 SLIT3 SRC SRGAP1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 WASL (see all 61) (see less)
2	Neurophysiological process Receptor-mediated axon growth repulsion	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTR2 ACTR3 ACTR3B ARHGEF11 ARHGEF12 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BRAF CDC42 CDK5 CFL1 CFL2 CTTN DPYSL2 DSTN EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 FER FES FYN GRB7 HBEGF LIMK1 LIMK2 MAPT NGEF NRP1 PAK1 PLXNA1 PLXNA2 PLXNB1 PTN RAC1 RAF1 RAP1A RHOA RND1 ROCK1 ROCK2 SDC3 SEMA3A SEMA4D SRC TIAM1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 VAV2 (see all 83) (see less)
3	Pathogenic Escherichia coli infection	WikiPathways	ABL1 ACTB ACTG1 ARHGEF2 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ARPC5L CD14 CDC42 CDH1 CLDN1 CTNNB1 CTTN EZR FYN HCLS1 ITGB1 KRT18 LY96 NCK1 NCK2 NCL OCLN PRKCA RHOA ROCK1 ROCK2 TLR4 TLR5 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB7P TUBB8 WAS WASL YWHAQ YWHAZ (see all 56) (see less)

Gene overlap in member pathways for Development Slit-Robo signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTB	Actin Beta	Protein Coding	3
2	ACTG1	Actin Gamma 1	Protein Coding	3
3	RHOA	Ras Homolog Family Member A	Protein Coding	3
4	CDC42	Cell Division Cycle 42	Protein Coding	3
5	CTTN	Cortactin	Protein Coding	3
6	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
7	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	3
8	TUBA4A	Tubulin Alpha 4a	Protein Coding	3
9	TUBA3C	Tubulin Alpha 3c	Protein Coding	3
10	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	3
11	TUBA1A	Tubulin Alpha 1a	Protein Coding	3
12	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	3
13	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	3
14	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	3
15	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	3
16	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	3
17	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	3
18	TUBA1B	Tubulin Alpha 1b	Protein Coding	3
19	TUBB3	Tubulin Beta 3 Class III	Protein Coding	3
20	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	3
21	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	3
22	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	3
23	TUBA8	Tubulin Alpha 8	Protein Coding	3
24	TUBB7P	Tubulin Beta 7 Pseudogene	Pseudogene	3
25	TUBAL3	Tubulin Alpha Like 3	Protein Coding	3
26	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	3
27	TUBB6	Tubulin Beta 6 Class V	Protein Coding	3
28	TUBA1C	Tubulin Alpha 1c	Protein Coding	3
29	TUBA3E	Tubulin Alpha 3e	Protein Coding	3
30	TUBA3D	Tubulin Alpha 3d	Protein Coding	3
31	TUBB	Tubulin Beta Class I	Protein Coding	3
32	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	3
33	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	3
34	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	2
35	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
36	CFL1	Cofilin 1	Protein Coding	2
37	CFL2	Cofilin 2	Protein Coding	2
38	DPYSL2	Dihydropyrimidinase Like 2	Protein Coding	2
39	LIMK1	LIM Domain Kinase 1	Protein Coding	2
40	MAPT	Microtubule Associated Protein Tau	Protein Coding	2
41	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
42	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
43	ACTR3	Actin Related Protein 3	Protein Coding	2
44	ACTR2	Actin Related Protein 2	Protein Coding	2
45	ACTR3B	Actin Related Protein 3B	Protein Coding	2
46	TUBA4B	Tubulin Alpha 4b	Protein Coding	2
47	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
48	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
49	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
50	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
51	PFN1	Profilin 1	Protein Coding	1
52	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
53	ROBO1	Roundabout Guidance Receptor 1	Protein Coding	1
54	ROBO2	Roundabout Guidance Receptor 2	Protein Coding	1
55	SLIT1	Slit Guidance Ligand 1	Protein Coding	1
56	SLIT3	Slit Guidance Ligand 3	Protein Coding	1
57	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
58	ROBO4	Roundabout Guidance Receptor 4	Protein Coding	1
59	ENAH	ENAH Actin Regulator	Protein Coding	1
60	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	1
61	ROBO3	Roundabout Guidance Receptor 3	Protein Coding	1
62	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
63	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	1
64	EFNA1	Ephrin A1	Protein Coding	1
65	EFNA2	Ephrin A2	Protein Coding	1
66	EFNA3	Ephrin A3	Protein Coding	1
67	EFNA4	Ephrin A4	Protein Coding	1
68	EFNA5	Ephrin A5	Protein Coding	1
69	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
70	EPHA2	EPH Receptor A2	Protein Coding	1
71	EPHA1	EPH Receptor A1	Protein Coding	1
72	EPHA3	EPH Receptor A3	Protein Coding	1
73	EPHA4	EPH Receptor A4	Protein Coding	1
74	EPHA5	EPH Receptor A5	Protein Coding	1
75	EPHA7	EPH Receptor A7	Protein Coding	1
76	EPHA8	EPH Receptor A8	Protein Coding	1
77	FER	FER Tyrosine Kinase	Protein Coding	1
78	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
79	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	1
80	LIMK2	LIM Domain Kinase 2	Protein Coding	1
81	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
82	PLXNA1	Plexin A1	Protein Coding	1
83	PLXNA2	Plexin A2	Protein Coding	1
84	PLXNB1	Plexin B1	Protein Coding	1
85	PTN	Pleiotrophin	Protein Coding	1
86	RAC1	Rac Family Small GTPase 1	Protein Coding	1
87	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
88	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
89	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
90	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
91	NRP1	Neuropilin 1	Protein Coding	1
92	SDC3	Syndecan 3	Protein Coding	1
93	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
94	SEMA3A	Semaphorin 3A	Protein Coding	1
95	SEMA4D	Semaphorin 4D	Protein Coding	1
96	DSTN	Destrin, Actin Depolymerizing Factor	Protein Coding	1
97	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
98	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
99	RND1	Rho Family GTPase 1	Protein Coding	1
100	EPHA6	EPH Receptor A6	Protein Coding	1
101	CDH1	Cadherin 1	Protein Coding	1
102	CD14	CD14 Molecule	Protein Coding	1
103	CLDN1	Claudin 1	Protein Coding	1
104	NCK2	NCK Adaptor Protein 2	Protein Coding	1
105	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
106	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
107	EZR	Ezrin	Protein Coding	1
108	TLR5	Toll Like Receptor 5	Protein Coding	1
109	TLR4	Toll Like Receptor 4	Protein Coding	1
110	PRKCA	Protein Kinase C Alpha	Protein Coding	1
111	NCL	Nucleolin	Protein Coding	1
112	NCK1	NCK Adaptor Protein 1	Protein Coding	1
113	KRT18	Keratin 18	Protein Coding	1
114	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
115	HCLS1	Hematopoietic Cell-Specific Lyn Substrate 1	Protein Coding	1
116	LY96	Lymphocyte Antigen 96	Protein Coding	1
117	CTNNB1	Catenin Beta 1	Protein Coding	1
118	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
119	OCLN	Occludin	Protein Coding	1
120	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
121	ARPC5L	Actin Related Protein 2/3 Complex Subunit 5 Like	Protein Coding	1

Disorders associated with Development Slit-Robo signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	ACTG1, TUBA1A, TUBA3E, TUBB, TUBB2B, TUBB3	9.66
2	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	7.18
3	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	6.58
4	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	5.88
5	Cakut	Enrichment	ACTG1, ROBO1, SLIT2, SRGAP1	4.81
6	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.78
7	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, YWHAZ	4.00
8	Microcephaly	Enrichment	ABL1, ACTB, ACTG1, CTNNB1, TUBB4A	3.83
9	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.66
10	Typical nemaline myopathy	Enrichment	ACTA1, CFL2	3.53
11	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.46
12	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.23
13	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	3.13
14	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	3.12
15	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	3.00
16	Isolated congenital microcephaly	Enrichment	OCLN, TUBA3E	2.71
17	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR	2.71
18	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR	2.63
19	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR	2.49
20	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, RAF1	2.43
21	Centronuclear myopathy	Enrichment	ACTA1, CFL2	2.40
22	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	2.38
23	Pseudo-torch syndrome 1	Enrichment	OCLN	2.38
24	Baraitser-winter syndrome 1	Enrichment	ACTB	2.38
25	Thrombocytopenia 1	Enrichment	WAS	2.38
26	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.38
27	Legionnaire disease	Enrichment	TLR5	2.38
28	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	2.38
29	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.38
30	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.38
31	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.38
32	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.38
33	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.38
34	Systemic lupus erythematosus 1	Enrichment	TLR5	2.38
35	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.38
36	Becker nevus syndrome	Enrichment	ACTB	2.38
37	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.38
38	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.38
39	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.38
40	Melioidosis	Enrichment	TLR5	2.38
41	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.38
42	Macular degeneration, age-related, 10	Enrichment	TLR4	2.38
43	Was-related disorders	Enrichment	WAS	2.38
44	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.38
45	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.38
46	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.38
47	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.38
48	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.38
49	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.38
50	Adenoid ameloblastoma	Enrichment	CTNNB1	2.38
51	Baraitser-winter syndrome	Enrichment	ACTB	2.38
52	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.38
53	Congenital myopathy 26	Enrichment	TUBA4A	2.38
54	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.38
55	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.38
56	Breast lobular carcinoma	Enrichment	CDH1	2.38
57	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.38
58	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.38
59	Nocarh syndrome	Enrichment	CDC42	2.38
60	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.38
61	Microcystic stromal tumor	Enrichment	CTNNB1	2.38
62	Nystagmus 8, congenital, autosomal recessive	Enrichment	ROBO1	2.35
63	Vesicoureteral reflux 2	Enrichment	ROBO2	2.35
64	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.35
65	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	2.35
66	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.35
67	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.35
68	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.35
69	Parkinson-dementia syndrome	Enrichment	MAPT	2.35
70	Aortic valve disease 3	Enrichment	ROBO4	2.35
71	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.35
72	Nemaline myopathy 7	Enrichment	CFL2	2.35
73	Progressive supranuclear palsy	Enrichment	MAPT	2.35
74	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.35
75	Conjugate gaze palsy	Enrichment	ROBO3	2.35
76	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.35
77	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.35
78	Thrombocytopenia 6	Enrichment	SRC	2.35
79	Autosomal recessive congenital nystagmus	Enrichment	ROBO1	2.35
80	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.35
81	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.35
82	Pituitary hormone deficiency, combined or isolated, 8	Enrichment	ROBO1	2.35
83	Neurooculorenal syndrome	Enrichment	ROBO1	2.35
84	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.35
85	Zebra body myopathy	Enrichment	ACTA1	2.35
86	Actin-accumulation myopathy	Enrichment	ACTA1	2.35
87	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.35
88	Congenital nystagmus	Enrichment	ROBO1	2.35
89	Actg2 visceral myopathy	Enrichment	ACTG2	2.35
90	Dandy-walker syndrome	Enrichment	BRAF, TUBA1A	2.32
91	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR	2.23
92	Noonan syndrome 5	Enrichment	RAF1	2.21
93	Noonan syndrome 7	Enrichment	BRAF	2.21
94	Leopard syndrome 3	Enrichment	BRAF	2.21
95	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.21
96	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.21
97	Lymphangioma	Enrichment	BRAF	2.21
98	Phace association	Enrichment	BRAF	2.21
99	Leopard syndrome 2	Enrichment	RAF1	2.21
100	Hypogonadotropic hypogonadism 16 with or without anosmia	Enrichment	SEMA3A	2.21
101	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.21
102	Trigonitis	Enrichment	RAF1	2.21
103	Dworschak-punetha neurodevelopmental syndrome	Enrichment	PLXNA1	2.21
104	Syringocystadenoma papilliferum	Enrichment	BRAF	2.21
105	Ganglioglioma	Enrichment	BRAF	2.21
106	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.21
107	Phace syndrome	Enrichment	BRAF	2.21
108	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.21
109	Classic hairy cell leukemia	Enrichment	BRAF	2.21
110	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.08
111	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.08
112	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.08
113	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.08
114	Wiskott-aldrich syndrome	Enrichment	WAS	2.08
115	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1	2.08
116	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.08
117	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.08
118	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.08
119	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	2.08
120	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.08
121	Keratoconus 9	Enrichment	TUBA3D	2.08
122	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.08
123	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.08
124	Lissencephaly 3	Enrichment	TUBA1A	2.08
125	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.08
126	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	2.08
127	Immune system disease	Enrichment	CDC42	2.08
128	Torsion dystonia 4	Enrichment	TUBB4A	2.08
129	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.08
130	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	2.08
131	Immunodeficiency 133	Enrichment	ARPC5	2.08
132	Teratoma	Enrichment	CTNNB1	2.08
133	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.08
134	Noonan syndrome 1	Enrichment	BRAF, RAF1	2.07
135	Gaze palsy, familial horizontal, with progressive scoliosis 1	Enrichment	ROBO3	2.05
136	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.05
137	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.05
138	Pick disease of brain	Enrichment	MAPT	2.05
139	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.05
140	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.05
141	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.05
142	Moyamoya disease 5	Enrichment	ACTA2	2.05
143	Atrial septal defect 5	Enrichment	ACTC1	2.05
144	Horizontal gaze palsy with progressive scoliosis	Enrichment	ROBO3	2.05
145	Intestinal obstruction	Enrichment	ACTG2	2.05
146	Congenital nervous system abnormality	Enrichment	CTNNB1, TUBA1A, TUBB4A	2.02
147	Nervous system disease	Enrichment	CTNNB1, TUBA1A, TUBB4A	2.02
148	Rasopathy	Enrichment	BRAF, RAF1	1.96
149	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	1.95
150	Fetal akinesia deformation sequence 1	Enrichment	ACTA1, TUBA1A	1.92
151	Pulmonic stenosis	Enrichment	BRAF	1.91
152	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.91
153	Desmoid disease, hereditary	Enrichment	CTNNB1	1.91
154	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.91
155	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.91
156	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.91
157	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	1.91
158	Anus, imperforate	Enrichment	CTNNB1	1.91
159	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.91
160	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.91
161	Desmoid tumor	Enrichment	CTNNB1	1.91
162	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.91
163	Cryptogenic cirrhosis	Enrichment	KRT18	1.91
164	Familial vesicoureteral reflux	Enrichment	ROBO2	1.87
165	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	1.82
166	Lung cancer	Enrichment	BRAF, EGFR	1.79
167	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.78
168	Pilomatrixoma	Enrichment	CTNNB1	1.78
169	Aminoacylase 1 deficiency	Enrichment	ACTB	1.78
170	Alazami syndrome	Enrichment	CTNNB1	1.78
171	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.78
172	Craniopharyngioma	Enrichment	CTNNB1	1.78
173	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.78
174	Thrombocytopenia	Enrichment	TUBB1, WAS	1.78
175	Nemaline myopathy 2	Enrichment	ACTA1	1.75
176	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.75
177	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.75
178	Amyotrophy, monomelic	Enrichment	SLIT1	1.75
179	Intermediate nemaline myopathy	Enrichment	ACTA1	1.75
180	Ataxia-telangiectasia	Enrichment	BRAF	1.74
181	Langerhans cell histiocytosis	Enrichment	BRAF	1.74
182	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.74
183	Tethered spinal cord syndrome	Enrichment	BRAF	1.74
184	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.74
185	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.69
186	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.69
187	Coloboma of choroid and retina	Enrichment	ACTG1	1.69
188	Visceral myopathy 1	Enrichment	ACTG2	1.65
189	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.65
190	Dementia	Enrichment	MAPT	1.65
191	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.65
192	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	1.62
193	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.62
194	Cardiofaciocutaneous syndrome	Enrichment	BRAF	1.62
195	Newborn respiratory distress syndrome	Enrichment	BRAF	1.62
196	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.61
197	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.61
198	Hemihyperplasia, isolated	Enrichment	RHOA	1.61
199	Adrenocortical carcinoma	Enrichment	CTNNB1	1.61
200	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.61
201	Cleft lip with or without cleft palate	Enrichment	CDH1	1.61
202	Moyamoya disease 1	Enrichment	ACTA2	1.57
203	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.57
204	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT, PFN1	1.55
205	Leukemia, chronic myeloid	Enrichment	ABL1	1.54
206	Gallbladder cancer	Enrichment	CTNNB1	1.54
207	Moyamoya angiopathy	Enrichment	ABL1	1.54
208	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.54
209	Cataract 6, multiple types	Enrichment	EPHA2	1.52
210	Cholangitis, primary sclerosing	Enrichment	SEMA4D	1.52
211	Aniridia	Enrichment	EPHA2	1.52
212	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	1.51
213	Myelofibrosis	Enrichment	SRC	1.51
214	Semantic dementia	Enrichment	MAPT	1.51
215	Follicular thyroid carcinoma	Enrichment	SRGAP1	1.51
216	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.51
217	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.49
218	Cryptorchidism	Enrichment	TUBA1A	1.49
219	Cowden syndrome 1	Enrichment	EGFR	1.44
220	Wilms tumor 5	Enrichment	BRAF	1.44
221	Lung squamous cell carcinoma	Enrichment	EGFR	1.44
222	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.44
223	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.44
224	Progressive non-fluent aphasia	Enrichment	MAPT	1.40
225	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.40
226	Renal agenesis, bilateral	Enrichment	ROBO1	1.40
227	Cat eye syndrome	Enrichment	ACTG1	1.39
228	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.38
229	Noonan syndrome 3	Enrichment	RAF1	1.38
230	Nemaline myopathy	Enrichment	ACTA1	1.36
231	Combined immunodeficiency	Enrichment	ARPC1B	1.35
232	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.35
233	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.35
234	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.32
235	Early-onset posterior polar cataract	Enrichment	EPHA2	1.32
236	Frontotemporal dementia 1	Enrichment	MAPT	1.32
237	Congenital hypothyroidism	Enrichment	TUBB1	1.31
238	Colorectal cancer	Enrichment	CDH1, CTNNB1	1.30
239	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1	1.30
240	Neural tube defects	Enrichment	ITGB1	1.28
241	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.27
242	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.27
243	Primary hyperaldosteronism	Enrichment	BRAF	1.27
244	Ventricular septal defect	Enrichment	BRAF	1.27
245	Medulloblastoma	Enrichment	CTNNB1	1.25
246	Heart disease	Enrichment	ABL1	1.25
247	Cleft lip/palate	Enrichment	CDH1	1.25
248	Aortic valve disease 1	Enrichment	ROBO4	1.24
249	Diaphragmatic hernia, congenital	Enrichment	ROBO4	1.24
250	Alzheimer's disease	Enrichment	MAPT	1.24
251	Melanoma	Enrichment	BRAF	1.23
252	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.22
253	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.22
254	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.22
255	Osteoporosis	Enrichment	SRC	1.21
256	Aortic aneurysm, familial thoracic 1	Enrichment	ROBO4	1.21
257	Pituitary stalk interruption syndrome	Enrichment	ROBO1	1.21
258	Hydrocephalus, congenital, 1	Enrichment	TUBB	1.19
259	Ovarian cancer	Enrichment	CDH1, CTNNB1	1.19
260	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.18
261	Polycystic liver disease	Enrichment	CTNNB1	1.17
262	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.17
263	Alzheimer disease, familial, 1	Enrichment	MAPT	1.13
264	Behcet syndrome	Enrichment	TLR4	1.12
265	Neuromuscular disease	Enrichment	ACTA1	1.11
266	Patent foramen ovale	Enrichment	ACTC1	1.11
267	Congenital myopathy	Enrichment	ACTA1	1.09
268	Cataract	Enrichment	EPHA2	1.08
269	Endometrial cancer	Enrichment	CDH1	1.08
270	Hepatoblastoma	Enrichment	CTNNB1	1.08
271	Williams-beuren syndrome	Enrichment	LIMK1	1.06
272	Hepatocellular carcinoma	Enrichment	CTNNB1	1.06
273	Wilms tumor 1	Enrichment	BRAF	1.06
274	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.04
275	Gliosarcoma	Enrichment	EGFR	1.03
276	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.00
277	Cataract 44	Enrichment	EPHA2	1.00
278	Giant cell glioblastoma	Enrichment	EGFR	1.00
279	Auditory neuropathy	Enrichment	TUBB4A	0.99
280	Parkinson disease, late-onset	Enrichment	MAPT	0.99
281	Early-onset nuclear cataract	Enrichment	EPHA2	0.98
282	Diffuse large b-cell lymphoma	Enrichment	BRAF	0.96
283	Tetralogy of fallot	Enrichment	ROBO1	0.96
284	Hydrops fetalis, nonimmune	Enrichment	ACTA1	0.96
285	Bladder cancer	Enrichment	CTNNB1	0.95
286	Prostate cancer	Enrichment	CDH1	0.95
287	Non-immune hydrops fetalis	Enrichment	ACTA1	0.88
288	Kallmann syndrome	Enrichment	SEMA3A	0.88
289	Connective tissue disease	Enrichment	ACTA2	0.87
290	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.86
291	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	0.86
292	Non-syndromic genetic deafness	Enrichment	ACTG1	0.86
293	Left ventricular noncompaction	Enrichment	ACTC1	0.84
294	Brugada syndrome	Enrichment	SEMA3A	0.83
295	Nonsyndromic hearing loss	Enrichment	ACTG1	0.80
296	Gastric cancer	Enrichment	CDH1	0.79
297	Differentiated thyroid carcinoma	Enrichment	BRAF	0.79
298	Myopathy	Enrichment	ACTA1	0.78
299	Optic atrophy plus syndrome	Enrichment	TUBB6	0.78
300	West syndrome	Enrichment	TUBA1A	0.78
301	Hereditary breast carcinoma	Enrichment	CDH1	0.78
302	Complex neurodevelopmental disorder	Enrichment	PLXNA1, TIAM1	0.76
303	Hypertrophic cardiomyopathy	Enrichment	ACTC1	0.75
304	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.74
305	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.73
306	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.71
307	Spastic ataxia	Enrichment	TUBB3	0.71
308	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1	0.67
309	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.67
310	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.65
311	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.58
312	Breast cancer	Enrichment	CDH1	0.57
313	Rare genetic deafness	Enrichment	ACTG1	0.55
314	Myeloma, multiple	Enrichment	BRAF	0.54
315	Leber plus disease	Enrichment	TUBB4B	0.49
316	Inherited cancer-predisposing syndrome	Enrichment	CDH1	0.37

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development Slit-Robo signaling

Pathway Network for Development Slit-Robo signaling

Pathway network for the Development Slit-Robo signaling SuperPath

Member Pathways for Development Slit-Robo signaling

Pathways in the Development Slit-Robo signaling SuperPath

Gene overlap in member pathways for Development Slit-Robo signaling SuperPath

Associated Genes for Development Slit-Robo signaling

Associated Disorders for Development Slit-Robo signaling

Disorders associated with Development Slit-Robo signaling SuperPath

STRING Interaction Network for Development Slit-Robo signaling

Sources for Development Slit-Robo signaling