Development_TGF-beta receptor signaling

No Pathway Network information available for Development_TGF-beta receptor signaling

Pathways in the Development_TGF-beta receptor signaling SuperPath

#	Name	Source	Genes
1	Development_TGF-beta receptor signaling	GeneGo (Thomson Reuters)	ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CAV1 CDC16 CDC23 CDC26 CDC27 CDKN1A CDKN2B CHUK CREBBP ELK1 EP300 ERBB2 ETV1 FKBP1A FOXH1 FZR1 GADD45B HRAS IKBKB IPO5 KLF10 KPNB1 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAP3K4 MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 NFKB1 NFKB2 NFKBIA RAF1 REL RELA RELB RPS6KA5 SERPINE1 SHC1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD7 SMURF1 SMURF2 SOS1 SOS2 SP1 TAB1 TGFB1 TGFBR1 TGFBR2 TNPO1 TSC22D1 XIAP YY1 ZFYVE9 (see all 72) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
2	CAV1	Caveolin 1	Protein Coding	1
3	CDC27	Cell Division Cycle 27	Protein Coding	1
4	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
5	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
6	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
7	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
8	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
9	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
10	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
11	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
12	ETV1	ETS Variant Transcription Factor 1	Protein Coding	1
13	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
14	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
15	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
16	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
17	TNPO1	Transportin 1	Protein Coding	1
18	IPO5	Importin 5	Protein Coding	1
19	SMAD2	SMAD Family Member 2	Protein Coding	1
20	SMAD3	SMAD Family Member 3	Protein Coding	1
21	SMAD4	SMAD Family Member 4	Protein Coding	1
22	SMAD7	SMAD Family Member 7	Protein Coding	1
23	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
24	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
25	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
26	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
27	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
28	SERPINE1	Serpin Family E Member 1	Protein Coding	1
29	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
30	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
31	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
32	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
33	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
34	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
35	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
36	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
37	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
38	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
39	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
40	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
41	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
42	SHC1	SHC Adaptor Protein 1	Protein Coding	1
43	SKI	SKI Proto-Oncogene	Protein Coding	1
44	SKIL	SKI Like Proto-Oncogene	Protein Coding	1
45	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
46	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
47	SP1	Sp1 Transcription Factor	Protein Coding	1
48	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
49	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
50	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
51	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
52	KLF10	KLF Transcription Factor 10	Protein Coding	1
53	YY1	YY1 Transcription Factor	Protein Coding	1
54	CDC23	Cell Division Cycle 23	Protein Coding	1
55	TSC22D1	TSC22 Domain Family Member 1	Protein Coding	1
56	CDC16	Cell Division Cycle 16	Protein Coding	1
57	FOXH1	Forkhead Box H1	Protein Coding	1
58	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
59	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	1
60	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	1
61	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
62	ANAPC13	Anaphase Promoting Complex Subunit 13	Protein Coding	1
63	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	1
64	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	1
65	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	1
66	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	1
67	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	1
68	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	1
69	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
70	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	1
71	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	1
72	CDC26	Cell Division Cycle 26	Protein Coding	1

Disorders associated with Development_TGF-beta receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.76
2	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	8.42
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	7.98
4	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFBR1, TGFBR2	7.05
5	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SKI, SMAD2, SMAD3, SMAD4, TGFBR1, TGFBR2	6.96
6	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	6.84
7	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	5.31
8	Lung non-small cell carcinoma	Enrichment	ERBB2, HRAS, MAP2K1	4.64
9	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.56
10	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.78
11	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.78
12	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.78
13	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.39
14	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.39
15	Bladder cancer	Enrichment	CDKN1A, ERBB2, HRAS	3.32
16	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN2B	3.24
17	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.24
18	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.12
19	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.01
20	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	2.91
21	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.91
22	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.55
23	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	2.35
24	Paget disease, extramammary	Enrichment	ERBB2	2.28
25	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.28
26	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.28
27	Noonan syndrome 5	Enrichment	RAF1	2.28
28	Noonan syndrome 4	Enrichment	SOS1	2.28
29	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.28
30	Melorheostosis, isolated	Enrichment	MAP2K1	2.28
31	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.28
32	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.28
33	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.28
34	Noonan syndrome 9	Enrichment	SOS2	2.28
35	Shprintzen-goldberg craniosynostosis syndrome	Enrichment	SKI	2.28
36	Fetal encasement syndrome	Enrichment	CHUK	2.28
37	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.28
38	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.28
39	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.28
40	Immunodeficiency 15b	Enrichment	IKBKB	2.28
41	Noonan syndrome 13	Enrichment	MAPK1	2.28
42	Immunodeficiency 15a	Enrichment	IKBKB	2.28
43	Immunodeficiency 92	Enrichment	REL	2.28
44	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.28
45	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.28
46	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.28
47	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.28
48	Melorheostosis	Enrichment	MAP2K1	2.28
49	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.28
50	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.28
51	Leopard syndrome 2	Enrichment	RAF1	2.28
52	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.28
53	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.28
54	Colorectal cancer 3	Enrichment	SMAD7	2.28
55	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.28
56	Immunodeficiency 53	Enrichment	RELB	2.28
57	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.28
58	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.28
59	Trigonitis	Enrichment	RAF1	2.28
60	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.28
61	Heritable thoracic aortic disease	Enrichment	SMAD4	2.28
62	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.28
63	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.28
64	Menke-hennekam syndrome	Enrichment	CREBBP	2.28
65	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.28
66	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.28
67	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.28
68	Fibromatosis, gingival, 1	Enrichment	SOS1	1.98
69	Myhre syndrome	Enrichment	SMAD4	1.98
70	Camurati-engelmann disease 1	Enrichment	TGFB1	1.98
71	Costello syndrome	Enrichment	HRAS	1.98
72	Thumb deformity	Enrichment	CREBBP	1.98
73	Pulmonic stenosis	Enrichment	SOS1	1.98
74	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.98
75	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.98
76	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.98
77	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.98
78	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.98
79	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.98
80	Gabriele-de vries syndrome	Enrichment	YY1	1.98
81	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.98
82	Menke-hennekam syndrome 2	Enrichment	EP300	1.98
83	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.98
84	Rela fusion-positive ependymoma	Enrichment	RELA	1.98
85	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.98
86	Camurati-engelmann disease	Enrichment	TGFB1	1.98
87	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.98
88	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.98
89	Insulinoma	Enrichment	YY1	1.98
90	Common variable immunodeficiency 12	Enrichment	NFKB1	1.98
91	Tafro syndrome	Enrichment	MAP2K2	1.98
92	Wooly hair nevus	Enrichment	HRAS	1.98
93	Colorectal cancer	Enrichment	EP300, ERBB2, SMAD4	1.96
94	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.91
95	Juvenile polyposis syndrome	Enrichment	SMAD4	1.80
96	Nuchal bleb, familial	Enrichment	SOS1	1.80
97	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.80
98	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.80
99	Tethered spinal cord syndrome	Enrichment	CREBBP	1.80
100	Large congenital melanocytic nevus	Enrichment	HRAS	1.80
101	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.80
102	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.80
103	Spermatocytoma	Enrichment	HRAS	1.80
104	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.68
105	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.68
106	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.68
107	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.68
108	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.68
109	Barrett esophagus	Enrichment	ERBB2	1.68
110	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.68
111	Epidermolytic nevus	Enrichment	HRAS	1.68
112	Gingival fibromatosis	Enrichment	SOS1	1.68
113	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.68
114	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.68
115	Gastric cancer	Enrichment	ERBB2, SMAD4	1.66
116	Goldberg-shprintzen syndrome	Enrichment	SKI	1.58
117	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.58
118	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.58
119	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.58
120	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.50
121	Limited scleroderma	Enrichment	CAV1	1.50
122	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.50
123	Hypertrichosis	Enrichment	CREBBP	1.50
124	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.50
125	Esophageal cancer	Enrichment	TGFBR2	1.44
126	Nevus, epidermal	Enrichment	HRAS	1.44
127	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.44
128	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.44
129	Gallbladder cancer	Enrichment	SMAD4	1.44
130	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.44
131	Pilomyxoid astrocytoma	Enrichment	RAF1	1.44
132	Follicular thyroid carcinoma	Enrichment	HRAS	1.44
133	Glioma susceptibility 1	Enrichment	ERBB2	1.38
134	Ewing sarcoma	Enrichment	ETV1	1.38
135	Charge syndrome	Enrichment	EP300	1.33
136	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.33
137	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.29
138	Pectus excavatum	Enrichment	TGFBR1	1.25
139	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.25
140	Specific learning disability	Enrichment	MAPK1	1.25
141	Breast cancer	Enrichment	CDKN2B, SHC1	1.22
142	Lip and oral cavity carcinoma	Enrichment	HRAS	1.21
143	Aortic valve disease 1	Enrichment	SOS1	1.17
144	Chromosome 1p36 deletion syndrome	Enrichment	SKI	1.17
145	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.14
146	Lung cancer susceptibility 3	Enrichment	ERBB2	1.14
147	Heart disease	Enrichment	CREBBP	1.14
148	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.14
149	Polydactyly, postaxial, type a1	Enrichment	EP300	1.11
150	Corpus callosum, agenesis of	Enrichment	CREBBP	1.11
151	Lynch syndrome	Enrichment	TGFBR2	1.11
152	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.11
153	Septopreoptic holoprosencephaly	Enrichment	FOXH1	1.11
154	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.11
155	Midline interhemispheric variant of holoprosencephaly	Enrichment	FOXH1	1.11
156	Rhabdomyosarcoma	Enrichment	HRAS	1.09
157	Gliosarcoma	Enrichment	NFKBIA	1.09
158	Microform holoprosencephaly	Enrichment	FOXH1	1.09
159	Lobar holoprosencephaly	Enrichment	FOXH1	1.09
160	Melanoma, cutaneous malignant 1	Enrichment	CDKN2B	1.06
161	Giant cell glioblastoma	Enrichment	NFKBIA	1.06
162	Alobar holoprosencephaly	Enrichment	FOXH1	1.06
163	Heart, malformation of	Enrichment	MAPK1	1.04
164	Semilobar holoprosencephaly	Enrichment	FOXH1	1.04
165	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.02
166	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.92
167	Autoinflammatory disease	Enrichment	XIAP	0.92
168	Scoliosis	Enrichment	CREBBP	0.92
169	Pancreatic cancer	Enrichment	SMAD4	0.90
170	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.89
171	Microcephaly	Enrichment	EP300, MAPK1	0.86
172	Hirschsprung disease 1	Enrichment	ERBB2	0.84
173	Differentiated thyroid carcinoma	Enrichment	HRAS	0.84
174	Non-immune hydrops fetalis	Enrichment	HRAS	0.82
175	Lung cancer	Enrichment	ERBB2	0.80
176	Cystic fibrosis	Enrichment	TGFB1	0.80
177	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.79
178	Severe combined immunodeficiency	Enrichment	IKBKB	0.79
179	Left ventricular noncompaction	Enrichment	RAF1	0.77
180	Thrombocytopenia	Enrichment	SMAD4	0.65
181	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.61
182	Myeloma, multiple	Enrichment	CREBBP	0.59
183	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	0.59
184	Autism	Enrichment	CREBBP	0.50
185	Dilated cardiomyopathy	Enrichment	RAF1	0.46
186	Ovarian cancer	Enrichment	ERBB2	0.38
187	Congenital nervous system abnormality	Enrichment	CREBBP	0.36
188	Nervous system disease	Enrichment	CREBBP	0.36
189	Autism spectrum disorder	Enrichment	MAP2K1	0.36
190	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.30

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development_TGF-beta receptor signaling

Pathway Network for Development_TGF-beta receptor signaling

Member Pathways for Development_TGF-beta receptor signaling

Pathways in the Development_TGF-beta receptor signaling SuperPath

Associated Genes for Development_TGF-beta receptor signaling

Associated Disorders for Development_TGF-beta receptor signaling

Disorders associated with Development_TGF-beta receptor signaling SuperPath

STRING Interaction Network for Development_TGF-beta receptor signaling

Sources for Development_TGF-beta receptor signaling