Development_Thrombopoetin signaling via JAK-STAT pathway

No Pathway Network information available for Development_Thrombopoetin signaling via JAK-STAT pathway

Pathways in the Development_Thrombopoetin signaling via JAK-STAT pathway SuperPath

#	Name	Source	Genes
1	Development_Thrombopoetin signaling via JAK-STAT pathway	GeneGo (Thomson Reuters)	BCL2L1 CCND1 CDKN1A CDKN1B CISH CRP JAK2 MPL OSM PIAS1 PIAS3 PTPN11 PTPN6 SERPINA3 SIRPA SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B TAP1 THPO (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SERPINA3	Serpin Family A Member 3	Protein Coding	1
2	CCND1	Cyclin D1	Protein Coding	1
3	BCL2L1	BCL2 Like 1	Protein Coding	1
4	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
5	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
6	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	1
7	CRP	C-Reactive Protein	Protein Coding	1
8	JAK2	Janus Kinase 2	Protein Coding	1
9	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	1
10	OSM	Oncostatin M	Protein Coding	1
11	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
12	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
13	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
14	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
15	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
16	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
17	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	1
18	THPO	Thrombopoietin	Protein Coding	1
19	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
20	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
21	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
22	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
23	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1

Disorders associated with Development_Thrombopoetin signaling via JAK-STAT pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Essential thrombocythemia	Enrichment	JAK2, MPL, THPO	6.83
2	Congenital amegakaryocytic thrombocytopenia	Enrichment	MPL, THPO	5.56
3	Dyskeratosis congenita, autosomal dominant 6	Enrichment	MPL, THPO	5.08
4	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	5.08
5	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	4.24
6	Myelofibrosis	Enrichment	JAK2, MPL	4.24
7	Thrombocytopenia	Enrichment	MPL, PTPN11, THPO	4.15
8	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.67
9	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	3.34
10	Metachondromatosis	Enrichment	PTPN11	2.77
11	Thrombocythemia 2	Enrichment	MPL	2.77
12	Dermatitis, atopic, 4	Enrichment	SOCS3	2.77
13	Leopard syndrome 1	Enrichment	PTPN11	2.77
14	Amegakaryocytic thrombocytopenia, congenital, 1	Enrichment	MPL	2.77
15	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.77
16	Amegakaryocytic thrombocytopenia, congenital, 2	Enrichment	THPO	2.77
17	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.77
18	Neuroendocrine tumor	Enrichment	CDKN1B	2.77
19	Immunodeficiency 31a	Enrichment	STAT1	2.77
20	Hereditary thrombocytosis with transverse limb defect	Enrichment	THPO	2.77
21	Immunodeficiency 31b	Enrichment	STAT1	2.77
22	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.77
23	Thrombocytopenia 9	Enrichment	THPO	2.77
24	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.77
25	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.77
26	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.77
27	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.77
28	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.77
29	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.77
30	Malignant astrocytoma	Enrichment	PTPN11	2.77
31	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.47
32	Thrombocythemia 3	Enrichment	JAK2	2.47
33	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.47
34	Immunodeficiency 31c	Enrichment	STAT1	2.47
35	Werner syndrome	Enrichment	PTPN11	2.47
36	Polycythemia	Enrichment	JAK2	2.47
37	Hypereosinophilic syndrome	Enrichment	JAK2	2.47
38	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.47
39	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.29
40	Thrombocythemia 1	Enrichment	THPO	2.29
41	Immune thrombocytopenia	Enrichment	SOCS1	2.29
42	Polycythemia vera	Enrichment	JAK2	2.29
43	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.29
44	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.29
45	Bacteremia 2	Enrichment	CISH	2.29
46	Hyper ige syndrome	Enrichment	STAT3	2.29
47	Tricuspid valve insufficiency	Enrichment	PTPN11	2.29
48	Erythrocytosis, familial, 1	Enrichment	JAK2	2.17
49	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.17
50	Budd-chiari syndrome	Enrichment	JAK2	2.17
51	Mhc class i deficiency 1	Enrichment	TAP1	2.17
52	Mantle cell lymphoma	Enrichment	CCND1	2.17
53	Mhc class i deficiency	Enrichment	TAP1	2.17
54	Tuberculosis	Enrichment	CISH	2.17
55	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.17
56	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.17
57	Immunodeficiency by defective expression of mhc class i	Enrichment	TAP1	2.17
58	Primary hyperparathyroidism	Enrichment	CDKN1B	2.17
59	Von hippel-lindau syndrome	Enrichment	CCND1	2.07
60	Lymphoma	Enrichment	PTPN11	2.07
61	Myeloproliferative neoplasm	Enrichment	JAK2	2.07
62	Patent ductus arteriosus	Enrichment	PTPN11	1.99
63	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.99
64	Noonan syndrome 3	Enrichment	PTPN11	1.93
65	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.87
66	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.82
67	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.77
68	Pectus excavatum	Enrichment	PTPN11	1.73
69	Specific learning disability	Enrichment	PTPN11	1.73
70	Epicanthus	Enrichment	PTPN11	1.70
71	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.70
72	Congenital long qt syndrome	Enrichment	PTPN11	1.70
73	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, PTPN11	1.68
74	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.60
75	Patent foramen ovale	Enrichment	PTPN11	1.52
76	Noonan syndrome 1	Enrichment	PTPN11	1.42
77	Malaria	Enrichment	CISH	1.42
78	Scoliosis	Enrichment	PTPN11	1.40
79	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.36
80	Rasopathy	Enrichment	PTPN11	1.36
81	Strabismus	Enrichment	PTPN11	1.35
82	Bladder cancer	Enrichment	CDKN1A	1.32
83	Long qt syndrome 1	Enrichment	PTPN11	1.30
84	Non-immune hydrops fetalis	Enrichment	PTPN11	1.29
85	Nephronophthisis	Enrichment	PIAS1	1.26
86	Systemic lupus erythematosus	Enrichment	SOCS1	1.19
87	Leukemia, acute myeloid	Enrichment	JAK2	1.18
88	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.15
89	Myeloma, multiple	Enrichment	CCND1	1.04
90	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.04
91	Primary ovarian insufficiency	Enrichment	JAK2	1.02
92	Colorectal cancer	Enrichment	CCND1	0.86
93	Ovarian cancer	Enrichment	CDKN1B	0.80
94	Autism spectrum disorder	Enrichment	PTPN11	0.77
95	Microcephaly	Enrichment	PTPN11	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development_Thrombopoetin signaling via JAK-STAT pathway

Pathway Network for Development_Thrombopoetin signaling via JAK-STAT pathway

Member Pathways for Development_Thrombopoetin signaling via JAK-STAT pathway

Pathways in the Development_Thrombopoetin signaling via JAK-STAT pathway SuperPath

Associated Genes for Development_Thrombopoetin signaling via JAK-STAT pathway

Associated Disorders for Development_Thrombopoetin signaling via JAK-STAT pathway

Disorders associated with Development_Thrombopoetin signaling via JAK-STAT pathway SuperPath

STRING Interaction Network for Development_Thrombopoetin signaling via JAK-STAT pathway

Sources for Development_Thrombopoetin signaling via JAK-STAT pathway