Development VEGF signaling via VEGFR2 - generic cascades

Pathway network for the Development VEGF signaling via VEGFR2 - generic cascades SuperPath

Sources:

GeneGo (Thomson Reuters)
R&D Systems

Pathways in the Development VEGF signaling via VEGFR2 - generic cascades SuperPath

#	Name	Source	Genes
1	Development VEGF signaling via VEGFR2 - generic cascades	GeneGo (Thomson Reuters)	ACTB ACTG1 AKT1 AKT2 AKT3 CCL2 CDC42 CHUK CTNNB1 FOS FYN GRB2 GSK3B HRAS HSP90AA1 HSP90AB1 HSP90B1 HSPB1 IKBKB IKBKG ITGAV ITGB3 ITPR1 ITPR2 ITPR3 JUN KDR MAP2K1 MAP2K2 MAP2K3 MAP3K1 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 NCK1 NF1 NFATC1 NFKB1 NFKBIA NFKBIB NFKBIE NOS2 NOS3 PAK1 PAK2 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLAU PLAUR PLCG1 PPP3CA PPP3CB PPP3CC PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 PTGS1 PTGS2 PTK2 PXN RAC1 RAF1 RASA1 RELA RHOA ROCK1 SH2D2A SHB SHC1 SHC2 SOS1 SOS2 SPHK1 SRC TCF7L2 TRAP1 VCL VEGFA (see all 96) (see less)
2	VEGF - VEGF R2 Signaling Pathways	R&D Systems	AKT1 AKT2 AKT3 ARAF ATF2 BAD BRAF CASP9 CD44 CDC42 CDH5 CREB1 CRK FOS FOSB FOSL1 FOXO1 FYN GAA GPC1 GPC2 GPC3 GPC5 GPC6 GRB2 HSPB1 IQGAP1 ITGAV ITGB3 JAK1 JAK2 JAK3 JUN JUNB JUND KDR KIAA1549L KRAS MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK5 NCK1 NOS3 NRP1 NRP2 PAK2 PDPK1 PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PLA2G4A PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 PTK2 PTPN11 PXN RAC1 RAF1 RAPGEF1 SDC1 SDC2 SDC3 SDC4 SH2D2A SHB SHC1 SOS1 SOS2 SPHK1 SPHK2 SRC STAT3 VEGFA YES1 (see all 94) (see less)
3	Development VEGF signaling and activation	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BRCA1 CHUK ESR1 FOS HRAS ICAM1 IKBKB IKBKG JUN KDR MAP2K1 MAP2K2 MAPK1 MAPK3 NF1 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 RAF1 RASA1 REL RELA RELB SELE SP1 SP3 SPHK1 SRC VCAM1 VEGFA (see all 54) (see less)

Gene overlap in member pathways for Development VEGF signaling via VEGFR2 - generic cascades SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
3	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
4	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
5	KDR	Kinase Insert Domain Receptor	Protein Coding	3
6	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
7	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
8	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
9	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
10	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
11	PRKCA	Protein Kinase C Alpha	Protein Coding	3
12	PRKCB	Protein Kinase C Beta	Protein Coding	3
13	PRKCD	Protein Kinase C Delta	Protein Coding	3
14	PRKCE	Protein Kinase C Epsilon	Protein Coding	3
15	PRKCG	Protein Kinase C Gamma	Protein Coding	3
16	PRKD1	Protein Kinase D1	Protein Coding	3
17	PRKCQ	Protein Kinase C Theta	Protein Coding	3
18	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
19	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
20	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
21	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
22	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
23	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
24	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
25	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	3
26	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
27	SPHK1	Sphingosine Kinase 1	Protein Coding	3
28	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
29	PRKD3	Protein Kinase D3	Protein Coding	3
30	PRKD2	Protein Kinase D2	Protein Coding	3
31	CDC42	Cell Division Cycle 42	Protein Coding	2
32	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
33	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
34	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
35	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
36	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
37	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	2
38	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
39	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
40	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
41	NCK1	NCK Adaptor Protein 1	Protein Coding	2
42	NF1	Neurofibromin 1	Protein Coding	2
43	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
44	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
45	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
46	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
47	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
48	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
49	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
50	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
51	PRKCH	Protein Kinase C Eta	Protein Coding	2
52	PRKCI	Protein Kinase C Iota	Protein Coding	2
53	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
54	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
55	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
56	PXN	Paxillin	Protein Coding	2
57	RAC1	Rac Family Small GTPase 1	Protein Coding	2
58	RASA1	RAS P21 Protein Activator 1	Protein Coding	2
59	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
60	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
61	SHB	SH2 Domain Containing Adaptor Protein B	Protein Coding	2
62	SHC1	SHC Adaptor Protein 1	Protein Coding	2
63	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
64	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
65	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
66	SH2D2A	SH2 Domain Containing 2A	Protein Coding	2
67	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
68	ACTB	Actin Beta	Protein Coding	1
69	ACTG1	Actin Gamma 1	Protein Coding	1
70	RHOA	Ras Homolog Family Member A	Protein Coding	1
71	CTNNB1	Catenin Beta 1	Protein Coding	1
72	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
73	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
74	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
75	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
76	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
77	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
78	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
79	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
80	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
81	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
82	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
83	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
84	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
85	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
86	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
87	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
88	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	1
89	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
90	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
91	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
92	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
93	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
94	VCL	Vinculin	Protein Coding	1
95	TRAP1	TNF Receptor Associated Protein 1	Protein Coding	1
96	SHC2	SHC Adaptor Protein 2	Protein Coding	1
97	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
98	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
99	CDH5	Cadherin 5	Protein Coding	1
100	JAK1	Janus Kinase 1	Protein Coding	1
101	JAK2	Janus Kinase 2	Protein Coding	1
102	JAK3	Janus Kinase 3	Protein Coding	1
103	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
104	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
105	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
106	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
107	CASP9	Caspase 9	Protein Coding	1
108	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
109	FOXO1	Forkhead Box O1	Protein Coding	1
110	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
111	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
112	SPHK2	Sphingosine Kinase 2	Protein Coding	1
113	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
114	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
115	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
116	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
117	ATF2	Activating Transcription Factor 2	Protein Coding	1
118	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
119	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
120	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
121	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
122	KIAA1549L	KIAA1549 Like	Protein Coding	1
123	GAA	Alpha Glucosidase	Protein Coding	1
124	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	1
125	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
126	NRP1	Neuropilin 1	Protein Coding	1
127	NRP2	Neuropilin 2	Protein Coding	1
128	SDC1	Syndecan 1	Protein Coding	1
129	SDC2	Syndecan 2	Protein Coding	1
130	SDC3	Syndecan 3	Protein Coding	1
131	SDC4	Syndecan 4	Protein Coding	1
132	GPC1	Glypican 1	Protein Coding	1
133	GPC2	Glypican 2	Protein Coding	1
134	GPC3	Glypican 3	Protein Coding	1
135	GPC5	Glypican 5	Protein Coding	1
136	GPC6	Glypican 6	Protein Coding	1
137	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
138	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
139	ESR1	Estrogen Receptor 1	Protein Coding	1
140	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
141	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
142	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
143	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
144	SELE	Selectin E	Protein Coding	1
145	SP1	Sp1 Transcription Factor	Protein Coding	1
146	SP3	Sp3 Transcription Factor	Protein Coding	1
147	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1

Disorders associated with Development VEGF signaling via VEGFR2 - generic cascades SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	10.51
3	Noonan syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1, SOS2	10.41
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.66
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.66
6	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.56
7	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1	7.33
8	Noonan syndrome 3	Enrichment	KRAS, PTPN11, RAF1, SOS1	7.13
9	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.62
10	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.49
11	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11, RAF1	5.89
12	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	5.69
13	Bladder cancer	Enrichment	BRCA1, HRAS, NF1, PIK3CA	5.31
14	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	5.02
15	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.96
16	Breast cancer	Enrichment	AKT1, BRCA1, ESR1, JUN, PIK3CA	4.94
17	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.81
18	Colorectal cancer	Enrichment	AKT1, BRCA1, PIK3CA, PIK3R1, SRC	4.62
19	Hereditary breast carcinoma	Enrichment	AKT1, BRCA1, ESR1, PIK3CA	4.57
20	Rhabdomyosarcoma	Enrichment	BRCA1, HRAS, NF1	4.49
21	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.33
22	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.33
23	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.33
24	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.32
25	Immune system disease	Enrichment	CDC42, PIK3CD	4.32
26	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.30
27	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	4.03
28	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.03
29	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3, STAT3	3.85
30	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	3.85
31	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.81
32	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.81
33	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.64
34	Hemangioma, capillary infantile	Enrichment	KDR, RASA1	3.64
35	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.64
36	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	3.55
37	Diffuse large b-cell lymphoma	Enrichment	BRAF, FOXO1, STAT3	3.54
38	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.49
39	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.49
40	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.37
41	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.33
42	Alzheimer disease 2	Enrichment	NOS3, PLAU	3.31
43	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.26
44	Gastric cancer	Enrichment	BRCA1, NF1, PIK3CA	3.18
45	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.16
46	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.14
47	Myelofibrosis	Enrichment	JAK2, SRC	3.01
48	Gallbladder cancer	Enrichment	BRAF, KRAS	3.01
49	Meningioma	Enrichment	AKT1, PIK3CA	3.00
50	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.00
51	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.76
52	Stroke, ischemic	Enrichment	NOS3, PRKCH	2.67
53	Specific learning disability	Enrichment	MAPK1, PTPN11	2.60
54	Juvenile myelomonocytic leukemia	Enrichment	KRAS, PTPN11	2.52
55	Endometrial cancer	Enrichment	BRCA1, PIK3CA	2.51
56	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	2.45
57	Malaria	Enrichment	ICAM1, IKBKG	2.43
58	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.40
59	Macrodactyly	Enrichment	PIK3CA	2.40
60	Proteus syndrome	Enrichment	AKT1	2.40
61	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.40
62	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.40
63	Incontinentia pigmenti	Enrichment	IKBKG	2.40
64	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.40
65	Noonan syndrome 5	Enrichment	RAF1	2.40
66	Melorheostosis, isolated	Enrichment	MAP2K1	2.40
67	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.40
68	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.40
69	Cowden syndrome 5	Enrichment	PIK3CA	2.40
70	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.40
71	Fetal encasement syndrome	Enrichment	CHUK	2.40
72	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.40
73	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.40
74	Immunodeficiency 15b	Enrichment	IKBKB	2.40
75	Noonan syndrome 13	Enrichment	MAPK1	2.40
76	Immunodeficiency 15a	Enrichment	IKBKB	2.40
77	Immunodeficiency 92	Enrichment	REL	2.40
78	Short syndrome	Enrichment	PIK3R1	2.40
79	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.40
80	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.40
81	Infant-type hemispheric glioma	Enrichment	BRCA1	2.40
82	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.40
83	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.40
84	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.40
85	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.40
86	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.40
87	Melorheostosis	Enrichment	MAP2K1	2.40
88	Leopard syndrome 2	Enrichment	RAF1	2.40
89	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.40
90	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.40
91	Cowden syndrome 6	Enrichment	AKT1	2.40
92	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.40
93	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.40
94	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.40
95	Thrombocytopenia 6	Enrichment	SRC	2.40
96	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.40
97	Immunodeficiency 53	Enrichment	RELB	2.40
98	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.40
99	Trigonitis	Enrichment	RAF1	2.40
100	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.40
101	Tufted angioma of skin	Enrichment	KDR	2.40
102	Plexiform neurofibroma	Enrichment	NF1	2.40
103	Neurofibroma	Enrichment	NF1	2.40
104	Hypospadias	Enrichment	PIK3CA	2.40
105	Capillary hemangioma	Enrichment	AKT3	2.40
106	Neurofibromatosis	Enrichment	NF1	2.40
107	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.40
108	Optic nerve glioma	Enrichment	NF1	2.40
109	Rare venous malformation	Enrichment	PIK3CA	2.40
110	Gorham's disease	Enrichment	RASA1	2.40
111	Diaphragmatic eventration	Enrichment	PIK3CA	2.40
112	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.40
113	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.40
114	Rare combined vascular malformation	Enrichment	PIK3CA	2.40
115	Cavernous lymphangioma	Enrichment	PIK3CA	2.40
116	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.40
117	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.40
118	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.40
119	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.40
120	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.40
121	Macrodactyly of toe	Enrichment	PIK3CA	2.40
122	Primary peritoneal carcinoma	Enrichment	BRCA1	2.40
123	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.40
124	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.39
125	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.37
126	Thrombocytopenia	Enrichment	ITGB3, PTPN11, SRC	2.35
127	Wilms tumor 1	Enrichment	BRAF, GPC3	2.33
128	Ovarian cancer	Enrichment	AKT1, CTNNB1, MAP3K1, PIK3CA	2.24
129	Prostate cancer	Enrichment	BRCA1, PIK3CA	2.23
130	Alzheimer disease, familial, 1	Enrichment	NOS3, PLAU	2.20
131	Myeloma, multiple	Enrichment	BRAF, KRAS, PIK3R2	2.16
132	Metachondromatosis	Enrichment	PTPN11	2.16
133	Glycoprotein storage disease	Enrichment	GAA	2.16
134	Oculoectodermal syndrome	Enrichment	KRAS	2.16
135	Pallister-killian syndrome	Enrichment	ARAF	2.16
136	Noonan syndrome 4	Enrichment	SOS1	2.16
137	Noonan syndrome 7	Enrichment	BRAF	2.16
138	Leopard syndrome 3	Enrichment	BRAF	2.16
139	Leopard syndrome 1	Enrichment	PTPN11	2.16
140	Noonan syndrome 9	Enrichment	SOS2	2.16
141	Knobloch syndrome 2	Enrichment	PAK2	2.16
142	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.16
143	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.16
144	Lymphangioma	Enrichment	BRAF	2.16
145	Phace association	Enrichment	BRAF	2.16
146	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.16
147	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.16
148	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.16
149	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.16
150	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.16
151	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.16
152	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.16
153	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.16
154	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.16
155	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.16
156	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.16
157	Congenital pulmonary airway malformation	Enrichment	KRAS	2.16
158	Pompe disease, late-onset	Enrichment	GAA	2.16
159	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.16
160	Nocarh syndrome	Enrichment	CDC42	2.16
161	Syringocystadenoma papilliferum	Enrichment	BRAF	2.16
162	Ganglioglioma	Enrichment	BRAF	2.16
163	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.16
164	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.16
165	Phace syndrome	Enrichment	BRAF	2.16
166	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.16
167	Classic hairy cell leukemia	Enrichment	BRAF	2.16
168	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.16
169	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.16
170	Malignant astrocytoma	Enrichment	PTPN11	2.16
171	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.15
172	Baraitser-winter syndrome 1	Enrichment	ACTB	2.15
173	46,xy sex reversal 6	Enrichment	MAP3K1	2.15
174	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.15
175	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.15
176	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.15
177	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.15
178	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.15
179	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.15
180	Becker nevus syndrome	Enrichment	ACTB	2.15
181	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.15
182	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.15
183	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.15
184	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.15
185	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.15
186	Adenoid ameloblastoma	Enrichment	CTNNB1	2.15
187	Baraitser-winter syndrome	Enrichment	ACTB	2.15
188	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.15
189	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.15
190	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.15
191	Microcystic stromal tumor	Enrichment	CTNNB1	2.15
192	Lung cancer	Enrichment	BRCA1, PIK3CA	2.15
193	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.12
194	Primary ovarian insufficiency	Enrichment	JAK2, KDR, NOS3	2.10
195	Cafe-au-lait spots, multiple	Enrichment	NF1	2.10
196	Costello syndrome	Enrichment	HRAS	2.10
197	Immunodeficiency 33	Enrichment	IKBKG	2.10
198	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.10
199	Keratosis, seborrheic	Enrichment	PIK3CA	2.10
200	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.10
201	Angioma, tufted	Enrichment	KDR	2.10
202	Noonan syndrome 8	Enrichment	PIK3CA	2.10
203	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.10
204	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.10
205	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.10
206	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.10
207	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	2.10
208	Pancreatic cancer 4	Enrichment	BRCA1	2.10
209	Rela fusion-positive ependymoma	Enrichment	RELA	2.10
210	Senior-loken syndrome 7	Enrichment	AKT3	2.10
211	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.10
212	Bardet-biedl syndrome 9	Enrichment	NF1	2.10
213	Bardet-biedl syndrome 16	Enrichment	AKT3	2.10
214	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.10
215	Inflammatory breast carcinoma	Enrichment	BRCA1	2.10
216	Peritoneum cancer	Enrichment	BRCA1	2.10
217	Bilateral breast cancer	Enrichment	BRCA1	2.10
218	Common variable immunodeficiency 12	Enrichment	NFKB1	2.10
219	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	2.10
220	Tafro syndrome	Enrichment	MAP2K2	2.10
221	Wooly hair nevus	Enrichment	HRAS	2.10
222	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	1.98
223	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1, MAPK1	1.95
224	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.92
225	Watson syndrome	Enrichment	NF1	1.92
226	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.92
227	Neurofibromatosis, familial spinal	Enrichment	NF1	1.92
228	Estrogen resistance	Enrichment	ESR1	1.92
229	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.92
230	Large congenital melanocytic nevus	Enrichment	HRAS	1.92
231	Wieacker-wolff syndrome	Enrichment	RASA1	1.92
232	Migraine without aura	Enrichment	ESR1	1.92
233	Brain cancer	Enrichment	NF1	1.92
234	Spermatocytoma	Enrichment	HRAS	1.92
235	Keratoacanthoma	Enrichment	PIK3CA	1.92
236	Fibromatosis, gingival, 1	Enrichment	SOS1	1.86
237	Omodysplasia 1	Enrichment	GPC6	1.86
238	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.86
239	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.86
240	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	1.86
241	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.86
242	Thrombocythemia 3	Enrichment	JAK2	1.86
243	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.86
244	Werner syndrome	Enrichment	PTPN11	1.86
245	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.86
246	Polycythemia	Enrichment	JAK2	1.86
247	Hypereosinophilic syndrome	Enrichment	JAK2	1.86
248	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.85
249	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.85
250	Quebec platelet disorder	Enrichment	PLAU	1.85
251	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.85
252	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.85
253	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.85
254	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.85
255	Teratoma	Enrichment	CTNNB1	1.85
256	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.80
257	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.80
258	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.80
259	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.80
260	Cholangiocarcinoma	Enrichment	BRCA1	1.80
261	Congenital generalized lipodystrophy	Enrichment	FOS	1.80
262	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.80
263	Hereditary ataxia	Enrichment	PRKCG	1.80
264	Cerebrovascular disease	Enrichment	PIK3CA	1.80
265	Embryonal rhabdomyosarcoma	Enrichment	NF1	1.80
266	Pilocytic astrocytoma	Enrichment	NF1	1.80
267	Epidermolytic nevus	Enrichment	HRAS	1.80
268	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.80
269	Cerebral malaria	Enrichment	ICAM1	1.80
270	Middle aortic syndrome	Enrichment	NF1	1.80
271	Severe covid-19	Enrichment	ITGAV, JAK3	1.77
272	Differentiated thyroid carcinoma	Enrichment	BRAF, KRAS	1.77
273	Non-immune hydrops fetalis	Enrichment	KRAS, PTPN11	1.71
274	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.70
275	Rhabdomyosarcoma 2	Enrichment	NF1	1.70
276	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.70
277	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1, NF1	1.69
278	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.69
279	Ataxia-telangiectasia	Enrichment	BRAF	1.69
280	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.69
281	Glycogen storage disease iv	Enrichment	GAA	1.69
282	Polycythemia vera	Enrichment	JAK2	1.69
283	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3	1.69
284	Nuchal bleb, familial	Enrichment	SOS1	1.69
285	Tethered spinal cord syndrome	Enrichment	BRAF	1.69
286	Hyper ige syndrome	Enrichment	STAT3	1.69
287	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.69
288	Melanoma of soft tissue	Enrichment	CREB1	1.69
289	Tricuspid valve insufficiency	Enrichment	PTPN11	1.69
290	Desmoid disease, hereditary	Enrichment	CTNNB1	1.68
291	Gillespie syndrome	Enrichment	ITPR1	1.68
292	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.68
293	Anus, imperforate	Enrichment	CTNNB1	1.68
294	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.68
295	Desmoid tumor	Enrichment	CTNNB1	1.68
296	Cowden syndrome 1	Enrichment	PIK3CA	1.63
297	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.63
298	Basal cell carcinoma 1	Enrichment	RASA1	1.63
299	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.63
300	Cakut	Enrichment	ACTG1, TRAP1	1.62
301	Erythrocytosis, familial, 1	Enrichment	JAK2	1.56
302	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.56
303	Glycogen storage disease ia	Enrichment	GAA	1.56
304	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.56
305	Budd-chiari syndrome	Enrichment	JAK2	1.56
306	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.56
307	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.56
308	Craniopharyngioma	Enrichment	BRAF	1.56
309	Newborn respiratory distress syndrome	Enrichment	BRAF	1.56
310	Adenosine deaminase deficiency	Enrichment	JAK3	1.56
311	Knobloch syndrome	Enrichment	PAK2	1.56
312	Gingival fibromatosis	Enrichment	SOS1	1.56
313	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.56
314	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.56
315	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.56
316	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.56
317	Megacolon	Enrichment	AKT3	1.56
318	Follicular thyroid carcinoma	Enrichment	HRAS	1.56
319	Overgrowth syndrome	Enrichment	PIK3R1	1.56
320	Pilomatrixoma	Enrichment	CTNNB1	1.55
321	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.55
322	Aminoacylase 1 deficiency	Enrichment	ACTB	1.55
323	Alazami syndrome	Enrichment	CTNNB1	1.55
324	Leukemia, acute myeloid	Enrichment	JAK2, KRAS	1.51
325	Ewing sarcoma	Enrichment	NF1	1.50
326	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.47
327	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.47
328	Knobloch syndrome 1	Enrichment	PAK2	1.47
329	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.47
330	Pre-eclampsia	Enrichment	NOS3	1.47
331	Lymphoma	Enrichment	PTPN11	1.47
332	Myeloproliferative neoplasm	Enrichment	JAK2	1.47
333	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.46
334	Coloboma of choroid and retina	Enrichment	ACTG1	1.46
335	Neurofibromatosis, type i	Enrichment	NF1	1.45
336	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.45
337	Coronary heart disease 5	Enrichment	IKBKG	1.45
338	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.45
339	Type 2 diabetes mellitus	Enrichment	AKT2, TCF7L2	1.45
340	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.41
341	Polymicrogyria	Enrichment	AKT3	1.41
342	Wilms tumor 5	Enrichment	BRAF	1.39
343	Patent ductus arteriosus	Enrichment	PTPN11	1.39
344	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.39
345	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.38
346	Congenital anomalies of kidney and urinary tract 1	Enrichment	TRAP1	1.38
347	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.38
348	Adrenocortical carcinoma	Enrichment	CTNNB1	1.38
349	Migraine with or without aura 1	Enrichment	ESR1	1.37
350	Uterine corpus cancer	Enrichment	BRCA1	1.37
351	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.32
352	Leukemia, chronic myeloid	Enrichment	KRAS	1.32
353	Essential thrombocythemia	Enrichment	JAK2	1.32
354	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.30
355	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.30
356	Familial isolated dilated cardiomyopathy	Enrichment	RAF1, VCL	1.27
357	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.27
358	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.27
359	Osteoporosis	Enrichment	SRC	1.26
360	Pheochromocytoma	Enrichment	NF1	1.26
361	Periventricular nodular heterotopia	Enrichment	BRCA1	1.26
362	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.26
363	Lynch syndrome	Enrichment	PIK3CA	1.24
364	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.22
365	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.22
366	Primary hyperaldosteronism	Enrichment	BRAF	1.22
367	Ventricular septal defect	Enrichment	BRAF	1.22
368	Gliosarcoma	Enrichment	NFKBIA	1.21
369	Giant cell glioblastoma	Enrichment	NFKBIA	1.18
370	Melanoma	Enrichment	BRAF	1.17
371	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.17
372	Cat eye syndrome	Enrichment	ACTG1	1.16
373	Heart, malformation of	Enrichment	MAPK1	1.16
374	Autism spectrum disorder	Enrichment	MAP2K1, NF1	1.16
375	Pectus excavatum	Enrichment	PTPN11	1.13
376	Glycogen storage disease	Enrichment	GAA	1.13
377	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.12
378	Epicanthus	Enrichment	PTPN11	1.10
379	Congenital long qt syndrome	Enrichment	PTPN11	1.10
380	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	1.09
381	Myocardial infarction	Enrichment	ESR1	1.08
382	Skin disease	Enrichment	NF1	1.08
383	Aortic valve disease 1	Enrichment	SOS1	1.06
384	Acute promyelocytic leukemia	Enrichment	STAT3	1.06
385	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.04
386	Multiple sclerosis	Enrichment	ITPR1	1.02
387	Medulloblastoma	Enrichment	CTNNB1	1.02
388	Pancreatic cancer	Enrichment	BRCA1	1.02
389	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, NF1	1.01
390	Tetralogy of fallot	Enrichment	KDR	1.01
391	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.01
392	Anterior segment dysgenesis	Enrichment	ITPR1	1.00
393	Creatine phosphokinase, elevated serum	Enrichment	GAA	0.98
394	Isolated elevated serum creatine phosphokinase levels	Enrichment	GAA	0.98
395	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	0.97
396	Hypertension, essential	Enrichment	NOS3	0.95
397	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.95
398	Dandy-walker syndrome	Enrichment	BRAF	0.95
399	Polycystic liver disease	Enrichment	CTNNB1	0.94
400	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.94
401	Patent foramen ovale	Enrichment	PTPN11	0.93
402	Human immunodeficiency virus type 1	Enrichment	CCL2	0.92
403	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.91
404	Severe combined immunodeficiency	Enrichment	IKBKB	0.91
405	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.88
406	Left ventricular noncompaction	Enrichment	RAF1	0.88
407	Lissencephaly	Enrichment	ACTG1	0.86
408	Hepatoblastoma	Enrichment	CTNNB1	0.86
409	Scoliosis	Enrichment	PTPN11	0.81
410	Strabismus	Enrichment	PTPN11	0.77
411	Hypertelorism	Enrichment	PIK3CA	0.73
412	Long qt syndrome 1	Enrichment	PTPN11	0.72
413	Non-syndromic genetic deafness	Enrichment	ACTG1	0.65
414	Myopathy	Enrichment	GAA	0.61
415	Charcot-marie-tooth disease	Enrichment	HSPB1	0.60
416	Nonsyndromic hearing loss	Enrichment	ACTG1	0.59
417	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.59
418	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.53
419	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.52
420	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.51
421	Spastic ataxia	Enrichment	ITPR1	0.50
422	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.49
423	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.48
424	Autism	Enrichment	TCF7L2	0.40
425	Rare genetic deafness	Enrichment	GAA	0.37
426	Congenital nervous system abnormality	Enrichment	CTNNB1	0.28
427	Nervous system disease	Enrichment	CTNNB1	0.28
428	Complex neurodevelopmental disorder	Enrichment	TCF7L2	0.23

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Development VEGF signaling via VEGFR2 - generic cascades

Pathway Network for Development VEGF signaling via VEGFR2 - generic cascades

Pathway network for the Development VEGF signaling via VEGFR2 - generic cascades SuperPath

Member Pathways for Development VEGF signaling via VEGFR2 - generic cascades

Pathways in the Development VEGF signaling via VEGFR2 - generic cascades SuperPath

Gene overlap in member pathways for Development VEGF signaling via VEGFR2 - generic cascades SuperPath

Associated Genes for Development VEGF signaling via VEGFR2 - generic cascades

Associated Disorders for Development VEGF signaling via VEGFR2 - generic cascades

Disorders associated with Development VEGF signaling via VEGFR2 - generic cascades SuperPath

STRING Interaction Network for Development VEGF signaling via VEGFR2 - generic cascades

Sources for Development VEGF signaling via VEGFR2 - generic cascades