Developmental Cell Lineages of the Integumentary System

Pathway network for the Developmental Cell Lineages of the Integumentary System SuperPath

Sources:

Reactome

Pathways in the Developmental Cell Lineages of the Integumentary System SuperPath

#	Name	Source	Genes
1	Developmental Cell Lineages of the Integumentary System	Reactome	ABCG2 ACTA2 ALDH1A1 ALDH1A3 AQP3 AREG CALML5 CASP14 CD44 CNN1 CSPG4 DLL1 DLX5 DMKN EGF EGFR EPCAM ERBB2 FABP5 FGF10 FLG GATA3 GJB3 HOPX ITGA6 ITGB1 ITGB4 IVL KLK5 KLK7 KPRP KRT1 KRT10 KRT14 KRT15 KRT19 KRT24 KRT5 KRT78 KRTDAP LGALS7 LGALS7B LORICRIN LRIG1 MME MYH11 NUMB PRSS3 SBSN SPINK5 SPRR2A TFAP2A TFAP2C TFRC TGFA VIM YAP1 (see all 57) (see less)
2	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Reactome	ABCG2 AQP3 CALML5 CASP14 CSPG4 DLL1 DMKN EGF FABP5 FLG GJB3 HOPX ITGA6 ITGB1 ITGB4 IVL KLK5 KLK7 KPRP KRT1 KRT10 KRT14 KRT15 KRT19 KRT24 KRT5 KRT78 KRTDAP LGALS7 LGALS7B LORICRIN LRIG1 NUMB PRSS3 SBSN SPINK5 SPRR2A TFRC YAP1 (see all 39) (see less)
3	Developmental Lineages of the Mammary Gland	Reactome	ACTA2 ALDH1A1 ALDH1A3 AREG CD44 CNN1 DLX5 EGF EGFR EPCAM ERBB2 FGF10 GATA3 ITGA6 ITGB1 KRT14 KRT5 MME MYH11 TFAP2A TFAP2C TGFA VIM (see all 23) (see less)
4	Developmental Lineage of Mammary Gland Myoepithelial Cells	Reactome	ACTA2 ALDH1A1 ALDH1A3 AREG CD44 CNN1 EGF EGFR EPCAM ERBB2 ITGA6 ITGB1 KRT14 KRT5 MME MYH11 TGFA VIM (see all 18) (see less)
5	Developmental Lineage of Mammary Stem Cells	Reactome	ALDH1A1 ALDH1A3 CD44 DLX5 EPCAM ERBB2 FGF10 GATA3 ITGA6 ITGB1 KRT5 TFAP2A TFAP2C (see all 13) (see less)

Gene overlap in member pathways for Developmental Cell Lineages of the Integumentary System SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ITGA6	Integrin Subunit Alpha 6	Protein Coding	5
2	ITGB1	Integrin Subunit Beta 1	Protein Coding	5
3	KRT5	Keratin 5	Protein Coding	5
4	EGF	Epidermal Growth Factor	Protein Coding	4
5	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	4
6	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	4
7	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	4
8	KRT14	Keratin 14	Protein Coding	4
9	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	4
10	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	4
11	CNN1	Calponin 1	Protein Coding	3
12	DLX5	Distal-Less Homeobox 5	Protein Coding	3
13	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
14	FGF10	Fibroblast Growth Factor 10	Protein Coding	3
15	GATA3	GATA Binding Protein 3	Protein Coding	3
16	AREG	Amphiregulin	Protein Coding	3
17	MME	Membrane Metalloendopeptidase	Protein Coding	3
18	MYH11	Myosin Heavy Chain 11	Protein Coding	3
19	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	3
20	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	3
21	TFAP2C	Transcription Factor AP-2 Gamma	Protein Coding	3
22	TGFA	Transforming Growth Factor Alpha	Protein Coding	3
23	VIM	Vimentin	Protein Coding	3
24	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	2
25	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	2
26	CSPG4	Chondroitin Sulfate Proteoglycan 4	Protein Coding	2
27	KRT24	Keratin 24	Protein Coding	2
28	KRT78	Keratin 78	Protein Coding	2
29	FABP5	Fatty Acid Binding Protein 5	Protein Coding	2
30	FLG	Filaggrin	Protein Coding	2
31	CASP14	Caspase 14	Protein Coding	2
32	KLK5	Kallikrein Related Peptidase 5	Protein Coding	2
33	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	2
34	GJB3	Gap Junction Protein Beta 3	Protein Coding	2
35	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	2
36	AQP3	Aquaporin 3 (Gill Blood Group)	Protein Coding	2
37	ITGB4	Integrin Subunit Beta 4	Protein Coding	2
38	IVL	Involucrin	Protein Coding	2
39	SBSN	Suprabasin	Protein Coding	2
40	KRT1	Keratin 1	Protein Coding	2
41	KRT10	Keratin 10	Protein Coding	2
42	KRT15	Keratin 15	Protein Coding	2
43	KRT19	Keratin 19	Protein Coding	2
44	KRTDAP	Keratinocyte Differentiation Associated Protein	Protein Coding	2
45	LGALS7	Galectin 7	Protein Coding	2
46	LORICRIN	Loricrin Cornified Envelope Precursor Protein	Protein Coding	2
47	KPRP	Keratinocyte Proline Rich Protein	Protein Coding	2
48	CALML5	Calmodulin Like 5	Protein Coding	2
49	PRSS3	Serine Protease 3	Protein Coding	2
50	KLK7	Kallikrein Related Peptidase 7	Protein Coding	2
51	LGALS7B	Galectin 7B	Protein Coding	2
52	SPRR2A	Small Proline Rich Protein 2A	Protein Coding	2
53	TFRC	Transferrin Receptor	Protein Coding	2
54	HOPX	HOP Homeobox	Protein Coding	2
55	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	2
56	DMKN	Dermokine	Protein Coding	2
57	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2

Disorders associated with Developmental Cell Lineages of the Integumentary System SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung cancer susceptibility 3	Enrichment	ACTA2, EGFR, ERBB2, FGF10	8.21
2	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4, KRT14, KRT5	6.66
3	Epidermolysis bullosa simplex	Enrichment	ITGB4, KRT14, KRT5	6.12
4	Epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT14, KRT5	5.78
5	Epidermolysis bullosa	Enrichment	ITGA6, KRT5	5.07
6	Lung cancer	Enrichment	ACTA2, EGFR, ERBB2	5.02
7	Epidermolysis bullosa simplex 1b, generalized intermediate	Enrichment	KRT14, KRT5	5.00
8	Epidermolysis bullosa simplex generalized type	Enrichment	KRT14, KRT5	5.00
9	Epidermolysis bullosa simplex 2f, with mottled pigmentation	Enrichment	KRT14, KRT5	4.78
10	Epidermolysis bullosa simplex 1a, generalized severe	Enrichment	KRT14, KRT5	4.78
11	Ichthyosis with confetti	Enrichment	KRT1, KRT10	4.62
12	Ichthyosis, annular epidermolytic, 1	Enrichment	KRT1, KRT10	4.62
13	Annular epidermolytic ichthyosis	Enrichment	KRT1, KRT10	4.62
14	Autosomal dominant epidermolytic ichthyosis	Enrichment	KRT1, KRT10	4.62
15	Skin disease	Enrichment	FLG, ITGB4, KRT14	4.49
16	Epidermolytic hyperkeratosis	Enrichment	KRT1, KRT10	4.32
17	Epidermolytic hyperkeratosis 1	Enrichment	KRT1, KRT10	4.10
18	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2	4.04
19	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	3.92
20	Microphthalmia	Enrichment	ALDH1A3, TFAP2A	3.71
21	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJB3, LORICRIN	3.65
22	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	3.54
23	Bladder cancer	Enrichment	EGFR, ERBB2	3.18
24	Gastric cancer	Enrichment	EPCAM, ERBB2	3.13
25	Paget disease, extramammary	Enrichment	ERBB2	3.02
26	Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive	Enrichment	DLX5	3.02
27	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	3.02
28	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	3.02
29	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	3.02
30	Lynch syndrome 8	Enrichment	EPCAM	3.02
31	Split hand-foot malformation 1 with sensorineural hearing loss	Enrichment	DLX5	3.02
32	Interstitial lung disease specific to childhood	Enrichment	FGF10	3.02
33	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	3.02
34	Dermatopathia pigmentosa reticularis	Enrichment	KRT14	2.88
35	Hypomagnesemia 4, renal	Enrichment	EGF	2.88
36	Naegeli-franceschetti-jadassohn syndrome	Enrichment	KRT14	2.88
37	Spinocerebellar ataxia 43	Enrichment	MME	2.88
38	Congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization	Enrichment	MME	2.88
39	Charcot-marie-tooth disease type 2t	Enrichment	MME	2.88
40	Mme-related autosomal dominant charcot marie tooth disease type 2	Enrichment	MME	2.88
41	Premature aging	Enrichment	VIM	2.88
42	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.88
43	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, MYH11	2.82
44	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	2.72
45	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.72
46	Epidermolysis bullosa simplex 2e, with migratory circinate erythema	Enrichment	KRT5	2.72
47	Diarrhea 5, with tufting enteropathy, congenital	Enrichment	EPCAM	2.72
48	Epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT5	2.72
49	Microphthalmia, isolated 8	Enrichment	ALDH1A3	2.72
50	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	2.72
51	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	2.72
52	Esotropia	Enrichment	TFAP2A	2.72
53	Epidermolysis bullosa simplex 2a, generalized severe	Enrichment	KRT5	2.72
54	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	2.72
55	Lens subluxation	Enrichment	TFAP2A	2.72
56	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11	2.58
57	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.58
58	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.58
59	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.58
60	Moyamoya disease 5	Enrichment	ACTA2	2.58
61	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11	2.58
62	Sjogren-larsson syndrome	Enrichment	KRT14	2.58
63	Cataract 30	Enrichment	VIM	2.58
64	Visceral myopathy 2	Enrichment	MYH11	2.58
65	Charcot-marie-tooth disease, axonal, type 2t	Enrichment	MME	2.58
66	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10	2.54
67	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	2.54
68	Epidermolysis bullosa simplex 2b, generalized intermediate	Enrichment	KRT5	2.54
69	End stage renal disease	Enrichment	GATA3	2.54
70	Epidermolysis bullosa simplex 2c, localized	Enrichment	KRT5	2.54
71	Isolated anophthalmia-microphthalmia syndrome	Enrichment	ALDH1A3	2.54
72	Ichthyosis hystrix, curth-macklin type	Enrichment	KRT1	2.54
73	Palmoplantar keratoderma, nonepidermolytic	Enrichment	KRT1	2.54
74	Vohwinkel syndrome, variant form	Enrichment	LORICRIN	2.54
75	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.54
76	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.54
77	Deafness, autosomal dominant 2b	Enrichment	GJB3	2.54
78	Ichthyosis, congenital, autosomal recessive 12	Enrichment	CASP14	2.54
79	Ichthyosis, annular epidermolytic, 2	Enrichment	KRT1	2.54
80	Netherton syndrome	Enrichment	SPINK5	2.54
81	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.54
82	Keratosis palmoplantaris striata iii	Enrichment	KRT1	2.54
83	Immunodeficiency 46	Enrichment	TFRC	2.54
84	Blood group, junior system	Enrichment	ABCG2	2.54
85	Neuropathy with hearing impairment	Enrichment	GJB3	2.54
86	Palmoplantar keratoderma, epidermolytic, 2	Enrichment	KRT1	2.54
87	Ichthyosis linearis circumflexa	Enrichment	SPINK5	2.54
88	Autosomal recessive epidermolytic ichthyosis	Enrichment	KRT10	2.54
89	Colorectal cancer	Enrichment	EPCAM, ERBB2	2.52
90	Branchiooculofacial syndrome	Enrichment	TFAP2A	2.42
91	Dowling-degos disease 1	Enrichment	KRT5	2.42
92	Barrett esophagus	Enrichment	ERBB2	2.42
93	Dowling-degos disease	Enrichment	KRT5	2.42
94	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.40
95	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.40
96	Tricuspid valve insufficiency	Enrichment	MYH11	2.40
97	Amblyopia	Enrichment	TFAP2A	2.32
98	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYH11	2.28
99	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	2.28
100	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	MYH11	2.28
101	Mitral valve insufficiency	Enrichment	MYH11	2.28
102	Branchiootorenal syndrome 1	Enrichment	TFAP2A	2.24
103	Split-hand/foot malformation 1	Enrichment	DLX5	2.24
104	Ichthyosis hystrix, lambert type	Enrichment	KRT10	2.24
105	Ichthyosis vulgaris	Enrichment	FLG	2.24
106	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	KRT1	2.24
107	Dermatitis, atopic, 2	Enrichment	FLG	2.24
108	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.24
109	Epidermolytic hyperkeratosis 2a, autosomal dominant	Enrichment	KRT10	2.24
110	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.24
111	Ichthyosis, x-linked	Enrichment	FLG	2.24
112	Dermatitis	Enrichment	FLG	2.24
113	Epidermolytic acanthoma	Enrichment	KRT10	2.24
114	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.24
115	Visceral myopathy 1	Enrichment	MYH11	2.18
116	Histiocytoid hemangioma	Enrichment	VIM	2.18
117	Branchiootorenal syndrome	Enrichment	TFAP2A	2.17
118	Glioma susceptibility 1	Enrichment	ERBB2	2.12
119	Isolated split hand-split foot malformation	Enrichment	DLX5	2.12
120	Ovarian cancer	Enrichment	EGFR, ERBB2	2.11
121	Cowden syndrome 1	Enrichment	EGFR	2.10
122	Moyamoya disease 1	Enrichment	ACTA2	2.10
123	Intestinal pseudo-obstruction	Enrichment	MYH11	2.10
124	Lung squamous cell carcinoma	Enrichment	EGFR	2.10
125	Orofacial cleft 1	Enrichment	FGF10	2.07
126	Colonic benign neoplasm	Enrichment	EPCAM	2.07
127	Palmoplantar keratoderma, epidermolytic, 1	Enrichment	KRT1	2.07
128	Epidermolytic hyperkeratosis 2b, autosomal recessive	Enrichment	KRT10	2.07
129	Keratosis palmoplantaris striata	Enrichment	KRT1	2.07
130	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.03
131	Cat eye syndrome	Enrichment	TFAP2A	2.02
132	Lynch syndrome 1	Enrichment	EPCAM	2.02
133	Nanophthalmos	Enrichment	ALDH1A3	1.98
134	Epicanthus	Enrichment	TFAP2A	1.94
135	Otitis media	Enrichment	SPINK5	1.94
136	Deafness, autosomal recessive 1a	Enrichment	GJB3	1.94
137	Dermatitis, atopic	Enrichment	FLG	1.94
138	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.94
139	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	1.94
140	Epidermolytic nevus	Enrichment	KRT10	1.94
141	Gjb2-related autosomal recessive nonsyndromic hearing loss	Enrichment	GJB3	1.94
142	Adult hepatocellular carcinoma	Enrichment	EGF	1.93
143	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11	1.93
144	Neural tube defects	Enrichment	ITGB1	1.91
145	Inherited cancer-predisposing syndrome	Enrichment	EGFR, EPCAM	1.89
146	Cataract 30, multiple types	Enrichment	VIM	1.88
147	Lynch syndrome	Enrichment	EPCAM	1.85
148	Aplasia cutis congenita	Enrichment	ITGB4	1.84
149	Lip and oral cavity carcinoma	Enrichment	EGFR	1.80
150	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.77
151	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.77
152	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11	1.73
153	Macs syndrome	Enrichment	ALDH1A3	1.72
154	Myopia	Enrichment	MYH11	1.70
155	Paroxysmal dystonia	Enrichment	FLG	1.70
156	Gliosarcoma	Enrichment	EGFR	1.68
157	Giant cell glioblastoma	Enrichment	EGFR	1.65
158	Arteriovenous malformations of the brain	Enrichment	EGFR	1.60
159	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MME	1.60
160	Hirschsprung disease 1	Enrichment	ERBB2	1.56
161	Tooth agenesis	Enrichment	TGFA	1.54
162	Combined immunodeficiency	Enrichment	TFRC	1.51
163	Ichthyosis	Enrichment	FLG	1.51
164	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.51
165	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.51
166	Cakut	Enrichment	GATA3	1.49
167	Microphthalmia/coloboma 12	Enrichment	YAP1	1.43
168	Multiple sclerosis	Enrichment	ITGB4	1.40
169	Hereditary breast carcinoma	Enrichment	EPCAM	1.38
170	Connective tissue disease	Enrichment	ACTA2	1.38
171	Peripheral nervous system disease	Enrichment	MME	1.38
172	Neuropathy	Enrichment	MME	1.38
173	Coloboma of macula	Enrichment	YAP1	1.37
174	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.37
175	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.37
176	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	FLG	1.35
177	Microform holoprosencephaly	Enrichment	DLL1	1.35
178	Lobar holoprosencephaly	Enrichment	DLL1	1.35
179	Alobar holoprosencephaly	Enrichment	DLL1	1.32
180	Hypertelorism	Enrichment	TFAP2A	1.31
181	Semilobar holoprosencephaly	Enrichment	DLL1	1.30
182	Autism	Enrichment	ALDH1A3	1.17
183	Breast cancer	Enrichment	EPCAM	1.16
184	Nonsyndromic hearing loss	Enrichment	GJB3	0.94
185	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.87
186	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GJB3	0.86
187	Myeloma, multiple	Enrichment	YAP1	0.83
188	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJB3	0.64
189	Microcephaly	Enrichment	FLG	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Developmental Cell Lineages of the Integumentary System

Pathway Network for Developmental Cell Lineages of the Integumentary System

Pathway network for the Developmental Cell Lineages of the Integumentary System SuperPath

Member Pathways for Developmental Cell Lineages of the Integumentary System

Pathways in the Developmental Cell Lineages of the Integumentary System SuperPath

Gene overlap in member pathways for Developmental Cell Lineages of the Integumentary System SuperPath

Associated Genes for Developmental Cell Lineages of the Integumentary System

Associated Disorders for Developmental Cell Lineages of the Integumentary System

Disorders associated with Developmental Cell Lineages of the Integumentary System SuperPath

STRING Interaction Network for Developmental Cell Lineages of the Integumentary System

Sources for Developmental Cell Lineages of the Integumentary System